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IID00014
 UniprotP04150
ProteinGlucocorticoid receptor
GeneNR3C1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
777
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seqdisorder 77-262
 Evidence CD Reference
       Region 77-262 disorder
Seq 385-777 Hetero trimer : IID00103Complex
 Evidence X-RAY 7prw B Reference
       Region 7prw B 385-417 disorder
       Region 7prw B 418-488 order
       Region 7prw B 489-525 disorder
       Region 7prw B 526-777 order
 Evidence X-RAY 7prw A Reference
       Region 7prw A 385-414 disorder
       Region 7prw A 415-488 order
       Region 7prw A 489-525 disorder
       Region 7prw A 526-777 order
 Evidence X-RAY 7prv B Reference
       Region 7prv B 385-417 disorder
       Region 7prv B 418-488 order
       Region 7prv B 489-526 disorder
       Region 7prv B 527-776 order
       Region 7prv B 777-777 disorder
 Evidence X-RAY 7prv A Reference
       Region 7prv A 385-416 disorder
       Region 7prv A 417-488 order
       Region 7prv A 489-527 disorder
       Region 7prv A 528-776 order
       Region 7prv A 777-777 disorder
Seq 411-506 Homo dimer :
 Evidence X-RAY 5cbx A Reference
       Region 5cbx A 415-418 disorder
       Region 5cbx A 419-490 order
       Region 5cbx A 491-495 disorder
 Evidence X-RAY 5cbx B Reference
       Region 5cbx B 415-416 disorder
       Region 5cbx B 417-490 order
       Region 5cbx B 491-495 disorder
 Evidence X-RAY 5cbx E Reference
       Region 5cbx E 415-416 disorder
       Region 5cbx E 417-489 order
       Region 5cbx E 490-495 disorder
 Evidence X-RAY 5cbx F Reference
       Region 5cbx F 415-416 disorder
       Region 5cbx F 417-490 order
       Region 5cbx F 491-495 disorder
 Evidence X-RAY 5cby A Reference
       Region 5cby A 415-416 disorder
       Region 5cby A 417-492 order
       Region 5cby A 493-495 disorder
 Evidence X-RAY 5cby B Reference
       Region 5cby B 415-417 disorder
       Region 5cby B 418-489 order
       Region 5cby B 490-495 disorder
 Evidence X-RAY 5cbz A Reference
       Region 5cbz A 419-490 order
       Region 5cbz A 491-495 disorder
 Evidence X-RAY 5cbz B Reference
       Region 5cbz B 419-491 order
       Region 5cbz B 492-495 disorder
 Evidence X-RAY 5cbz E Reference
       Region 5cbz E 419-491 order
       Region 5cbz E 492-495 disorder
 Evidence X-RAY 5cbz F Reference
       Region 5cbz F 419-489 order
       Region 5cbz F 490-495 disorder
 Evidence X-RAY 5cc1 A Reference
       Region 5cc1 A 417-491 order
       Region 5cc1 A 492-506 disorder
 Evidence X-RAY 5cc1 B Reference
       Region 5cc1 B 417-417 disorder
       Region 5cc1 B 418-490 order
       Region 5cc1 B 491-506 disorder
 Evidence X-RAY 5cc1 W Reference
       Region 5cc1 W 417-491 order
       Region 5cc1 W 492-506 disorder
 Evidence X-RAY 5cc1 X Reference
       Region 5cc1 X 417-417 disorder
       Region 5cc1 X 418-490 order
       Region 5cc1 X 491-506 disorder
 Evidence X-RAY 5e69 A Reference
       Region 5e69 A 417-417 disorder
       Region 5e69 A 418-490 order
       Region 5e69 A 491-506 disorder
 Evidence X-RAY 5e69 B Reference
       Region 5e69 B 417-417 disorder
       Region 5e69 B 418-490 order
       Region 5e69 B 491-506 disorder
 Evidence X-RAY 5e6a A Reference
       Region 5e6a A 417-417 disorder
       Region 5e6a A 418-490 order
