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IID00065
 UniprotQ01167
ProteinForkhead box protein K2
GeneFOXK2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
660
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 256-353 Homo dimer :
 Evidence X-RAY 2c6y B Reference
       Region 2c6y B 256-350 order
       Region 2c6y B 351-353 disorder
 Evidence X-RAY 2c6y A Reference
       Region 2c6y A 256-353 order
Seq 256-353 Monomer :
 Evidence NMR 1jxs A Reference
       Region 1jxs A 256-353 order
       Region 1jxs A 256-256 high_rmsd
       Region 1jxs A 322-328 high_rmsd
       Region 1jxs A 351-353 high_rmsd
Seqphosphorylation
    30-30 Phosphoserine
    239-239 Phosphoserine
    373-373 Phosphoserine; by CDK1 and CDK2
    398-398 Phosphoserine
    424-424 Phosphoserine
    428-428 Phosphoserine; by CDK1 and CDK2
    599-599 Phosphoserine
Seqacetylation
    2-2 N-acetylalanine
 
Prediction
NeProc
Disorder 1-31,96-100,163-255,348-660
Order 32-95,106-162,256-347
ProS 1-9,163-171,180-197,208-210,348-352,365-371,467-472,482-486,556-560,571-581,654-660
AlphaFold
Disorder 1-34,62-62,87-109,158-255,352-660
Order 35-61,63-86,110-157,256-351
Pfam Hmmer
PF00498 54-146 9.7e-07
PF00250 258-353 1.4e-66
SEG 2-34 ,85-101 ,449-476 ,500-513 ,545-564
Function
Function in SwissProt
Transcriptional regulator that recognizes the core sequence 5'-TAAACA-3'. Binds to NFAT-like motifs (purine-rich) in the IL2 promoter (PubMed:1339390). Positively regulates WNT/beta-catenin signaling by translocating DVL proteins into the nucleus (PubMed:25805136). Also binds to HIV-1 long terminal repeat. May be involved in both positive and negative regulation of important viral and cellular promoter elements (PubMed:1909027).