Search Keyword:


Search option:


IID00014
 UniprotP04150
ProteinGlucocorticoid receptor
GeneNR3C1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
777
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seqdisorder 77-262
 Evidence CD Reference
       Region 77-262 disorder
Seq 411-506 Homo dimer :
 Evidence X-RAY 5emq B Reference
       Region 5emq B 411-417 disorder
       Region 5emq B 418-489 order
       Region 5emq B 490-500 disorder
 Evidence X-RAY 5emq A Reference
       Region 5emq A 411-418 disorder
       Region 5emq A 419-488 order
       Region 5emq A 489-500 disorder
 Evidence X-RAY 5emp B Reference
       Region 5emp B 411-418 disorder
       Region 5emp B 419-489 order
       Region 5emp B 490-500 disorder
 Evidence X-RAY 5emp A Reference
       Region 5emp A 411-418 disorder
       Region 5emp A 419-489 order
       Region 5emp A 490-500 disorder
 Evidence X-RAY 5emc B Reference
       Region 5emc B 411-417 disorder
       Region 5emc B 418-489 order
       Region 5emc B 490-500 disorder
 Evidence X-RAY 5emc A Reference
       Region 5emc A 411-418 disorder
       Region 5emc A 419-488 order
       Region 5emc A 489-500 disorder
 Evidence X-RAY 5e6d B Reference
       Region 5e6d B 417-418 disorder
       Region 5e6d B 419-490 order
       Region 5e6d B 491-506 disorder
 Evidence X-RAY 5e6d A Reference
       Region 5e6d A 417-417 disorder
       Region 5e6d A 418-490 order
       Region 5e6d A 491-506 disorder
 Evidence X-RAY 5e6c B Reference
       Region 5e6c B 417-418 disorder
       Region 5e6c B 419-490 order
       Region 5e6c B 491-506 disorder
 Evidence X-RAY 5e6c A Reference
       Region 5e6c A 417-417 disorder
       Region 5e6c A 418-495 order
       Region 5e6c A 496-506 disorder
 Evidence X-RAY 5e6b B Reference
       Region 5e6b B 417-417 disorder
       Region 5e6b B 418-490 order
       Region 5e6b B 491-506 disorder
 Evidence X-RAY 5e6b A Reference
       Region 5e6b A 417-490 order
       Region 5e6b A 491-506 disorder
 Evidence X-RAY 5e6a B Reference
       Region 5e6a B 417-417 disorder
       Region 5e6a B 418-490 order
       Region 5e6a B 491-506 disorder
 Evidence X-RAY 5e6a A Reference
       Region 5e6a A 417-417 disorder
       Region 5e6a A 418-490 order
       Region 5e6a A 491-506 disorder
 Evidence X-RAY 5e69 B Reference
       Region 5e69 B 417-417 disorder
       Region 5e69 B 418-490 order
       Region 5e69 B 491-506 disorder
 Evidence X-RAY 5e69 A Reference
       Region 5e69 A 417-417 disorder
       Region 5e69 A 418-490 order
       Region 5e69 A 491-506 disorder
 Evidence X-RAY 5cc1 X Reference
       Region 5cc1 X 417-417 disorder
       Region 5cc1 X 418-490 order
       Region 5cc1 X 491-506 disorder
 Evidence X-RAY 5cc1 W Reference
       Region 5cc1 W 417-491 order
       Region 5cc1 W 492-506 disorder
 Evidence X-RAY 5cc1 B Reference
       Region 5cc1 B 417-417 disorder
       Region 5cc1 B 418-490 order
       Region 5cc1 B 491-506 disorder
 Evidence X-RAY 5cc1 A Reference
       Region 5cc1 A 417-491 order
       Region 5cc1 A 492-506 disorder
 Evidence X-RAY 5cbz F Reference
       Region 5cbz F 419-489 order
       Region 5cbz F 490-495 disorder
 Evidence X-RAY 5cbz E Reference
       Region 5cbz E 419-491 order
       Region 5cbz E 492-495 disorder
 Evidence X-RAY 5cbz B Reference
       Region 5cbz B 419-491 order
       Region 5cbz B 492-495 disorder
 Evidence X-RAY 5cbz A Reference