       Region 5e6a A 491-506 disorder
 Evidence X-RAY 5e6a B Reference
       Region 5e6a B 417-417 disorder
       Region 5e6a B 418-490 order
       Region 5e6a B 491-506 disorder
 Evidence X-RAY 5e6b A Reference
       Region 5e6b A 417-490 order
       Region 5e6b A 491-506 disorder
 Evidence X-RAY 5e6b B Reference
       Region 5e6b B 417-417 disorder
       Region 5e6b B 418-490 order
       Region 5e6b B 491-506 disorder
 Evidence X-RAY 5e6c A Reference
       Region 5e6c A 417-417 disorder
       Region 5e6c A 418-495 order
       Region 5e6c A 496-506 disorder
 Evidence X-RAY 5e6c B Reference
       Region 5e6c B 417-418 disorder
       Region 5e6c B 419-490 order
       Region 5e6c B 491-506 disorder
 Evidence X-RAY 5e6d A Reference
       Region 5e6d A 417-417 disorder
       Region 5e6d A 418-490 order
       Region 5e6d A 491-506 disorder
 Evidence X-RAY 5e6d B Reference
       Region 5e6d B 417-418 disorder
       Region 5e6d B 419-490 order
       Region 5e6d B 491-506 disorder
 Evidence X-RAY 5emc A Reference
       Region 5emc A 411-418 disorder
       Region 5emc A 419-488 order
       Region 5emc A 489-500 disorder
 Evidence X-RAY 5emc B Reference
       Region 5emc B 411-417 disorder
       Region 5emc B 418-489 order
       Region 5emc B 490-500 disorder
 Evidence X-RAY 5emp A Reference
       Region 5emp A 411-418 disorder
       Region 5emp A 419-489 order
       Region 5emp A 490-500 disorder
 Evidence X-RAY 5emp B Reference
       Region 5emp B 411-418 disorder
       Region 5emp B 419-489 order
       Region 5emp B 490-500 disorder
 Evidence X-RAY 5emq A Reference
       Region 5emq A 411-418 disorder
       Region 5emq A 419-488 order
       Region 5emq A 489-500 disorder
 Evidence X-RAY 5emq B Reference
       Region 5emq B 411-417 disorder
       Region 5emq B 418-489 order
       Region 5emq B 490-500 disorder
 Evidence X-RAY 6bqu A Reference
       Region 6bqu A 421-489 order
       Region 6bqu A 490-490 disorder
 Evidence X-RAY 6bqu B Reference
       Region 6bqu B 421-490 order
 Evidence X-RAY 6x6d A Reference
       Region 6x6d A 417-490 order
 Evidence X-RAY 6x6d B Reference
       Region 6x6d B 417-417 disorder
       Region 6x6d B 418-490 order
 Evidence X-RAY 6x6e A Reference
       Region 6x6e A 417-418 disorder
       Region 6x6e A 419-491 order
 Evidence X-RAY 6x6e B Reference
       Region 6x6e B 417-418 disorder
       Region 6x6e B 419-489 order
       Region 6x6e B 490-491 disorder
Seq 417-506 Homo dimer :
 Evidence X-RAY 4hn5 A Reference
       Region 4hn5 A 417-418 disorder
       Region 4hn5 A 419-490 order
       Region 4hn5 A 491-506 disorder
 Evidence X-RAY 4hn5 B Reference
       Region 4hn5 B 417-417 disorder
       Region 4hn5 B 418-490 order
       Region 4hn5 B 491-506 disorder
 Evidence X-RAY 4hn6 A Reference
       Region 4hn6 A 417-418 disorder
       Region 4hn6 A 419-490 order
       Region 4hn6 A 491-506 disorder
 Evidence X-RAY 4hn6 B Reference
       Region 4hn6 B 417-418 disorder
       Region 4hn6 B 419-490 order
       Region 4hn6 B 491-506 disorder
 Evidence X-RAY 5va0 A Reference
       Region 5va0 A 419-488 order
       Region 5va0 A 489-490 disorder
 Evidence X-RAY 5va0 B Reference
       Region 5va0 B 419-490 order
 Evidence X-RAY 5va7 A Reference
       Region 5va7 A 419-488 order
