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IID00044  Flap endonuclease 1 (Homo sapiens) P39748
  :order  :disorder  :conflict  :PDB cluster  :ProS  :SCOP Domain  :Pfam Domain
Networkxml
Experiment
380
fasta
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-336 Monomer :
 Evidence X-RAY 5fv7 A Reference
       Region 5fv7 A 1-1 disorder
       Region 5fv7 A 2-44 order
       Region 5fv7 A 45-59 disorder
       Region 5fv7 A 60-96 order
       Region 5fv7 A 97-130 disorder
       Region 5fv7 A 131-195 order
       Region 5fv7 A 196-200 disorder
       Region 5fv7 A 201-336 order
 Evidence X-RAY 5fv7 B Reference
       Region 5fv7 B 1-1 disorder
       Region 5fv7 B 2-43 order
       Region 5fv7 B 44-59 disorder
       Region 5fv7 B 60-93 order
       Region 5fv7 B 94-130 disorder
       Region 5fv7 B 131-194 order
       Region 5fv7 B 195-201 disorder
       Region 5fv7 B 202-335 order
       Region 5fv7 B 336-336 disorder
 Evidence X-RAY 5k97 A Reference
       Region 5k97 A 2-336 order
 Evidence X-RAY 5kse A Reference
       Region 5kse A 2-336 order
 Evidence X-RAY 3q8k A Reference
       Region 3q8k A 2-336 order
 Evidence X-RAY 3q8l A Reference
       Region 3q8l A 2-336 order
 Evidence X-RAY 3q8m A Reference
       Region 3q8m A 2-336 order
 Evidence X-RAY 3q8m B Reference
       Region 3q8m B 2-335 order
       Region 3q8m B 336-336 disorder
 Evidence X-RAY 5um9 A Reference
       Region 5um9 A 2-336 order
Seq 2-380 Hetero hexamer : IID00022Complex
 Evidence X-RAY 1ul1 X Reference
       Region 1ul1 X 2-46 order
       Region 1ul1 X 47-59 disorder
       Region 1ul1 X 60-99 order
       Region 1ul1 X 100-128 disorder
       Region 1ul1 X 129-198 order
       Region 1ul1 X 199-199 disorder
       Region 1ul1 X 200-357 order
       Region 1ul1 X 358-380 disorder
 Evidence X-RAY 1ul1 Y Reference
       Region 1ul1 Y 2-44 order
       Region 1ul1 Y 45-59 disorder
       Region 1ul1 Y 60-102 order
       Region 1ul1 Y 103-133 disorder
       Region 1ul1 Y 134-359 order
       Region 1ul1 Y 360-380 disorder
 Evidence X-RAY 1ul1 Z Reference
       Region 1ul1 Z 2-113 order
       Region 1ul1 Z 114-119 disorder
       Region 1ul1 Z 120-356 order
       Region 1ul1 Z 357-380 disorder
Seq 331-350 Hetero hexamer : IID00022Complex
 Evidence X-RAY 1u7b B Reference
       Region 1u7b B 331-335 disorder
       Region 1u7b B 336-348 order
       Region 1u7b B 349-350 disorder
Seq 335-350 Hetero tetramer : IID00022Complex
 Evidence X-RAY 5e0v C Reference
       Region 5e0v C 335-348 order
       Region 5e0v C 349-350 disorder
 Evidence X-RAY 5e0v D Reference
       Region 5e0v D 335-347 order
       Region 5e0v D 348-350 disorder
Seq 352-370 Hetero dimer : IID50009Complex
 Evidence X-RAY 3uvu B Reference
       Region 3uvu B 352-370 order
SeqProS verified 45-59,103-133 This region interacts with DNA :
       Region 3q8l A 2-336 order
       Region 3q8k A 2-336 order
       Region 3q8m A 2-336 order
       Region 3q8m B 2-335 order
       Region 5kse A 2-336 order
       Region 5k97 A 2-336 order
       Region 5um9 A 2-336 order
       Region 1ul1 Y 45-59 disorder
       Region 1ul1 Y 103-133 disorder
SeqProS possible 335-348 PIP box motif. Hetero tetramer : IID00022Complex
       Region 5e0v C 335-348 order
       Region 5e0v D 335-347 order
SeqProS possible 336-348 PIP box motif. Hetero hexamer : IID00022Complex
       Region 1u7b B 336-348 order
SeqProS verified 352-370 Hetero dimer : IID50009Complex
       Region 3uvu B 352-370 order
       Region 1ul1 Z 357-380 disorder
Seqphosphorylation
    187-187 Phosphoserine; by CDK2
    197-197 Phosphoserine
    255-255 Phosphoserine
    293-293 Phosphoserine
    335-335 Phosphoserine
    336-336 Phosphothreonine
    364-364 Phosphothreonine
Seqacetylation
    80-80 N6-acetyllysine
    354-354 N6-acetyllysine
    375-375 N6-acetyllysine
    377-377 N6-acetyllysine
    380-380 N6-acetyllysine
 
Prediction
DICHOT
Disorder 1-1,358-380
Known Domain 2-357
SCOPe RPS-Blast
     1ul1X2 2-217 3e-78 c.120.1.2 5' to 3' exonuclease domain of DNA pol...
     1ul1X1 218-357 1e-48 a.60.7.1 5' to 3' exonuclease domain of DNA po...
SCOP Hmmer
     1ul1X2 2-233 3.7e-75 c.120.1.2 5' to 3' exonucl...
     1ul1X1 218-355 1.5e-44 a.60.7.1 5' to 3' exonuc...
Pfam RPS-Blast
     PF00752 63-105 4e-07 XPG N-terminal domain
     PF00867 148-233 1e-19 XPG I-region
     PF01367 221-264 1e-05 5'-3' exonuclease, C-termin...
Pfam Hmmer
    PF00752 1-107 1e-41 XPG N-terminal domain
    PF00867 147-233 3.5e-34 XPG I-region