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IID00037
 UniprotP31751
ProteinRAC-beta serine/threonine-protein kinase
GeneAKT2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
481
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-111 Monomer :
 Evidence NMR 1p6s A Reference
       Region 1p6s A 1-111 order
       Region 1p6s A 1-1 high_rmsd
       Region 1p6s A 44-48 high_rmsd
       Region 1p6s A 79-84 high_rmsd
Seq 143-481 Monomer :
 Evidence X-RAY 1gzk A Reference
       Region 1gzk A 146-188 order
       Region 1gzk A 189-197 disorder
       Region 1gzk A 198-296 order
       Region 1gzk A 297-312 disorder
       Region 1gzk A 313-441 order
       Region 1gzk A 442-460 disorder
 Evidence X-RAY 1gzn A Reference
       Region 1gzn A 146-188 order
       Region 1gzn A 189-197 disorder
       Region 1gzn A 198-296 order
       Region 1gzn A 297-312 disorder
       Region 1gzn A 313-441 order
       Region 1gzn A 442-480 disorder
 Evidence X-RAY 1gzo A Reference
       Region 1gzo A 146-188 order
       Region 1gzo A 189-197 disorder
       Region 1gzo A 198-296 order
       Region 1gzo A 297-312 disorder
       Region 1gzo A 313-441 order
       Region 1gzo A 442-460 disorder
 Evidence X-RAY 1mrv A Reference
       Region 1mrv A 143-146 disorder
       Region 1mrv A 147-188 order
       Region 1mrv A 189-202 disorder
       Region 1mrv A 203-294 order
       Region 1mrv A 295-313 disorder
       Region 1mrv A 314-440 order
       Region 1mrv A 441-481 disorder
 Evidence X-RAY 1mry A Reference
       Region 1mry A 143-145 disorder
       Region 1mry A 146-189 order
       Region 1mry A 190-201 disorder
       Region 1mry A 202-297 order
       Region 1mry A 298-310 disorder
       Region 1mry A 311-440 order
       Region 1mry A 441-481 disorder
Seq 146-480 Homo dimer :
 Evidence X-RAY 3d0e B Reference
       Region 3d0e B 146-454 order
       Region 3d0e B 455-465 disorder
       Region 3d0e B 466-480 order
 Evidence X-RAY 3d0e A Reference
       Region 3d0e A 146-454 order
       Region 3d0e A 455-465 disorder
       Region 3d0e A 466-480 order
Seq 146-481 Hetero dimer : IID00052Complex
 Evidence X-RAY 3e87 A Reference
       Region 3e87 A 146-453 order
       Region 3e87 A 454-465 disorder
       Region 3e87 A 466-480 order
 Evidence X-RAY 3e87 B Reference
       Region 3e87 B 146-453 order
       Region 3e87 B 454-465 disorder
       Region 3e87 B 466-480 order
 Evidence X-RAY 3e88 A Reference
       Region 3e88 A 146-451 order
       Region 3e88 A 452-465 disorder
       Region 3e88 A 466-480 order
 Evidence X-RAY 3e88 B Reference
       Region 3e88 B 146-451 order
       Region 3e88 B 452-465 disorder
       Region 3e88 B 466-480 order
 Evidence X-RAY 3e8d A Reference
       Region 3e8d A 146-448 order
       Region 3e8d A 449-467 disorder
       Region 3e8d A 468-480 order
 Evidence X-RAY 3e8d B Reference
       Region 3e8d B 146-448 order
       Region 3e8d B 449-465 disorder
       Region 3e8d B 466-480 order
 Evidence X-RAY 2jdo A Reference
       Region 2jdo A 146-449 order
       Region 2jdo A 450-467 disorder
 Evidence X-RAY 2jdr A Reference
       Region 2jdr A 146-449 order
       Region 2jdr A 450-467 disorder
 Evidence X-RAY 1o6k A Reference
       Region 1o6k A 146-449 order
       Region 1o6k A 450-465 disorder
       Region 1o6k A 466-479 order
       Region 1o6k A 480-481 disorder
 Evidence X-RAY 1o6l A Reference
       Region 1o6l A 146-449 order
       Region 1o6l A 450-467 disorder
 Evidence X-RAY 2uw9 A Reference
       Region 2uw9 A 146-449 order
       Region 2uw9 A 450-467 disorder
 Evidence X-RAY 2x39 A Reference
       Region 2x39 A 146-449 order
 Evidence X-RAY 2xh5 A Reference
       Region 2xh5 A 146-449 order
       Region 2xh5 A 450-467 disorder
SeqProS verified 189-197,297-312 Hetero dimer : IID00052Complex
       Region 3e87 A 146-453 order
       Region 3e87 B 146-453 order
       Region 2uw9 A 146-449 order
       Region 1o6l A 146-449 order
       Region 2jdo A 146-449 order
       Region 1o6k A 146-449 order
       Region 3e8d A 146-448 order
       Region 3e8d B 146-448 order
       Region 3e88 A 146-451 order
       Region 3e88 B 146-451 order
       Region 2jdr A 146-449 order
       Region 2xh5 A 146-449 order
       Region 2x39 A 146-449 order
       Region 1gzn A 189-197 disorder
       Region 1gzn A 297-312 disorder
Seqphosphorylation
    309-309 Phosphothreonine; by PDPK1
    474-474 Phosphoserine
    126-126 Phosphoserine
    34-34 Phosphoserine
    447-447 Phosphoserine
    451-451 Phosphothreonine
    478-478 Phosphoserine
Seqacetylation
    1-1 N-acetylmethionine
 
Prediction
NeProc
Disorder 1-1,110-146,456-460
Order 2-109,147-455,466-481
AlphaFold
Disorder 1-3,16-20,44-52,78-84,114-145,324-325,447-469,478-481
Order 4-15,21-43,53-77,85-113,146-323,326-446,470-477
Pfam Hmmer
PF00169 6-108 3.1e-24
PF00069 152-409 1.1e-111
PF00433 429-479 1e-11
Function
Function in SwissProt
One of the few specific substrates of AKT2 identified recently is PITX2. Phosphorylation of PITX2 impairs its association with the CCND1 mRNA-stabilizing complex thus shortening the half-life of CCND1. AKT2 seems also to be the principal isoform responsible of the regulation of glucose uptake. Phosphorylates C2CD5 on 'Ser-197' during insulin-stimulated adipocytes. AKT2 is also specifically involved in skeletal muscle differentiation, one of its substrates in this process being ANKRD2. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis. Phosphorylates CLK2 on 'Thr-343'.
Biological Process
Diagram with PDB data
AKT2/GSK3BStructure of activated form of PKB kinase domain S474D with GSK3 peptide and AMP-PNP
See also
Diagram with PDB data
CREB1/CRBBP/KMT2AAllosteric communication in the KIX domain proceeds through dynamic re-packing of the hydrophobic core