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IID00070
 UniprotQ09472
ProteinHistone acetyltransferase p300
GeneEP300
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
2414
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 323-423 Hetero dimer : IID00179Complex
 Evidence NMR 1p4q B Reference
       Region 1p4q B 323-423 order
       Region 1p4q B 323-328 high_rmsd
       Region 1p4q B 421-423 high_rmsd
Seq 323-423 Hetero dimer : IID00085Complex
 Evidence NMR 1l3e B Reference
       Region 1l3e B 323-423 order
       Region 1l3e B 323-327 high_rmsd
       Region 1l3e B 420-423 high_rmsd
Seqdisorder 401-566
 Evidence NMR Reference
       Region 401-566 disorder
Seq 1040-1161 Monomer :
 Evidence X-RAY 5bt3 A Reference
       Region 5bt3 A 1048-1161 order
 Evidence X-RAY 3i3j A Reference
       Region 3i3j A 1040-1046 disorder
       Region 3i3j A 1047-1160 order
       Region 3i3j A 1161-1161 disorder
 Evidence X-RAY 3i3j J Reference
       Region 3i3j J 1040-1047 disorder
       Region 3i3j J 1048-1160 order
       Region 3i3j J 1161-1161 disorder
 Evidence X-RAY 3i3j K Reference
       Region 3i3j K 1040-1046 disorder
       Region 3i3j K 1047-1160 order
       Region 3i3j K 1161-1161 disorder
 Evidence X-RAY 3i3j L Reference
       Region 3i3j L 1040-1047 disorder
       Region 3i3j L 1048-1160 order
       Region 3i3j L 1161-1161 disorder
 Evidence X-RAY 3i3j B Reference
       Region 3i3j B 1040-1047 disorder
       Region 3i3j B 1048-1161 order
 Evidence X-RAY 3i3j C Reference
       Region 3i3j C 1040-1046 disorder
       Region 3i3j C 1047-1160 order
       Region 3i3j C 1161-1161 disorder
 Evidence X-RAY 3i3j D Reference
       Region 3i3j D 1040-1047 disorder
       Region 3i3j D 1048-1160 order
       Region 3i3j D 1161-1161 disorder
 Evidence X-RAY 3i3j E Reference
       Region 3i3j E 1040-1046 disorder
       Region 3i3j E 1047-1161 order
 Evidence X-RAY 3i3j F Reference
       Region 3i3j F 1040-1048 disorder
       Region 3i3j F 1049-1159 order
       Region 3i3j F 1160-1161 disorder
 Evidence X-RAY 3i3j G Reference
       Region 3i3j G 1040-1047 disorder
       Region 3i3j G 1048-1160 order
       Region 3i3j G 1161-1161 disorder
 Evidence X-RAY 3i3j H Reference
       Region 3i3j H 1040-1047 disorder
       Region 3i3j H 1048-1160 order
       Region 3i3j H 1161-1161 disorder
 Evidence X-RAY 3i3j I Reference
       Region 3i3j I 1040-1046 disorder
       Region 3i3j I 1047-1161 order
 Evidence X-RAY 5lpk A Reference
       Region 5lpk A 1040-1045 disorder
       Region 5lpk A 1046-1161 order
 Evidence X-RAY 5lpk B Reference
       Region 5lpk B 1040-1048 disorder
       Region 5lpk B 1049-1160 order
       Region 5lpk B 1161-1161 disorder
 Evidence X-RAY 5lpk C Reference
       Region 5lpk C 1040-1047 disorder
       Region 5lpk C 1048-1161 order
 Evidence X-RAY 5lpk D Reference
       Region 5lpk D 1040-1046 disorder
       Region 5lpk D 1047-1161 order
 Evidence X-RAY 5lpk E Reference
       Region 5lpk E 1040-1046 disorder
       Region 5lpk E 1047-1159 order
       Region 5lpk E 1160-1161 disorder
 Evidence X-RAY 5lpk F Reference
       Region 5lpk F 1040-1046 disorder
       Region 5lpk F 1047-1161 order
 Evidence X-RAY 5lpk G Reference
       Region 5lpk G 1040-1046 disorder
       Region 5lpk G 1047-1160 order
       Region 5lpk G 1161-1161 disorder
 Evidence X-RAY 5lpm A Reference
       Region 5lpm A 1048-1161 order
 Evidence X-RAY 5lpm B Reference
       Region 5lpm B 1048-1161 order
