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IID00111
 UniprotO60885
ProteinBromodomain-containing protein 4
GeneBRD4
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1362
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 41-168 Hetero dimer : IID00207Complex
 Evidence X-RAY 4kv1 A Reference
       Region 4kv1 A 41-168 order
 Evidence X-RAY 4kv1 B Reference
       Region 4kv1 B 41-42 disorder
       Region 4kv1 B 43-168 order
Seq 42-183 Monomer :
 Evidence X-RAY 2oss A Reference
       Region 2oss A 44-168 order
 Evidence X-RAY 2yel A Reference
       Region 2yel A 44-168 order
 Evidence X-RAY 3mxf A Reference
       Region 3mxf A 42-168 order
 Evidence X-RAY 3p5o A Reference
       Region 3p5o A 44-168 order
 Evidence X-RAY 3svf A Reference
       Region 3svf A 44-168 order
 Evidence X-RAY 3svg A Reference
       Region 3svg A 44-168 order
 Evidence X-RAY 3u5j A Reference
       Region 3u5j A 44-168 order
 Evidence X-RAY 3u5k A Reference
       Region 3u5k A 44-167 order
       Region 3u5k A 168-168 disorder
 Evidence X-RAY 3u5k B Reference
       Region 3u5k B 44-166 order
       Region 3u5k B 167-168 disorder
 Evidence X-RAY 3u5k C Reference
       Region 3u5k C 44-165 order
       Region 3u5k C 166-168 disorder
 Evidence X-RAY 3u5k D Reference
       Region 3u5k D 44-53 order
       Region 3u5k D 54-56 disorder
       Region 3u5k D 57-167 order
       Region 3u5k D 168-168 disorder
 Evidence X-RAY 3u5l A Reference
       Region 3u5l A 44-168 order
 Evidence X-RAY 3zyu A Reference
       Region 3zyu A 44-168 order
 Evidence X-RAY 3zyu B Reference
       Region 3zyu B 44-167 order
       Region 3zyu B 168-168 disorder
 Evidence X-RAY 4a9l A Reference
       Region 4a9l A 44-167 order
       Region 4a9l A 168-168 disorder
 Evidence X-RAY 4bjx A Reference
       Region 4bjx A 44-168 order
 Evidence X-RAY 4bw1 A Reference
       Region 4bw1 A 44-168 order
 Evidence X-RAY 4bw2 A Reference
       Region 4bw2 A 44-168 order
 Evidence X-RAY 4bw3 A Reference
       Region 4bw3 A 44-168 order
 Evidence X-RAY 4bw4 A Reference
       Region 4bw4 A 44-168 order
 Evidence X-RAY 4c66 A Reference
       Region 4c66 A 44-167 order
 Evidence X-RAY 4c67 A Reference
       Region 4c67 A 44-168 order
 Evidence X-RAY 4cfk A Reference
       Region 4cfk A 44-168 order
 Evidence X-RAY 4cfl A Reference
       Region 4cfl A 44-168 order
 Evidence X-RAY 4cl9 A Reference
       Region 4cl9 A 44-168 order
 Evidence X-RAY 4clb A Reference
       Region 4clb A 44-168 order
 Evidence X-RAY 4don A Reference
       Region 4don A 44-166 order
 Evidence X-RAY 4e96 A Reference
       Region 4e96 A 44-165 order
       Region 4e96 A 166-168 disorder
 Evidence X-RAY 4f3i A Reference
       Region 4f3i A 44-168 order
 Evidence X-RAY 4gpj A Reference
       Region 4gpj A 44-168 order
 Evidence X-RAY 4hbv A Reference
       Region 4hbv A 42-168 order
 Evidence X-RAY 4hbw A Reference
       Region 4hbw A 42-168 order
 Evidence X-RAY 4hbx A Reference
       Region 4hbx A 42-168 order
 Evidence X-RAY 4hby A Reference
       Region 4hby A 44-168 order
 Evidence X-RAY 4hxk A Reference
