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IID00126
 UniprotP24928
ProteinDNA-directed RNA polymerase II subunit RPB1
GenePOLR2A
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1970
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seqdisorder 1593-1960
 Evidence CD¸ NMR Reference
       Region 1593-1960 disorder
Seq 1713-1740 Hetero tetramer : Q5V8Z9
 Evidence X-RAY 5m3j X Reference
       Region 5m3j X 1713-1718 disorder
       Region 5m3j X 1719-1727 order
       Region 5m3j X 1728-1740 disorder
Seq 1713-1740 Hetero tetramer : H6QM92
 Evidence X-RAY 5m3h Y Reference
       Region 5m3h Y 1713-1717 disorder
       Region 5m3h Y 1718-1727 order
       Region 5m3h Y 1728-1740 disorder
 Evidence X-RAY 5m3h X Reference
       Region 5m3h X 1713-1718 order
       Region 5m3h X 1719-1740 disorder
Seq 1787-1805 Hetero dimer : Q96P16
 Evidence X-RAY 4jxt B Reference
       Region 4jxt B 1787-1787 disorder
       Region 4jxt B 1788-1798 order
       Region 4jxt B 1799-1805 disorder
Seq 1790-1803 Hetero dimer : IID00590Complex
 Evidence X-RAY 3d9k Z Reference
       Region 3d9k Z 1790-1798 order
       Region 3d9k Z 1799-1803 disorder
 Evidence X-RAY 3d9k Y Reference
       Region 3d9k Y 1790-1794 disorder
       Region 3d9k Y 1795-1801 order
       Region 3d9k Y 1802-1803 disorder
 Evidence X-RAY 3d9l Y Reference
       Region 3d9l Y 1790-1799 order
       Region 3d9l Y 1800-1803 disorder
 Evidence X-RAY 3d9l Z Reference
       Region 3d9l Z 1790-1794 disorder
       Region 3d9l Z 1795-1802 order
       Region 3d9l Z 1803-1803 disorder
 Evidence X-RAY 3d9m Z Reference
       Region 3d9m Z 1790-1794 disorder
       Region 3d9m Z 1795-1803 order
 Evidence X-RAY 3d9m Y Reference
       Region 3d9m Y 1790-1792 order
       Region 3d9m Y 1793-1803 disorder
 Evidence X-RAY 3d9n Y Reference
       Region 3d9n Y 1790-1794 disorder
       Region 3d9n Y 1795-1803 order
 Evidence X-RAY 3d9n Z Reference
       Region 3d9n Z 1790-1794 disorder
       Region 3d9n Z 1795-1803 order
 Evidence X-RAY 3d9p Z Reference
       Region 3d9p Z 1790-1794 disorder
       Region 3d9p Z 1795-1802 order
       Region 3d9p Z 1803-1803 disorder
 Evidence X-RAY 3d9p Y Reference
       Region 3d9p Y 1790-1792 order
       Region 3d9p Y 1793-1803 disorder
Seq 1790-1803 Hetero trimer : IID00590Complex
 Evidence X-RAY 3d9o Z Reference
       Region 3d9o Z 1790-1794 disorder
       Region 3d9o Z 1795-1803 order
Seq 1795-1803 Hetero dimer : IID00394Complex
 Evidence X-RAY 2ghq C Reference
       Region 2ghq C 1795-1797 disorder
       Region 2ghq C 1798-1802 order
       Region 2ghq C 1803-1803 disorder
 Evidence X-RAY 2ghq D Reference
       Region 2ghq D 1795-1803 order
 Evidence X-RAY 2ght C Reference
       Region 2ght C 1796-1797 disorder
       Region 2ght C 1798-1802 order
       Region 2ght C 1803-1803 disorder
 Evidence X-RAY 2ght D Reference
       Region 2ght D 1796-1803 order
Seq 1804-1816 Hetero dimer : IID00499Complex
 Evidence NMR 2lto B Reference
       Region 2lto B 1804-1816 order
SeqProS verified 1713-1727 Hetero tetramer : H6QM92
       Region 5m3h X 1713-1718 order
       Region 5m3h Y 1718-1727 order
       Region 1593-1960 disorder
SeqProS verified 1719-1727 Hetero tetramer : Q5V8Z9
       Region 5m3j X 1719-1727 order
       Region 1593-1960 disorder
SeqProS verified 1788-1803 Hetero trimer : IID00590Complex