 Evidence X-RAY 5nu5 A Reference
       Region 5nu5 A 1048-1161 order
 Evidence X-RAY 5nu5 B Reference
       Region 5nu5 B 1048-1161 order
Seq 1043-1519,1581-1666 Hetero dimer :
 Evidence X-RAY 5lkx A Reference
       Region 5lkx A 1043-1045 disorder
       Region 5lkx A 1046-1216 order
       Region 5lkx A 1217-1222 disorder
       Region 5lkx A 1223-1519 order
       Region 5lkx A 1581-1661 order
       Region 5lkx A 1662-1666 disorder
Seq 1043-1519,1581-1666 Hetero dimer :
 Evidence X-RAY 5lkt A Reference
       Region 5lkt A 1043-1045 disorder
       Region 5lkt A 1046-1178 order
       Region 5lkt A 1179-1182 disorder
       Region 5lkt A 1183-1216 order
       Region 5lkt A 1217-1222 disorder
       Region 5lkt A 1223-1519 order
       Region 5lkt A 1581-1662 order
       Region 5lkt A 1663-1666 disorder
Seq 1043-1519,1581-1666 Hetero tetramer :
 Evidence X-RAY 4bhw B Reference
       Region 4bhw B 1043-1045 disorder
       Region 4bhw B 1046-1519 order
       Region 4bhw B 1581-1664 order
       Region 4bhw B 1665-1666 disorder
 Evidence X-RAY 4bhw A Reference
       Region 4bhw A 1043-1045 disorder
       Region 4bhw A 1046-1519 order
       Region 4bhw A 1581-1664 order
       Region 4bhw A 1665-1666 disorder
Seq 1043-1519,1581-1666 Hetero dimer :
 Evidence X-RAY 5lku A Reference
       Region 5lku A 1043-1047 disorder
       Region 5lku A 1048-1216 order
       Region 5lku A 1217-1222 disorder
       Region 5lku A 1223-1519 order
       Region 5lku A 1581-1661 order
       Region 5lku A 1662-1666 disorder
Seq 1043-1519,1581-1666 Hetero dimer :
 Evidence X-RAY 5lkz A Reference
       Region 5lkz A 1043-1045 disorder
       Region 5lkz A 1046-1179 order
       Region 5lkz A 1180-1181 disorder
       Region 5lkz A 1182-1207 order
       Region 5lkz A 1208-1210 disorder
       Region 5lkz A 1211-1216 order
       Region 5lkz A 1217-1222 disorder
       Region 5lkz A 1223-1519 order
       Region 5lkz A 1581-1662 order
       Region 5lkz A 1663-1666 disorder
Seq 1287-1666 Monomer :
 Evidence X-RAY 3biy A Reference
       Region 3biy A 1287-1519 order
       Region 3biy A 1520-1580 disorder
       Region 3biy A 1581-1664 order
       Region 3biy A 1665-1666 disorder
 Evidence X-RAY 4pzr A Reference
       Region 4pzr A 1287-1532 order
       Region 4pzr A 1533-1578 disorder
       Region 4pzr A 1579-1664 order
 Evidence X-RAY 4pzs A Reference
       Region 4pzs A 1287-1534 order
       Region 4pzs A 1535-1578 disorder
       Region 4pzs A 1579-1664 order
 Evidence X-RAY 4pzt A Reference
       Region 4pzt A 1287-1534 order
       Region 4pzt A 1535-1578 disorder
       Region 4pzt A 1579-1664 order
Seq 1287-1522,1555-1666 Hetero dimer :
 Evidence X-RAY 5kj2 A Reference
       Region 5kj2 A 1287-1522 order
       Region 5kj2 A 1555-1558 order
       Region 5kj2 A 1559-1578 disorder
       Region 5kj2 A 1579-1661 order
       Region 5kj2 A 1662-1666 disorder
Seq 1723-1812 Hetero dimer : IID00015Complex
 Evidence NMR 2mzd A Reference
       Region 2mzd A 1723-1812 order
       Region 2mzd A 1723-1724 high_rmsd
       Region 2mzd A 1812-1812 high_rmsd
Seq 1723-1812 Hetero dimer : IID00541Complex
 Evidence NMR 2mh0 B Reference
       Region 2mh0 B 1723-1812 order
       Region 2mh0 B 1723-1723 high_rmsd
Seq 1723-1812 Hetero dimer : IID00015Complex
 Evidence NMR 2k8f A Reference
       Region 2k8f A 1723-1812 order
Seq 1723-1818 Hetero dimer : IID00618Complex
 Evidence X-RAY 3t92 A Reference
       Region 3t92 A 1723-1728 disorder