       Region 5cbz A 419-490 order
       Region 5cbz A 491-495 disorder
 Evidence X-RAY 5cby B Reference
       Region 5cby B 415-417 disorder
       Region 5cby B 418-489 order
       Region 5cby B 490-495 disorder
 Evidence X-RAY 5cby A Reference
       Region 5cby A 415-416 disorder
       Region 5cby A 417-492 order
       Region 5cby A 493-495 disorder
 Evidence X-RAY 5cbx F Reference
       Region 5cbx F 415-416 disorder
       Region 5cbx F 417-490 order
       Region 5cbx F 491-495 disorder
 Evidence X-RAY 5cbx E Reference
       Region 5cbx E 415-416 disorder
       Region 5cbx E 417-489 order
       Region 5cbx E 490-495 disorder
 Evidence X-RAY 5cbx B Reference
       Region 5cbx B 415-416 disorder
       Region 5cbx B 417-490 order
       Region 5cbx B 491-495 disorder
 Evidence X-RAY 5cbx A Reference
       Region 5cbx A 415-418 disorder
       Region 5cbx A 419-490 order
       Region 5cbx A 491-495 disorder
Seq 417-506 Homo dimer :
 Evidence X-RAY 5va7 B Reference
       Region 5va7 B 419-488 order
 Evidence X-RAY 5va7 A Reference
       Region 5va7 A 419-488 order
 Evidence X-RAY 5va0 B Reference
       Region 5va0 B 419-490 order
 Evidence X-RAY 5va0 A Reference
       Region 5va0 A 419-488 order
       Region 5va0 A 489-490 disorder
 Evidence X-RAY 4hn6 B Reference
       Region 4hn6 B 417-418 disorder
       Region 4hn6 B 419-490 order
       Region 4hn6 B 491-506 disorder
 Evidence X-RAY 4hn6 A Reference
       Region 4hn6 A 417-418 disorder
       Region 4hn6 A 419-490 order
       Region 4hn6 A 491-506 disorder
 Evidence X-RAY 4hn5 B Reference
       Region 4hn5 B 417-417 disorder
       Region 4hn5 B 418-490 order
       Region 4hn5 B 491-506 disorder
 Evidence X-RAY 4hn5 A Reference
       Region 4hn5 A 417-418 disorder
       Region 4hn5 A 419-490 order
       Region 4hn5 A 491-506 disorder
Seq 500-777 Hetero dimer : IID00082Complex
 Evidence X-RAY 4udd A Reference
       Region 4udd A 500-528 disorder
       Region 4udd A 529-777 order
 Evidence X-RAY 6el9 A Reference
       Region 6el9 A 500-529 disorder
       Region 6el9 A 530-776 order
       Region 6el9 A 777-777 disorder
 Evidence X-RAY 6el7 A Reference
       Region 6el7 A 500-529 disorder
       Region 6el7 A 530-776 order
       Region 6el7 A 777-777 disorder
 Evidence X-RAY 6el6 A Reference
       Region 6el6 A 500-529 disorder
       Region 6el6 A 530-776 order
       Region 6el6 A 777-777 disorder
 Evidence X-RAY 4csj A Reference
       Region 4csj A 500-529 disorder
       Region 4csj A 530-776 order
       Region 4csj A 777-777 disorder
 Evidence X-RAY 4udc A Reference
       Region 4udc A 500-528 disorder
       Region 4udc A 529-776 order
       Region 4udc A 777-777 disorder
 Evidence X-RAY 1p93 D Reference
       Region 1p93 D 500-526 disorder
       Region 1p93 D 527-704 order
       Region 1p93 D 705-707 disorder
       Region 1p93 D 708-776 order
       Region 1p93 D 777-777 disorder
 Evidence X-RAY 1p93 C Reference
       Region 1p93 C 500-526 disorder
       Region 1p93 C 527-704 order
       Region 1p93 C 705-707 disorder
       Region 1p93 C 708-776 order
       Region 1p93 C 777-777 disorder
 Evidence X-RAY 1p93 B Reference
       Region 1p93 B 500-528 disorder
       Region 1p93 B 529-704 order
       Region 1p93 B 705-707 disorder
       Region 1p93 B 708-776 order
       Region 1p93 B 777-777 disorder
 Evidence X-RAY 1p93 A Reference
       Region 1p93 A 500-526 disorder