       Region 4hxk A 44-167 order
 Evidence X-RAY 4hxl A Reference
       Region 4hxl A 44-167 order
 Evidence X-RAY 4hxm A Reference
       Region 4hxm A 44-166 order
 Evidence X-RAY 4hxn A Reference
       Region 4hxn A 44-167 order
 Evidence X-RAY 4hxo A Reference
       Region 4hxo A 44-167 order
 Evidence X-RAY 4hxp A Reference
       Region 4hxp A 44-166 order
 Evidence X-RAY 4hxr A Reference
       Region 4hxr A 44-167 order
 Evidence X-RAY 4hxs A Reference
       Region 4hxs A 44-166 order
 Evidence X-RAY 4ioo A Reference
       Region 4ioo A 44-167 order
       Region 4ioo A 168-168 disorder
 Evidence X-RAY 4ioq A Reference
       Region 4ioq A 44-167 order
       Region 4ioq A 168-168 disorder
 Evidence X-RAY 4ior A Reference
       Region 4ior A 44-167 order
       Region 4ior A 168-168 disorder
 Evidence X-RAY 4j0r A Reference
       Region 4j0r A 44-168 order
 Evidence X-RAY 4j0s A Reference
       Region 4j0s A 44-168 order
 Evidence X-RAY 4j3i A Reference
       Region 4j3i A 44-168 order
 Evidence X-RAY 4lr6 A Reference
       Region 4lr6 A 42-166 order
       Region 4lr6 A 167-168 disorder
 Evidence X-RAY 4lrg A Reference
       Region 4lrg A 42-168 order
 Evidence X-RAY 4lyi A Reference
       Region 4lyi A 44-168 order
 Evidence X-RAY 4lys A Reference
       Region 4lys A 44-166 order
       Region 4lys A 167-168 disorder
 Evidence X-RAY 4lyw A Reference
       Region 4lyw A 44-168 order
 Evidence X-RAY 4lzr A Reference
       Region 4lzr A 44-168 order
 Evidence X-RAY 4lzs A Reference
       Region 4lzs A 44-168 order
 Evidence X-RAY 4men A Reference
       Region 4men A 44-168 order
 Evidence X-RAY 4meo A Reference
       Region 4meo A 44-168 order
 Evidence X-RAY 4mep A Reference
       Region 4mep A 44-168 order
 Evidence X-RAY 4meq A Reference
       Region 4meq A 44-168 order
 Evidence X-RAY 4mr3 A Reference
       Region 4mr3 A 44-168 order
 Evidence X-RAY 4mr4 A Reference
       Region 4mr4 A 44-168 order
 Evidence X-RAY 4nqm A Reference
       Region 4nqm A 44-168 order
 Evidence X-RAY 4nr8 A Reference
       Region 4nr8 A 44-166 order
       Region 4nr8 A 167-168 disorder
 Evidence X-RAY 4nuc A Reference
       Region 4nuc A 44-167 order
       Region 4nuc A 168-168 disorder
 Evidence X-RAY 4nud A Reference
       Region 4nud A 44-166 order
       Region 4nud A 167-168 disorder
 Evidence X-RAY 4nue A Reference
       Region 4nue A 44-167 order
       Region 4nue A 168-168 disorder
 Evidence X-RAY 4o70 A Reference
       Region 4o70 A 44-168 order
 Evidence X-RAY 4o70 B Reference
       Region 4o70 B 44-168 order
 Evidence X-RAY 4o71 A Reference
       Region 4o71 A 44-168 order
 Evidence X-RAY 4o71 B Reference
       Region 4o71 B 44-168 order
 Evidence X-RAY 4o72 A Reference
       Region 4o72 A 44-168 order
 Evidence X-RAY 4o74 A Reference
       Region 4o74 A 44-168 order
 Evidence X-RAY 4o74 B Reference
       Region 4o74 B 44-168 order
 Evidence X-RAY 4o75 A Reference
       Region 4o75 A 44-168 order
 Evidence X-RAY 4o76 A Reference
       Region 4o76 A 44-168 order
 Evidence X-RAY 4o76 B Reference
       Region 4o76 B 44-168 order
