Search Keyword:


Search option:


IID00185  Protein CASC3 (Homo sapiens) O15234  LLPSCytoplasm, Cytoplasmic ribonucleoprotein granule.
Cytoplasm, Stress granule.
Nucleus speckle.
  :order  :disorder  :conflict  :PDB cluster  :ProS  :SCOP Domain  :Pfam Domain
Networkxml
Experiment
703
fasta
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 137-250 Hetero trimer : IID00370Complex
 Evidence X-RAY 2j0u T Reference
       Region 2j0u T 137-216 disorder
       Region 2j0u T 217-225 order
       Region 2j0u T 226-250 disorder
Seq 137-286 Hetero undecamer : IID00370Complex,IID00375Complex
 Evidence X-RAY 2xb2 S Reference
       Region 2xb2 S 137-168 disorder
       Region 2xb2 S 169-194 order
       Region 2xb2 S 195-215 disorder
       Region 2xb2 S 216-246 order
       Region 2xb2 S 247-286 disorder
 Evidence X-RAY 2xb2 T Reference
       Region 2xb2 T 137-168 disorder
       Region 2xb2 T 169-194 order
       Region 2xb2 T 195-215 disorder
       Region 2xb2 T 216-248 order
       Region 2xb2 T 249-286 disorder
Seq 137-286 Hetero tetramer : IID00370Complex,IID00375Complex
 Evidence X-RAY 2j0s T Reference
       Region 2j0s T 137-168 disorder
       Region 2j0s T 169-196 order
       Region 2j0s T 197-214 disorder
       Region 2j0s T 215-230 order
       Region 2j0s T 231-286 disorder
Seq 137-286 Hetero tetramer : IID00370Complex,IID00375Complex
 Evidence X-RAY 3ex7 D Reference
       Region 3ex7 D 138-171 disorder
       Region 3ex7 D 172-194 order
       Region 3ex7 D 195-215 disorder
       Region 3ex7 D 216-249 order
       Region 3ex7 D 250-283 disorder
 Evidence X-RAY 3ex7 I Reference
       Region 3ex7 I 138-166 disorder
       Region 3ex7 I 167-194 order
       Region 3ex7 I 195-215 disorder
       Region 3ex7 I 216-249 order
       Region 3ex7 I 250-283 disorder
 Evidence X-RAY 2hyi J Reference
       Region 2hyi J 170-175 disorder
       Region 2hyi J 176-195 order
       Region 2hyi J 196-215 disorder
       Region 2hyi J 216-246 order
 Evidence X-RAY 2j0q T Reference
       Region 2j0q T 137-167 disorder
       Region 2j0q T 168-197 order
       Region 2j0q T 198-213 disorder
       Region 2j0q T 214-248 order
       Region 2j0q T 249-286 disorder
 Evidence X-RAY 2j0q I Reference
       Region 2j0q I 137-167 disorder
       Region 2j0q I 168-196 order
       Region 2j0q I 197-214 disorder
       Region 2j0q I 215-248 order
       Region 2j0q I 249-286 disorder
Seq 170-246 Hetero tetramer : IID00370Complex,IID00375Complex
 Evidence X-RAY 2hyi D Reference
       Region 2hyi D 170-194 order
       Region 2hyi D 195-215 disorder
       Region 2hyi D 216-246 order
SeqProS verified 167-197,226-248 This complex contains elF4AIII, Btz, Mago andY14. Hetero tetramer : IID00370Complex,IID00375Complex
       Region 3ex7 D 172-194 order
       Region 3ex7 I 167-194 order
       Region 2j0q I 168-196 order
       Region 2j0q T 168-197 order
       Region 2hyi J 176-195 order
       Region 3ex7 D 216-249 order
       Region 3ex7 I 216-249 order
       Region 2j0q I 215-248 order
       Region 2j0q T 214-248 order
       Region 2hyi J 216-246 order
       Region 2j0u T 137-216 disorder
       Region 2j0u T 226-250 disorder
SeqProS verified 167-196,226-248 This region is disordered in the CASC3 elF4AIII complex, and ordered in the CASC3, elF4AIII, Mago, and Y14 and UPF3b. Hetero undecamer : IID00370Complex,IID00375Complex
       Region 2xb2 S 169-194 order
       Region 2xb2 T 169-194 order
       Region 2xb2 S 216-246 order
       Region 2xb2 T 216-248 order
       Region 2j0u T 137-216 disorder
       Region 2j0u T 226-250 disorder
SeqProS verified 169-196,226-248 This complex contains elF4AIII, Btz, Mago andY14. Hetero tetramer : IID00370Complex,IID00375Complex
       Region 2j0s T 169-196 order
       Region 2j0s T 215-230 order
       Region 2j0u T 137-216 disorder
       Region 2j0u T 226-250 disorder
SeqProS verified 170-194,226-248 This complex contains elF4AIII, Btz, Mago andY14. Hetero tetramer : IID00370Complex,IID00375Complex
       Region 2hyi D 170-194 order
       Region 2hyi D 216-246 order
       Region 2j0u T 137-216 disorder
       Region 2j0u T 226-250 disorder
Seqphosphorylation
    35-35 Phosphoserine
    117-117 Phosphoserine
    148-148 Phosphoserine
    265-265 Phosphoserine
    357-357 Phosphothreonine
    363-363 Phosphoserine
    373-373 Phosphoserine
    477-477 Phosphoserine
 
Prediction
DICHOT
Disorder 1-169,247-703
Known Domain 170-246
Pfam RPS-Blast
     PF09405 145-247 6e-06 CASC3/Barentsz eIF4AIII bin...
     PF12851 352-703 2e-04 Oxygenase domain of the 2OG...
Pfam Hmmer
    PF09405 144-248 3.9e-28 CASC3/Barentsz eIF4AIII bi...