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IID00186
 UniprotO15392
ProteinBaculoviral IAP repeat-containing protein 5
GeneBIRC5
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
142
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-142 Hetero tetramer :
 Evidence X-RAY 3ued C Reference
       Region 3ued C 1-3 disorder
       Region 3ued C 4-142 order
 Evidence X-RAY 3ued A Reference
       Region 3ued A 1-4 disorder
       Region 3ued A 5-141 order
       Region 3ued A 142-142 disorder
Seq 1-142 Hetero tetramer : Q5FBB7
 Evidence X-RAY 4a0i B Reference
       Region 4a0i B 1-4 disorder
       Region 4a0i B 5-141 order
       Region 4a0i B 142-142 disorder
 Evidence X-RAY 4a0i A Reference
       Region 4a0i A 1-4 disorder
       Region 4a0i A 5-140 order
       Region 4a0i A 141-142 disorder
Seq 1-142 Hetero tetramer : IID00062Complex,IID00215Complex,IID00224Complex
 Evidence X-RAY 6yih A Reference
       Region 6yih A 1-3 disorder
       Region 6yih A 4-138 order
       Region 6yih A 139-142 disorder
 Evidence X-RAY 6yif A Reference
       Region 6yif A 1-4 disorder
       Region 6yif A 5-134 order
       Region 6yif A 135-142 disorder
Seq 1-142 Hetero dimer : IID00062Complex
 Evidence X-RAY 4a0j A Reference
       Region 4a0j A 1-4 disorder
       Region 4a0j A 5-140 order
       Region 4a0j A 141-142 disorder
 Evidence X-RAY 4a0j B Reference
       Region 4a0j B 1-4 disorder
       Region 4a0j B 5-141 order
       Region 4a0j B 142-142 disorder
 Evidence X-RAY 4a0n A Reference
       Region 4a0n A 1-10 disorder
       Region 4a0n A 11-141 order
       Region 4a0n A 142-142 disorder
 Evidence X-RAY 7lbq A Reference
       Region 7lbq A 1-7 disorder
       Region 7lbq A 8-141 order
       Region 7lbq A 142-142 disorder
Seq 1-142 Hetero hexamer : IID00215Complex,IID00224Complex
 Evidence X-RAY 6yie D Reference
       Region 6yie D 1-4 disorder
       Region 6yie D 5-137 order
       Region 6yie D 138-142 disorder
 Evidence X-RAY 6yie A Reference
       Region 6yie A 1-4 disorder
       Region 6yie A 5-139 order
       Region 6yie A 140-142 disorder
Seq 1-142 Homo dimer :
 Evidence X-RAY 1e31 A Reference
       Region 1e31 A 1-4 disorder
       Region 1e31 A 5-140 order
       Region 1e31 A 141-142 disorder
 Evidence X-RAY 1e31 B Reference
       Region 1e31 B 1-4 disorder
       Region 1e31 B 5-142 order
 Evidence X-RAY 1f3h A Reference
       Region 1f3h A 1-4 disorder
       Region 1f3h A 5-140 order
       Region 1f3h A 141-142 disorder
 Evidence X-RAY 1f3h B Reference
       Region 1f3h B 1-5 disorder
       Region 1f3h B 6-140 order
       Region 1f3h B 141-142 disorder
 Evidence X-RAY 3uec A Reference
       Region 3uec A 1-4 disorder
       Region 3uec A 5-142 order
 Evidence X-RAY 3ueg A Reference
       Region 3ueg A 1-4 disorder
       Region 3ueg A 5-141 order
       Region 3ueg A 142-142 disorder
 Evidence X-RAY 3ueg B Reference
       Region 3ueg B 1-4 disorder
       Region 3ueg B 5-142 order
 Evidence X-RAY 3ueh A Reference
       Region 3ueh A 1-4 disorder
       Region 3ueh A 5-141 order
       Region 3ueh A 142-142 disorder
 Evidence X-RAY 3ueh B Reference
       Region 3ueh B 1-4 disorder
       Region 3ueh B 5-141 order
       Region 3ueh B 142-142 disorder
 Evidence X-RAY 3uei A Reference
       Region 3uei A 1-4 disorder
       Region 3uei A 5-141 order
       Region 3uei A 142-142 disorder
 Evidence X-RAY 3uei B Reference
       Region 3uei B 1-4 disorder
       Region 3uei B 5-142 order
 Evidence X-RAY 6sho A Reference
       Region 6sho A 1-5 disorder
       Region 6sho A 6-140 order
       Region 6sho A 141-142 disorder
 Evidence X-RAY 6sho B Reference
       Region 6sho B 1-5 disorder
       Region 6sho B 6-140 order
       Region 6sho B 141-142 disorder
 Evidence NMR 1xox A Reference
       Region 1xox A 1-117 order
 Evidence NMR 1xox B Reference
       Region 1xox B 1-117 order
Seq 1-142 Hetero trimer : IID00215Complex,IID00224Complex
 Evidence X-RAY 2qfa A Reference
       Region 2qfa A 1-4 disorder
       Region 2qfa A 5-141 order
       Region 2qfa A 142-142 disorder
Seq 1-142 Hetero dimer : IID00215Complex
 Evidence X-RAY 2raw A Reference
       Region 2raw A 1-4 disorder
       Region 2raw A 5-141 order
       Region 2raw A 142-142 disorder
 Evidence X-RAY 2rax A Reference
       Region 2rax A 1-4 disorder
       Region 2rax A 5-119 order
       Region 2rax A 120-120 disorder
 Evidence X-RAY 2rax E Reference
       Region 2rax E 1-4 disorder
       Region 2rax E 5-119 order
       Region 2rax E 120-120 disorder
