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IID00106
UniprotQ9UNA4
ProteinDNA polymerase iota
GenePOLI
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
740
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-445 Monomer :
 Evidence X-RAY 1zet A Reference
       Region 1zet A 52-439 order
 Evidence X-RAY 3g6v A Reference
       Region 3g6v A 26-49 disorder
       Region 3g6v A 50-395 order
       Region 3g6v A 396-403 disorder
       Region 3g6v A 404-419 order
       Region 3g6v A 420-428 disorder
       Region 3g6v A 429-439 order
       Region 3g6v A 440-445 disorder
 Evidence X-RAY 3g6x A Reference
       Region 3g6x A 26-49 disorder
       Region 3g6x A 50-395 order
       Region 3g6x A 396-403 disorder
       Region 3g6x A 404-419 order
       Region 3g6x A 420-428 disorder
       Region 3g6x A 429-439 order
       Region 3g6x A 440-445 disorder
 Evidence X-RAY 3g6y A Reference
       Region 3g6y A 26-49 disorder
       Region 3g6y A 50-395 order
       Region 3g6y A 396-403 disorder
       Region 3g6y A 404-419 order
       Region 3g6y A 420-428 disorder
       Region 3g6y A 429-439 order
       Region 3g6y A 440-445 disorder
 Evidence X-RAY 3gv5 B Reference
       Region 3gv5 B 26-52 disorder
       Region 3gv5 B 53-375 order
       Region 3gv5 B 376-380 disorder
       Region 3gv5 B 381-397 order
       Region 3gv5 B 398-400 disorder
       Region 3gv5 B 401-439 order
       Region 3gv5 B 440-445 disorder
 Evidence X-RAY 3gv5 D Reference
       Region 3gv5 D 26-50 disorder
       Region 3gv5 D 51-376 order
       Region 3gv5 D 377-380 disorder
       Region 3gv5 D 381-397 order
       Region 3gv5 D 398-400 disorder
       Region 3gv5 D 401-440 order
       Region 3gv5 D 441-445 disorder
 Evidence X-RAY 3gv7 B Reference
       Region 3gv7 B 26-50 disorder
       Region 3gv7 B 51-374 order
       Region 3gv7 B 375-380 disorder
       Region 3gv7 B 381-396 order
       Region 3gv7 B 397-402 disorder
       Region 3gv7 B 403-439 order
       Region 3gv7 B 440-445 disorder
 Evidence X-RAY 3gv8 B Reference
       Region 3gv8 B 26-50 disorder
       Region 3gv8 B 51-358 order
       Region 3gv8 B 359-361 disorder
       Region 3gv8 B 362-374 order
       Region 3gv8 B 375-380 disorder
       Region 3gv8 B 381-396 order
       Region 3gv8 B 397-402 disorder
       Region 3gv8 B 403-439 order
       Region 3gv8 B 440-445 disorder
 Evidence X-RAY 3h40 A Reference
       Region 3h40 A 51-395 order
       Region 3h40 A 396-403 disorder
       Region 3h40 A 404-419 order
       Region 3h40 A 420-428 disorder
       Region 3h40 A 429-439 order
 Evidence X-RAY 3h4b A Reference
       Region 3h4b A 50-395 order
       Region 3h4b A 396-403 disorder
       Region 3h4b A 404-419 order
       Region 3h4b A 420-428 disorder
       Region 3h4b A 429-439 order
 Evidence X-RAY 3h4d A Reference
       Region 3h4d A 50-395 order
       Region 3h4d A 396-403 disorder
       Region 3h4d A 404-419 order
       Region 3h4d A 420-428 disorder
       Region 3h4d A 429-439 order
 Evidence X-RAY 3ngd A Reference
       Region 3ngd A 26-50 disorder
       Region 3ngd A 51-376 order
       Region 3ngd A 377-380 disorder
       Region 3ngd A 381-396 order
       Region 3ngd A 397-402 disorder
       Region 3ngd A 403-419 order
       Region 3ngd A 420-428 disorder
       Region 3ngd A 429-439 order
       Region 3ngd A 440-445 disorder
 Evidence X-RAY 3osn A Reference
       Region 3osn A 26-49 disorder