 Evidence X-RAY 4o76 C Reference
       Region 4o76 C 44-168 order
 Evidence X-RAY 4o76 D Reference
       Region 4o76 D 44-168 order
 Evidence X-RAY 4o77 A Reference
       Region 4o77 A 44-168 order
 Evidence X-RAY 4o77 B Reference
       Region 4o77 B 44-168 order
 Evidence X-RAY 4o78 A Reference
       Region 4o78 A 44-168 order
 Evidence X-RAY 4o7a A Reference
       Region 4o7a A 44-168 order
 Evidence X-RAY 4o7b A Reference
       Region 4o7b A 44-168 order
 Evidence X-RAY 4o7c A Reference
       Region 4o7c A 44-168 order
 Evidence X-RAY 4o7e A Reference
       Region 4o7e A 44-168 order
 Evidence X-RAY 4o7e B Reference
       Region 4o7e B 44-168 order
 Evidence X-RAY 4o7f A Reference
       Region 4o7f A 44-168 order
 Evidence X-RAY 4o7f B Reference
       Region 4o7f B 44-168 order
 Evidence X-RAY 4ogi A Reference
       Region 4ogi A 44-168 order
 Evidence X-RAY 4ogi B Reference
       Region 4ogi B 44-168 order
 Evidence X-RAY 4ogj A Reference
       Region 4ogj A 44-168 order
 Evidence X-RAY 4ogj B Reference
       Region 4ogj B 44-168 order
 Evidence X-RAY 4pce A Reference
       Region 4pce A 44-168 order
 Evidence X-RAY 4pci A Reference
       Region 4pci A 44-167 order
       Region 4pci A 168-168 disorder
 Evidence X-RAY 4ps5 A Reference
       Region 4ps5 A 44-168 order
 Evidence X-RAY 4ps5 B Reference
       Region 4ps5 B 44-168 order
 Evidence X-RAY 4qb3 A Reference
       Region 4qb3 A 44-168 order
 Evidence X-RAY 4qr3 A Reference
       Region 4qr3 A 44-166 order
 Evidence X-RAY 4qr4 A Reference
       Region 4qr4 A 44-166 order
 Evidence X-RAY 4qr5 A Reference
       Region 4qr5 A 44-166 order
 Evidence X-RAY 4qzs A Reference
       Region 4qzs A 44-168 order
 Evidence X-RAY 4uix A Reference
       Region 4uix A 44-168 order
 Evidence X-RAY 4uix B Reference
       Region 4uix B 44-167 order
       Region 4uix B 168-168 disorder
 Evidence X-RAY 4uix C Reference
       Region 4uix C 44-50 order
       Region 4uix C 51-57 disorder
       Region 4uix C 58-163 order
       Region 4uix C 164-168 disorder
 Evidence X-RAY 4uiy A Reference
       Region 4uiy A 44-168 order
 Evidence X-RAY 4uiz A Reference
       Region 4uiz A 44-168 order
 Evidence X-RAY 4uyd A Reference
       Region 4uyd A 44-168 order
       Region 4uyd A 169-183 disorder
 Evidence X-RAY 4whw A Reference
       Region 4whw A 44-166 order
       Region 4whw A 167-168 disorder
 Evidence X-RAY 4wiv A Reference
       Region 4wiv A 44-168 order
 Evidence X-RAY 4x2i A Reference
       Region 4x2i A 42-166 order
 Evidence X-RAY 4xy9 A Reference
       Region 4xy9 A 42-168 order
 Evidence X-RAY 4xya A Reference
       Region 4xya A 42-168 order
 Evidence X-RAY 4yh3 A Reference
       Region 4yh3 A 44-169 order
       Region 4yh3 A 170-170 disorder
 Evidence X-RAY 4yh4 A Reference
       Region 4yh4 A 44-168 order
       Region 4yh4 A 169-170 disorder
 Evidence X-RAY 4z1q A Reference
       Region 4z1q A 42-42 disorder
       Region 4z1q A 43-166 order
       Region 4z1q A 167-167 disorder
 Evidence X-RAY 4z1q B Reference
       Region 4z1q B 42-167 order