       Region 1p93 A 527-704 order
       Region 1p93 A 705-707 disorder
       Region 1p93 A 708-776 order
       Region 1p93 A 777-777 disorder
 Evidence X-RAY 4p6x K Reference
       Region 4p6x K 523-777 order
 Evidence X-RAY 4p6x I Reference
       Region 4p6x I 523-777 order
 Evidence X-RAY 4p6x G Reference
       Region 4p6x G 523-776 order
       Region 4p6x G 777-777 disorder
 Evidence X-RAY 4p6x E Reference
       Region 4p6x E 523-777 order
 Evidence X-RAY 4p6x C Reference
       Region 4p6x C 523-777 order
 Evidence X-RAY 4p6x A Reference
       Region 4p6x A 523-525 disorder
       Region 4p6x A 526-777 order
 Evidence X-RAY 4p6w A Reference
       Region 4p6w A 526-777 order
 Evidence X-RAY 5nft A Reference
       Region 5nft A 500-528 disorder
       Region 5nft A 529-776 order
       Region 5nft A 777-777 disorder
 Evidence X-RAY 5nfp A Reference
       Region 5nfp A 500-529 disorder
       Region 5nfp A 530-776 order
       Region 5nfp A 777-777 disorder
 Evidence X-RAY 3k23 C Reference
       Region 3k23 C 521-524 disorder
       Region 3k23 C 525-681 order
       Region 3k23 C 682-682 disorder
       Region 3k23 C 683-745 order
       Region 3k23 C 746-746 disorder
       Region 3k23 C 747-764 order
       Region 3k23 C 765-767 disorder
       Region 3k23 C 768-775 order
       Region 3k23 C 776-777 disorder
 Evidence X-RAY 3k23 B Reference
       Region 3k23 B 521-526 disorder
       Region 3k23 B 527-705 order
       Region 3k23 B 706-708 disorder
       Region 3k23 B 709-776 order
       Region 3k23 B 777-777 disorder
 Evidence X-RAY 3k23 A Reference
       Region 3k23 A 521-524 disorder
       Region 3k23 A 525-549 order
       Region 3k23 A 550-550 disorder
       Region 3k23 A 551-632 order
       Region 3k23 A 633-637 disorder
       Region 3k23 A 638-743 order
       Region 3k23 A 744-744 disorder
       Region 3k23 A 745-776 order
       Region 3k23 A 777-777 disorder
 Evidence X-RAY 3k22 B Reference
       Region 3k22 B 521-523 disorder
       Region 3k22 B 524-616 order
       Region 3k22 B 617-617 disorder
       Region 3k22 B 618-705 order
       Region 3k22 B 706-706 disorder
       Region 3k22 B 707-707 order
       Region 3k22 B 708-708 disorder
       Region 3k22 B 709-776 order
       Region 3k22 B 777-777 disorder
 Evidence X-RAY 3k22 A Reference
       Region 3k22 A 521-525 disorder
       Region 3k22 A 526-616 order
       Region 3k22 A 617-617 disorder
       Region 3k22 A 618-776 order
       Region 3k22 A 777-777 disorder
 Evidence X-RAY 5g5w A Reference
       Region 5g5w A 500-529 disorder
       Region 5g5w A 530-776 order
       Region 5g5w A 777-777 disorder
 Evidence X-RAY 5g3j A Reference
       Region 5g3j A 500-528 disorder
       Region 5g3j A 529-776 order
       Region 5g3j A 777-777 disorder
Seq 500-777 Monomer :
 Evidence X-RAY 1nhz A Reference
       Region 1nhz A 500-529 disorder
       Region 1nhz A 530-759 order
       Region 1nhz A 760-767 disorder
       Region 1nhz A 768-776 order
       Region 1nhz A 777-777 disorder
Seq 521-777 Hetero tetramer : IID00082Complex
 Evidence X-RAY 1m2z D Reference
       Region 1m2z D 521-524 disorder
       Region 1m2z D 525-777 order
 Evidence X-RAY 1m2z A Reference
       Region 1m2z A 521-522 disorder
       Region 1m2z A 523-777 order
Seq 521-777 Hetero tetramer : IID00082Complex
 Evidence X-RAY 3e7c B Reference
       Region 3e7c B 521-524 disorder
       Region 3e7c B 525-615 order
