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IID00127  Mothers against decapentaplegic homolog 2 (Homo sapiens) Q15796
  :order  :disorder  :conflict  :PDB cluster  :ProS  :SCOP Domain  :Pfam Domain
Networkxml
Experiment
467
fasta
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 241-467 Homo trimer :
 Evidence X-RAY 1khx A Reference
       Region 1khx A 241-264 disorder
       Region 1khx A 265-467 order
Seq 261-456 Hetero dimer : IID00112Complex
 Evidence X-RAY 1dev A Reference
       Region 1dev A 261-262 disorder
       Region 1dev A 263-456 order
 Evidence X-RAY 1dev C Reference
       Region 1dev C 261-423 order
       Region 1dev C 424-427 disorder
       Region 1dev C 428-456 order
Seq 270-467 Hetero trimer : IID00132Complex
 Evidence X-RAY 1u7v A Reference
       Region 1u7v A 270-467 order
 Evidence X-RAY 1u7v C Reference
       Region 1u7v C 270-271 disorder
       Region 1u7v C 272-467 order
Seqdisorder 457-467
 Evidence X-RAY Reference
       Region 457-467 disorder
SeqProS verified 261-264 Hetero dimer : IID00112Complex
       Region 1dev C 261-423 order
       Region 1khx A 241-264 disorder
SeqProS verified 457-467 Hetero trimer : IID00132Complex
       Region 1u7v A 270-467 order
       Region 1u7v C 272-467 order
       Region 457-467 disorder
Seqphosphorylation
    8-8 Phosphothreonine; by MAPK3
    220-220 Phosphothreonine
    240-240 Phosphoserine; by CAMK2
    245-245 Phosphoserine
    250-250 Phosphoserine
    255-255 Phosphoserine
    458-458 Phosphoserine
    460-460 Phosphoserine
    464-464 Phosphoserine
    465-465 Phosphoserine; by TGFBR1
    467-467 Phosphoserine; by TGFBR1
Seqacetylation
    2-2 N-acetylserine
    19-19 N6-acetyllysine
 
Prediction
DICHOT
Disorder 1-40,173-264,465-467
Known Domain 41-172,265-464
SCOPe RPS-Blast
     1ozjA 7-172 2e-39 d.164.1.1 SMAD MH1 domain
     1mjsA 271-460 3e-62 b.26.1.1 Smad1
SCOP Hmmer
     1mhdA_ 31-171 5.4e-45 d.164.1.1 SMAD MH1 domain
     1dd1A_ 217-458 2.2e-100 b.26.1.1 Smad1
Pfam RPS-Blast
     PF03165 111-171 2e-20 MH1 domain
     PF03166 290-443 5e-31 MH2 domain
Pfam Hmmer
    PF03165 41-171 7.9e-47 MH1 domain
    PF03166 273-443 1.9e-83 MH2 domain