       Region 3osn A 50-396 order
       Region 3osn A 397-401 disorder
       Region 3osn A 402-439 order
       Region 3osn A 440-445 disorder
 Evidence X-RAY 3q8p B Reference
       Region 3q8p B 26-51 disorder
       Region 3q8p B 52-375 order
       Region 3q8p B 376-380 disorder
       Region 3q8p B 381-397 order
       Region 3q8p B 398-400 disorder
       Region 3q8p B 401-439 order
       Region 3q8p B 440-445 disorder
 Evidence X-RAY 3q8q B Reference
       Region 3q8q B 26-51 disorder
       Region 3q8q B 52-375 order
       Region 3q8q B 376-380 disorder
       Region 3q8q B 381-397 order
       Region 3q8q B 398-400 disorder
       Region 3q8q B 401-439 order
       Region 3q8q B 440-445 disorder
 Evidence X-RAY 3q8r B Reference
       Region 3q8r B 26-51 disorder
       Region 3q8r B 52-375 order
       Region 3q8r B 376-380 disorder
       Region 3q8r B 381-395 order
       Region 3q8r B 396-400 disorder
       Region 3q8r B 401-439 order
       Region 3q8r B 440-445 disorder
 Evidence X-RAY 3q8s B Reference
       Region 3q8s B 26-51 disorder
       Region 3q8s B 52-375 order
       Region 3q8s B 376-380 disorder
       Region 3q8s B 381-397 order
       Region 3q8s B 398-400 disorder
       Region 3q8s B 401-439 order
       Region 3q8s B 440-445 disorder
 Evidence X-RAY 4ebc A Reference
       Region 4ebc A 26-50 disorder
       Region 4ebc A 51-360 order
       Region 4ebc A 361-361 disorder
       Region 4ebc A 362-374 order
       Region 4ebc A 375-380 disorder
       Region 4ebc A 381-396 order
       Region 4ebc A 397-402 disorder
       Region 4ebc A 403-439 order
       Region 4ebc A 440-445 disorder
 Evidence X-RAY 4ebd A Reference
       Region 4ebd A 26-50 disorder
       Region 4ebd A 51-360 order
       Region 4ebd A 361-361 disorder
       Region 4ebd A 362-374 order
       Region 4ebd A 375-380 disorder
       Region 4ebd A 381-396 order
       Region 4ebd A 397-402 disorder
       Region 4ebd A 403-439 order
       Region 4ebd A 440-445 disorder
 Evidence X-RAY 4ebe A Reference
       Region 4ebe A 26-50 disorder
       Region 4ebe A 51-360 order
       Region 4ebe A 361-361 disorder
       Region 4ebe A 362-374 order
       Region 4ebe A 375-380 disorder
       Region 4ebe A 381-396 order
       Region 4ebe A 397-402 disorder
       Region 4ebe A 403-439 order
       Region 4ebe A 440-445 disorder
 Evidence X-RAY 4eyh B Reference
       Region 4eyh B 26-50 disorder
       Region 4eyh B 51-373 order
       Region 4eyh B 374-380 disorder
       Region 4eyh B 381-396 order
       Region 4eyh B 397-401 disorder
       Region 4eyh B 402-439 order
       Region 4eyh B 440-445 disorder
 Evidence X-RAY 4eyi B Reference
       Region 4eyi B 26-50 disorder
       Region 4eyi B 51-374 order
       Region 4eyi B 375-381 disorder
       Region 4eyi B 382-396 order
       Region 4eyi B 397-402 disorder
       Region 4eyi B 403-441 order
       Region 4eyi B 442-445 disorder
 Evidence X-RAY 4fs1 A Reference
       Region 4fs1 A 26-50 disorder
       Region 4fs1 A 51-395 order
       Region 4fs1 A 396-401 disorder
       Region 4fs1 A 402-439 order
       Region 4fs1 A 440-445 disorder
 Evidence X-RAY 4fs2 A Reference
       Region 4fs2 A 26-50 disorder
       Region 4fs2 A 51-396 order
       Region 4fs2 A 397-402 disorder
       Region 4fs2 A 403-439 order
       Region 4fs2 A 440-445 disorder
 Evidence X-RAY 5kt2 A Reference
       Region 5kt2 A 26-50 disorder
