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IID00143
 UniprotP14678
ProteinSmall nuclear ribonucleoprotein-associated proteins B and B'
GeneSNRPB
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
240
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-91 Hetero dimer : IID00161Complex
 Evidence X-RAY 1d3b B Reference
       Region 1d3b B 1-6 disorder
       Region 1d3b B 7-87 order
       Region 1d3b B 88-91 disorder
 Evidence X-RAY 1d3b D Reference
       Region 1d3b D 1-1 disorder
       Region 1d3b D 2-87 order
       Region 1d3b D 88-91 disorder
 Evidence X-RAY 1d3b F Reference
       Region 1d3b F 1-4 disorder
       Region 1d3b F 5-87 order
       Region 1d3b F 88-91 disorder
 Evidence X-RAY 1d3b H Reference
       Region 1d3b H 1-2 disorder
       Region 1d3b H 3-88 order
       Region 1d3b H 89-91 disorder
 Evidence X-RAY 1d3b J Reference
       Region 1d3b J 1-1 disorder
       Region 1d3b J 2-87 order
       Region 1d3b J 88-91 disorder
 Evidence X-RAY 1d3b L Reference
       Region 1d3b L 1-1 disorder
       Region 1d3b L 2-91 order
Seq 1-95 Hetero 36mer : IID00138Complex,IID00157Complex,IID00158Complex,IID00159Complex,IID00161Complex
 Evidence X-RAY 4pjo p Reference
       Region 4pjo p 1-5 disorder
       Region 4pjo p 6-91 order
       Region 4pjo p 92-95 disorder
 Evidence X-RAY 4pjo b Reference
       Region 4pjo b 1-5 disorder
       Region 4pjo b 6-53 order
       Region 4pjo b 54-59 disorder
       Region 4pjo b 60-89 order
       Region 4pjo b 90-95 disorder
 Evidence X-RAY 4pjo P Reference
       Region 4pjo P 1-5 disorder
       Region 4pjo P 6-88 order
       Region 4pjo P 89-95 disorder
 Evidence X-RAY 4pjo B Reference
       Region 4pjo B 1-5 disorder
       Region 4pjo B 6-88 order
       Region 4pjo B 89-95 disorder
Seq 1-174 Hetero nonamer : IID00138Complex,IID00159Complex,IID00161Complex
 Evidence X-RAY 3cw1 I Reference
       Region 3cw1 I 1-7 disorder
       Region 3cw1 I 8-47 order
       Region 3cw1 I 48-64 disorder
       Region 3cw1 I 65-87 order
       Region 3cw1 I 88-174 disorder
Seq 1-174 Hetero nonamer : IID00138Complex,IID00159Complex,IID00161Complex
 Evidence X-RAY 3cw1 A Reference
       Region 3cw1 A 1-6 disorder
       Region 3cw1 A 7-47 order
       Region 3cw1 A 48-64 disorder
       Region 3cw1 A 65-87 order
       Region 3cw1 A 88-174 disorder
 Evidence X-RAY 3cw1 H Reference
       Region 3cw1 H 1-6 disorder
       Region 3cw1 H 7-47 order
       Region 3cw1 H 48-64 disorder
       Region 3cw1 H 65-87 order
       Region 3cw1 H 88-174 disorder
 Evidence X-RAY 3cw1 J Reference
       Region 3cw1 J 1-6 disorder
       Region 3cw1 J 7-47 order
       Region 3cw1 J 48-64 disorder
       Region 3cw1 J 65-86 order
       Region 3cw1 J 87-174 disorder
Seq 1-229 Hetero nonamer : IID00159Complex,IID00161Complex
 Evidence X-RAY 3pgw B Reference
       Region 3pgw B 1-5 disorder
       Region 3pgw B 6-86 order
       Region 3pgw B 87-229 disorder
 Evidence X-RAY 3pgw Q Reference
       Region 3pgw Q 1-4 disorder
       Region 3pgw Q 5-53 order
       Region 3pgw Q 54-63 disorder
       Region 3pgw Q 64-90 order
       Region 3pgw Q 91-229 disorder
 
Prediction
NeProc
Disorder 1-8,54-240
Order 9-53
ProS 61-86,104-115,126-137
AlphaFold
Disorder 1-5,90-135,137-138,145-190,192-200,202-229,231-236
Order 6-89,136-136,139-144,191-191,201-201,230-230,237-240
Pfam Hmmer
PF01423 7-82 4.1e-21
SEG 98-117 ,151-164 ,169-240
Function
Function in SwissProt
Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. As part of the U7 snRNP it is involved in histone 3'-end processing.