 Evidence X-RAY 4z1s A Reference
       Region 4z1s A 42-166 order
 Evidence X-RAY 4z1s B Reference
       Region 4z1s B 42-165 order
       Region 4z1s B 166-166 disorder
 Evidence X-RAY 4zc9 A Reference
       Region 4zc9 A 44-168 order
 Evidence X-RAY 4zw1 A Reference
       Region 4zw1 A 44-166 order
       Region 4zw1 A 167-168 disorder
 Evidence X-RAY 5a5s A Reference
       Region 5a5s A 44-168 order
 Evidence X-RAY 5a85 A Reference
       Region 5a85 A 44-167 order
       Region 5a85 A 168-168 disorder
 Evidence X-RAY 5acy A Reference
       Region 5acy A 44-168 order
 Evidence X-RAY 5acy B Reference
       Region 5acy B 44-168 order
 Evidence X-RAY 5ad2 A Reference
       Region 5ad2 A 44-168 order
 Evidence X-RAY 5ad2 B Reference
       Region 5ad2 B 44-168 order
 Evidence X-RAY 5ad3 A Reference
       Region 5ad3 A 44-168 order
 Evidence X-RAY 5ad3 B Reference
       Region 5ad3 B 44-168 order
 Evidence X-RAY 5bt4 A Reference
       Region 5bt4 A 44-168 order
 Evidence X-RAY 5bt4 B Reference
       Region 5bt4 B 44-167 order
       Region 5bt4 B 168-168 disorder
 Evidence X-RAY 5bt4 C Reference
       Region 5bt4 C 44-167 order
       Region 5bt4 C 168-168 disorder
 Evidence X-RAY 5cfw A Reference
       Region 5cfw A 44-168 order
 Evidence 5coi A Reference
       Region 5coi A 44-167 order
       Region 5coi A 168-168 disorder
 Evidence 5cp5 A Reference
       Region 5cp5 A 44-166 order
       Region 5cp5 A 167-168 disorder
 Evidence 5cpe A Reference
       Region 5cpe A 44-166 order
       Region 5cpe A 167-168 disorder
 Evidence 5cqt A Reference
       Region 5cqt A 44-166 order
       Region 5cqt A 167-168 disorder
 Evidence X-RAY 5crm A Reference
       Region 5crm A 44-165 order
       Region 5crm A 166-168 disorder
 Evidence 5crz A Reference
       Region 5crz A 44-165 order
       Region 5crz A 166-168 disorder
 Evidence 5cs8 A Reference
       Region 5cs8 A 44-165 order
       Region 5cs8 A 166-168 disorder
 Evidence 5ctl A Reference
       Region 5ctl A 44-165 order
       Region 5ctl A 166-168 disorder
 Evidence 5cy9 A Reference
       Region 5cy9 A 44-167 order
       Region 5cy9 A 168-168 disorder
 Evidence X-RAY 5d0c A Reference
       Region 5d0c A 44-166 order
       Region 5d0c A 167-168 disorder
 Evidence X-RAY 5d24 A Reference
       Region 5d24 A 43-168 order
 Evidence X-RAY 5d25 A Reference
       Region 5d25 A 43-166 order
       Region 5d25 A 167-168 disorder
 Evidence X-RAY 5d26 A Reference
       Region 5d26 A 42-168 order
 Evidence X-RAY 5d3h A Reference
       Region 5d3h A 44-167 order
       Region 5d3h A 168-168 disorder
 Evidence X-RAY 5d3j A Reference
       Region 5d3j A 43-168 order
 Evidence X-RAY 5d3l A Reference
       Region 5d3l A 42-168 order
 Evidence X-RAY 5d3n A Reference
       Region 5d3n A 43-168 order
 Evidence X-RAY 5d3p A Reference
       Region 5d3p A 42-168 order
 Evidence X-RAY 5d3r A Reference
       Region 5d3r A 42-168 order
 Evidence X-RAY 5d3s A Reference
       Region 5d3s A 44-167 order
       Region 5d3s A 168-168 disorder
 Evidence X-RAY 5d3t A Reference
       Region 5d3t A 42-168 order
