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IID00104  SUMO-activating enzyme subunit 2 (Homo sapiens) Q9UBT2
  :order  :disorder  :conflict  :PDB cluster  :ProS  :SCOP Domain  :Pfam Domain
Networkxml
Experiment
640
fasta
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-640 Hetero trimer : IID00378Complex,IID00397Complex
 Evidence X-RAY 1y8r B Reference
       Region 1y8r B 1-3 disorder
       Region 1y8r B 4-218 order
       Region 1y8r B 219-239 disorder
       Region 1y8r B 240-290 order
       Region 1y8r B 291-304 disorder
       Region 1y8r B 305-550 order
       Region 1y8r B 551-640 disorder
 Evidence X-RAY 1y8r E Reference
       Region 1y8r E 1-3 disorder
       Region 1y8r E 4-218 order
       Region 1y8r E 219-237 disorder
       Region 1y8r E 238-290 order
       Region 1y8r E 291-304 disorder
       Region 1y8r E 305-550 order
       Region 1y8r E 551-640 disorder
Seq 1-640 Hetero dimer : IID00397Complex
 Evidence X-RAY 1y8q B Reference
       Region 1y8q B 1-5 disorder
       Region 1y8q B 6-218 order
       Region 1y8q B 219-239 disorder
       Region 1y8q B 240-290 order
       Region 1y8q B 291-304 disorder
       Region 1y8q B 305-550 order
       Region 1y8q B 551-640 disorder
 Evidence X-RAY 1y8q D Reference
       Region 1y8q D 1-3 disorder
       Region 1y8q D 4-218 order
       Region 1y8q D 219-237 disorder
       Region 1y8q D 238-290 order
       Region 1y8q D 291-304 disorder
       Region 1y8q D 305-550 order
       Region 1y8q D 551-640 disorder
Seq 1-640 Hetero trimer : IID00378Complex,IID00397Complex
 Evidence X-RAY 3kyc B Reference
       Region 3kyc B 1-4 disorder
       Region 3kyc B 5-217 order
       Region 3kyc B 218-234 disorder
       Region 3kyc B 235-291 order
       Region 3kyc B 292-304 disorder
       Region 3kyc B 305-548 order
       Region 3kyc B 549-606 disorder
       Region 3kyc B 607-640 order
 Evidence X-RAY 3kyd B Reference
       Region 3kyd B 1-3 disorder
       Region 3kyd B 4-197 order
       Region 3kyd B 198-239 disorder
       Region 3kyd B 240-290 order
       Region 3kyd B 291-308 disorder
       Region 3kyd B 309-336 order
       Region 3kyd B 337-344 disorder
       Region 3kyd B 345-548 order
       Region 3kyd B 549-549 disorder
Seq 166-382 Hetero dimer : P63279
 Evidence NMR 2px9 A Reference
       Region 2px9 A 166-382 order
       Region 2px9 A 222-235 high_rmsd
       Region 2px9 A 294-300 high_rmsd
Seq 445-561 Hetero dimer : P63279
 Evidence X-RAY 5fq2 B Reference
       Region 5fq2 B 446-446 disorder
       Region 5fq2 B 447-547 order
 Evidence X-RAY 4w5v B Reference
       Region 4w5v B 445-549 order
       Region 4w5v B 550-561 disorder
SeqProS verified 198-217,337-344,607-640 The 198-217 and 337-344 are disordered in the closed form due to the conformational change in the Cys domain. The 607-640 is disordered without SUMO. (PubMed=20164921) Hetero trimer : IID00378Complex,IID00397Complex
       Region 3kyc B 5-217 order
       Region 3kyc B 305-548 order
       Region 3kyc B 607-640 order
       Region 3kyd B 198-239 disorder
       Region 3kyd B 337-344 disorder
       Region 1y8r E 551-640 disorder
Seqphosphorylation
    207-207 Phosphoserine
    507-507 Phosphoserine
    592-592 Phosphoserine
Seqacetylation
    271-271 N6-acetyllysine; alternate
    613-613 N6-acetyllysine; alternate
 
Prediction
DICHOT
Disorder 1-5,551-640
Known Domain 6-550
SCOPe RPS-Blast
     1ngvB 10-535 2e-78 c.111.1.2 Amyloid beta precursor protein-binding...
SCOP Hmmer
     1yovB1 10-522 3e-105 Activating enzymes of the...
Pfam RPS-Blast
     PF10585 179-377 2e-13 Ubiquitin-activating enzyme...
     PF14732 452-536 6e-24 Ubiquitin/SUMO-activating e...
     PF16195 549-636 7e-26 SUMO-activating enzyme subu...
Pfam Hmmer
    PF00899 10-441 2e-78 ThiF family
    PF14732 452-537 5.3e-27 Ubiquitin/SUMO-activating ...
    PF16195 549-634 2e-31 SUMO-activating enzyme subun...