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IID00061
 UniprotP63104
Protein14-3-3 protein zeta/delta
GeneYWHAZ
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
245
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-229 Hetero tetramer : IID00295Complex
 Evidence X-RAY 8ah2 A Reference
       Region 8ah2 A 1-1 disorder
       Region 8ah2 A 2-69 order
       Region 8ah2 A 70-71 disorder
       Region 8ah2 A 72-229 order
 Evidence X-RAY 8ah2 C Reference
       Region 8ah2 C 1-1 disorder
       Region 8ah2 C 2-69 order
       Region 8ah2 C 70-70 disorder
       Region 8ah2 C 71-229 order
Seq 1-229 Hetero tetramer : P06463
 Evidence X-RAY 6zfg A Reference
       Region 6zfg A 1-229 order
 Evidence X-RAY 6zfg B Reference
       Region 6zfg B 1-229 order
Seq 1-229 Hetero tetramer : P06463
 Evidence X-RAY 6zfd A Reference
       Region 6zfd A 1-229 order
 Evidence X-RAY 6zfd B Reference
       Region 6zfd B 1-229 order
Seq 1-229 Hetero dimer : Q92934
 Evidence X-RAY 7q16 A Reference
       Region 7q16 A 1-1 disorder
       Region 7q16 A 2-229 order
Seq 1-230 Hetero octamer : IID00866Complex
 Evidence X-RAY 6eww A Reference
       Region 6eww A 1-69 order
       Region 6eww A 70-73 disorder
       Region 6eww A 74-202 order
       Region 6eww A 203-211 disorder
       Region 6eww A 212-229 order
       Region 6eww A 230-230 disorder
 Evidence X-RAY 6eww B Reference
       Region 6eww B 1-68 order
       Region 6eww B 69-72 disorder
       Region 6eww B 73-204 order
       Region 6eww B 205-207 disorder
       Region 6eww B 208-229 order
       Region 6eww B 230-230 disorder
 Evidence X-RAY 6eww C Reference
       Region 6eww C 1-69 order
       Region 6eww C 70-74 disorder
       Region 6eww C 75-133 order
       Region 6eww C 134-137 disorder
       Region 6eww C 138-230 order
 Evidence X-RAY 6eww D Reference
       Region 6eww D 1-1 disorder
       Region 6eww D 2-67 order
       Region 6eww D 68-76 disorder
       Region 6eww D 77-229 order
       Region 6eww D 230-230 disorder
Seq 1-230 Hetero tetramer : IID00522Complex
 Evidence X-RAY 5exa A Reference
       Region 5exa A 1-1 disorder
       Region 5exa A 2-230 order
 Evidence X-RAY 5exa B Reference
       Region 5exa B 1-230 order
Seq 1-230 Hetero trimer : IID00292Complex
 Evidence X-RAY 4fj3 A Reference
       Region 4fj3 A 1-1 disorder
       Region 4fj3 A 2-69 order
       Region 4fj3 A 70-72 disorder
       Region 4fj3 A 73-203 order
       Region 4fj3 A 204-209 disorder
       Region 4fj3 A 210-230 order
 Evidence X-RAY 4fj3 B Reference
       Region 4fj3 B 1-1 disorder
       Region 4fj3 B 2-69 order
       Region 4fj3 B 70-71 disorder
       Region 4fj3 B 72-133 order
       Region 4fj3 B 134-136 disorder
       Region 4fj3 B 137-203 order
       Region 4fj3 B 204-205 disorder
       Region 4fj3 B 206-230 order
 Evidence X-RAY 4ihl A Reference
       Region 4ihl A 1-230 order
 Evidence X-RAY 4ihl B Reference
       Region 4ihl B 1-70 order
       Region 4ihl B 71-72 disorder
       Region 4ihl B 73-135 order
       Region 4ihl B 136-136 disorder
       Region 4ihl B 137-230 order
Seq 1-230 Hetero tetramer : P0DTC9
 Evidence X-RAY 7zit A Reference
       Region 7zit A 1-230 order
 Evidence X-RAY 7zit B Reference
