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IID00091
 UniprotQ92731
ProteinEstrogen receptor beta
GeneESR2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
530
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seqdisorder 1-103
 Evidence CD Reference
       Region 1-103 disorder
Seqdisorder 1-103
 Evidence NMR Reference
       Region 1-103 disorder
Seq 255-509 Monomer :
 Evidence X-RAY 1l2j A Reference
       Region 1l2j A 256-260 disorder
       Region 1l2j A 261-284 order
       Region 1l2j A 285-289 disorder
       Region 1l2j A 290-408 order
       Region 1l2j A 409-412 disorder
       Region 1l2j A 413-501 order
       Region 1l2j A 502-505 disorder
 Evidence X-RAY 1l2j B Reference
       Region 1l2j B 256-280 order
       Region 1l2j B 281-293 disorder
       Region 1l2j B 294-410 order
       Region 1l2j B 411-412 disorder
       Region 1l2j B 413-479 order
       Region 1l2j B 480-484 disorder
       Region 1l2j B 485-497 order
       Region 1l2j B 498-505 disorder
 Evidence X-RAY 1nde A Reference
       Region 1nde A 256-260 disorder
       Region 1nde A 261-286 order
       Region 1nde A 287-288 disorder
       Region 1nde A 289-411 order
       Region 1nde A 412-415 disorder
       Region 1nde A 416-482 order
       Region 1nde A 483-485 disorder
       Region 1nde A 486-500 order
       Region 1nde A 501-501 disorder
 Evidence X-RAY 1qkm A Reference
       Region 1qkm A 255-259 disorder
       Region 1qkm A 260-285 order
       Region 1qkm A 286-291 disorder
       Region 1qkm A 292-414 order
       Region 1qkm A 415-419 disorder
       Region 1qkm A 420-500 order
       Region 1qkm A 501-509 disorder
Seq 256-509 Homo dimer :
 Evidence X-RAY 1u3q A Reference
       Region 1u3q A 261-262 disorder
       Region 1u3q A 263-411 order
       Region 1u3q A 412-420 disorder
       Region 1u3q A 421-497 order
       Region 1u3q A 498-500 disorder
 Evidence X-RAY 1u3q C Reference
       Region 1u3q C 261-262 disorder
       Region 1u3q C 263-411 order
       Region 1u3q C 412-420 disorder
       Region 1u3q C 421-497 order
       Region 1u3q C 498-500 disorder
 Evidence X-RAY 1u3q B Reference
       Region 1u3q B 261-410 order
       Region 1u3q B 411-420 disorder
       Region 1u3q B 421-497 order
       Region 1u3q B 498-500 disorder
 Evidence X-RAY 1u3q D Reference
       Region 1u3q D 261-262 disorder
       Region 1u3q D 263-411 order
       Region 1u3q D 412-420 disorder
       Region 1u3q D 421-497 order
       Region 1u3q D 498-500 disorder
 Evidence X-RAY 2fsz A Reference
       Region 2fsz A 257-263 disorder
       Region 2fsz A 264-410 order
       Region 2fsz A 411-422 disorder
       Region 2fsz A 423-479 order
       Region 2fsz A 480-482 disorder
       Region 2fsz A 483-501 order
       Region 2fsz A 502-502 disorder
 Evidence X-RAY 2fsz B Reference
       Region 2fsz B 257-259 disorder
       Region 2fsz B 260-410 order
       Region 2fsz B 411-422 disorder
       Region 2fsz B 423-479 order
       Region 2fsz B 480-482 disorder
       Region 2fsz B 483-501 order
       Region 2fsz B 502-502 disorder
 Evidence X-RAY 2giu A Reference
       Region 2giu A 260-285 order
       Region 2giu A 286-291 disorder
       Region 2giu A 292-369 order
       Region 2giu A 370-370 disorder
       Region 2giu A 371-414 order
       Region 2giu A 415-419 disorder