       Region 5kt2 A 51-375 order
       Region 5kt2 A 376-380 disorder
       Region 5kt2 A 381-398 order
       Region 5kt2 A 399-401 disorder
       Region 5kt2 A 402-439 order
       Region 5kt2 A 440-445 disorder
 Evidence X-RAY 5kt3 A Reference
       Region 5kt3 A 26-50 disorder
       Region 5kt3 A 51-374 order
       Region 5kt3 A 375-380 disorder
       Region 5kt3 A 381-397 order
       Region 5kt3 A 398-401 disorder
       Region 5kt3 A 402-439 order
       Region 5kt3 A 440-445 disorder
 Evidence X-RAY 5kt4 A Reference
       Region 5kt4 A 1-50 disorder
       Region 5kt4 A 51-374 order
       Region 5kt4 A 375-380 disorder
       Region 5kt4 A 381-398 order
       Region 5kt4 A 399-401 disorder
       Region 5kt4 A 402-423 order
       Region 5kt4 A 424-425 disorder
       Region 5kt4 A 426-439 order
       Region 5kt4 A 440-445 disorder
 Evidence X-RAY 5kt5 A Reference
       Region 5kt5 A 1-50 disorder
       Region 5kt5 A 51-375 order
       Region 5kt5 A 376-380 disorder
       Region 5kt5 A 381-398 order
       Region 5kt5 A 399-401 disorder
       Region 5kt5 A 402-423 order
       Region 5kt5 A 424-425 disorder
       Region 5kt5 A 426-439 order
       Region 5kt5 A 440-445 disorder
 Evidence X-RAY 5kt6 A Reference
       Region 5kt6 A 1-50 disorder
       Region 5kt6 A 51-375 order
       Region 5kt6 A 376-380 disorder
       Region 5kt6 A 381-398 order
       Region 5kt6 A 399-401 disorder
       Region 5kt6 A 402-439 order
       Region 5kt6 A 440-445 disorder
 Evidence X-RAY 5kt7 A Reference
       Region 5kt7 A 1-50 disorder
       Region 5kt7 A 51-374 order
       Region 5kt7 A 375-380 disorder
       Region 5kt7 A 381-397 order
       Region 5kt7 A 398-401 disorder
       Region 5kt7 A 402-439 order
       Region 5kt7 A 440-445 disorder
 Evidence X-RAY 5ulw A Reference
       Region 5ulw A 26-50 disorder
       Region 5ulw A 51-375 order
       Region 5ulw A 376-380 disorder
       Region 5ulw A 381-396 order
       Region 5ulw A 397-402 disorder
       Region 5ulw A 403-422 order
       Region 5ulw A 423-427 disorder
       Region 5ulw A 428-439 order
       Region 5ulw A 440-445 disorder
 Evidence X-RAY 5ulx A Reference
       Region 5ulx A 26-50 disorder
       Region 5ulx A 51-375 order
       Region 5ulx A 376-380 disorder
       Region 5ulx A 381-396 order
       Region 5ulx A 397-402 disorder
       Region 5ulx A 403-422 order
       Region 5ulx A 423-427 disorder
       Region 5ulx A 428-439 order
       Region 5ulx A 440-445 disorder
Seq 26-445 Homo dimer :
 Evidence X-RAY 1t3n A Reference
       Region 1t3n A 52-439 order
 Evidence X-RAY 1t3n B Reference
       Region 1t3n B 52-439 order
 Evidence X-RAY 2alz A Reference
       Region 2alz A 50-395 order
       Region 2alz A 396-403 disorder
       Region 2alz A 404-419 order
       Region 2alz A 420-428 disorder
       Region 2alz A 429-439 order
 Evidence X-RAY 2dpi A Reference
       Region 2dpi A 26-50 disorder
       Region 2dpi A 51-395 order
       Region 2dpi A 396-403 disorder
       Region 2dpi A 404-419 order
       Region 2dpi A 420-428 disorder
       Region 2dpi A 429-439 order
       Region 2dpi A 440-445 disorder
 Evidence X-RAY 2dpj A Reference
       Region 2dpj A 26-49 disorder
       Region 2dpj A 50-395 order
       Region 2dpj A 396-403 disorder
       Region 2dpj A 404-419 order
       Region 2dpj A 420-428 disorder
       Region 2dpj A 429-439 order
       Region 2dpj A 440-445 disorder