       Region 7zit B 1-230 order
Seq 1-230 Hetero tetramer : IID00823Complex
 Evidence X-RAY 6f08 A Reference
       Region 6f08 A 1-68 order
       Region 6f08 A 69-73 disorder
       Region 6f08 A 74-112 order
       Region 6f08 A 113-113 disorder
       Region 6f08 A 114-230 order
 Evidence X-RAY 6f08 B Reference
       Region 6f08 B 1-133 order
       Region 6f08 B 134-135 disorder
       Region 6f08 B 136-205 order
       Region 6f08 B 206-209 disorder
       Region 6f08 B 210-230 order
 Evidence X-RAY 6f08 I Reference
       Region 6f08 I 1-1 disorder
       Region 6f08 I 2-68 order
       Region 6f08 I 69-73 disorder
       Region 6f08 I 74-135 order
       Region 6f08 I 136-136 disorder
       Region 6f08 I 137-230 order
 Evidence X-RAY 6f08 J Reference
       Region 6f08 J 1-69 order
       Region 6f08 J 70-72 disorder
       Region 6f08 J 73-133 order
       Region 6f08 J 134-138 disorder
       Region 6f08 J 139-204 order
       Region 6f08 J 205-210 disorder
       Region 6f08 J 211-230 order
Seq 1-230 Hetero tetramer : IID00801Complex
 Evidence X-RAY 6f09 P Reference
       Region 6f09 P 1-1 disorder
       Region 6f09 P 2-33 order
       Region 6f09 P 34-34 disorder
       Region 6f09 P 35-134 order
       Region 6f09 P 135-135 disorder
       Region 6f09 P 136-230 order
 Evidence X-RAY 6f09 Q Reference
       Region 6f09 Q 1-1 disorder
       Region 6f09 Q 2-70 order
       Region 6f09 Q 71-71 disorder
       Region 6f09 Q 72-73 order
       Region 6f09 Q 74-75 disorder
       Region 6f09 Q 76-229 order
       Region 6f09 Q 230-230 disorder
 Evidence X-RAY 6f09 R Reference
       Region 6f09 R 1-1 disorder
       Region 6f09 R 2-70 order
       Region 6f09 R 71-71 disorder
       Region 6f09 R 72-201 order
       Region 6f09 R 202-202 disorder
       Region 6f09 R 203-204 order
       Region 6f09 R 205-206 disorder
       Region 6f09 R 207-230 order
 Evidence X-RAY 6f09 S Reference
       Region 6f09 S 1-1 disorder
       Region 6f09 S 2-135 order
       Region 6f09 S 136-136 disorder
       Region 6f09 S 137-230 order
Seq 1-230 Hetero octamer : IID00014Complex
 Evidence X-RAY 6yo8 A Reference
       Region 6yo8 A 1-230 order
 Evidence X-RAY 6yo8 B Reference
       Region 6yo8 B 1-230 order
 Evidence X-RAY 6yo8 C Reference
       Region 6yo8 C 1-71 order
       Region 6yo8 C 72-76 disorder
       Region 6yo8 C 77-230 order
 Evidence X-RAY 6yo8 D Reference
       Region 6yo8 D 1-230 order
Seq 1-230 Hetero tetramer : Q99683
 Evidence X-RAY 6ejl A Reference
       Region 6ejl A 1-69 order
       Region 6ejl A 70-71 disorder
       Region 6ejl A 72-133 order
       Region 6ejl A 134-136 disorder
       Region 6ejl A 137-230 order
 Evidence X-RAY 6ejl B Reference
       Region 6ejl B 1-68 order
       Region 6ejl B 69-72 disorder
       Region 6ejl B 73-228 order
       Region 6ejl B 229-230 disorder
Seq 1-230 Hetero tetramer : IID00014Complex
 Evidence X-RAY 6ymo A Reference
       Region 6ymo A 1-230 order
 Evidence X-RAY 6ymo B Reference
       Region 6ymo B 1-230 order
Seq 1-230 Hetero tetramer : IID00014Complex
 Evidence X-RAY 6yos A Reference
       Region 6yos A 1-68 order
       Region 6yos A 69-74 disorder
       Region 6yos A 75-230 order
 Evidence X-RAY 6yos B Reference