 Evidence X-RAY 5va7 B Reference
       Region 5va7 B 419-488 order
Seq 418-506 Homo octamer :
 Evidence X-RAY 6cfn H Reference
       Region 6cfn H 418-418 disorder
       Region 6cfn H 419-487 order
       Region 6cfn H 488-506 disorder
 Evidence X-RAY 6cfn G Reference
       Region 6cfn G 418-487 order
       Region 6cfn G 488-506 disorder
 Evidence X-RAY 6cfn F Reference
       Region 6cfn F 418-495 order
       Region 6cfn F 496-506 disorder
 Evidence X-RAY 6cfn E Reference
       Region 6cfn E 418-418 disorder
       Region 6cfn E 419-497 order
       Region 6cfn E 498-506 disorder
 Evidence X-RAY 6cfn D Reference
       Region 6cfn D 418-419 disorder
       Region 6cfn D 420-487 order
       Region 6cfn D 488-506 disorder
 Evidence X-RAY 6cfn C Reference
       Region 6cfn C 418-419 disorder
       Region 6cfn C 420-500 order
       Region 6cfn C 501-506 disorder
 Evidence X-RAY 6cfn B Reference
       Region 6cfn B 418-418 disorder
       Region 6cfn B 419-488 order
       Region 6cfn B 489-506 disorder
 Evidence X-RAY 6cfn A Reference
       Region 6cfn A 418-418 disorder
       Region 6cfn A 419-498 order
       Region 6cfn A 499-506 disorder
Seq 500-777 Monomer :
 Evidence X-RAY 1nhz A Reference
       Region 1nhz A 500-529 disorder
       Region 1nhz A 530-759 order
       Region 1nhz A 760-767 disorder
       Region 1nhz A 768-776 order
       Region 1nhz A 777-777 disorder
Seq 500-777 Hetero dimer : IID00082Complex
 Evidence X-RAY 5g3j A Reference
       Region 5g3j A 500-528 disorder
       Region 5g3j A 529-776 order
       Region 5g3j A 777-777 disorder
 Evidence X-RAY 5g5w A Reference
       Region 5g5w A 500-529 disorder
       Region 5g5w A 530-776 order
       Region 5g5w A 777-777 disorder
 Evidence X-RAY 3k22 A Reference
       Region 3k22 A 521-525 disorder
       Region 3k22 A 526-616 order
       Region 3k22 A 617-617 disorder
       Region 3k22 A 618-776 order
       Region 3k22 A 777-777 disorder
 Evidence X-RAY 3k22 B Reference
       Region 3k22 B 521-523 disorder
       Region 3k22 B 524-616 order
       Region 3k22 B 617-617 disorder
       Region 3k22 B 618-705 order
       Region 3k22 B 706-706 disorder
       Region 3k22 B 707-707 order
       Region 3k22 B 708-708 disorder
       Region 3k22 B 709-776 order
       Region 3k22 B 777-777 disorder
 Evidence X-RAY 3k23 A Reference
       Region 3k23 A 521-524 disorder
       Region 3k23 A 525-549 order
       Region 3k23 A 550-550 disorder
       Region 3k23 A 551-632 order
       Region 3k23 A 633-637 disorder
       Region 3k23 A 638-743 order
       Region 3k23 A 744-744 disorder
       Region 3k23 A 745-776 order
       Region 3k23 A 777-777 disorder
 Evidence X-RAY 3k23 B Reference
       Region 3k23 B 521-526 disorder
       Region 3k23 B 527-705 order
       Region 3k23 B 706-708 disorder
       Region 3k23 B 709-776 order
       Region 3k23 B 777-777 disorder
 Evidence X-RAY 3k23 C Reference
       Region 3k23 C 521-524 disorder
       Region 3k23 C 525-681 order
       Region 3k23 C 682-682 disorder
       Region 3k23 C 683-745 order
       Region 3k23 C 746-746 disorder
       Region 3k23 C 747-764 order
       Region 3k23 C 765-767 disorder
       Region 3k23 C 768-775 order
       Region 3k23 C 776-777 disorder
 Evidence X-RAY 5nfp A Reference
       Region 5nfp A 500-529 disorder
