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IID00172
 UniprotQ15208
ProteinSerine/threonine-protein kinase 38
GeneSTK38
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
465
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 62-87 Hetero tetramer : IID50022Complex
 Evidence NMR 1psb C Reference
       Region 1psb C 62-87 order
       Region 1psb C 62-70 high_rmsd
       Region 1psb C 86-87 high_rmsd
 Evidence NMR 1psb D Reference
       Region 1psb D 62-87 order
       Region 1psb D 62-70 high_rmsd
SeqProS possible 62-87 N-terminal regurator motif of NDR (nuclear Dbf2 related kinase) Hetero tetramer : IID50022Complex
       Region 1psb C 62-87 order
       Region 1psb D 62-87 order
Seqphosphorylation
    74-74 Phosphothreonine
    264-264 Phosphoserine
    281-281 Phosphoserine; by autocatalysis
    444-444 Phosphothreonine; by STK24/MST3
Seqacetylation
    2-2 N-acetylalanine
 
Prediction
NeProc
Disorder 1-14,254-265,416-435,461-465
Order 15-253,266-415,436-460
ProS 11-14,254-265,461-461
AlphaFold
Disorder 1-10,144-144,231-238,420-439,441-441,450-465
Order 11-143,145-230,239-419,440-440,442-449
Pfam Hmmer
PF00069 89-382 2.4e-69
PF00433 400-449 2e-10
Function
Function in SwissProt
Negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2.