 Evidence X-RAY 5dlx A Reference
       Region 5dlx A 44-166 order
       Region 5dlx A 167-168 disorder
 Evidence X-RAY 5dlz A Reference
       Region 5dlz A 44-168 order
 Evidence X-RAY 5dw2 A Reference
       Region 5dw2 A 44-168 order
       Region 5dw2 A 169-170 disorder
 Evidence 5dx4 A Reference
       Region 5dx4 A 44-167 order
       Region 5dx4 A 168-168 disorder
 Evidence X-RAY 5e0r A Reference
       Region 5e0r A 44-168 order
 Evidence X-RAY 5egu A Reference
       Region 5egu A 44-54 order
       Region 5egu A 55-57 disorder
       Region 5egu A 58-167 order
       Region 5egu A 168-168 disorder
 Evidence X-RAY 5egu B Reference
       Region 5egu B 44-52 disorder
       Region 5egu B 53-168 order
 Evidence X-RAY 5egu C Reference
       Region 5egu C 44-59 disorder
       Region 5egu C 60-167 order
       Region 5egu C 168-168 disorder
 Evidence X-RAY 5egu D Reference
       Region 5egu D 44-166 order
       Region 5egu D 167-168 disorder
 Evidence X-RAY 5ei4 A Reference
       Region 5ei4 A 44-168 order
 Evidence X-RAY 5eis A Reference
       Region 5eis A 44-168 order
 Evidence X-RAY 5f5z A Reference
       Region 5f5z A 44-168 order
 Evidence X-RAY 5f60 A Reference
       Region 5f60 A 44-168 order
 Evidence X-RAY 5f61 A Reference
       Region 5f61 A 44-168 order
 Evidence X-RAY 5f61 B Reference
       Region 5f61 B 44-168 order
 Evidence X-RAY 5f62 A Reference
       Region 5f62 A 44-168 order
 Evidence X-RAY 5f63 A Reference
       Region 5f63 A 44-168 order
 Evidence X-RAY 5fbx A Reference
       Region 5fbx A 44-168 order
 Evidence X-RAY 5h21 A Reference
       Region 5h21 A 44-166 order
       Region 5h21 A 167-167 disorder
 Evidence X-RAY 5hcl A Reference
       Region 5hcl A 44-168 order
 Evidence X-RAY 5hls A Reference
       Region 5hls A 42-168 order
 Evidence X-RAY 5hm0 A Reference
       Region 5hm0 A 42-166 order
       Region 5hm0 A 167-168 disorder
 Evidence X-RAY 5hq5 A Reference
       Region 5hq5 A 44-168 order
 Evidence X-RAY 5hq6 A Reference
       Region 5hq6 A 44-166 order
 Evidence X-RAY 5hq7 A Reference
       Region 5hq7 A 44-167 order
 Evidence X-RAY 5i80 A Reference
       Region 5i80 A 42-167 order
 Evidence X-RAY 5i88 A Reference
       Region 5i88 A 42-167 order
 Evidence X-RAY 5igk A Reference
       Region 5igk A 44-168 order
 Evidence X-RAY 5kdh A Reference
       Region 5kdh A 44-168 order
 Evidence X-RAY 5kj0 A Reference
       Region 5kj0 A 44-168 order
 Evidence X-RAY 5ku3 A Reference
       Region 5ku3 A 42-167 order
 Evidence X-RAY 5lj1 A Reference
       Region 5lj1 A 42-168 order
 Evidence X-RAY 5lj2 A Reference
       Region 5lj2 A 42-168 order
 Evidence X-RAY 5lrq A Reference
       Region 5lrq A 42-163 order
 Evidence X-RAY 5luu A Reference
       Region 5luu A 44-168 order
 Evidence X-RAY 5m39 A Reference
       Region 5m39 A 42-165 order
       Region 5m39 A 166-168 disorder
 Evidence X-RAY 5m39 B Reference
       Region 5m39 B 42-167 order
       Region 5m39 B 168-168 disorder
 Evidence X-RAY 5m3a A Reference
       Region 5m3a A 44-168 order
 Evidence X-RAY 5mkz A Reference
       Region 5mkz A 44-168 order