       Region 5nfp A 530-776 order
       Region 5nfp A 777-777 disorder
 Evidence X-RAY 5nft A Reference
       Region 5nft A 500-528 disorder
       Region 5nft A 529-776 order
       Region 5nft A 777-777 disorder
 Evidence X-RAY 4p6w A Reference
       Region 4p6w A 526-777 order
 Evidence X-RAY 4p6x A Reference
       Region 4p6x A 523-525 disorder
       Region 4p6x A 526-777 order
 Evidence X-RAY 4p6x C Reference
       Region 4p6x C 523-777 order
 Evidence X-RAY 4p6x E Reference
       Region 4p6x E 523-777 order
 Evidence X-RAY 4p6x G Reference
       Region 4p6x G 523-776 order
       Region 4p6x G 777-777 disorder
 Evidence X-RAY 4p6x I Reference
       Region 4p6x I 523-777 order
 Evidence X-RAY 4p6x K Reference
       Region 4p6x K 523-777 order
 Evidence X-RAY 1p93 A Reference
       Region 1p93 A 500-526 disorder
       Region 1p93 A 527-704 order
       Region 1p93 A 705-707 disorder
       Region 1p93 A 708-776 order
       Region 1p93 A 777-777 disorder
 Evidence X-RAY 1p93 B Reference
       Region 1p93 B 500-528 disorder
       Region 1p93 B 529-704 order
       Region 1p93 B 705-707 disorder
       Region 1p93 B 708-776 order
       Region 1p93 B 777-777 disorder
 Evidence X-RAY 1p93 C Reference
       Region 1p93 C 500-526 disorder
       Region 1p93 C 527-704 order
       Region 1p93 C 705-707 disorder
       Region 1p93 C 708-776 order
       Region 1p93 C 777-777 disorder
 Evidence X-RAY 1p93 D Reference
       Region 1p93 D 500-526 disorder
       Region 1p93 D 527-704 order
       Region 1p93 D 705-707 disorder
       Region 1p93 D 708-776 order
       Region 1p93 D 777-777 disorder
 Evidence X-RAY 4udc A Reference
       Region 4udc A 500-528 disorder
       Region 4udc A 529-776 order
       Region 4udc A 777-777 disorder
 Evidence X-RAY 4csj A Reference
       Region 4csj A 500-529 disorder
       Region 4csj A 530-776 order
       Region 4csj A 777-777 disorder
 Evidence X-RAY 6el6 A Reference
       Region 6el6 A 500-529 disorder
       Region 6el6 A 530-776 order
       Region 6el6 A 777-777 disorder
 Evidence X-RAY 6el7 A Reference
       Region 6el7 A 500-529 disorder
       Region 6el7 A 530-776 order
       Region 6el7 A 777-777 disorder
 Evidence X-RAY 6el9 A Reference
       Region 6el9 A 500-529 disorder
       Region 6el9 A 530-776 order
       Region 6el9 A 777-777 disorder
 Evidence X-RAY 4udd A Reference
       Region 4udd A 500-528 disorder
       Region 4udd A 529-777 order
Seq 518-530 Hetero octamer : IID00061Complex
 Evidence X-RAY 6yo8 H Reference
       Region 6yo8 H 518-519 disorder
       Region 6yo8 H 520-530 order
 Evidence X-RAY 6yo8 G Reference
       Region 6yo8 G 518-519 disorder
       Region 6yo8 G 520-530 order
 Evidence X-RAY 6yo8 F Reference
       Region 6yo8 F 518-518 disorder
       Region 6yo8 F 519-530 order
 Evidence X-RAY 6yo8 E Reference
       Region 6yo8 E 518-518 disorder
       Region 6yo8 E 519-530 order
Seq 518-530 Hetero tetramer : IID00061Complex
 Evidence X-RAY 8a9g D Reference
       Region 8a9g D 518-530 order
 Evidence X-RAY 8a9g C Reference
       Region 8a9g C 518-518 disorder
       Region 8a9g C 519-530 order
Seq 518-530,611-623 Hetero tetramer : IID00061Complex
 Evidence X-RAY 6yos C Reference
       Region 6yos C 518-519 disorder
       Region 6yos C 520-528 order
