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IID00161
 UniprotP62318
ProteinSmall nuclear ribonucleoprotein Sm D3
GeneSNRPD3
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
126
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-75 Hetero dimer : IID00143Complex
 Evidence X-RAY 1d3b A Reference
       Region 1d3b A 1-3 disorder
       Region 1d3b A 4-75 order
 Evidence X-RAY 1d3b C Reference
       Region 1d3b C 1-4 disorder
       Region 1d3b C 5-75 order
 Evidence X-RAY 1d3b E Reference
       Region 1d3b E 1-1 disorder
       Region 1d3b E 2-75 order
 Evidence X-RAY 1d3b G Reference
       Region 1d3b G 1-2 disorder
       Region 1d3b G 3-75 order
 Evidence X-RAY 1d3b I Reference
       Region 1d3b I 1-2 disorder
       Region 1d3b I 3-75 order
 Evidence X-RAY 1d3b K Reference
       Region 1d3b K 1-4 disorder
       Region 1d3b K 5-75 order
Seq 1-126 Hetero nonamer : IID00138Complex,IID00139Complex,IID00143Complex,IID00158Complex
 Evidence X-RAY 3cw1 T Reference
       Region 3cw1 T 1-5 disorder
       Region 3cw1 T 6-81 order
       Region 3cw1 T 82-126 disorder
Seq 1-126 Hetero 36mer : IID00138Complex,IID00139Complex,IID00143Complex,IID00158Complex
 Evidence X-RAY 4pjo o Reference
       Region 4pjo o 1-2 disorder
       Region 4pjo o 3-83 order
       Region 4pjo o 84-126 disorder
 Evidence X-RAY 4pjo a Reference
       Region 4pjo a 1-1 disorder
       Region 4pjo a 2-84 order
       Region 4pjo a 85-126 disorder
 Evidence X-RAY 4pjo O Reference
       Region 4pjo O 1-1 disorder
       Region 4pjo O 2-83 order
       Region 4pjo O 84-126 disorder
 Evidence X-RAY 4pjo A Reference
       Region 4pjo A 1-84 order
       Region 4pjo A 85-126 disorder
Seq 1-126 Hetero nonamer : IID00138Complex,IID00139Complex,IID00143Complex,IID00158Complex
 Evidence X-RAY 3cw1 D Reference
       Region 3cw1 D 1-5 disorder
       Region 3cw1 D 6-81 order
       Region 3cw1 D 82-126 disorder
 Evidence X-RAY 3cw1 S Reference
       Region 3cw1 S 1-5 disorder
       Region 3cw1 S 6-81 order
       Region 3cw1 S 82-126 disorder
 Evidence X-RAY 3cw1 U Reference
       Region 3cw1 U 1-5 disorder
       Region 3cw1 U 6-81 order
       Region 3cw1 U 82-126 disorder
Seq 1-126 Hetero nonamer : IID00143Complex,IID00158Complex
 Evidence X-RAY 3pgw Z Reference
       Region 3pgw Z 1-4 disorder
       Region 3pgw Z 5-84 order
       Region 3pgw Z 85-126 disorder
 Evidence X-RAY 3pgw W Reference
       Region 3pgw W 1-2 disorder
       Region 3pgw W 3-94 order
       Region 3pgw W 95-126 disorder
Seq 54-63 Hetero trimer : P01889
 Evidence X-RAY 3vri C Reference
       Region 3vri C 54-63 order
Seqacetylation
    2-2 N-acetylserine
 
Prediction
NeProc
Disorder 86-126
Order 1-85
ProS 100-122
AlphaFold
Disorder 1-1,85-100,109-126
Order 2-84,101-108
Pfam Hmmer
PF01423 8-73 3.4e-17
SEG 110-119
Function
Function in SwissProt
Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. As part of the U7 snRNP it is involved in histone 3'-end processing.