 Evidence X-RAY 5mli A Reference
       Region 5mli A 42-168 order
 Evidence X-RAY 5n2m A Reference
       Region 5n2m A 44-168 order
 Evidence X-RAY 5ti2 A Reference
       Region 5ti2 A 44-168 order
 Evidence X-RAY 5ti3 A Reference
       Region 5ti3 A 44-168 order
 Evidence X-RAY 5ti4 A Reference
       Region 5ti4 A 44-168 order
 Evidence X-RAY 5ti5 A Reference
       Region 5ti5 A 44-168 order
 Evidence X-RAY 5ti6 A Reference
       Region 5ti6 A 44-168 order
 Evidence X-RAY 5ti7 A Reference
       Region 5ti7 A 44-168 order
 Evidence X-RAY 5u28 A Reference
       Region 5u28 A 44-176 order
       Region 5u28 A 177-180 disorder
 Evidence X-RAY 5u2e A Reference
       Region 5u2e A 42-172 order
       Region 5u2e A 173-180 disorder
 Evidence X-RAY 5u2e B Reference
       Region 5u2e B 42-164 order
       Region 5u2e B 165-180 disorder
 Evidence X-RAY 5u2f A Reference
       Region 5u2f A 42-42 disorder
       Region 5u2f A 43-173 order
       Region 5u2f A 174-180 disorder
 Evidence X-RAY 5u2f B Reference
       Region 5u2f B 42-171 order
       Region 5u2f B 172-180 disorder
 Evidence X-RAY 5ula A Reference
       Region 5ula A 44-162 order
       Region 5ula A 163-168 disorder
 Evidence X-RAY 5ula B Reference
       Region 5ula B 44-165 order
       Region 5ula B 166-168 disorder
 Evidence X-RAY 5uvw C Reference
       Region 5uvw C 57-165 order
 Evidence X-RAY 5uvw A Reference
       Region 5uvw A 57-165 order
 Evidence X-RAY 5uvw B Reference
       Region 5uvw B 57-59 disorder
       Region 5uvw B 60-165 order
 Evidence X-RAY 5vom A Reference
       Region 5vom A 44-167 order
       Region 5vom A 168-168 disorder
 Evidence X-RAY 5vom B Reference
       Region 5vom B 44-167 order
       Region 5vom B 168-168 disorder
 Evidence X-RAY 5wuu A Reference
       Region 5wuu A 44-166 order
       Region 5wuu A 167-167 disorder
 Evidence X-RAY 5y1y A Reference
       Region 5y1y A 44-166 order
       Region 5y1y A 167-167 disorder
 Evidence NMR 5z9c A Reference
       Region 5z9c A 53-168 order
       Region 5z9c A 53-55 high_rmsd
Seq 44-168 Homo dimer :
 Evidence X-RAY 5khm A Reference
       Region 5khm A 44-168 order
 Evidence X-RAY 5khm B Reference
       Region 5khm B 44-167 order
       Region 5khm B 168-168 disorder
Seq 44-168 Hetero dimer : IID00058Complex
 Evidence X-RAY 3uvw A Reference
       Region 3uvw A 44-168 order
Seq 44-168 Hetero dimer : IID00058Complex
 Evidence X-RAY 3uvy A Reference
       Region 3uvy A 44-58 disorder
       Region 3uvy A 59-167 order
       Region 3uvy A 168-168 disorder
Seq 44-168 Hetero trimer : IID00058Complex
 Evidence X-RAY 3uw9 C Reference
       Region 3uw9 C 44-55 disorder
       Region 3uw9 C 56-167 order
       Region 3uw9 C 168-168 disorder
 Evidence X-RAY 3uw9 A Reference
       Region 3uw9 A 44-166 order
       Region 3uw9 A 167-168 disorder
 Evidence X-RAY 3uw9 D Reference
       Region 3uw9 D 44-58 disorder
       Region 3uw9 D 59-167 order
       Region 3uw9 D 168-168 disorder
 Evidence X-RAY 3uw9 B Reference
       Region 3uw9 B 44-57 disorder
       Region 3uw9 B 58-166 order
       Region 3uw9 B 167-168 disorder
