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IID00156
 UniprotP62304
ProteinSmall nuclear ribonucleoprotein E
GeneSNRPE
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
92
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-92 Hetero nonamer : IID00157Complex,IID00158Complex
 Evidence X-RAY 3pgw E Reference
       Region 3pgw E 1-6 disorder
       Region 3pgw E 7-90 order
       Region 3pgw E 91-92 disorder
 Evidence X-RAY 3pgw H Reference
       Region 3pgw H 1-89 order
       Region 3pgw H 90-92 disorder
Seq 1-92 Hetero 36mer : IID00138Complex,IID00157Complex,IID00158Complex
 Evidence X-RAY 4pjo S Reference
       Region 4pjo S 1-13 disorder
       Region 4pjo S 14-90 order
       Region 4pjo S 91-92 disorder
 Evidence X-RAY 4pjo E Reference
       Region 4pjo E 1-13 disorder
       Region 4pjo E 14-90 order
       Region 4pjo E 91-92 disorder
Seq 1-92 Hetero hexamer : IID00157Complex,IID00158Complex
 Evidence X-RAY 4f7u E Reference
       Region 4f7u E 1-12 disorder
       Region 4f7u E 13-90 order
       Region 4f7u E 91-92 disorder
 Evidence X-RAY 4f7u H Reference
       Region 4f7u H 1-13 disorder
       Region 4f7u H 14-91 order
       Region 4f7u H 92-92 disorder
Seq 1-92 Hetero nonamer : IID00157Complex,IID00158Complex
 Evidence X-RAY 3cw1 E Reference
       Region 3cw1 E 1-17 disorder
       Region 3cw1 E 18-92 order
 Evidence X-RAY 3cw1 W Reference
       Region 3cw1 W 1-17 disorder
       Region 3cw1 W 18-92 order
 Evidence X-RAY 3cw1 Y Reference
       Region 3cw1 Y 1-17 disorder
       Region 3cw1 Y 18-92 order
Seq 1-92 Hetero nonamer : IID00157Complex,IID00158Complex
 Evidence X-RAY 3cw1 X Reference
       Region 3cw1 X 1-17 disorder
       Region 3cw1 X 18-92 order
 
Prediction
NeProc
Disorder 1-12
Order 13-92
ProS 1-6
AlphaFold
Disorder 1-9,92-92
Order 10-91
Pfam Hmmer
PF01423 23-89 1.1e-20
SEG 5-16
Function
Function in SwissProt
Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. As part of the U7 snRNP it is involved in histone 3'-end processing. May indirectly play a role in hair development.