       Region 3e7c B 616-617 disorder
       Region 3e7c B 618-703 order
       Region 3e7c B 704-708 disorder
       Region 3e7c B 709-776 order
       Region 3e7c B 777-777 disorder
 Evidence X-RAY 3e7c A Reference
       Region 3e7c A 521-525 disorder
       Region 3e7c A 526-615 order
       Region 3e7c A 616-618 disorder
       Region 3e7c A 619-776 order
       Region 3e7c A 777-777 disorder
 Evidence X-RAY 3cld B Reference
       Region 3cld B 521-527 disorder
       Region 3cld B 528-615 order
       Region 3cld B 616-618 disorder
       Region 3cld B 619-704 order
       Region 3cld B 705-709 disorder
       Region 3cld B 710-776 order
       Region 3cld B 777-777 disorder
 Evidence X-RAY 3cld A Reference
       Region 3cld A 521-525 disorder
       Region 3cld A 526-615 order
       Region 3cld A 616-618 disorder
       Region 3cld A 619-704 order
       Region 3cld A 705-709 disorder
       Region 3cld A 710-776 order
       Region 3cld A 777-777 disorder
Seq 522-777 Hetero tetramer : IID00189Complex
 Evidence X-RAY 4mdd B Reference
       Region 4mdd B 522-530 disorder
       Region 4mdd B 531-741 order
       Region 4mdd B 742-767 disorder
       Region 4mdd B 768-776 order
       Region 4mdd B 777-777 disorder
 Evidence X-RAY 4mdd A Reference
       Region 4mdd A 522-529 disorder
       Region 4mdd A 530-776 order
       Region 4mdd A 777-777 disorder
Seq 522-777 Hetero dimer :
 Evidence X-RAY 4lsj A Reference
       Region 4lsj A 522-525 disorder
       Region 4lsj A 526-702 order
       Region 4lsj A 703-710 disorder
       Region 4lsj A 711-777 order
Seq 522-777 Homo dimer :
 Evidence X-RAY 5uc3 B Reference
       Region 5uc3 B 522-525 disorder
       Region 5uc3 B 526-615 order
       Region 5uc3 B 616-616 disorder
       Region 5uc3 B 617-747 order
       Region 5uc3 B 748-766 disorder
       Region 5uc3 B 767-776 order
       Region 5uc3 B 777-777 disorder
 Evidence X-RAY 5uc3 A Reference
       Region 5uc3 A 522-525 disorder
       Region 5uc3 A 526-747 order
       Region 5uc3 A 748-766 disorder
       Region 5uc3 A 767-776 order
       Region 5uc3 A 777-777 disorder
Seq 522-777 Hetero tetramer :
 Evidence X-RAY 4lsj A Reference
       Region 4lsj A 522-525 disorder
       Region 4lsj A 526-702 order
       Region 4lsj A 703-710 disorder
       Region 4lsj A 711-777 order
Seq 525-777 Hetero dimer : IID00083Complex
 Evidence X-RAY 3bqd A Reference
       Region 3bqd A 525-777 order
Seq 528-777 Hetero trimer : IID00189Complex
 Evidence X-RAY 3h52 C Reference
       Region 3h52 C 528-740 order
       Region 3h52 C 741-753 disorder
       Region 3h52 C 754-776 order
       Region 3h52 C 777-777 disorder
 Evidence X-RAY 3h52 B Reference
       Region 3h52 B 528-776 order
       Region 3h52 B 777-777 disorder
 Evidence X-RAY 3h52 D Reference
       Region 3h52 D 528-529 disorder
       Region 3h52 D 530-741 order
       Region 3h52 D 742-750 disorder
       Region 3h52 D 751-761 order
       Region 3h52 D 762-765 disorder
       Region 3h52 D 766-776 order
       Region 3h52 D 777-777 disorder
 Evidence X-RAY 3h52 A Reference
       Region 3h52 A 528-762 order
       Region 3h52 A 763-766 disorder
       Region 3h52 A 767-776 order
       Region 3h52 A 777-777 disorder
Seqphosphorylation
    404-404 Phosphoserine; by GSK3-beta
    267-267 Phosphoserine
    226-226 Phosphoserine
    211-211 Phosphoserine
    203-203 Phosphoserine
    141-141 Phosphoserine