       Region 2giu A 420-479 order
       Region 2giu A 480-483 disorder
       Region 2giu A 484-500 order
 Evidence X-RAY 2i0g A Reference
       Region 2i0g A 256-260 disorder
       Region 2i0g A 261-285 order
       Region 2i0g A 286-291 disorder
       Region 2i0g A 292-414 order
       Region 2i0g A 415-421 disorder
       Region 2i0g A 422-480 order
       Region 2i0g A 481-484 disorder
       Region 2i0g A 485-498 order
       Region 2i0g A 499-505 disorder
 Evidence X-RAY 2i0g B Reference
       Region 2i0g B 256-259 disorder
       Region 2i0g B 260-285 order
       Region 2i0g B 286-291 disorder
       Region 2i0g B 292-414 order
       Region 2i0g B 415-421 disorder
       Region 2i0g B 422-480 order
       Region 2i0g B 481-484 disorder
       Region 2i0g B 485-498 order
       Region 2i0g B 499-505 disorder
 Evidence X-RAY 2jj3 A Reference
       Region 2jj3 A 256-260 disorder
       Region 2jj3 A 261-285 order
       Region 2jj3 A 286-291 disorder
       Region 2jj3 A 292-414 order
       Region 2jj3 A 415-421 disorder
       Region 2jj3 A 422-480 order
       Region 2jj3 A 481-482 disorder
       Region 2jj3 A 483-498 order
       Region 2jj3 A 499-505 disorder
 Evidence X-RAY 2jj3 B Reference
       Region 2jj3 B 256-259 disorder
       Region 2jj3 B 260-285 order
       Region 2jj3 B 286-291 disorder
       Region 2jj3 B 292-414 order
       Region 2jj3 B 415-421 disorder
       Region 2jj3 B 422-480 order
       Region 2jj3 B 481-482 disorder
       Region 2jj3 B 483-500 order
       Region 2jj3 B 501-505 disorder
 Evidence X-RAY 2qtu A Reference
       Region 2qtu A 256-260 disorder
       Region 2qtu A 261-285 order
       Region 2qtu A 286-291 disorder
       Region 2qtu A 292-414 order
       Region 2qtu A 415-421 disorder
       Region 2qtu A 422-480 order
       Region 2qtu A 481-486 disorder
       Region 2qtu A 487-498 order
       Region 2qtu A 499-505 disorder
 Evidence X-RAY 2qtu B Reference
       Region 2qtu B 256-259 disorder
       Region 2qtu B 260-285 order
       Region 2qtu B 286-291 disorder
       Region 2qtu B 292-414 order
       Region 2qtu B 415-421 disorder
       Region 2qtu B 422-480 order
       Region 2qtu B 481-486 disorder
       Region 2qtu B 487-500 order
       Region 2qtu B 501-505 disorder
 Evidence X-RAY 2yly A Reference
       Region 2yly A 260-260 disorder
       Region 2yly A 261-282 order
       Region 2yly A 283-288 disorder
       Region 2yly A 289-409 order
       Region 2yly A 410-419 disorder
       Region 2yly A 420-420 order
       Region 2yly A 421-421 disorder
       Region 2yly A 422-497 order
       Region 2yly A 498-500 disorder
 Evidence X-RAY 2yly B Reference
       Region 2yly B 260-282 order
       Region 2yly B 283-288 disorder
       Region 2yly B 289-409 order
       Region 2yly B 410-419 disorder
       Region 2yly B 420-420 order
       Region 2yly B 421-421 disorder
       Region 2yly B 422-498 order
       Region 2yly B 499-500 disorder
 Evidence X-RAY 2z4b A Reference
       Region 2z4b A 256-260 disorder
       Region 2z4b A 261-285 order
       Region 2z4b A 286-291 disorder
       Region 2z4b A 292-414 order
       Region 2z4b A 415-421 disorder
       Region 2z4b A 422-480 order
       Region 2z4b A 481-484 disorder
       Region 2z4b A 485-498 order
       Region 2z4b A 499-505 disorder