       Region 6yos B 1-68 order
       Region 6yos B 69-72 disorder
       Region 6yos B 73-204 order
       Region 6yos B 205-210 disorder
       Region 6yos B 211-229 order
       Region 6yos B 230-230 disorder
Seq 1-230 Hetero tetramer : IID00522Complex
 Evidence X-RAY 5ewz A Reference
       Region 5ewz A 1-1 disorder
       Region 5ewz A 2-230 order
 Evidence X-RAY 5ewz B Reference
       Region 5ewz B 1-69 order
       Region 5ewz B 70-72 disorder
       Region 5ewz B 73-230 order
Seq 1-230 Hetero tetramer : IID00198Complex
 Evidence X-RAY 5m37 A Reference
       Region 5m37 A 1-230 order
 Evidence X-RAY 5m37 B Reference
       Region 5m37 B 1-1 disorder
       Region 5m37 B 2-70 order
       Region 5m37 B 71-72 disorder
       Region 5m37 B 73-230 order
Seq 1-230 Hetero tetramer : IID00782Complex
 Evidence X-RAY 6u2h A Reference
       Region 6u2h A 1-230 order
 Evidence X-RAY 6u2h B Reference
       Region 6u2h B 1-202 order
       Region 6u2h B 203-209 disorder
       Region 6u2h B 210-229 order
       Region 6u2h B 230-230 disorder
 Evidence X-RAY 6xag A Reference
       Region 6xag A 1-230 order
 Evidence X-RAY 6xag B Reference
       Region 6xag B 1-202 order
       Region 6xag B 203-209 disorder
       Region 6xag B 210-229 order
       Region 6xag B 230-230 disorder
Seq 1-230 Hetero tetramer : IID00014Complex
 Evidence X-RAY 8a9g A Reference
       Region 8a9g A 1-230 order
 Evidence X-RAY 8a9g B Reference
       Region 8a9g B 1-230 order
Seq 1-230 Hetero tetramer : Q93SQ3
 Evidence X-RAY 4n7g A Reference
       Region 4n7g A 1-203 order
       Region 4n7g A 204-204 disorder
       Region 4n7g A 205-230 order
 Evidence X-RAY 4n7y A Reference
       Region 4n7y A 1-230 order
 Evidence X-RAY 4n7y B Reference
       Region 4n7y B 1-70 order
       Region 4n7y B 71-72 disorder
       Region 4n7y B 73-203 order
       Region 4n7y B 204-205 disorder
       Region 4n7y B 206-207 order
       Region 4n7y B 208-210 disorder
       Region 4n7y B 211-230 order
 Evidence X-RAY 4n84 A 206 deletion Reference
       Region 4n84 A 1-205 order
       Region 4n84 A 207-209 disorder
       Region 4n84 A 210-230 order
 Evidence X-RAY 4n84 B 206 deletion Reference
       Region 4n84 B 1-70 order
       Region 4n84 B 71-72 disorder
       Region 4n84 B 73-204 order
       Region 4n84 B 205-205 disorder
       Region 4n84 B 207-207 disorder
       Region 4n84 B 208-230 order
 Evidence X-RAY 5j31 A Reference
       Region 5j31 A 1-206 order
       Region 5j31 A 207-207 disorder
       Region 5j31 A 208-230 order
 Evidence X-RAY 5j31 B Reference
       Region 5j31 B 1-206 order
       Region 5j31 B 207-207 disorder
       Region 5j31 B 208-230 order
Seq 1-230 Hetero tetramer : IID00613Complex
 Evidence X-RAY 4zdr A Reference
       Region 4zdr A 1-70 order
       Region 4zdr A 71-72 disorder
       Region 4zdr A 73-230 order
 Evidence X-RAY 4zdr B Reference
       Region 4zdr B 1-70 order
       Region 4zdr B 71-72 disorder
       Region 4zdr B 73-208 order
       Region 4zdr B 209-209 disorder
       Region 4zdr B 210-230 order
Seq 1-230 Hetero tetramer :
 Evidence X-RAY 2o02 A Reference
       Region 2o02 A 1-68 order
       Region 2o02 A 69-74 disorder
       Region 2o02 A 75-230 order
