Search Keyword:


Search option:


IID00064  Transcription factor E2F1 (Homo sapiens) Q01094
  :order  :disorder  :conflict  :PDB cluster  :ProS  :SCOP Domain  :Pfam Domain
Networkxml
Experiment
437
fasta
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 87-95 Hetero trimer : IID00032Complex
 Evidence X-RAY 1h24 E Reference
       Region 1h24 E 87-95 order
Seq 104-120 Hetero trimer : Q9BXT4
 Evidence X-RAY 5m9n C Reference
       Region 5m9n C 104-105 disorder
       Region 5m9n C 106-106 order
       Region 5m9n C 107-109 disorder
       Region 5m9n C 110-111 order
       Region 5m9n C 112-120 disorder
Seq 108-116 Hetero dimer : Q7KZF4
 Evidence X-RAY 5m9o B Reference
       Region 5m9o B 108-111 disorder
       Region 5m9o B 112-114 order
       Region 5m9o B 115-116 disorder
Seq 200-301 Hetero trimer : IID00017Complex,IID00076Complex
 Evidence X-RAY 2aze B Reference
       Region 2aze B 200-200 disorder
       Region 2aze B 201-301 order
Seq 409-426 Hetero trimer : IID00017Complex
 Evidence X-RAY 1o9k P Reference
       Region 1o9k P 409-426 order
 Evidence X-RAY 1o9k Q Reference
       Region 1o9k Q 409-426 order
 Evidence X-RAY 1o9k R Reference
       Region 1o9k R 409-426 order
 Evidence X-RAY 1o9k S Reference
       Region 1o9k S 409-426 order
SeqProS possible 87-95 Cyclin binding motif Hetero trimer : IID00032Complex
       Region 1h24 E 87-95 order
SeqProS possible 409-426 This region binds to Rb (IID00017). The binding region in Rb has another binding fragment from E1A (IID90003), which is a verfied ProS. Hetero trimer : IID00017Complex
       Region 1o9k P 409-426 order
       Region 1o9k Q 409-426 order
       Region 1o9k R 409-426 order
       Region 1o9k S 409-426 order
Seqphosphorylation
    364-364 Phosphoserine; by CHEK2
    375-375 Phosphoserine
Seqacetylation
    117-117 N6-acetyllysine
    120-120 N6-acetyllysine
    125-125 N6-acetyllysine
 
Prediction
DICHOT
Disorder 1-125,191-200,302-437
Known Domain 126-190,201-301
SCOPe RPS-Blast
     1cf7A 126-190 3e-19 a.4.5.17 Cell cycle transcription factor DP-2
     2azeB1 201-301 8e-27 e.63.1.2 Transcription factor E2F1
SCOP Hmmer
     1cf7A_ 127-191 3e-21 a.4.5.17 Cell cycle transc...
     2azeB1 202-301 9.8e-35 e.63.1.2 Transcription f...
Pfam RPS-Blast
     PF02319 156-192 1e-11 E2F/DP family winged-helix ...
     PF16421 206-298 2e-25 E2F transcription factor CC...
Pfam Hmmer
    PF02319 129-192 6.6e-27 E2F/DP family winged-helix...
    PF16421 206-299 3.6e-40 E2F transcription factor C...