 Evidence X-RAY 2z4b B Reference
       Region 2z4b B 256-259 disorder
       Region 2z4b B 260-285 order
       Region 2z4b B 286-291 disorder
       Region 2z4b B 292-414 order
       Region 2z4b B 415-421 disorder
       Region 2z4b B 422-480 order
       Region 2z4b B 481-484 disorder
       Region 2z4b B 485-500 order
       Region 2z4b B 501-505 disorder
 Evidence X-RAY 5toa A Reference
       Region 5toa A 262-285 order
       Region 5toa A 286-286 disorder
       Region 5toa A 287-411 order
       Region 5toa A 412-420 disorder
       Region 5toa A 421-501 order
       Region 5toa A 502-509 disorder
 Evidence X-RAY 5toa B Reference
       Region 5toa B 262-412 order
       Region 5toa B 413-421 disorder
       Region 5toa B 422-501 order
       Region 5toa B 502-509 disorder
Seq 261-500 Hetero dimer : IID00083Complex
 Evidence X-RAY 3oll A Reference
       Region 3oll A 261-261 disorder
       Region 3oll A 262-417 order
       Region 3oll A 418-419 disorder
       Region 3oll A 420-498 order
       Region 3oll A 499-500 disorder
 Evidence X-RAY 3oll B Reference
       Region 3oll B 261-261 disorder
       Region 3oll B 262-417 order
       Region 3oll B 418-420 disorder
       Region 3oll B 421-498 order
       Region 3oll B 499-500 disorder
 Evidence X-RAY 3ols A Reference
       Region 3ols A 261-263 disorder
       Region 3ols A 264-415 order
       Region 3ols A 416-420 disorder
       Region 3ols A 421-497 order
       Region 3ols A 498-500 disorder
 Evidence X-RAY 3ols B Reference
       Region 3ols B 261-263 disorder
       Region 3ols B 264-416 order
       Region 3ols B 417-424 disorder
       Region 3ols B 425-495 order
       Region 3ols B 496-500 disorder
 Evidence X-RAY 3omo A Reference
       Region 3omo A 261-263 disorder
       Region 3omo A 264-415 order
       Region 3omo A 416-420 disorder
       Region 3omo A 421-497 order
       Region 3omo A 498-500 disorder
 Evidence X-RAY 3omo B Reference
       Region 3omo B 261-263 disorder
       Region 3omo B 264-416 order
       Region 3omo B 417-424 disorder
       Region 3omo B 425-495 order
       Region 3omo B 496-500 disorder
 Evidence X-RAY 3omp A Reference
       Region 3omp A 261-263 disorder
       Region 3omp A 264-415 order
       Region 3omp A 416-420 disorder
       Region 3omp A 421-497 order
       Region 3omp A 498-500 disorder
 Evidence X-RAY 3omp B Reference
       Region 3omp B 261-263 disorder
       Region 3omp B 264-416 order
       Region 3omp B 417-424 disorder
       Region 3omp B 425-495 order
       Region 3omp B 496-500 disorder
 Evidence X-RAY 3omq A Reference
       Region 3omq A 261-263 disorder
       Region 3omq A 264-415 order
       Region 3omq A 416-420 disorder
       Region 3omq A 421-497 order
       Region 3omq A 498-500 disorder
 Evidence X-RAY 3omq B Reference
       Region 3omq B 261-263 disorder
       Region 3omq B 264-416 order
       Region 3omq B 417-424 disorder
       Region 3omq B 425-495 order
       Region 3omq B 496-500 disorder
Seq 261-500 Hetero dimer :
 Evidence X-RAY 4j26 B Reference
       Region 4j26 B 261-410 order
       Region 4j26 B 411-419 disorder
       Region 4j26 B 420-498 order
       Region 4j26 B 499-500 disorder
Seq 261-500 Hetero dimer :
 Evidence X-RAY 4j26 A Reference
       Region 4j26 A 261-409 order
       Region 4j26 A 410-419 disorder