 Evidence X-RAY 2fll A Reference
       Region 2fll A 26-49 disorder
       Region 2fll A 50-395 order
       Region 2fll A 396-403 disorder
       Region 2fll A 404-419 order
       Region 2fll A 420-428 disorder
       Region 2fll A 429-439 order
       Region 2fll A 440-445 disorder
 Evidence X-RAY 2fln A Reference
       Region 2fln A 26-50 disorder
       Region 2fln A 51-374 order
       Region 2fln A 375-380 disorder
       Region 2fln A 381-395 order
       Region 2fln A 396-403 disorder
       Region 2fln A 404-419 order
       Region 2fln A 420-428 disorder
       Region 2fln A 429-439 order
       Region 2fln A 440-445 disorder
 Evidence X-RAY 2flp A Reference
       Region 2flp A 26-50 disorder
       Region 2flp A 51-374 order
       Region 2flp A 375-379 disorder
       Region 2flp A 380-395 order
       Region 2flp A 396-403 disorder
       Region 2flp A 404-419 order
       Region 2flp A 420-428 disorder
       Region 2flp A 429-439 order
       Region 2flp A 440-445 disorder
 Evidence X-RAY 3epg A Reference
       Region 3epg A 26-49 disorder
       Region 3epg A 50-375 order
       Region 3epg A 376-379 disorder
       Region 3epg A 380-396 order
       Region 3epg A 397-402 disorder
       Region 3epg A 403-422 order
       Region 3epg A 423-427 disorder
       Region 3epg A 428-439 order
       Region 3epg A 440-445 disorder
 Evidence X-RAY 3epi A Reference
       Region 3epi A 26-49 disorder
       Region 3epi A 50-375 order
       Region 3epi A 376-380 disorder
       Region 3epi A 381-396 order
       Region 3epi A 397-402 disorder
       Region 3epi A 403-421 order
       Region 3epi A 422-427 disorder
       Region 3epi A 428-439 order
       Region 3epi A 440-445 disorder
Seq 516-555 Hetero dimer : P0CG47
 Evidence NMR 2mbb A Reference
       Region 2mbb A 516-518 disorder
       Region 2mbb A 519-555 order
Seq 697-740 Hetero dimer : P0CG47,P0CG48,P62979
 Evidence NMR 2khw A Reference
       Region 2khw A 697-700 disorder
       Region 2khw A 701-732 order
       Region 2khw A 733-740 disorder
Seq 697-740 Monomer :
 Evidence NMR 2khu A Reference
       Region 2khu A 697-700 disorder
       Region 2khu A 701-732 order
       Region 2khu A 733-740 disorder
 Evidence NMR 2l0g A Reference
       Region 2l0g A 704-730 order
Seq 699-740 Hetero dimer : P62979
 Evidence NMR 2l0f B Reference
       Region 2l0f B 699-740 order
Seq 704-730 Hetero dimer : P62979
 Evidence NMR 2ktf B Reference
       Region 2ktf B 704-730 order
 
Prediction
NeProc
Disorder 1-49,439-696,733-740
Order 50-438,697-732
ProS 1-7,21-28,448-453,511-547,576-580,617-628,638-650,683-696,733-740
AlphaFold
Disorder 1-50,378-380,442-522,546-701,732-740
Order 51-377,381-441,523-545,702-731
Pfam Hmmer
PF00817 58-440 3.2e-63
SEG 5-30 ,589-598 ,605-624
Function
Function in SwissProt
Error-prone DNA polymerase specifically involved in DNA repair (PubMed:11013228, PubMed:11387224). Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls (PubMed:11013228, PubMed:11387224, PubMed:14630940, PubMed:15199127). Favors Hoogsteen base-pairing in the active site (PubMed:15254543). Inserts the correct base with high-fidelity opposite an adenosine template (PubMed:15254543). Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine (PubMed:11013228). May play a role in hypermutation of immunogobulin genes (PubMed:12410315). Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity (PubMed:11251121, PubMed:14630940).