       Region 6yos C 529-530 disorder
       Region 6yos C 611-612 disorder
       Region 6yos C 613-621 order
       Region 6yos C 622-623 disorder
Seq 521-777 Hetero tetramer : IID00082Complex
 Evidence X-RAY 3cld A Reference
       Region 3cld A 521-525 disorder
       Region 3cld A 526-615 order
       Region 3cld A 616-618 disorder
       Region 3cld A 619-704 order
       Region 3cld A 705-709 disorder
       Region 3cld A 710-776 order
       Region 3cld A 777-777 disorder
 Evidence X-RAY 3cld B Reference
       Region 3cld B 521-527 disorder
       Region 3cld B 528-615 order
       Region 3cld B 616-618 disorder
       Region 3cld B 619-704 order
       Region 3cld B 705-709 disorder
       Region 3cld B 710-776 order
       Region 3cld B 777-777 disorder
 Evidence X-RAY 3e7c A Reference
       Region 3e7c A 521-525 disorder
       Region 3e7c A 526-615 order
       Region 3e7c A 616-618 disorder
       Region 3e7c A 619-776 order
       Region 3e7c A 777-777 disorder
 Evidence X-RAY 3e7c B Reference
       Region 3e7c B 521-524 disorder
       Region 3e7c B 525-615 order
       Region 3e7c B 616-617 disorder
       Region 3e7c B 618-703 order
       Region 3e7c B 704-708 disorder
       Region 3e7c B 709-776 order
       Region 3e7c B 777-777 disorder
Seq 521-777 Hetero tetramer : IID00082Complex
 Evidence X-RAY 1m2z D Reference
       Region 1m2z D 521-524 disorder
       Region 1m2z D 525-777 order
 Evidence X-RAY 1m2z A Reference
       Region 1m2z A 521-522 disorder
       Region 1m2z A 523-777 order
Seq 522-549 Hetero tetramer : G5AQS2
 Evidence X-RAY 5uc1 B Reference
       Region 5uc1 B 522-523 disorder
       Region 5uc1 B 524-549 order
 Evidence X-RAY 5uc1 A Reference
       Region 5uc1 A 522-523 disorder
       Region 5uc1 A 524-549 order
Seq 522-777 Hetero tetramer : IID00189Complex
 Evidence X-RAY 4mdd B Reference
       Region 4mdd B 522-530 disorder
       Region 4mdd B 531-741 order
       Region 4mdd B 742-767 disorder
       Region 4mdd B 768-776 order
       Region 4mdd B 777-777 disorder
 Evidence X-RAY 4mdd A Reference
       Region 4mdd A 522-529 disorder
       Region 4mdd A 530-776 order
       Region 4mdd A 777-777 disorder
Seq 522-777 Hetero tetramer :
 Evidence X-RAY 4lsj A Reference
       Region 4lsj A 522-525 disorder
       Region 4lsj A 526-702 order
       Region 4lsj A 703-710 disorder
       Region 4lsj A 711-777 order
Seq 522-777 Homo dimer :
 Evidence X-RAY 6dxk A Reference
       Region 6dxk A 522-529 disorder
       Region 6dxk A 530-776 order
       Region 6dxk A 777-777 disorder
 Evidence X-RAY 6dxk B Reference
       Region 6dxk B 522-529 disorder
       Region 6dxk B 530-777 order
 Evidence X-RAY 5uc3 A Reference
       Region 5uc3 A 522-525 disorder
       Region 5uc3 A 526-747 order
       Region 5uc3 A 748-766 disorder
       Region 5uc3 A 767-776 order
       Region 5uc3 A 777-777 disorder
 Evidence X-RAY 5uc3 B Reference
       Region 5uc3 B 522-525 disorder
       Region 5uc3 B 526-615 order
       Region 5uc3 B 616-616 disorder
       Region 5uc3 B 617-747 order
       Region 5uc3 B 748-766 disorder
       Region 5uc3 B 767-776 order
       Region 5uc3 B 777-777 disorder
Seq 522-777 Hetero dimer :
 Evidence X-RAY 4lsj A Reference
       Region 4lsj A 522-525 disorder
       Region 4lsj A 526-702 order
