SeqProS possible 201-209 The S214 only (2lay) orT202 and S206 (2lax) were phosphorylated. This linker region is disordered in the smad3. (PubMed=12154125)
Hetero dimer : IID00304Complex
SeqProS possible 208-217 The S214 only (2laz) or S210 and S214 (2lb0) were phosphorylated. This linker region is disordered in the smad3. (PubMed=12154125)
Hetero dimer : IID00328Complex
SeqProS verified 454-465 While the tail of subunit D is disordered, the tails of the three NCS related subunits are well ordered and assume novel arrangements. ... These two distinct modes of tail interactions suggest a mechanism for asymmetric heterotrimer formation. (PMID: 11779505)
Homo trimer :
Transcriptional modulator that plays a role in various cellular processes, including embryonic development, cell differentiation, and tissue homeostasis (PubMed:9335504). Upon BMP ligand binding to their receptors at the cell surface, is phosphorylated by activated type I BMP receptors (BMPRIs) and associates with SMAD4 to form an heteromeric complex which translocates into the nucleus acting as transcription factor (PubMed:33667543). In turn, the hetero-trimeric complex recognizes cis-regulatory elements containing Smad Binding Elements (SBEs) to modulate the outcome of the signaling network (PubMed:33667543). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Positively regulates BMP4-induced expression of odontogenic development regulator MSX1 following IPO7-mediated nuclear import (By similarity).