       Region 4j26 A 420-498 order
       Region 4j26 A 499-500 disorder
Seq 261-500 Hetero dimer :
 Evidence X-RAY 4j24 D Reference
       Region 4j24 D 261-263 disorder
       Region 4j24 D 264-409 order
       Region 4j24 D 410-422 disorder
       Region 4j24 D 423-497 order
       Region 4j24 D 498-500 disorder
Seq 261-500 Hetero dimer :
 Evidence X-RAY 4j24 C Reference
       Region 4j24 C 261-261 disorder
       Region 4j24 C 262-409 order
       Region 4j24 C 410-421 disorder
       Region 4j24 C 422-498 order
       Region 4j24 C 499-500 disorder
Seq 261-500 Hetero tetramer : IID00082Complex
 Evidence X-RAY 2yjd B Reference
       Region 2yjd B 261-262 disorder
       Region 2yjd B 263-409 order
       Region 2yjd B 410-421 disorder
       Region 2yjd B 422-497 order
       Region 2yjd B 498-500 disorder
 Evidence X-RAY 2yjd A Reference
       Region 2yjd A 261-262 disorder
       Region 2yjd A 263-409 order
       Region 2yjd A 410-421 disorder
       Region 2yjd A 422-497 order
       Region 2yjd A 498-500 disorder
Seq 261-500 Hetero dimer :
 Evidence X-RAY 4j24 A Reference
       Region 4j24 A 261-261 disorder
       Region 4j24 A 262-409 order
       Region 4j24 A 410-421 disorder
       Region 4j24 A 422-498 order
       Region 4j24 A 499-500 disorder
Seq 261-500 Hetero dimer :
 Evidence X-RAY 4j24 B Reference
       Region 4j24 B 261-410 order
       Region 4j24 B 411-420 disorder
       Region 4j24 B 421-498 order
       Region 4j24 B 499-500 disorder
Seq 261-501 Hetero dimer :
 Evidence X-RAY 1u9e B Reference
       Region 1u9e B 261-262 disorder
       Region 1u9e B 263-410 order
       Region 1u9e B 411-421 disorder
       Region 1u9e B 422-501 order
Seq 261-501 Hetero dimer :
 Evidence X-RAY 1u9e A Reference
       Region 1u9e A 261-262 disorder
       Region 1u9e A 263-409 order
       Region 1u9e A 410-421 disorder
       Region 1u9e A 422-497 order
       Region 1u9e A 498-501 disorder
Seq 261-530 Hetero tetramer : IID00083Complex
 Evidence X-RAY 1u3r A Reference
       Region 1u3r A 261-262 disorder
       Region 1u3r A 263-410 order
       Region 1u3r A 411-417 disorder
       Region 1u3r A 418-500 order
       Region 1u3r A 501-501 disorder
 Evidence X-RAY 1u3r B Reference
       Region 1u3r B 261-262 disorder
       Region 1u3r B 263-409 order
       Region 1u3r B 410-421 disorder
       Region 1u3r B 422-501 order
 Evidence X-RAY 1u3s A Reference
       Region 1u3s A 261-262 disorder
       Region 1u3s A 263-411 order
       Region 1u3s A 412-419 disorder
       Region 1u3s A 420-497 order
       Region 1u3s A 498-500 disorder
 Evidence X-RAY 1u3s B Reference
       Region 1u3s B 261-262 disorder
       Region 1u3s B 263-409 order
       Region 1u3s B 410-421 disorder
       Region 1u3s B 422-497 order
       Region 1u3s B 498-500 disorder
 Evidence X-RAY 1x76 A Reference
       Region 1x76 A 261-262 disorder
       Region 1x76 A 263-410 order
       Region 1x76 A 411-420 disorder
       Region 1x76 A 421-497 order
       Region 1x76 A 498-500 disorder
 Evidence X-RAY 1x76 B Reference
       Region 1x76 B 261-262 disorder
       Region 1x76 B 263-410 order
       Region 1x76 B 411-420 disorder
       Region 1x76 B 421-497 order
       Region 1x76 B 498-500 disorder
 Evidence X-RAY 1x78 A Reference
       Region 1x78 A 261-262 disorder
       Region 1x78 A 263-410 order
