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IID00189
UniprotO75376
ProteinNuclear receptor corepressor 1
GeneNCOR1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
2440
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 433-486 Monomer :
 Evidence NMR 2eqr A Reference
       Region 2eqr A 433-486 order
       Region 2eqr A 433-438 high_rmsd
       Region 2eqr A 484-486 high_rmsd
Seq 2045-2065 Hetero tetramer : IID00033Complex
 Evidence X-RAY 3n00 B Reference
       Region 3n00 B 2045-2065 order
Seq 2045-2065 Hetero dimer : IID00033Complex
 Evidence X-RAY 3n00 B Reference
       Region 3n00 B 2045-2065 order
Seq 2047-2065 Hetero tetramer : IID00365Complex
 Evidence X-RAY 3kmz C Reference
       Region 3kmz C 2047-2065 order
 Evidence X-RAY 3kmz D Reference
       Region 3kmz D 2047-2065 order
Seq 2258-2276 Hetero trimer : IID00014Complex
 Evidence X-RAY 3h52 N Reference
       Region 3h52 N 2258-2259 disorder
       Region 3h52 N 2260-2274 order
       Region 3h52 N 2275-2276 disorder
 Evidence X-RAY 3h52 M Reference
       Region 3h52 M 2258-2264 disorder
       Region 3h52 M 2265-2274 order
       Region 3h52 M 2275-2276 disorder
Seq 2259-2275 Hetero tetramer : IID00391Complex
 Evidence X-RAY 4wvd D Reference
       Region 4wvd D 2259-2275 order
 Evidence X-RAY 4wvd C Reference
       Region 4wvd C 2259-2259 disorder
       Region 4wvd C 2260-2275 order
Seq 2260-2274 Hetero tetramer : IID00014Complex
 Evidence X-RAY 4mdd D Reference
       Region 4mdd D 2260-2261 disorder
       Region 4mdd D 2262-2273 order
       Region 4mdd D 2274-2274 disorder
 Evidence X-RAY 4mdd C Reference
       Region 4mdd C 2260-2260 disorder
       Region 4mdd C 2261-2273 order
       Region 4mdd C 2274-2274 disorder
SeqProS possible 2045-2065 This region may be ProS because of similarity to other nuclear receptor co-repressors/co-acitivators. (e.g. IID00050, 74, 82, 83, 103) Hetero tetramer : IID00033Complex
       Region 3n00 B 2045-2065 order
SeqProS possible 2045-2065 This region may be ProS because of similarity to other nuclear receptor co-repressors/co-acitivators. (e.g. IID00050, 74, 82, 83, 103) Hetero dimer : IID00033Complex
       Region 3n00 B 2045-2065 order
SeqProS possible 2047-2065 This region may be ProS because of similarity to other nuclear receptor co-repressors/co-acitivators.(e.g. IID00050, 74, 82, 83, 103) Hetero tetramer : IID00365Complex
       Region 3kmz C 2047-2065 order
       Region 3kmz D 2047-2065 order
SeqProS possible 2259-2275 This region may be ProS because of similarity to other nuclear receptor co-repressors/co-acitivators.(e.g. IID00050, 74, 82, 83, 103) Hetero tetramer : IID00391Complex
       Region 4wvd C 2260-2275 order
       Region 4wvd D 2259-2275 order
SeqProS possible 2260-2274 This region may be ProS because of similarity to other nuclear receptor co-repressors/co-acitivators.(e.g. IID00050, 74, 82, 83, 103) Hetero trimer : IID00014Complex
       Region 3h52 M 2265-2274 order
       Region 3h52 N 2260-2274 order
SeqProS possible 2261-2273 This region may be ProS because of similarity to other nuclear receptor co-repressors/co-acitivators.(e.g. IID00050, 74, 82, 83, 103) Hetero tetramer : IID00014Complex
       Region 4mdd C 2261-2273 order
       Region 4mdd D 2262-2273 order
Seqphosphorylation
    2438-2438 Phosphoserine
    2436-2436 Phosphoserine
    2399-2399 Phosphothreonine
    2184-2184 Phosphoserine
    2151-2151 Phosphoserine
    2136-2136 Phosphoserine
    2120-2120 Phosphoserine
    2102-2102 Phosphoserine
    1981-1981 Phosphoserine
    1977-1977 Phosphoserine
    1592-1592 Phosphoserine
    1472-1472 Phosphoserine
    1450-1450 Phosphoserine
    1367-1367 Phosphothreonine
    1322-1322 Phosphoserine
    1263-1263 Phosphoserine
    1281-1281 Phosphoserine
    1249-1249 Phosphoserine
    1196-1196 Phosphoserine
    1111-1111 Phosphoserine
    1195-1195 Phosphoserine
    999-999 Phosphoserine
    224-224 Phosphoserine
    172-172 Phosphoserine
Seqacetylation
    1412-1412 N6-acetyllysine; alternate
    1336-1336 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-177,216-232,329-389,491-506,554-631,684-2440
Order 178-215,233-328,390-490,507-553,632-683
ProS 10-14,26-31,40-46,66-78,85-91,150-157,173-177,329-329,337-343,367-378,383-389,491-494,554-557,614-631,684-694,712-719,895-901,925-928,1160-1169,1184-1188,1247-1250,1676-1680,1930-1937,2048-2063,2145-2148,2263-2267,2360-2374,2418-2440
AlphaFold
Disorder 1-177,216-233,255-255,258-258,260-262,264-266,356-375,377-377,400-428,431-431,434-438,495-626,687-957,974-1612,1615-1721,1724-1821,1823-1824,1826-2440
Order 178-215,234-254,256-257,259-259,263-263,267-355,376-376,378-399,429-430,432-433,439-494,627-686,958-973,1613-1614,1722-1723,1822-1822,1825-1825
Pfam Hmmer
PF00249 437-482 6.6e-11
PF00249 625-670 1.3e-14
SEG 51-73 ,194-231 ,348-365 ,511-553 ,557-568 ,592-626 ,710-731 ,752-768 ,974-982 ,1023-1036 ,1443-1454 ,1707-1734 ,1817-1831 ,1952-1963 ,2019-2035 ,2067-2086
Function
Function in SwissProt
Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6.