       Region 3d9o Z 1795-1803 order
       Region 1593-1960 disorder
SeqProS verified 1788-1803 Hetero dimer : Q96P16
       Region 4jxt B 1788-1798 order
       Region 1593-1960 disorder
SeqProS verified 1788-1803 Hetero dimer : IID00590Complex
       Region 3d9n Y 1795-1803 order
       Region 3d9n Z 1795-1803 order
       Region 3d9k Y 1795-1801 order
       Region 3d9k Z 1790-1798 order
       Region 3d9p Y 1790-1792 order
       Region 3d9p Z 1795-1802 order
       Region 3d9l Y 1790-1799 order
       Region 3d9l Z 1795-1802 order
       Region 3d9m Y 1790-1792 order
       Region 3d9m Z 1795-1803 order
       Region 1593-1960 disorder
SeqProS verified 1795-1803 Hetero dimer : IID00394Complex
       Region 2ghq C 1798-1802 order
       Region 2ghq D 1795-1803 order
       Region 2ght C 1798-1802 order
       Region 2ght D 1796-1803 order
       Region 1593-1960 disorder
SeqProS verified 1804-1816 Hetero dimer : IID00499Complex
       Region 2lto B 1804-1816 order
       Region 1593-1960 disorder
Seqphosphorylation
    1933-1933 Phosphothreonine
    1934-1934 Phosphoserine
    1930-1930 Phosphotyrosine
    1931-1931 Phosphoserine
    1929-1929 Phosphothreonine
    1926-1926 Phosphothreonine
    1927-1927 Phosphoserine
    1923-1923 Phosphotyrosine
    1920-1920 Phosphoserine
    1919-1919 Phosphothreonine
    1917-1917 Phosphoserine
    1916-1916 Phosphotyrosine
    1915-1915 Phosphothreonine
    1913-1913 Phosphoserine
    1912-1912 Phosphothreonine
    1909-1909 Phosphotyrosine
    1906-1906 Phosphoserine
    1899-1899 Phosphoserine
    1896-1896 Phosphoserine
    1894-1894 Phosphothreonine
    1885-1885 Phosphothreonine
    1874-1874 Phosphotyrosine
    1875-1875 Phosphoserine
    1877-1877 Phosphothreonine
    1878-1878 Phosphoserine
    1881-1881 Phosphotyrosine
    1882-1882 Phosphoserine
    1870-1870 Phosphothreonine
    1868-1868 Phosphoserine
    1867-1867 Phosphotyrosine
    1864-1864 Phosphoserine
    1861-1861 Phosphoserine
    1863-1863 Phosphothreonine
    1860-1860 Phosphotyrosine
    1857-1857 Phosphoserine
    1854-1854 Phosphothreonine
    1850-1850 Phosphoserine
    1849-1849 Phosphoserine
    1847-1847 Phosphoserine
    1845-1845 Phosphoserine
    1843-1843 Phosphoserine
    1840-1840 Phosphothreonine
    217-217 Phosphoserine
    27-27 Phosphoserine
Seqacetylation
    1936-1936 N6-acetyllysine; alternate
    1922-1922 N6-acetyllysine; alternate
    1887-1887 N6-acetyllysine; alternate
    1866-1866 N6-acetyllysine; alternate
    1-1 N-acetylmethionine
 
Prediction
NeProc
Disorder 1-10,162-178,333-348,1267-1277,1487-1970
Order 11-161,179-267,274-332,349-1266,1279-1486
ProS 5-10,162-178,333-348,1502-1523,1528-1562,1585-1590,1621-1633,1654-1658,1687-1692,1697-1706,1718-1723,1746-1749,1767-1784,1796-1800,1809-1818,1851-1858,1872-1877,1884-1888,1913-1921,1938-1970
AlphaFold
Disorder 1-11,156-182,267-269,432-433,729-731,1103-1117,1199-1203,1264-1280,1389-1389,1487-1525,1538-1538,1541-1970
Order 12-155,183-266,270-431,434-728,732-1102,1118-1198,1204-1263,1281-1388,1390-1486,1526-1537,1539-1540
Pfam Hmmer
PF04997 15-354 1.8e-164
PF00623 356-521 1.7e-111
PF04983 524-692 8.6e-80
PF05000 717-823 3e-55
PF04998 830-1428 8.3e-150
SEG 951-964 ,1271-1283 ,1541-1560 ,1562-1587 ,1608-1959
Function
Function in SwissProt
(Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicate and transcriptase for the viral RNA circular genome.