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IID00113  Mothers against decapentaplegic homolog 3 (Homo sapiens) P84022
  :order  :disorder  :conflict  :PDB cluster  :ProS  :SCOP Domain  :Pfam Domain
Networkxml
Experiment
425
fasta
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-144 Homo dimer :
 Evidence X-RAY 1mhd A Reference
       Region 1mhd A 1-9 disorder
       Region 1mhd A 10-132 order
 Evidence X-RAY 1mhd B Reference
       Region 1mhd B 1-9 disorder
       Region 1mhd B 10-132 order
 Evidence X-RAY 5odg A Reference
       Region 5odg A 11-135 order
 Evidence X-RAY 5odg B Reference
       Region 5odg B 11-134 order
       Region 5odg B 135-135 disorder
 Evidence X-RAY 1ozj A Reference
       Region 1ozj A 1-6 disorder
       Region 1ozj A 7-132 order
       Region 1ozj A 133-144 disorder
 Evidence X-RAY 1ozj B Reference
       Region 1ozj B 1-8 disorder
       Region 1ozj B 9-132 order
       Region 1ozj B 133-144 disorder
Seq 11-135 Homo dimer :
 Evidence X-RAY 5od6 A Reference
       Region 5od6 A 11-134 order
       Region 5od6 A 135-135 disorder
 Evidence X-RAY 5od6 B Reference
       Region 5od6 B 11-135 order
Seqdisorder 146-219
 Evidence X-RAY Reference
       Region 146-219 disorder
Seq 178-189 Hetero dimer : IID00114Complex
 Evidence NMR 2lb2 B Reference
       Region 2lb2 B 178-189 order
Seq 202-211 Hetero dimer : IID00114Complex
 Evidence NMR 2laj B Reference
       Region 2laj B 202-211 order
Seqdisorder 219-228
 Evidence X-RAY Reference
       Region 219-228 disorder
Seq 220-425 Hetero tetramer : IID00112Complex
 Evidence X-RAY 1mk2 A Reference
       Region 1mk2 A 220-416 order
       Region 1mk2 A 417-425 disorder
Seq 228-425 Hetero trimer : IID00132Complex
 Evidence X-RAY 1u7f A Reference
       Region 1u7f A 228-425 order
 Evidence X-RAY 1u7f C Reference
       Region 1u7f C 228-229 disorder
       Region 1u7f C 230-425 order
Seq 229-425 Monomer :
 Evidence X-RAY 1mjs A Reference
       Region 1mjs A 229-323 order
       Region 1mjs A 324-328 disorder
       Region 1mjs A 329-380 order
       Region 1mjs A 381-387 disorder
       Region 1mjs A 388-418 order
       Region 1mjs A 419-425 disorder
SeqProS verified 178-189 Hetero dimer : IID00114Complex
       Region 2lb2 B 178-189 order
       Region 146-219 disorder
SeqProS verified 202-211 Hetero dimer : IID00114Complex
       Region 2laj B 202-211 order
       Region 146-219 disorder
SeqProS verified 220-228,324-328 Hetero tetramer : IID00112Complex
       Region 1mk2 A 220-416 order
       Region 219-228 disorder
       Region 1mjs A 324-328 disorder
SeqProS verified 324-328,419-424 This region is ordered when Smad3 is phosphorylated. Hetero trimer : IID00132Complex
       Region 1u7f A 228-425 order
       Region 1u7f C 230-425 order
       Region 1mjs A 324-328 disorder
       Region 1mk2 A 417-425 disorder
Seqphosphorylation
    8-8 Phosphothreonine; by CDK2 and CDK4
    179-179 Phosphothreonine; by CDK2
    204-204 Phosphoserine; by GSK3 and MAPK
    208-208 Phosphoserine; by MAPK
    213-213 Phosphoserine; by CDK2 and CDK4
    416-416 Phosphoserine
    418-418 Phosphoserine; by CK1
    422-422 Phosphoserine; by TGFBR1
    423-423 Phosphoserine; by TGFBR1
    425-425 Phosphoserine; by TGFBR1
Seqacetylation
    2-2 N-acetylserine
    378-378 N6-acetyllysine
 
Prediction
DICHOT
Disorder 1-9,133-222,423-425
Known Domain 10-132,223-422
SCOPe RPS-Blast
     1ozjA 7-132 7e-45 d.164.1.1 SMAD MH1 domain
     1mjsA 229-418 1e-60 b.26.1.1 Smad1
SCOP Hmmer
     1mhdA_ 10-131 1.8e-54 d.164.1.1 SMAD MH1 domain
     1dd1A_ 176-416 1.7e-100 b.26.1.1 Smad1
Pfam RPS-Blast
     PF03165 71-131 1e-18 MH1 domain
     PF03166 248-401 1e-28 MH2 domain
Pfam Hmmer
    PF03165 31-131 1.6e-47 MH1 domain
    PF03166 231-401 2.5e-83 MH2 domain