 Evidence X-RAY 2o02 B Reference
       Region 2o02 B 1-230 order
Seq 1-230 Hetero trimer : IID00540Complex
 Evidence X-RAY 5d2d A Reference
       Region 5d2d A 1-69 order
       Region 5d2d A 70-70 disorder
       Region 5d2d A 71-230 order
 Evidence X-RAY 5d2d B Reference
       Region 5d2d B 1-69 order
       Region 5d2d B 70-72 disorder
       Region 5d2d B 73-229 order
       Region 5d2d B 230-230 disorder
 Evidence X-RAY 5d3f A Reference
       Region 5d3f A 1-1 disorder
       Region 5d3f A 2-68 order
       Region 5d3f A 69-75 disorder
       Region 5d3f A 76-229 order
       Region 5d3f A 230-230 disorder
 Evidence X-RAY 5d3f B Reference
       Region 5d3f B 1-1 disorder
       Region 5d3f B 2-68 order
       Region 5d3f B 69-72 disorder
       Region 5d3f B 73-229 order
       Region 5d3f B 230-230 disorder
Seq 1-230 Hetero tetramer : IID00888Complex
 Evidence X-RAY 5nas A Reference
       Region 5nas A 1-230 order
 Evidence X-RAY 5nas B Reference
       Region 5nas B 1-230 order
Seq 1-245 Hetero dimer : Q6UUV9
 Evidence X-RAY 7d8h A Reference
       Region 7d8h A 1-230 order
       Region 7d8h A 231-245 disorder
Seq 1-245 Hetero dimer : IID00815Complex
 Evidence X-RAY 4bg6 A Reference
       Region 4bg6 A 1-69 order
       Region 4bg6 A 70-72 disorder
       Region 4bg6 A 73-231 order
       Region 4bg6 A 232-245 disorder
 Evidence X-RAY 4bg6 B Reference
       Region 4bg6 B 1-1 disorder
       Region 4bg6 B 2-230 order
       Region 4bg6 B 231-245 disorder
Seq 1-245 Hetero tetramer : IID00896Complex
 Evidence X-RAY 4wrq A Reference
       Region 4wrq A 1-66 order
       Region 4wrq A 67-76 disorder
       Region 4wrq A 77-230 order
       Region 4wrq A 231-245 disorder
 Evidence X-RAY 4wrq B Reference
       Region 4wrq B 1-229 order
       Region 4wrq B 230-245 disorder
Seq 1-245 Hetero dimer : Q9P0N9
 Evidence X-RAY 5ulo A Reference
       Region 5ulo A 1-68 order
       Region 5ulo A 69-71 disorder
       Region 5ulo A 72-134 order
       Region 5ulo A 135-135 disorder
       Region 5ulo A 136-229 order
       Region 5ulo A 230-245 disorder
 Evidence X-RAY 5ulo B Reference
       Region 5ulo B 1-134 order
       Region 5ulo B 135-135 disorder
       Region 5ulo B 136-229 order
       Region 5ulo B 230-245 disorder
Seq 1-245 Hetero tetramer : IID90034Complex
 Evidence X-RAY 1qjb A Reference
       Region 1qjb A 1-68 order
       Region 1qjb A 69-72 disorder
       Region 1qjb A 73-232 order
       Region 1qjb A 233-245 disorder
 Evidence X-RAY 1qjb B Reference
       Region 1qjb B 1-232 order
       Region 1qjb B 233-245 disorder
Seq 1-245 Hetero tetramer : IID00062Complex
 Evidence X-RAY 2c1j A Reference
       Region 2c1j A 1-230 order
       Region 2c1j A 231-245 disorder
 Evidence X-RAY 2c1j B Reference
       Region 2c1j B 1-230 order
       Region 2c1j B 231-245 disorder
Seq 1-245 Homo dimer :
 Evidence X-RAY 3rdh A Reference
       Region 3rdh A 1-230 order
       Region 3rdh A 231-245 disorder
 Evidence X-RAY 3rdh B Reference
       Region 3rdh B 1-230 order
       Region 3rdh B 231-245 disorder
 Evidence X-RAY 3rdh C Reference
       Region 3rdh C 1-230 order
       Region 3rdh C 231-245 disorder
 Evidence X-RAY 3rdh D Reference
       Region 3rdh D 1-230 order
