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IID00182
 UniprotQ9Y294
ProteinHistone chaperone ASF1A
GeneASF1A
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
204
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-155 Hetero trimer : IID00545Complex
 Evidence X-RAY 3aad B Reference
       Region 3aad B 1-153 order
       Region 3aad B 154-155 disorder
 Evidence X-RAY 3aad D Reference
       Region 3aad D 1-152 order
       Region 3aad D 153-155 disorder
Seq 1-156 Monomer :
 Evidence NMR 1tey A Reference
       Region 1tey A 1-156 order
Seq 1-156 Hetero dimer : IID00088Complex
 Evidence NMR 2iij A Reference
       Region 2iij A 1-156 order
Seq 1-157 Hetero dimer : IID00154Complex
 Evidence X-RAY 2i32 A Reference
       Region 2i32 A 1-154 order
       Region 2i32 A 155-157 disorder
 Evidence X-RAY 2i32 B Reference
       Region 2i32 B 1-154 order
       Region 2i32 B 155-157 disorder
Seq 1-172 Hetero trimer : IID50145Complex,IID50147Complex
 Evidence X-RAY 2io5 A Reference
       Region 2io5 A 1-154 order
       Region 2io5 A 155-172 disorder
Seq 1-175 Hetero tetramer : IID00058Complex,IID00062Complex
 Evidence X-RAY 5c3i E Reference
       Region 5c3i E 1-1 disorder
       Region 5c3i E 2-154 order
       Region 5c3i E 155-175 disorder
 Evidence X-RAY 5c3i I Reference
       Region 5c3i I 1-1 disorder
       Region 5c3i I 2-154 order
       Region 5c3i I 155-175 disorder
 Evidence X-RAY 5c3i M Reference
       Region 5c3i M 1-1 disorder
       Region 5c3i M 2-153 order
       Region 5c3i M 154-175 disorder
 Evidence X-RAY 5c3i Q Reference
       Region 5c3i Q 1-1 disorder
       Region 5c3i Q 2-155 order
       Region 5c3i Q 156-175 disorder
 Evidence X-RAY 5c3i U Reference
       Region 5c3i U 1-2 disorder
       Region 5c3i U 3-152 order
       Region 5c3i U 153-175 disorder
Seq 1-175 Hetero tetramer : IID00058Complex,IID00062Complex,IID00715Complex
 Evidence X-RAY 5c3i A Reference
       Region 5c3i A 1-1 disorder
       Region 5c3i A 2-153 order
       Region 5c3i A 154-175 disorder
Seqphosphorylation
    192-192 Phosphoserine; by PRKDC and TLK2
 
Prediction
NeProc
Disorder 156-204
Order 1-155
ProS 200-204
AlphaFold
Disorder 156-204
Order 1-155
Pfam Hmmer
PF04729 1-155 2.3e-117
Function
Function in SwissProt
Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.