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IID00019
 UniprotP0C0S5
ProteinHistone H2A.Z
GeneH2AZ1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
128
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-128 Hetero octamer : IID00016Complex,IID00058Complex,IID00062Complex,P06899
 Evidence X-RAY 5b31 G Reference
       Region 5b31 G 1-16 disorder
       Region 5b31 G 17-120 order
       Region 5b31 G 121-128 disorder
Seq 1-128 Hetero octamer : IID00016Complex,IID00058Complex,IID00239Complex,P06899
 Evidence X-RAY 5b32 G Reference
       Region 5b32 G 1-16 disorder
       Region 5b32 G 17-120 order
       Region 5b32 G 121-128 disorder
Seq 1-128 Hetero octamer : IID50135Complex,IID50147Complex,P62806
 Evidence X-RAY 1f66 G Reference
       Region 1f66 G 1-16 disorder
       Region 1f66 G 17-123 order
       Region 1f66 G 124-128 disorder
 Evidence X-RAY 1f66 C Reference
       Region 1f66 C 1-16 disorder
       Region 1f66 C 17-119 order
       Region 1f66 C 120-128 disorder
Seq 1-128 Hetero octamer : IID00058Complex,IID00239Complex,P06899
 Evidence X-RAY 5b33 G Reference
       Region 5b33 G 1-17 disorder
       Region 5b33 G 18-121 order
       Region 5b33 G 122-128 disorder
 Evidence X-RAY 5b33 C Reference
       Region 5b33 C 1-16 disorder
       Region 5b33 C 17-121 order
       Region 5b33 C 122-128 disorder
Seq 1-128 Hetero octamer : IID00058Complex,IID00062Complex,P06899
 Evidence X-RAY 3wa9 C Reference
       Region 3wa9 C 1-15 disorder
       Region 3wa9 C 16-121 order
       Region 3wa9 C 122-128 disorder
 Evidence X-RAY 3wa9 G Reference
       Region 3wa9 G 1-17 disorder
       Region 3wa9 G 18-121 order
       Region 3wa9 G 122-128 disorder
Seq 16-114 Hetero decamer : IID00870Complex,Q16778
 Evidence X-RAY 4nft D Reference
       Region 4nft D 16-18 disorder
       Region 4nft D 19-107 order
       Region 4nft D 108-114 disorder
 Evidence X-RAY 4nft C Reference
       Region 4nft C 16-18 disorder
       Region 4nft C 19-107 order
       Region 4nft C 108-114 disorder
 Evidence X-RAY 4nft B Reference
       Region 4nft B 16-16 order
       Region 4nft B 17-18 disorder
       Region 4nft B 19-107 order
       Region 4nft B 108-114 disorder
 Evidence X-RAY 4nft A Reference
       Region 4nft A 16-16 order
       Region 4nft A 17-18 disorder
       Region 4nft A 19-107 order
       Region 4nft A 108-114 disorder
Seq 19-128 Hetero trimer : P06899,Q15906
 Evidence X-RAY 5fug G Reference
       Region 5fug G 19-40 order
       Region 5fug G 41-44 disorder
       Region 5fug G 45-104 order
       Region 5fug G 105-128 disorder
 Evidence X-RAY 5fug D Reference
       Region 5fug D 19-40 order
       Region 5fug D 41-45 disorder
       Region 5fug D 46-107 order
       Region 5fug D 108-128 disorder
 Evidence X-RAY 5fug A Reference
       Region 5fug A 19-107 order
       Region 5fug A 108-128 disorder
 Evidence X-RAY 5fug J Reference
       Region 5fug J 19-103 order
       Region 5fug J 104-128 disorder
Seq 19-128 Hetero trimer : IID00870Complex,P06899
 Evidence X-RAY 4cay A Reference
       Region 4cay A 19-40 order
       Region 4cay A 41-44 disorder
       Region 4cay A 45-108 order
       Region 4cay A 109-128 disorder
Seq 22-113 Hetero dimer : Q9VKM6
 Evidence X-RAY 5chl B Reference
       Region 5chl B 22-106 order
       Region 5chl B 107-113 disorder
Seqacetylation
    5-5 N6-acetyllysine; alternate
    8-8 N6-acetyllysine; alternate
    12-12 N6-acetyllysine; alternate
    14-14 N6-acetyllysine; alternate
 
Prediction
NeProc
Disorder 1-21,121-128
Order 22-120
ProS 14-21
AlphaFold
Disorder 1-12,122-128
Order 13-121
Pfam Hmmer
PF00125 20-94 2.3e-24
SEG 2-17
Function
Function in SwissProt
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division.
Biological Process
See also
Diagram with PDB data
ANP32E/H2AZ1/H2BC11Crystal structure of a human Anp32e-H2A.Z-H2B complex