       Region 3rdh D 231-245 disorder
 Evidence X-RAY 5jm4 A Reference
       Region 5jm4 A 1-1 disorder
       Region 5jm4 A 2-70 order
       Region 5jm4 A 71-71 disorder
       Region 5jm4 A 72-229 order
 Evidence X-RAY 5jm4 B Reference
       Region 5jm4 B 1-207 order
       Region 5jm4 B 208-208 disorder
       Region 5jm4 B 209-229 order
 Evidence X-RAY 6fn9 A Reference
       Region 6fn9 A 1-1 disorder
       Region 6fn9 A 2-210 order
       Region 6fn9 A 211-211 disorder
       Region 6fn9 A 212-230 order
 Evidence X-RAY 6fn9 B Reference
       Region 6fn9 B 1-69 order
       Region 6fn9 B 70-72 disorder
       Region 6fn9 B 73-204 order
       Region 6fn9 B 205-207 disorder
       Region 6fn9 B 208-230 order
 Evidence X-RAY 6fna A Reference
       Region 6fna A 1-230 order
 Evidence X-RAY 6fna B Reference
       Region 6fna B 1-70 order
       Region 6fna B 71-72 disorder
       Region 6fna B 73-229 order
       Region 6fna B 230-230 disorder
 Evidence X-RAY 6fnb A Reference
       Region 6fnb A 1-69 order
       Region 6fnb A 70-70 disorder
       Region 6fnb A 71-229 order
       Region 6fnb A 230-230 disorder
 Evidence X-RAY 6fnb B Reference
       Region 6fnb B 1-70 order
       Region 6fnb B 71-71 disorder
       Region 6fnb B 72-230 order
 Evidence X-RAY 6fnc A Reference
       Region 6fnc A 1-207 order
       Region 6fnc A 208-210 disorder
       Region 6fnc A 211-230 order
 Evidence X-RAY 6fnc B Reference
       Region 6fnc B 1-206 order
       Region 6fnc B 207-207 disorder
       Region 6fnc B 208-230 order
 Evidence X-RAY 6rlz A Reference
       Region 6rlz A 1-2 disorder
       Region 6rlz A 3-205 order
       Region 6rlz A 206-206 disorder
       Region 6rlz A 207-230 order
 Evidence X-RAY 6rlz B Reference
       Region 6rlz B 1-1 disorder
       Region 6rlz B 2-205 order
       Region 6rlz B 206-208 disorder
       Region 6rlz B 209-230 order
Seq 1-245 Hetero tetramer : Q6UUV9
 Evidence X-RAY 7d8p A Reference
       Region 7d8p A 1-69 order
       Region 7d8p A 70-72 disorder
       Region 7d8p A 73-207 order
       Region 7d8p A 208-209 disorder
       Region 7d8p A 210-230 order
       Region 7d8p A 231-245 disorder
 Evidence X-RAY 7d8p B Reference
       Region 7d8p B 1-1 disorder
       Region 7d8p B 2-230 order
       Region 7d8p B 231-245 disorder
Seq 1-245 Hetero tetramer : IID00292Complex
 Evidence X-RAY 3cu8 A Reference
       Region 3cu8 A 1-1 disorder
       Region 3cu8 A 2-230 order
       Region 3cu8 A 231-245 disorder
 Evidence X-RAY 3cu8 B Reference
       Region 3cu8 B 1-70 order
       Region 3cu8 B 71-72 disorder
       Region 3cu8 B 73-230 order
       Region 3cu8 B 231-245 disorder
 Evidence X-RAY 3nkx A Reference
       Region 3nkx A 1-1 disorder
       Region 3nkx A 2-230 order
       Region 3nkx A 231-245 disorder
 Evidence X-RAY 3nkx B Reference
       Region 3nkx B 1-70 order
       Region 3nkx B 71-72 disorder
       Region 3nkx B 73-230 order
       Region 3nkx B 231-245 disorder
Seq 1-245 Hetero tetramer : Q9P289
 Evidence X-RAY 5xy9 A Reference
       Region 5xy9 A 1-232 order
       Region 5xy9 A 233-245 disorder
 Evidence X-RAY 5xy9 B Reference
       Region 5xy9 B 1-230 order
       Region 5xy9 B 231-245 disorder
