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IID00159
 UniprotP62314
ProteinSmall nuclear ribonucleoprotein Sm D1
GeneSNRPD1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
119
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-119 Hetero hexamer : A1ZAW5,IID00160Complex
 Evidence X-RAY 4f7u A Reference
       Region 4f7u A 1-82 order
       Region 4f7u A 83-119 disorder
 Evidence X-RAY 4f7u C Reference
       Region 4f7u C 1-1 disorder
       Region 4f7u C 2-82 order
       Region 4f7u C 83-119 disorder
Seq 1-119 Hetero nonamer : IID00143Complex,IID00160Complex
 Evidence X-RAY 3cw1 B Reference
       Region 3cw1 B 1-1 disorder
       Region 3cw1 B 2-78 order
       Region 3cw1 B 79-119 disorder
 Evidence X-RAY 3cw1 M Reference
       Region 3cw1 M 1-1 disorder
       Region 3cw1 M 2-78 order
       Region 3cw1 M 79-119 disorder
 Evidence X-RAY 3cw1 O Reference
       Region 3cw1 O 1-1 disorder
       Region 3cw1 O 2-78 order
       Region 3cw1 O 79-119 disorder
Seq 1-119 Hetero nonamer : IID00143Complex,IID00160Complex
 Evidence X-RAY 3cw1 N Reference
       Region 3cw1 N 1-1 disorder
       Region 3cw1 N 2-77 order
       Region 3cw1 N 78-119 disorder
Seq 1-119 Hetero dimer : IID00160Complex
 Evidence X-RAY 1b34 A Reference
       Region 1b34 A 1-1 disorder
       Region 1b34 A 2-81 order
       Region 1b34 A 82-119 disorder
Seq 1-119 Hetero nonamer : IID00138Complex,IID00143Complex,IID00160Complex
 Evidence X-RAY 3pgw X Reference
       Region 3pgw X 1-85 order
       Region 3pgw X 86-119 disorder
 Evidence X-RAY 3pgw U Reference
       Region 3pgw U 1-85 order
       Region 3pgw U 86-119 disorder
Seq 2-85 Hetero 36mer : IID00138Complex,IID00143Complex,IID00160Complex
 Evidence X-RAY 4pjo c Reference
       Region 4pjo c 2-83 order
       Region 4pjo c 84-85 disorder
 Evidence X-RAY 4pjo Q Reference
       Region 4pjo Q 2-82 order
       Region 4pjo Q 83-85 disorder
 Evidence X-RAY 4pjo C Reference
       Region 4pjo C 2-82 order
       Region 4pjo C 83-85 disorder
 
Prediction
NeProc
Disorder 1-2,84-119
Order 3-83
ProS 1-2,99-106
AlphaFold
Disorder 88-119
Order 1-87
Pfam Hmmer
PF01423 5-70 2.1e-20
SEG 97-119
Function
Function in SwissProt
Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through nonspecific electrostatic contacts with RNA.