Seq 44-168 Hetero dimer : IID00058Complex
 Evidence X-RAY 3uvx A Reference
       Region 3uvx A 44-168 order
Seq 333-460 Hetero dimer : IID00207Complex
 Evidence NMR 2lsp B Reference
       Region 2lsp B 333-460 order
       Region 2lsp B 333-342 high_rmsd
Seq 333-460 Monomer :
 Evidence NMR 2i8n A Reference
       Region 2i8n A 352-457 order
 Evidence X-RAY 2ouo A Reference
       Region 2ouo A 333-348 disorder
       Region 2ouo A 349-459 order
       Region 2ouo A 460-460 disorder
 Evidence X-RAY 4z93 A Reference
       Region 4z93 A 349-460 order
 Evidence X-RAY 5jwm A Reference
       Region 5jwm A 333-349 disorder
       Region 5jwm A 350-459 order
       Region 5jwm A 460-460 disorder
 Evidence X-RAY 5jwm B Reference
       Region 5jwm B 333-349 disorder
       Region 5jwm B 350-459 order
       Region 5jwm B 460-460 disorder
 Evidence X-RAY 5u2c A Reference
       Region 5u2c A 342-458 order
       Region 5u2c A 459-460 disorder
 Evidence X-RAY 5u2c B Reference
       Region 5u2c B 342-348 disorder
       Region 5u2c B 349-459 order
       Region 5u2c B 460-460 disorder
 Evidence X-RAY 5ueo A Reference
       Region 5ueo A 352-457 order
 Evidence X-RAY 5ueo B Reference
       Region 5ueo B 352-457 order
 Evidence X-RAY 5uep A Reference
       Region 5uep A 352-457 order
 Evidence X-RAY 5ueq A Reference
       Region 5ueq A 352-457 order
 Evidence X-RAY 5uer A Reference
       Region 5uer A 352-457 order
 Evidence X-RAY 5ues A Reference
       Region 5ues A 352-457 order
 Evidence X-RAY 5uet A Reference
       Region 5uet A 352-457 order
 Evidence X-RAY 5ueu A Reference
       Region 5ueu A 352-457 order
 Evidence X-RAY 5ueu B Reference
       Region 5ueu B 352-457 order
 Evidence X-RAY 5uev A Reference
       Region 5uev A 352-457 order
 Evidence X-RAY 5uex A Reference
       Region 5uex A 352-457 order
 Evidence X-RAY 5uey A Reference
       Region 5uey A 352-457 order
 Evidence X-RAY 5uez A Reference
       Region 5uez A 352-457 order
 Evidence X-RAY 5uf0 A Reference
       Region 5uf0 A 352-457 order
 Evidence X-RAY 5uoo A Reference
       Region 5uoo A 333-347 disorder
       Region 5uoo A 348-460 order
 Evidence X-RAY 5uvs A Reference
       Region 5uvs A 352-457 order
 Evidence X-RAY 5uvt A Reference
       Region 5uvt A 352-457 order
 Evidence X-RAY 5uvu A Reference
       Region 5uvu A 352-457 order
 Evidence X-RAY 5uvv A Reference
       Region 5uvv A 352-457 order
 Evidence X-RAY 5uvv B Reference
       Region 5uvv B 352-457 order
 Evidence X-RAY 5uvx A Reference
       Region 5uvx A 352-457 order
 Evidence X-RAY 5uvx B Reference
       Region 5uvx B 352-352 disorder
       Region 5uvx B 353-457 order
 Evidence X-RAY 5uvy A Reference
       Region 5uvy A 352-457 order
 Evidence X-RAY 5uvz A Reference
       Region 5uvz A 352-457 order
Seq 333-460 Homo dimer :
 Evidence X-RAY 2yem A Reference
       Region 2yem A 333-348 disorder
       Region 2yem A 349-458 order
       Region 2yem A 459-460 disorder
 Evidence X-RAY 2yem B Reference
       Region 2yem B 333-348 disorder
       Region 2yem B 349-459 order
       Region 2yem B 460-460 disorder
