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IID00134
 UniprotO14745
ProteinNa(+)/H(+) exchange regulatory cofactor NHE-RF1
GeneNHERF1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
358
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 11-94 Hetero dimer : P09619
 Evidence X-RAY 1gq5 A Reference
       Region 1gq5 A 11-94 order
Seq 11-94 Hetero dimer : P07550
 Evidence X-RAY 1gq4 A Reference
       Region 1gq4 A 11-94 order
Seq 11-120 Monomer :
 Evidence X-RAY 1g9o A Reference
       Region 1g9o A 11-99 order
 Evidence X-RAY 1i92 A Reference
       Region 1i92 A 11-94 order
 Evidence X-RAY 4jl7 A Reference
       Region 4jl7 A 11-95 order
 Evidence X-RAY 4lmm A Reference
       Region 4lmm A 11-94 order
 Evidence NMR 2m0t A Reference
       Region 2m0t A 11-120 order
       Region 2m0t A 114-120 high_rmsd
 Evidence X-RAY 4mpa A Reference
       Region 4mpa A 11-94 order
 Evidence X-RAY 4n6x A Reference
       Region 4n6x A 11-94 order
 Evidence X-RAY 4pqw A Reference
       Region 4pqw A 11-94 order
Seq 11-120 Hetero dimer :
 Evidence NMR 2m0u A Reference
       Region 2m0u A 11-120 order
       Region 2m0u A 114-120 high_rmsd
Seq 150-234 Hetero dimer : IID00625Complex
 Evidence X-RAY 4q3h A Reference
       Region 4q3h A 150-234 order
Seq 150-234 Hetero dimer : IID00625Complex
 Evidence X-RAY 4q3h B Reference
       Region 4q3h B 150-234 order
Seq 150-270 Monomer :
 Evidence X-RAY 2ozf A Reference
       Region 2ozf A 150-235 order
 Evidence NMR 2jxo A Reference
       Region 2jxo A 150-240 order
       Region 2jxo A 238-240 high_rmsd
 Evidence NMR 2kjd A Reference
       Region 2kjd A 150-270 order
       Region 2kjd A 258-270 high_rmsd
Seq 150-270 Hetero dimer :
 Evidence NMR 2m0v A Reference
       Region 2m0v A 150-270 order
       Region 2m0v A 258-270 high_rmsd
Seq 150-358 Monomer :
 Evidence NMR 2krg A Reference
       Region 2krg A 150-252 order
       Region 2krg A 253-358 disorder
Seq 321-358 Hetero dimer : IID00344Complex
 Evidence X-RAY 1sgh B Reference
       Region 1sgh B 321-358 order
Seq 331-358 Hetero dimer : IID50114Complex
 Evidence X-RAY 2d10 E Reference
       Region 2d10 E 331-338 disorder
       Region 2d10 E 339-358 order
 Evidence X-RAY 2d10 F Reference
       Region 2d10 F 331-338 disorder
       Region 2d10 F 339-358 order
 Evidence X-RAY 2d10 G Reference
       Region 2d10 G 331-338 disorder
       Region 2d10 G 339-358 order
 Evidence X-RAY 2d10 H Reference
       Region 2d10 H 331-338 disorder
       Region 2d10 H 339-358 order
SeqProS verified 321-358 Hetero dimer : IID00344Complex
       Region 1sgh B 321-358 order
       Region 2krg A 253-358 disorder
SeqProS verified 339-358 Hetero dimer : IID50114Complex
       Region 2d10 E 339-358 order
       Region 2d10 F 339-358 order
       Region 2d10 G 339-358 order
       Region 2d10 H 339-358 order
       Region 2krg A 253-358 disorder
Seqphosphorylation
    302-302 Phosphoserine
    46-46 Phosphoserine
    2-2 Phosphoserine
    162-162 Phosphoserine
    269-269 Phosphoserine
    280-280 Phosphoserine
    290-290 Phosphoserine
    291-291 Phosphoserine
    293-293 Phosphothreonine
    294-294 Phosphoserine
    299-299 Phosphoserine
Seqacetylation
    2-2 N-acetylserine
 
Prediction
NeProc
Disorder 1-8,107-145,249-358
Order 9-106,146-248
ProS 107-114,124-145,249-260,319-358
AlphaFold
Disorder 1-11,32-33,98-149,253-273,278-280,286-292,294-294,299-301,317-317,321-321,338-338,342-342,345-358
Order 12-31,34-97,150-252,274-277,281-285,293-293,295-298,302-316,318-320,322-337,339-341,343-344
Pfam Hmmer
PF00595 14-91 5.5e-13
PF00595 154-231 8e-15
SEG 113-132 ,269-285 ,307-319
Function
Function in SwissProt
Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Involved in the regulation of phosphate reabsorption in the renal proximal tubules. Involved in sperm capacitation. May participate in the regulation of the chloride and bicarbonate homeostasis in spermatozoa.