       Region 4lsj A 703-710 disorder
       Region 4lsj A 711-777 order
Seq 525-777 Hetero dimer : IID00083Complex
 Evidence X-RAY 3bqd A Reference
       Region 3bqd A 525-777 order
Seq 528-777 Hetero trimer : IID00189Complex
 Evidence X-RAY 3h52 A Reference
       Region 3h52 A 528-762 order
       Region 3h52 A 763-766 disorder
       Region 3h52 A 767-776 order
       Region 3h52 A 777-777 disorder
 Evidence X-RAY 3h52 D Reference
       Region 3h52 D 528-529 disorder
       Region 3h52 D 530-741 order
       Region 3h52 D 742-750 disorder
       Region 3h52 D 751-761 order
       Region 3h52 D 762-765 disorder
       Region 3h52 D 766-776 order
       Region 3h52 D 777-777 disorder
 Evidence X-RAY 3h52 B Reference
       Region 3h52 B 528-776 order
       Region 3h52 B 777-777 disorder
 Evidence X-RAY 3h52 C Reference
       Region 3h52 C 528-740 order
       Region 3h52 C 741-753 disorder
       Region 3h52 C 754-776 order
       Region 3h52 C 777-777 disorder
Seq 529-777 Hetero dimer : IID00103Complex
 Evidence X-RAY 7prx A Reference
       Region 7prx A 529-776 order
       Region 7prx A 777-777 disorder
Seq 611-623 Hetero tetramer : IID00061Complex
 Evidence X-RAY 6ymo D Reference
       Region 6ymo D 611-614 disorder
       Region 6ymo D 615-620 order
       Region 6ymo D 621-623 disorder
 Evidence X-RAY 6ymo C Reference
       Region 6ymo C 611-615 disorder
       Region 6ymo C 616-620 order
       Region 6ymo C 621-623 disorder
SeqProS verified 518-530 Hetero tetramer : IID00061Complex
       Region 8a9g C 519-530 order
       Region 8a9g D 518-530 order
       Region 1nhz A 500-529 disorder
SeqProS verified 518-530 Hetero octamer : IID00061Complex
       Region 6yo8 E 519-530 order
       Region 6yo8 F 519-530 order
       Region 6yo8 G 520-530 order
       Region 6yo8 H 520-530 order
       Region 1nhz A 500-529 disorder
SeqProS verified 518-530 Hetero tetramer : IID00061Complex
       Region 6yos C 520-528 order
       Region 1nhz A 500-529 disorder
Seqphosphorylation
    404-404 Phosphoserine; by GSK3-beta
    267-267 Phosphoserine
    226-226 Phosphoserine
    211-211 Phosphoserine
    203-203 Phosphoserine
    141-141 Phosphoserine
    134-134 Phosphoserine
    113-113 Phosphoserine
    45-45 Phosphoserine
    8-8 Phosphothreonine
Seqacetylation
    1-1 N-acetylmethionine
    1-1 N-acetylmethionine
    495-495 N6-acetyllysine
    494-494 N6-acetyllysine
    492-492 N6-acetyllysine
    480-480 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-179,234-418,487-529
Order 180-233,419-486,530-777
ProS 5-36,63-80,86-90,112-131,137-140,145-179,237-248,275-305,328-337,362-367,374-377,386-402,487-500
AlphaFold
Disorder 1-417,490-529,616-618,706-706,777-777
Order 418-489,530-615,619-705,707-776
Pfam Hmmer
PF00105 419-494 4.9e-46
PF00104 568-756 2.1e-45
SEG 39-56 ,141-150 ,394-418
Function
Function in SwissProt
Has lowest transcriptional activation activity of all isoforms created by alternative initiation (PubMed:15866175, PubMed:23820903). Has transcriptional repression activity (PubMed:23303127).
Biological Process
See also
Diagram with PDB data
NCOA1/RARACrystal structure of RARalpha ligand binding domain in complex with an agonist ligand (Am580) and a coactivator fragment
EHMT2/CBX3Crystal structure of the complex of human chromobox homolog 3 (CBX3) with peptide