 Evidence X-RAY 2rax X Reference
       Region 2rax X 1-4 disorder
       Region 2rax X 5-119 order
       Region 2rax X 120-120 disorder
Seq 1-142 Hetero tetramer : Q9NR28
 Evidence X-RAY 3uij B Reference
       Region 3uij B 1-4 disorder
       Region 3uij B 5-140 order
       Region 3uij B 141-142 disorder
 Evidence X-RAY 3uij A Reference
       Region 3uij A 1-4 disorder
       Region 3uij A 5-140 order
       Region 3uij A 141-142 disorder
 Evidence X-RAY 3uih B Reference
       Region 3uih B 1-5 disorder
       Region 3uih B 6-140 order
       Region 3uih B 141-142 disorder
 Evidence X-RAY 3uih A Reference
       Region 3uih A 1-4 disorder
       Region 3uih A 5-140 order
       Region 3uih A 141-142 disorder
Seq 1-142 Hetero tetramer : IID00062Complex
 Evidence X-RAY 3uee A Reference
       Region 3uee A 1-4 disorder
       Region 3uee A 5-141 order
       Region 3uee A 142-142 disorder
 Evidence X-RAY 3uee C Reference
       Region 3uee C 1-4 disorder
       Region 3uee C 5-142 order
 Evidence X-RAY 3uef A Reference
       Region 3uef A 1-4 disorder
       Region 3uef A 5-140 order
       Region 3uef A 141-142 disorder
 Evidence X-RAY 3uef C Reference
       Region 3uef C 1-4 disorder
       Region 3uef C 5-141 order
       Region 3uef C 142-142 disorder
 Evidence X-RAY 3uig A Reference
       Region 3uig A 1-4 disorder
       Region 3uig A 5-139 order
       Region 3uig A 140-142 disorder
 Evidence X-RAY 3uig B Reference
       Region 3uig B 1-4 disorder
       Region 3uig B 5-140 order
       Region 3uig B 141-142 disorder
 Evidence X-RAY 3uii A Reference
       Region 3uii A 1-4 disorder
       Region 3uii A 5-139 order
       Region 3uii A 140-142 disorder
 Evidence X-RAY 3uii B Reference
       Region 3uii B 1-4 disorder
       Region 3uii B 5-139 order
       Region 3uii B 140-142 disorder
 Evidence X-RAY 3uik A Reference
       Region 3uik A 1-4 disorder
       Region 3uik A 5-139 order
       Region 3uik A 140-142 disorder
 Evidence X-RAY 3uik B Reference
       Region 3uik B 1-4 disorder
       Region 3uik B 5-139 order
       Region 3uik B 140-142 disorder
 Evidence X-RAY 7lbk A Reference
       Region 7lbk A 1-5 disorder
       Region 7lbk A 6-142 order
 Evidence X-RAY 7lbk B Reference
       Region 7lbk B 1-4 disorder
       Region 7lbk B 5-140 order
       Region 7lbk B 141-142 disorder
 Evidence X-RAY 7lbo A Reference
       Region 7lbo A 1-4 disorder
       Region 7lbo A 5-141 order
       Region 7lbo A 142-142 disorder
 Evidence X-RAY 7lbo B Reference
       Region 7lbo B 1-4 disorder
       Region 7lbo B 5-140 order
       Region 7lbo B 141-142 disorder
 Evidence X-RAY 7lbp A Reference
       Region 7lbp A 1-4 disorder
       Region 7lbp A 5-141 order
       Region 7lbp A 142-142 disorder
 Evidence X-RAY 7lbp C Reference
       Region 7lbp C 1-4 disorder
       Region 7lbp C 5-142 order
Seqphosphorylation
    117-117 Phosphothreonine; by AURKB
    48-48 Phosphothreonine; by CK2; in vitro
    34-34 Phosphothreonine; by CDK1 and CDK15
    20-20 Phosphoserine; by AURKC
Seqacetylation
    23-23 N6-acetyllysine
    129-129 N6-acetyllysine
    121-121 N6-acetyllysine
    115-115 N6-acetyllysine
    112-112 N6-acetyllysine
    110-110 N6-acetyllysine
    90-90 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-4,142-142
Order 5-141
ProS 142-142
AlphaFold
Disorder 1-4
Order 5-142
Pfam Hmmer
PF00653 18-88 4.4e-33
SEG 114-130
Function
Function in SwissProt
Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (PubMed:9859993, PubMed:21364656, PubMed:20627126, PubMed:25778398, PubMed:28218735). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (PubMed:16322459). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules (PubMed:20826784). Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis (PubMed:20929775). The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules (PubMed:18591255). May counteract a default induction of apoptosis in G2/M phase (PubMed:9859993). The acetylated form represses STAT3 transactivation of target gene promoters (PubMed:20826784). May play a role in neoplasia (PubMed:10626797). Inhibitor of CASP3 and CASP7 (PubMed:21536684). Essential for the maintenance of mitochondrial integrity and function (PubMed:25778398). Isoform 2 and isoform 3 do not appear to play vital roles in mitosis (PubMed:12773388, PubMed:16291752). Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform (PubMed:10626797).
Biological Process
See also
Diagram with PDB data
AURKB/INCENPHuman Aurora B Kinase in complex with INCENP and VX-680