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IID00160
 UniprotP62316
ProteinSmall nuclear ribonucleoprotein Sm D2
GeneSNRPD2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
118
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-118 Hetero hexamer : IID00157Complex,IID00159Complex
 Evidence X-RAY 4f7u B Reference
       Region 4f7u B 1-21 disorder
       Region 4f7u B 22-76 order
       Region 4f7u B 77-89 disorder
       Region 4f7u B 90-114 order
       Region 4f7u B 115-118 disorder
 Evidence X-RAY 4f7u D Reference
       Region 4f7u D 1-15 disorder
       Region 4f7u D 16-76 order
       Region 4f7u D 77-89 disorder
       Region 4f7u D 90-113 order
       Region 4f7u D 114-118 disorder
Seq 1-118 Hetero nonamer : IID00157Complex,IID00159Complex
 Evidence X-RAY 3cw1 C Reference
       Region 3cw1 C 1-10 disorder
       Region 3cw1 C 11-75 order
       Region 3cw1 C 76-91 disorder
       Region 3cw1 C 92-114 order
       Region 3cw1 C 115-118 disorder
 Evidence X-RAY 3cw1 P Reference
       Region 3cw1 P 1-10 disorder
       Region 3cw1 P 11-75 order
       Region 3cw1 P 76-91 disorder
       Region 3cw1 P 92-112 order
       Region 3cw1 P 113-118 disorder
 Evidence X-RAY 3cw1 R Reference
       Region 3cw1 R 1-10 disorder
       Region 3cw1 R 11-73 order
       Region 3cw1 R 74-91 disorder
       Region 3cw1 R 92-113 order
       Region 3cw1 R 114-118 disorder
Seq 1-118 Hetero nonamer : IID00157Complex,IID00159Complex
 Evidence X-RAY 3cw1 Q Reference
       Region 3cw1 Q 1-10 disorder
       Region 3cw1 Q 11-76 order
       Region 3cw1 Q 77-91 disorder
       Region 3cw1 Q 92-114 order
       Region 3cw1 Q 115-118 disorder
Seq 1-118 Hetero dimer : IID00159Complex
 Evidence X-RAY 1b34 B Reference
       Region 1b34 B 1-25 disorder
       Region 1b34 B 26-73 order
       Region 1b34 B 74-92 disorder
       Region 1b34 B 93-118 order
Seq 1-118 Hetero 36mer : IID00138Complex,IID00157Complex,IID00159Complex
 Evidence X-RAY 4pjo r Reference
       Region 4pjo r 78-87 disorder
       Region 4pjo r 88-114 order
       Region 4pjo r 115-118 disorder
 Evidence X-RAY 4pjo d Reference
       Region 4pjo d 1-12 disorder
       Region 4pjo d 13-77 order
       Region 4pjo d 78-87 disorder
       Region 4pjo d 88-114 order
       Region 4pjo d 115-118 disorder
 Evidence X-RAY 4pjo R Reference
       Region 4pjo R 1-9 disorder
       Region 4pjo R 10-77 order
       Region 4pjo R 78-88 disorder
       Region 4pjo R 89-116 order
       Region 4pjo R 117-118 disorder
 Evidence X-RAY 4pjo D Reference
       Region 4pjo D 1-9 disorder
       Region 4pjo D 10-77 order
       Region 4pjo D 78-86 disorder
       Region 4pjo D 87-116 order
       Region 4pjo D 117-118 disorder
Seq 1-118 Hetero nonamer : IID00138Complex,IID00157Complex,IID00159Complex
 Evidence X-RAY 3pgw V Reference
       Region 3pgw V 1-1 disorder
       Region 3pgw V 2-76 order
       Region 3pgw V 77-89 disorder
       Region 3pgw V 90-117 order
       Region 3pgw V 118-118 disorder
 Evidence X-RAY 3pgw Y Reference
       Region 3pgw Y 1-1 disorder
       Region 3pgw Y 2-112 order
       Region 3pgw Y 113-118 disorder
Seqphosphorylation
    12-12 Phosphothreonine
    9-9 Phosphoserine
Seqacetylation
    2-2 N-acetylserine
 
Prediction
NeProc
Disorder 1-25,114-118
Order 26-113
ProS 1-25,114-118
AlphaFold
Disorder 1-1,114-118
Order 2-113
Pfam Hmmer
PF01423 30-111 2e-16
SEG 77-90
Function
Function in SwissProt
Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP.