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IID00137
 UniprotP04083
ProteinAnnexin A1
GeneANXA1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
346
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 2-12 Hetero dimer : IID50073Complex
 Evidence X-RAY 1qls D Reference
       Region 1qls D 2-12 order
Seq 2-26 Monomer :
 Evidence NMR 5vfw A Reference
       Region 5vfw A 2-26 order
       Region 5vfw A 2-3 high_rmsd
       Region 5vfw A 16-20 high_rmsd
       Region 5vfw A 25-26 high_rmsd
Seq 33-346 Monomer :
 Evidence X-RAY 1ain A Reference
       Region 1ain A 33-346 order
Seq 41-113 Monomer :
 Evidence NMR 1bo9 A Reference
       Region 1bo9 A 41-113 order
SeqProS possible 2-12 The N-terminal alpha helix seems to be necessary for binding to S100C. (PubMed=10673436) Hetero dimer : IID50073Complex
       Region 1qls D 2-12 order
SeqProS possible 2-26 Same region of the homolog (P19619, IID50311) is disordered in the free state. :
       Region 5vfw A 2-26 order
Seqphosphorylation
    41-41 Phosphothreonine
    136-136 Phosphothreonine
    37-37 Phosphoserine
    34-34 Phosphoserine
    27-27 Phosphoserine; by PKC
    21-21 Phosphotyrosine; by EGFR
    5-5 Phosphoserine; by TRPM7
Seqacetylation
    312-312 N6-acetyllysine
    239-239 N6-acetyllysine
    58-58 N6-acetyllysine
    2-2 N-acetylalanine
 
Prediction
NeProc
Disorder 13-30
Order 1-12,31-346
ProS 13-19
AlphaFold
Disorder 1-1,247-250,252-252,346-346
Order 2-246,251-251,253-345
Pfam Hmmer
PF00191 46-111 3.9e-25
PF00191 118-183 1.8e-32
PF00191 201-267 5e-23
PF00191 277-342 4.2e-32
Function
Function in SwissProt
Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades (PubMed:22879591, PubMed:15187149, PubMed:25664854). Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (PubMed:15187149). Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration (PubMed:15187149). Promotes resolution of inflammation and wound healing (PubMed:25664854). Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2 (PubMed:22879591).
Biological Process
Diagram with PDB data
ANXA1An engineered cyclic peptide alleviates symptoms of inflammation in a murine model of inflammatory bowel disease
ANXA1/S100A11S100C (S100A11),OR CALGIZZARIN, IN COMPLEX WITH ANNEXIN I N-TERMINUS