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IID00174  Mothers against decapentaplegic homolog 1 (Homo sapiens) Q15797
  :order  :disorder  :conflict  :PDB cluster  :ProS  :SCOP Domain  :Pfam Domain
Networkxml
Experiment
465
fasta
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 201-209 Hetero dimer : IID00304Complex
 Evidence NMR 2lax B Reference
       Region 2lax B 201-209 order
 Evidence NMR 2lay B Reference
       Region 2lay B 201-209 order
Seq 208-217 Hetero dimer : IID00328Complex
 Evidence NMR 2laz B Reference
       Region 2laz B 210-217 order
 Evidence NMR 2lb0 B Reference
       Region 2lb0 B 208-217 order
Seqdisorder 217-267
 Evidence X-RAY Reference
       Region 217-267 disorder
Seq 220-233 Hetero dimer : IID00328Complex
 Evidence NMR 2lb1 B Reference
       Region 2lb1 B 220-220 disorder
       Region 2lb1 B 221-233 order
Seq 222-233 Hetero dimer : IID00304Complex
 Evidence NMR 2law B Reference
       Region 2law B 222-233 order
Seq 248-465 Homo trimer :
 Evidence X-RAY 1khu A Reference
       Region 1khu A 248-267 disorder
       Region 1khu A 268-465 order
 Evidence X-RAY 1khu B Reference
       Region 1khu B 248-268 disorder
       Region 1khu B 269-465 order
 Evidence X-RAY 1khu C Reference
       Region 1khu C 248-268 disorder
       Region 1khu C 269-465 order
 Evidence X-RAY 1khu D Reference
       Region 1khu D 248-269 disorder
       Region 1khu D 270-453 order
       Region 1khu D 454-465 disorder
Seq 456-465 Hetero dimer : Q9WUD1
 Evidence X-RAY 3q47 C Reference
       Region 3q47 C 456-458 disorder
       Region 3q47 C 459-464 order
 Evidence X-RAY 3q4a C Reference
       Region 3q4a C 456-459 disorder
       Region 3q4a C 460-465 order
SeqProS possible 201-209 The S214 only (2lay) orT202 and S206 (2lax) were phosphorylated. This linker region is disordered in the smad3. (PubMed=12154125) Hetero dimer : IID00304Complex
       Region 2lax B 201-209 order
       Region 2lay B 201-209 order
SeqProS possible 208-217 The S214 only (2laz) or S210 and S214 (2lb0) were phosphorylated. This linker region is disordered in the smad3. (PubMed=12154125) Hetero dimer : IID00328Complex
       Region 2lb0 B 208-217 order
       Region 2laz B 210-217 order
SeqProS verified 221-233 Hetero dimer : IID00328Complex
       Region 2lb1 B 221-233 order
       Region 217-267 disorder
SeqProS verified 222-233 Hetero dimer : IID00304Complex
       Region 2law B 222-233 order
       Region 217-267 disorder
SeqProS verified 454-465 While the C-terminal tail is disordered in the unphosphorylated form, but ordered in the phosphorylated form. This tail interactions make the heterotrimer formation. Homo trimer :
       Region 1khu A 268-465 order
       Region 1khu B 269-465 order
       Region 1khu C 269-465 order
       Region 1khu D 454-465 disorder
Seqphosphorylation
    322-322 Phosphothreonine; by MINK1
    463-463 Phosphoserine
    465-465 Phosphoserine
Seqacetylation
    1-1 N-acetylmethionine
 
Prediction
DICHOT
Disorder 1-8,133-267
Known Domain 9-132,268-465
SCOPe RPS-Blast
     1ozjA 9-132 2e-40 d.164.1.1 SMAD MH1 domain
     1mjsA 268-457 4e-55 b.26.1.1 Smad1
SCOP Hmmer
     1mhdA_ 13-131 3.5e-48 d.164.1.1 SMAD MH1 domain
     1dd1A_ 221-456 8.2e-99 b.26.1.1 Smad1
Pfam RPS-Blast
     PF03165 71-131 9e-18 MH1 domain
     PF03166 287-441 5e-31 MH2 domain
Pfam Hmmer
    PF03165 31-131 9.4e-46 MH1 domain
    PF03166 269-441 3.2e-79 MH2 domain