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IID00140
 UniprotP11831
ProteinSerum response factor
GeneSRF
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
508
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 132-223 Homo dimer :
 Evidence X-RAY 1srs B Reference
       Region 1srs B 132-139 disorder
       Region 1srs B 140-219 order
       Region 1srs B 220-223 disorder
 Evidence X-RAY 1srs A Reference
       Region 1srs A 132-139 disorder
       Region 1srs A 140-223 order
Seq 132-223 Hetero trimer : IID00148Complex
 Evidence X-RAY 1hbx A Reference
       Region 1hbx A 132-136 disorder
       Region 1hbx A 137-223 order
 Evidence X-RAY 1hbx B Reference
       Region 1hbx B 132-137 disorder
       Region 1hbx B 138-223 order
 Evidence X-RAY 1hbx D Reference
       Region 1hbx D 132-137 disorder
       Region 1hbx D 138-223 order
 Evidence X-RAY 1hbx E Reference
       Region 1hbx E 132-134 disorder
       Region 1hbx E 135-223 order
Seq 133-235 Hetero trimer : IID00148Complex
 Evidence X-RAY 1k6o C Reference
       Region 1k6o C 133-137 disorder
       Region 1k6o C 138-221 order
       Region 1k6o C 222-235 disorder
 Evidence X-RAY 1k6o B Reference
       Region 1k6o B 133-136 disorder
       Region 1k6o B 137-221 order
       Region 1k6o B 222-235 disorder
Seqphosphorylation
    77-77 Phosphoserine
    79-79 Phosphoserine
    83-83 Phosphoserine
    103-103 Phosphoserine
    85-85 Phosphoserine
    224-224 Phosphoserine
    253-253 Phosphoserine
    435-435 Phosphoserine; by dsDNA kinase
    446-446 Phosphoserine; by dsDNA kinase
 
Prediction
NeProc
Disorder 1-142,215-508
Order 143-214
ProS 21-29,65-69,87-98,215-223,231-252,259-268,490-502
AlphaFold
Disorder 1-134,227-508
Order 135-226
Pfam Hmmer
PF00319 149-199 2.7e-27
SEG 6-22 ,24-46 ,52-75 ,77-94 ,221-233 ,304-318 ,350-369 ,372-387
Function
Function in SwissProt
SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Required for cardiac differentiation and maturation.