Seq 333-460 Hetero tetramer : IID00371Complex
 Evidence X-RAY 5t35 A Reference
       Region 5t35 A 333-348 disorder
       Region 5t35 A 349-459 order
       Region 5t35 A 460-460 disorder
 Evidence X-RAY 5t35 E Reference
       Region 5t35 E 333-348 disorder
       Region 5t35 E 349-459 order
       Region 5t35 E 460-460 disorder
Seq 333-460 Hetero dimer : IID00624Complex
 Evidence NMR 2mjv B Reference
       Region 2mjv B 333-460 order
       Region 2mjv B 333-342 high_rmsd
Seq 351-459 Hetero dimer : IID00207Complex
 Evidence X-RAY 4kv4 A Reference
       Region 4kv4 A 351-459 order
Seq 600-678 Hetero dimer : Q8UN00
 Evidence NMR 2n3k A Reference
       Region 2n3k A 600-678 order
       Region 2n3k A 600-603 high_rmsd
       Region 2n3k A 677-678 high_rmsd
Seq 601-683 Hetero dimer : Q9QR71
 Evidence NMR 2nd0 A Reference
       Region 2nd0 A 601-683 order
       Region 2nd0 A 601-604 high_rmsd
       Region 2nd0 A 683-683 high_rmsd
Seq 601-683 Hetero dimer : IID00496Complex
 Evidence NMR 2nd1 A Reference
       Region 2nd1 A 601-683 order
       Region 2nd1 A 683-683 high_rmsd
Seq 601-683 Hetero dimer : IID00496Complex
 Evidence NMR 2ncz A Reference
       Region 2ncz A 601-683 order
       Region 2ncz A 679-683 high_rmsd
Seq 601-683 Hetero dimer : Q6NYC1
 Evidence NMR 6bnh A Reference
       Region 6bnh A 601-683 order
       Region 6bnh A 601-601 high_rmsd
       Region 6bnh A 679-683 high_rmsd
Seq 1343-1362 Hetero dimer : P03120
 Evidence X-RAY 2nnu B Reference
       Region 2nnu B 1343-1362 order
Seqphosphorylation
    1204-1204 Phosphoserine
    1201-1201 Phosphoserine
    1126-1126 Phosphoserine
    1117-1117 Phosphoserine
    601-601 Phosphoserine
    503-503 Phosphoserine; by CK2
    499-499 Phosphoserine; by CK2
    498-498 Phosphoserine; by CK2
    494-494 Phosphoserine; by CK2
    492-492 Phosphoserine; by CK2
    488-488 Phosphoserine; by CK2
    484-484 Phosphoserine; by CK2
    470-470 Phosphoserine
Seqacetylation
    1111-1111 N6-acetyllysine; alternate
 
Prediction
NeProc
Disorder 1-56,167-349,460-536,568-617,642-1216,1304-1342
Order 57-166,350-459,537-567,618-641,1217-1303,1343-1362
ProS 9-21,47-56,242-245,299-302,329-337,505-513,520-527,577-580,594-617,642-677,1160-1164,1192-1207,1320-1342
AlphaFold
Disorder 1-42,174-350,459-506,527-607,645-650,652-652,677-1223,1288-1289,1291-1322,1340-1352,1357-1357,1359-1362
Order 43-173,351-458,507-526,608-644,651-651,653-676,1224-1287,1290-1290,1323-1339,1353-1356,1358-1358
Pfam Hmmer
PF00439 63-152 2.4e-45
PF00439 356-445 9.1e-41
SEG 23-54 ,178-183 ,197-224 ,234-273 ,293-303 ,305-318 ,327-337 ,458-503 ,535-588 ,699-718 ,738-793 ,825-851 ,877-923 ,926-936 ,950-1001 ,1009-1038 ,1164-1175 ,1211-1223 ,1228-1253 ,1270-1313 ,1323-1343
Function
Function in SwissProt
Isoform B
Acts as a chromatin insulator in the DNA damage response pathway. Inhibits DNA damage response signaling by recruiting the condensin-2 complex to acetylated histones, leading to chromatin structure remodeling, insulating the region from DNA damage response by limiting spreading of histone H2AFX/H2A.x phosphorylation.