Seq 1-245 Hetero dimer : IID00062Complex
 Evidence X-RAY 2c1n A Reference
       Region 2c1n A 1-133 order
       Region 2c1n A 134-138 disorder
       Region 2c1n A 139-230 order
       Region 2c1n A 231-245 disorder
 Evidence X-RAY 2c1n B Reference
       Region 2c1n B 1-133 order
       Region 2c1n B 134-138 disorder
       Region 2c1n B 139-230 order
       Region 2c1n B 231-245 disorder
Seq 1-245 Hetero tetramer : IID00613Complex
 Evidence X-RAY 5wxn A Reference
       Region 5wxn A 1-230 order
       Region 5wxn A 231-245 disorder
 Evidence X-RAY 5wxn B Reference
       Region 5wxn B 1-230 order
       Region 5wxn B 231-245 disorder
Seq 1-245 Hetero trimer : IID00066Complex
 Evidence X-RAY 2wh0 A Reference
       Region 2wh0 A 1-1 disorder
       Region 2wh0 A 2-70 order
       Region 2wh0 A 71-71 disorder
       Region 2wh0 A 72-203 order
       Region 2wh0 A 204-209 disorder
       Region 2wh0 A 210-229 order
       Region 2wh0 A 230-245 disorder
 Evidence X-RAY 2wh0 B Reference
       Region 2wh0 B 1-1 disorder
       Region 2wh0 B 2-228 order
       Region 2wh0 B 229-245 disorder
 Evidence X-RAY 2wh0 C Reference
       Region 2wh0 C 1-3 disorder
       Region 2wh0 C 4-229 order
       Region 2wh0 C 230-245 disorder
 Evidence X-RAY 2wh0 D Reference
       Region 2wh0 D 1-1 disorder
       Region 2wh0 D 2-66 order
       Region 2wh0 D 67-71 disorder
       Region 2wh0 D 72-204 order
       Region 2wh0 D 205-205 disorder
       Region 2wh0 D 206-229 order
       Region 2wh0 D 230-245 disorder
Seq 1-245 Hetero octamer : IID00866Complex
 Evidence X-RAY 6ef5 A Reference
       Region 6ef5 A 1-70 order
       Region 6ef5 A 71-71 disorder
       Region 6ef5 A 72-206 order
       Region 6ef5 A 207-210 disorder
       Region 6ef5 A 211-230 order
       Region 6ef5 A 231-245 disorder
 Evidence X-RAY 6ef5 B Reference
       Region 6ef5 B 1-69 order
       Region 6ef5 B 70-71 disorder
       Region 6ef5 B 72-229 order
       Region 6ef5 B 230-245 disorder
 Evidence X-RAY 6ef5 C Reference
       Region 6ef5 C 1-70 order
       Region 6ef5 C 71-73 disorder
       Region 6ef5 C 74-203 order
       Region 6ef5 C 204-209 disorder
       Region 6ef5 C 210-230 order
       Region 6ef5 C 231-245 disorder
 Evidence X-RAY 6ef5 D Reference
       Region 6ef5 D 1-230 order
       Region 6ef5 D 231-245 disorder
Seq 1-245 Hetero tetramer : IID50013Complex
 Evidence X-RAY 1ib1 C Reference
       Region 1ib1 C 1-1 disorder
       Region 1ib1 C 2-228 order
       Region 1ib1 C 229-245 disorder
 Evidence X-RAY 1ib1 D Reference
       Region 1ib1 D 1-1 disorder
       Region 1ib1 D 2-228 order
       Region 1ib1 D 229-245 disorder
Seq 1-245 Hetero tetramer :
 Evidence X-RAY 1qja A Reference
       Region 1qja A 1-66 order
       Region 1qja A 67-76 disorder
       Region 1qja A 77-133 order
       Region 1qja A 134-136 disorder
       Region 1qja A 137-230 order
       Region 1qja A 231-245 disorder
 Evidence X-RAY 1qja B Reference
       Region 1qja B 1-133 order
       Region 1qja B 134-137 disorder
       Region 1qja B 138-229 order
       Region 1qja B 230-245 disorder
Seq 1-245 Hetero tetramer : Q6UUV9
 Evidence X-RAY 7d9v A Reference
       Region 7d9v A 1-230 order
       Region 7d9v A 231-245 disorder