    134-134 Phosphoserine
    113-113 Phosphoserine
    45-45 Phosphoserine
    8-8 Phosphothreonine
Seqacetylation
    1-1 N-acetylmethionine
    1-1 N-acetylmethionine
    495-495 N6-acetyllysine
    494-494 N6-acetyllysine
    492-492 N6-acetyllysine
    480-480 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-179,234-418,487-529
Order 180-233,419-486,530-777
ProS 5-36,63-80,86-90,112-131,137-140,145-179,237-248,275-305,328-337,362-367,374-377,386-402,487-500
AlphaFold
Disorder 1-417,490-529,616-618,706-706,777-777
Order 418-489,530-615,619-705,707-776
Pfam Hmmer
PF00105 419-494 4.9e-46
PF00104 568-756 2.1e-45
SEG 39-56 ,141-150 ,394-418
Function
Function in SwissProt
Receptor for glucocorticoids (GC) (PubMed:27120390). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:9590696). Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (By similarity).
Isoform Alpha
Has transcriptional activation and repression activity (PubMed:15866175, PubMed:19248771, PubMed:20484466, PubMed:23820903, PubMed:11435610, PubMed:15769988, PubMed:17635946, PubMed:19141540, PubMed:21664385). Mediates glucocorticoid-induced apoptosis (PubMed:23303127). Promotes accurate chromosome segregation during mitosis (PubMed:25847991). May act as a tumor suppressor (PubMed:25847991). May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression (By similarity).
Isoform Beta
Acts as a dominant negative inhibitor of isoform Alpha (PubMed:7769088, PubMed:8621628, PubMed:20484466). Has intrinsic transcriptional activity independent of isoform Alpha when both isoforms are coexpressed (PubMed:19248771, PubMed:26711253). Loses this transcription modulator function on its own (PubMed:20484466). Has no hormone-binding activity (PubMed:8621628). May play a role in controlling glucose metabolism by maintaining insulin sensitivity (By similarity). Reduces hepatic gluconeogenesis through down-regulation of PEPCK in an isoform Alpha-dependent manner (PubMed:26711253). Directly regulates STAT1 expression in isoform Alpha-independent manner (PubMed:26711253).
Isoform Alpha-2
Has lower transcriptional activation activity than isoform Alpha. Exerts a dominant negative effect on isoform Alpha trans-repression mechanism (PubMed:20484466).
Isoform GR-P
Increases activity of isoform Alpha.
Isoform Alpha-B
More effective than isoform Alpha in transcriptional activation, but not repression activity.
Isoform 10
Has transcriptional activation activity.
Isoform Alpha-C1
Has transcriptional activation activity.
Isoform Alpha-C2
Has transcriptional activation activity.
Isoform Alpha-C3
Has highest transcriptional activation activity of all isoforms created by alternative initiation (PubMed:15866175, PubMed:23820903). Has transcriptional repression activity (PubMed:23303127). Mediates glucocorticoid-induced apoptosis (PubMed:23303127, PubMed:23820903).
Isoform Alpha-D1
Has transcriptional activation activity.
Isoform Alpha-D2
Has transcriptional activation activity.
Isoform Alpha-D3
Has lowest transcriptional activation activity of all isoforms created by alternative initiation (PubMed:15866175, PubMed:23820903). Has transcriptional repression activity (PubMed:23303127).
Biological Process
See also
Diagram with PDB data
NCOA1/RARACrystal structure of RARalpha ligand binding domain in complex with an agonist ligand (Am580) and a coactivator fragment
EHMT2/CBX3Crystal structure of the complex of human chromobox homolog 3 (CBX3) with peptide