       Region 1x78 A 411-420 disorder
       Region 1x78 A 421-500 order
 Evidence X-RAY 1x78 B Reference
       Region 1x78 B 261-262 disorder
       Region 1x78 B 263-410 order
       Region 1x78 B 411-420 disorder
       Region 1x78 B 421-500 order
 Evidence X-RAY 1x7b A Reference
       Region 1x7b A 261-262 disorder
       Region 1x7b A 263-410 order
       Region 1x7b A 411-420 disorder
       Region 1x7b A 421-500 order
 Evidence X-RAY 1x7b B Reference
       Region 1x7b B 261-262 disorder
       Region 1x7b B 263-410 order
       Region 1x7b B 411-420 disorder
       Region 1x7b B 421-497 order
       Region 1x7b B 498-500 disorder
 Evidence X-RAY 1x7j A Reference
       Region 1x7j A 261-262 disorder
       Region 1x7j A 263-410 order
       Region 1x7j A 411-420 disorder
       Region 1x7j A 421-497 order
       Region 1x7j A 498-500 disorder
 Evidence X-RAY 1x7j B Reference
       Region 1x7j B 261-262 disorder
       Region 1x7j B 263-410 order
       Region 1x7j B 411-420 disorder
       Region 1x7j B 421-497 order
       Region 1x7j B 498-500 disorder
 Evidence X-RAY 1yy4 A Reference
       Region 1yy4 A 263-410 order
       Region 1yy4 A 411-420 disorder
       Region 1yy4 A 421-497 order
       Region 1yy4 A 498-530 disorder
 Evidence X-RAY 1yy4 B Reference
       Region 1yy4 B 263-410 order
       Region 1yy4 B 411-420 disorder
       Region 1yy4 B 421-497 order
       Region 1yy4 B 498-530 disorder
 Evidence X-RAY 1yye A Reference
       Region 1yye A 263-410 order
       Region 1yye A 411-420 disorder
       Region 1yye A 421-500 order
       Region 1yye A 501-530 disorder
 Evidence X-RAY 1yye B Reference
       Region 1yye B 263-410 order
       Region 1yye B 411-420 disorder
       Region 1yye B 421-496 order
       Region 1yye B 497-530 disorder
 Evidence X-RAY 1zaf A Reference
       Region 1zaf A 263-410 order
       Region 1zaf A 411-420 disorder
       Region 1zaf A 421-500 order
 Evidence X-RAY 1zaf B Reference
       Region 1zaf B 263-410 order
       Region 1zaf B 411-420 disorder
       Region 1zaf B 421-500 order
 Evidence X-RAY 2nv7 A Reference
       Region 2nv7 A 263-410 order
       Region 2nv7 A 411-420 disorder
       Region 2nv7 A 421-500 order
 Evidence X-RAY 2nv7 B Reference
       Region 2nv7 B 263-410 order
       Region 2nv7 B 411-420 disorder
       Region 2nv7 B 421-497 order
       Region 2nv7 B 498-500 disorder
Seq 262-509 Hetero tetramer : Q9HCD5
 Evidence X-RAY 4zi1 A Reference
       Region 4zi1 A 262-408 order
       Region 4zi1 A 409-419 disorder
       Region 4zi1 A 420-502 order
       Region 4zi1 A 503-509 disorder
Seqphosphorylation
    105-105 Phosphoserine
    87-87 Phosphoserine
 
Prediction
NeProc
Disorder 1-145,219-275,283-286,502-530
Order 146-218,276-282,287-412,420-501
ProS 9-17,24-56,77-91,105-110,219-227,263-275,283-286
AlphaFold
Disorder 1-145,180-180,217-261,408-419,500-530
Order 146-179,181-216,262-407,420-499
Pfam Hmmer
PF00105 147-222 6.4e-47
PF00104 303-494 4.6e-50
SEG 5-21
Function
Function in SwissProt
Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner (PubMed:20074560). Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.
Biological Process
See also
Diagram with PDB data
NCOA1/RARACrystal structure of RARalpha ligand binding domain in complex with an agonist ligand (Am580) and a coactivator fragment