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IID00045
 UniprotP41235
ProteinHepatocyte nuclear factor 4-alpha
GeneHNF4A
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
474
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 55-377 Hetero tetramer : IID00082Complex
 Evidence X-RAY 4iqr A Reference
       Region 4iqr A 55-57 disorder
       Region 4iqr A 58-133 order
       Region 4iqr A 134-151 disorder
       Region 4iqr A 152-377 order
 Evidence X-RAY 4iqr B Reference
       Region 4iqr B 55-57 disorder
       Region 4iqr B 58-162 order
       Region 4iqr B 163-174 disorder
       Region 4iqr B 175-377 order
 Evidence X-RAY 4iqr E Reference
       Region 4iqr E 55-57 disorder
       Region 4iqr E 58-132 order
       Region 4iqr E 133-149 disorder
       Region 4iqr E 150-377 order
 Evidence X-RAY 4iqr F Reference
       Region 4iqr F 55-57 disorder
       Region 4iqr F 58-163 order
       Region 4iqr F 164-169 disorder
       Region 4iqr F 170-377 order
Seq 58-135 Homo dimer :
 Evidence X-RAY 3cbb B Reference
       Region 3cbb B 58-135 order
 Evidence X-RAY 3cbb A Reference
       Region 3cbb A 58-133 order
       Region 3cbb A 134-135 disorder
Seq 142-377 Homo octamer :
 Evidence X-RAY 4b7w D Reference
       Region 4b7w D 142-176 disorder
       Region 4b7w D 177-376 order
       Region 4b7w D 377-377 disorder
 Evidence X-RAY 4b7w C Reference
       Region 4b7w C 142-174 disorder
       Region 4b7w C 175-376 order
       Region 4b7w C 377-377 disorder
 Evidence X-RAY 4b7w B Reference
       Region 4b7w B 142-176 disorder
       Region 4b7w B 177-376 order
       Region 4b7w B 377-377 disorder
 Evidence X-RAY 4b7w A Reference
       Region 4b7w A 142-174 disorder
       Region 4b7w A 175-376 order
       Region 4b7w A 377-377 disorder
Seq 142-378 Hetero dimer : IID00083Complex
 Evidence X-RAY 1pzl A Reference
       Region 1pzl A 142-145 disorder
       Region 1pzl A 146-166 order
       Region 1pzl A 167-172 disorder
       Region 1pzl A 173-378 order
Seq 148-377 Hetero dimer :
 Evidence X-RAY 3fs1 A Reference
       Region 3fs1 A 148-377 order
Seqphosphorylation
    142-142 Phosphoserine
    143-143 Phosphoserine
    144-144 Phosphotyrosine
    166-166 Phosphothreonine
    313-313 Phosphoserine; by AMPK
    167-167 Phosphoserine
    432-432 Phosphothreonine
    429-429 Phosphothreonine
    436-436 Phosphoserine
Seqacetylation
    458-458 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-56,131-177,381-474
Order 57-130,178-380
ProS 7-32,131-140,151-164,174-177,445-448,464-474
AlphaFold
Disorder 1-57,139-149,167-174,377-474
Order 58-138,150-166,175-376
Pfam Hmmer
PF00105 58-133 3.8e-51
PF00104 192-373 4.7e-59
SEG 337-341 ,382-393 ,426-445
Function
Function in SwissProt
Transcriptionally controlled transcription factor. Binds to DNA sites required for the transcription of alpha 1-antitrypsin, apolipoprotein CIII, transthyretin genes and HNF1-alpha. May be essential for development of the liver, kidney and intestine.
Biological Process
See also
Diagram with PDB data
NCOA1/RARACrystal structure of RARalpha ligand binding domain in complex with an agonist ligand (Am580) and a coactivator fragment