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IID00036  Replication protein A 70 kDa DNA-binding subunit (Homo sapiens) P27694
  :order  :disorder  :conflict  :PDB cluster  :ProS  :SCOP Domain  :Pfam Domain
Networkxml
Experiment
616
fasta
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-120 Hetero dimer : Q96LW4
 Evidence X-RAY 5n85 A Reference
       Region 5n85 A 1-120 order
Seq 1-120 Hetero dimer : Q96LW4
 Evidence X-RAY 5n8a A Reference
       Region 5n8a A 1-120 order
Seq 1-120 Hetero hexamer : IID00015Complex
 Evidence X-RAY 2b3g A Reference
       Region 2b3g A 1-34 order
       Region 2b3g A 35-37 disorder
       Region 2b3g A 38-120 order
Seq 1-120 Monomer :
 Evidence X-RAY 2b29 A Reference
       Region 2b29 A 1-2 disorder
       Region 2b29 A 3-120 order
 Evidence X-RAY 5e7n A Reference
       Region 5e7n A 1-120 order
 Evidence X-RAY 4ijh A Reference
       Region 4ijh A 1-120 order
 Evidence X-RAY 4ijl A Reference
       Region 4ijl A 1-120 order
 Evidence X-RAY 4ipc A Reference
       Region 4ipc A 1-120 order
 Evidence X-RAY 4ipd A Reference
       Region 4ipd A 1-120 order
 Evidence X-RAY 4ipg A Reference
       Region 4ipg A 1-120 order
 Evidence X-RAY 4iph A Reference
       Region 4iph A 1-120 order
 Evidence X-RAY 4luo A Reference
       Region 4luo A 1-120 order
 Evidence X-RAY 4luv A Reference
       Region 4luv A 1-120 order
 Evidence X-RAY 4luz A Reference
       Region 4luz A 1-120 order
 Evidence X-RAY 4lw1 A Reference
       Region 4lw1 A 1-120 order
 Evidence X-RAY 4lwc A Reference
       Region 4lwc A 1-120 order
 Evidence X-RAY 4o0a A Reference
       Region 4o0a A 1-120 order
 Evidence X-RAY 4r4c A Reference
       Region 4r4c A 1-120 order
 Evidence X-RAY 4r4i A Reference
       Region 4r4i A 1-120 order
 Evidence X-RAY 4r4o A Reference
       Region 4r4o A 1-120 order
 Evidence X-RAY 4r4q A Reference
       Region 4r4q A 1-120 order
 Evidence X-RAY 4r4t A Reference
       Region 4r4t A 1-120 order
 Evidence NMR 1ewi A Reference
       Region 1ewi A 1-114 order
Seq 1-120 Hetero dimer : Q8WXE1
 Evidence X-RAY 4nb3 A Reference
       Region 4nb3 A 1-120 order
 Evidence X-RAY 4nb3 B Reference
       Region 4nb3 B 1-120 order
Seq 3-120 Hetero octamer : P51530
 Evidence X-RAY 5eay A Reference
       Region 5eay A 3-34 order
       Region 5eay A 35-37 disorder
       Region 5eay A 38-120 order
 Evidence X-RAY 5eay B Reference
       Region 5eay B 3-34 order
       Region 5eay B 35-37 disorder
       Region 5eay B 38-120 order
 Evidence X-RAY 5eay C Reference
       Region 5eay C 3-4 disorder
       Region 5eay C 5-34 order
       Region 5eay C 35-38 disorder
       Region 5eay C 39-120 order
 Evidence X-RAY 5eay D Reference
       Region 5eay D 3-3 disorder
       Region 5eay D 4-34 order
       Region 5eay D 35-38 disorder
       Region 5eay D 39-119 order
       Region 5eay D 120-120 disorder
Seqdisorder 116-168
 Evidence NMR Reference
       Region 116-168 disorder
Seq 181-422 Monomer :
 Evidence X-RAY 1jmc A Reference
       Region 1jmc A 181-182 disorder
       Region 1jmc A 183-420 order
       Region 1jmc A 421-422 disorder
Seq 182-432 Homo dimer :
 Evidence X-RAY 1fgu A Reference
       Region 1fgu A 182-426 order
       Region 1fgu A 427-432 disorder
 Evidence X-RAY 1fgu B Reference
       Region 1fgu B 182-289 order
       Region 1fgu B 290-297 disorder
       Region 1fgu B 298-426 order
       Region 1fgu B 427-432 disorder
Seq 436-616 Hetero hexamer : IID00026Complex,IID00040Complex
 Evidence X-RAY 1l1o C Reference
       Region 1l1o C 436-438 disorder
       Region 1l1o C 439-581 order
       Region 1l1o C 582-586 disorder
       Region 1l1o C 587-616 order
 Evidence X-RAY 1l1o F Reference
       Region 1l1o F 436-438 disorder
       Region 1l1o F 439-579 order
       Region 1l1o F 580-586 disorder
       Region 1l1o F 587-616 order
Seqphosphorylation
    180-180 Phosphothreonine
    191-191 Phosphothreonine
    384-384 Phosphoserine
Seqacetylation
    1-1 N-acetylmethionine
    163-163 N6-acetyllysine; alternate
    167-167 N6-acetyllysine; alternate
    259-259 N6-acetyllysine; alternate
 
Prediction
DICHOT
Disorder 1-2,121-181,427-438
Known Domain 3-120,182-426,439-616
SCOPe RPS-Blast
     4ipcA1 1-120 6e-40 b.40.4.3 Archaeal ssDNA-binding protein
     1jmcA1 183-298 1e-42 b.40.4.3 Archaeal ssDNA-binding protein
     1jmcA2 299-420 3e-43 b.40.4.3 Archaeal ssDNA-binding protein
     1l1oC 439-616 2e-56 b.40.4.3 Archaeal ssDNA-binding protein
SCOP Hmmer
     1ewiA_ 1-114 9e-44 b.40.4.3 Archaeal ssDNA-bind...
     1fguA1 183-293 1.2e-39 b.40.4.3 Archaeal ssDNA-...
     1fguA2 299-423 4.6e-41 b.40.4.3 Archaeal ssDNA-...
     1l1oC_ 440-612 1.7e-66 b.40.4.3 Archaeal ssDNA-...
Pfam RPS-Blast
     PF04057 5-103 7e-23 Replication factor-A protein ...
     PF02721 226-315 1e-12 Domain of unknown function ...
     PF16900 306-398 4e-17 Replication protein A OB do...
     PF08646 461-582 1e-13 Replication factor-A C term...
Pfam Hmmer
    PF04057 5-104 2.2e-39 Replication factor-A protein...
    PF01336 197-280 9e-15 OB-fold nucleic acid binding...
    PF16900 305-402 1.9e-38 Replication protein A OB d...
    PF08646 461-606 1e-59 Replication factor-A C termi...