       Region 3t92 A 1729-1818 order
Seq 1723-1836 Monomer :
 Evidence X-RAY 3io2 A Reference
       Region 3io2 A 1723-1725 disorder
       Region 3io2 A 1726-1834 order
       Region 3io2 A 1835-1836 disorder
Seq 1726-1835 Hetero heptamer : IID00240Complex
 Evidence X-RAY 3p57 P Reference
       Region 3p57 P 1726-1771 order
       Region 3p57 P 1772-1778 disorder
       Region 3p57 P 1779-1835 order
Seqphosphorylation
    89-89 Phosphoserine; by AMPK
    499-499 Phosphoserine
    1038-1038 Phosphoserine
    1726-1726 Phosphoserine
Seqacetylation
    2-2 N-acetylalanine
    418-418 N6-acetyllysine
    423-423 N6-acetyllysine
    636-636 N6-acetyllysine
    977-977 N6-acetyllysine
    1020-1020 N6-acetyllysine; alternate
    1024-1024 N6-acetyllysine; alternate
    1180-1180 N6-acetyllysine
    1336-1336 N6-acetyllysine
    1473-1473 N6-acetyllysine
    1499-1499 N6-acetyllysine; by autocatalysis
    1542-1542 N6-acetyllysine
    1546-1546 N6-acetyllysine
    1549-1549 N6-acetyllysine; by autocatalysis
    1554-1554 N6-acetyllysine; by autocatalysis
    1555-1555 N6-acetyllysine
    1558-1558 N6-acetyllysine
    1560-1560 N6-acetyllysine; by autocatalysis
    1583-1583 N6-acetyllysine
    1699-1699 N6-acetyllysine
    1704-1704 N6-acetyllysine
    1707-1707 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-333,423-1001,1030-1045,1541-1567,1707-1729,1816-2414
Order 334-422,1002-1029,1046-1282,1287-1540,1568-1706,1730-1815
ProS 1-24,30-50,330-333,423-431,543-547,569-594,631-639,944-949,979-983,1541-1567,1707-1718,1821-1836,2068-2076,2409-2414
AlphaFold
Disorder 1-331,357-363,421-568,593-601,651-651,653-1045,1173-1173,1181-1182,1187-1187,1216-1223,1442-1443,1530-1578,1662-1669,1675-1679,1687-1687,1699-1700,1708-1732,1734-1734,1774-1778,1824-1824,1827-2064,2076-2079,2082-2083,2085-2085,2087-2414
Order 332-356,364-420,569-592,602-650,652-652,1046-1172,1174-1180,1183-1186,1188-1215,1224-1441,1444-1529,1579-1661,1670-1674,1680-1686,1688-1698,1701-1707,1733-1733,1735-1773,1779-1823,1825-1826,2065-2075,2080-2081,2084-2084,2086-2086
Pfam Hmmer
PF02135 332-416 2.5e-47
PF02172 566-646 2.5e-52
PF00439 1054-1144 1.9e-42
PF06001 1145-1205 1.7e-30
PF06010 1280-1517 8.7e-187
PF00569 1664-1705 2e-19
PF02135 1727-1806 4.2e-40
SEG 18-28 ,161-177 ,295-313 ,481-501 ,669-682 ,831-848 ,851-877 ,880-944 ,1008-1022 ,1029-1041 ,1513-1536 ,1545-1562 ,1609-1623 ,1811-1837 ,1848-1885 ,1901-1926 ,1956-1972 ,1990-2009 ,2054-2074 ,2097-2123 ,2145-2157 ,2186-2195 ,2210-2244 ,2257-2268 ,2306-2349 ,2391-2412
Function
Function in SwissProt
(Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein.
Biological Process
See also
Diagram with PDB data
E1A_ADE05/CREBBPNMR structure of CBP TAZ2 and adenoviral E1A complex
TP53/EP300Structural Basis for the Regulation of p53 Function by p300
TP53/CREBBPNMR Structure of CBP Bromodomain in complex with p53 peptide
TP53/SETD7Crystal structure of a ternary complex of the methyltransferase SET9 (also known as SET7/9) with a P53 peptide and SAH
TP53/SMYD2Structure of SMYD2 in complex with p53 and SAH
TCF4/CREBBPThe structure of E-protein activation domain 1 bound to the KIX domain of CBP/p300 elucidates leukemia induction by E2A-PBX1
TCF3/EP300Solution NMR structure of the p300 Taz2:ETAD1 complex
HIF1A/EP300NMR Structures of the HIF-1alpha CTAD/p300 CH1 Complex
TCF12/RUNX1T1Complex structure of AML1-ETO NHR2 domain with HEB fragment
CITED2/EP300Structural basis for negative regulation of hypoxia-inducible factor-1alpha by CITED2