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IID00029
 UniprotP17931
ProteinGalectin-3
GeneLGALS3
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
250
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 105-250 Monomer :
 Evidence X-RAY 1a3k A Reference
       Region 1a3k A 114-250 order
 Evidence X-RAY 1kjl A Reference
       Region 1kjl A 105-112 disorder
       Region 1kjl A 113-250 order
 Evidence X-RAY 1kjr A Reference
       Region 1kjr A 105-112 disorder
       Region 1kjr A 113-250 order
 Evidence X-RAY 2nmn A Reference
       Region 2nmn A 113-250 order
 Evidence X-RAY 2nmo A Reference
       Region 2nmo A 113-250 order
 Evidence X-RAY 2nn8 A Reference
       Region 2nn8 A 113-250 order
 Evidence X-RAY 2xg3 A Reference
       Region 2xg3 A 114-250 order
 Evidence X-RAY 3ayd A Reference
       Region 3ayd A 117-250 order
 Evidence X-RAY 3t1l A Reference
       Region 3t1l A 108-112 disorder
       Region 3t1l A 113-250 order
 Evidence X-RAY 3t1m A Reference
       Region 3t1m A 108-113 disorder
       Region 3t1m A 114-250 order
 Evidence X-RAY 3zsj A Reference
       Region 3zsj A 113-250 order
 Evidence X-RAY 3zsk A Reference
       Region 3zsk A 114-250 order
 Evidence X-RAY 3zsl A Reference
       Region 3zsl A 114-250 order
 Evidence X-RAY 3zsm A Reference
       Region 3zsm A 114-250 order
 Evidence X-RAY 4bli A Reference
       Region 4bli A 114-250 order
 Evidence X-RAY 4blj A Reference
       Region 4blj A 114-250 order
 Evidence X-RAY 4bm8 A Reference
       Region 4bm8 A 114-250 order
 Evidence X-RAY 4jc1 A Reference
       Region 4jc1 A 108-112 disorder
       Region 4jc1 A 113-250 order
 Evidence X-RAY 4jck A Reference
       Region 4jck A 108-112 disorder
       Region 4jck A 113-250 order
 Evidence X-RAY 4lbj A Reference
       Region 4lbj A 114-250 order
 Evidence X-RAY 4lbk A Reference
       Region 4lbk A 114-250 order
 Evidence X-RAY 4lbl A Reference
       Region 4lbl A 114-250 order
 Evidence X-RAY 4lbm A Reference
       Region 4lbm A 112-250 order
 Evidence X-RAY 4lbn A Reference
       Region 4lbn A 112-250 order
 Evidence X-RAY 4lbo A Reference
       Region 4lbo A 113-250 order
 Evidence X-RAY 4r9a A Reference
       Region 4r9a A 111-112 disorder
       Region 4r9a A 113-250 order
 Evidence X-RAY 4r9b A Reference
       Region 4r9b A 111-112 disorder
       Region 4r9b A 113-250 order
 Evidence X-RAY 4r9c A Reference
       Region 4r9c A 111-112 disorder
       Region 4r9c A 113-250 order
 Evidence X-RAY 4r9d A Reference
       Region 4r9d A 111-112 disorder
       Region 4r9d A 113-250 order
 Evidence X-RAY 4rl7 A Reference
       Region 4rl7 A 111-112 disorder
       Region 4rl7 A 113-250 order
 Evidence X-RAY 4xbn A Reference
       Region 4xbn A 113-250 order
 Evidence X-RAY 5e88 A Reference
       Region 5e88 A 114-250 order
 Evidence X-RAY 5e89 A Reference
       Region 5e89 A 114-250 order
 Evidence X-RAY 5e8a A Reference
       Region 5e8a A 114-250 order
 Evidence X-RAY 5exo A Reference
       Region 5exo A 112-113 disorder
       Region 5exo A 114-250 order
 Evidence X-RAY 5h9p A Reference
       Region 5h9p A 113-250 order
 Evidence X-RAY 5h9r A Reference
       Region 5h9r A 113-250 order
 Evidence X-RAY 5iuq A Reference
       Region 5iuq A 113-250 order
 Evidence X-RAY 5nf7 A Reference
       Region 5nf7 A 106-112 disorder
       Region 5nf7 A 113-250 order
 Evidence X-RAY 5nf9 A Reference
       Region 5nf9 A 106-112 disorder
       Region 5nf9 A 113-250 order
 Evidence X-RAY 5nfa A Reference
       Region 5nfa A 106-112 disorder
       Region 5nfa A 113-250 order
 Evidence X-RAY 5nfb A Reference
       Region 5nfb A 106-112 disorder
       Region 5nfb A 113-250 order
 Evidence X-RAY 5nfc A Reference
       Region 5nfc A 106-112 disorder
       Region 5nfc A 113-250 order
Seq 117-250 Homo dimer :
 Evidence X-RAY 3aya A Reference
       Region 3aya A 117-250 order
 Evidence X-RAY 3aya B Reference
       Region 3aya B 117-250 order
 Evidence X-RAY 3ayc A Reference
       Region 3ayc A 117-250 order
 Evidence X-RAY 3ayc B Reference
       Region 3ayc B 117-250 order
 Evidence X-RAY 3aye A Reference
       Region 3aye A 117-250 order
 Evidence X-RAY 3aye B Reference
       Region 3aye B 117-250 order
Seqphosphorylation
    6-6 Phosphoserine
    12-12 Phosphoserine
    188-188 Phosphoserine
Seqacetylation
    2-2 N-acetylalanine
 
Prediction
NeProc
Disorder 1-106
Order 112-250
ProS 1-14,19-46,52-56,61-66,76-82,100-106
AlphaFold
Disorder 1-111
Order 112-250
Pfam Hmmer
PF00337 117-247 5.4e-57
SEG 29-113
Function
Function in SwissProt
Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.