 Evidence X-RAY 7d9v B Reference
       Region 7d9v B 1-230 order
       Region 7d9v B 231-245 disorder
Seq 1-245 Hetero tetramer : IID50013Complex
 Evidence X-RAY 1ib1 A Reference
       Region 1ib1 A 1-1 disorder
       Region 1ib1 A 2-228 order
       Region 1ib1 A 229-245 disorder
 Evidence X-RAY 1ib1 B Reference
       Region 1ib1 B 1-1 disorder
       Region 1ib1 B 2-228 order
       Region 1ib1 B 229-245 disorder
Seq 1-245 Hetero dimer : IID00615Complex
 Evidence X-RAY 4hkc A Reference
       Region 4hkc A 1-1 disorder
       Region 4hkc A 2-230 order
       Region 4hkc A 231-245 disorder
Seq 2-230 Hetero trimer : IID00198Complex
 Evidence X-RAY 5m36 A Reference
       Region 5m36 A 2-69 order
       Region 5m36 A 70-72 disorder
       Region 5m36 A 73-204 order
       Region 5m36 A 205-209 disorder
       Region 5m36 A 210-230 order
 Evidence X-RAY 5m36 B Reference
       Region 5m36 B 2-67 order
       Region 5m36 B 68-70 disorder
       Region 5m36 B 71-204 order
       Region 5m36 B 205-210 disorder
       Region 5m36 B 211-229 order
       Region 5m36 B 230-230 disorder
Seq 2-230 Hetero tetramer : IID00198Complex
 Evidence X-RAY 5m35 A Reference
       Region 5m35 A 2-204 order
       Region 5m35 A 205-205 disorder
       Region 5m35 A 206-230 order
 Evidence X-RAY 5m35 B Reference
       Region 5m35 B 2-70 order
       Region 5m35 B 71-72 disorder
       Region 5m35 B 73-204 order
       Region 5m35 B 205-208 disorder
       Region 5m35 B 209-230 order
Seqphosphorylation
    232-232 Phosphothreonine; by CK1
    58-58 Phosphoserine; by PKA and PKB/AKT1
    184-184 Phosphoserine; by MAPK8
    207-207 Phosphoserine
    210-210 Phosphoserine
Seqacetylation
    1-1 N-acetylmethionine
    3-3 N6-acetyllysine
    68-68 N6-acetyllysine
 
Prediction
NeProc
Disorder 233-245
Order 1-232
ProS 233-237,242-245
AlphaFold
Disorder 233-245
Order 1-232
Pfam Hmmer
PF00244 3-236 3.2e-151
SEG 234-244
Function
Function in SwissProt
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:14578935, PubMed:15071501, PubMed:15644438, PubMed:16376338, PubMed:16959763, PubMed:31024343, PubMed:9360956). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35662396). Binding generally results in the modulation of the activity of the binding partner (PubMed:35662396). Promotes cytosolic retention and inactivation of TFEB transcription factor by binding to phosphorylated TFEB (PubMed:35662396). Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (PubMed:16959763). In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity).
Biological Process
See also
Diagram with PDB data
RAF1/YWHAZHuman 14-3-3 isoform zeta in complex with a diphoyphorylated C-RAF peptide and Cotylenin A
CFTR/YWHAZCrystal structure of human 14-3-3 zeta in complex with CFTR R-domain peptide pS753-pS768
ITGA4/YWHAZ14-3-3-zeta in complex with S1011 phosphorylated integrin alpha-4 peptide
H3C1/YWHAZMolecular basis for the recognition of phosphorylated and phosphoacetylated histone H3 by 14-3-3
PRKCE/YWHAZRecognition of an intrachain tandem 14-3-3 binding site within protein kinase C epsilon
STK11/YWHAZStructure of the LKB1 and 14-3-3 complex
AANAT/YWHAZCRYSTAL STRUCTURE OF THE 14-3-3 ZETA:SEROTONIN N-ACETYLTRANSFERASE COMPLEX
GAB2/GRB2Grb2 SH3C (3)