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IID00193
 UniprotP11940
ProteinPolyadenylate-binding protein 1
GenePABPC1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
636
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-190 Monomer :
 Evidence X-RAY 1cvj A Reference
       Region 1cvj A 1-10 disorder
       Region 1cvj A 11-179 order
       Region 1cvj A 180-190 disorder
 Evidence X-RAY 1cvj B Reference
       Region 1cvj B 1-10 disorder
       Region 1cvj B 11-132 order
       Region 1cvj B 133-136 disorder
       Region 1cvj B 137-159 order
       Region 1cvj B 160-169 disorder
       Region 1cvj B 170-175 order
       Region 1cvj B 176-190 disorder
 Evidence X-RAY 1cvj C Reference
       Region 1cvj C 1-10 disorder
       Region 1cvj C 11-178 order
       Region 1cvj C 179-190 disorder
 Evidence X-RAY 1cvj D Reference
       Region 1cvj D 1-10 disorder
       Region 1cvj D 11-132 order
       Region 1cvj D 133-136 disorder
       Region 1cvj D 137-175 order
       Region 1cvj D 176-190 disorder
 Evidence X-RAY 1cvj E Reference
       Region 1cvj E 1-10 disorder
       Region 1cvj E 11-178 order
       Region 1cvj E 179-190 disorder
 Evidence X-RAY 1cvj F Reference
       Region 1cvj F 1-10 disorder
       Region 1cvj F 11-101 order
       Region 1cvj F 102-111 disorder
       Region 1cvj F 112-132 order
       Region 1cvj F 133-136 disorder
       Region 1cvj F 137-149 order
       Region 1cvj F 150-167 disorder
       Region 1cvj F 168-173 order
       Region 1cvj F 174-190 disorder
 Evidence X-RAY 1cvj G Reference
       Region 1cvj G 1-10 disorder
       Region 1cvj G 11-175 order
       Region 1cvj G 176-190 disorder
 Evidence X-RAY 1cvj H Reference
       Region 1cvj H 1-10 disorder
       Region 1cvj H 11-103 order
       Region 1cvj H 104-112 disorder
       Region 1cvj H 113-132 order
       Region 1cvj H 133-136 disorder
       Region 1cvj H 137-152 order
       Region 1cvj H 153-172 disorder
       Region 1cvj H 173-175 order
       Region 1cvj H 176-190 disorder
Seq 1-190 Hetero dimer : Q04637
 Evidence X-RAY 4f02 A Reference
       Region 4f02 A 1-9 disorder
       Region 4f02 A 10-184 order
       Region 4f02 A 185-190 disorder
 Evidence X-RAY 4f02 D Reference
       Region 4f02 D 1-9 disorder
       Region 4f02 D 10-183 order
       Region 4f02 D 184-190 disorder
Seq 90-199 Monomer :
 Evidence NMR 2k8g A Reference
       Region 2k8g A 90-182 order
       Region 2k8g A 90-94 high_rmsd
       Region 2k8g A 176-182 high_rmsd
 Evidence X-RAY 4f25 A Reference
       Region 4f25 A 99-178 order
       Region 4f25 A 179-199 disorder
 Evidence X-RAY 4f26 A Reference
       Region 4f26 A 99-175 order
       Region 4f26 A 176-199 disorder
Seq 447-458 Hetero octamer : Q9WVG6
 Evidence X-RAY 5lgp E Reference
       Region 5lgp E 447-447 disorder
       Region 5lgp E 448-458 order
 Evidence X-RAY 5lgp F Reference
       Region 5lgp F 447-458 order
 Evidence X-RAY 5lgp G Reference
       Region 5lgp G 447-447 disorder
       Region 5lgp G 448-458 order
 Evidence X-RAY 5lgp H Reference
       Region 5lgp H 447-458 order
 Evidence X-RAY 5lgr E Reference
       Region 5lgr E 447-447 disorder
       Region 5lgr E 448-458 order
 Evidence X-RAY 5lgr F Reference
       Region 5lgr F 447-458 order
 Evidence X-RAY 5lgr G Reference
       Region 5lgr G 447-450 disorder
       Region 5lgr G 451-458 order
 Evidence X-RAY 5lgr H Reference
       Region 5lgr H 447-458 order
Seq 449-466 Hetero trimer : Q86X55
 Evidence X-RAY 5dxa I Reference
       Region 5dxa I 449-457 disorder
       Region 5dxa I 458-464 order
       Region 5dxa I 465-466 disorder
Seq 449-466 Hetero tetramer : Q86X55
 Evidence X-RAY 5dx1 F Reference
       Region 5dx1 F 449-451 disorder
       Region 5dx1 F 452-460 order
       Region 5dx1 F 461-466 disorder
 Evidence X-RAY 5dx1 G Reference
       Region 5dx1 G 449-451 disorder
       Region 5dx1 G 452-461 order
       Region 5dx1 G 462-466 disorder
 Evidence X-RAY 5dx1 H Reference
       Region 5dx1 H 449-451 disorder
       Region 5dx1 H 452-460 order
       Region 5dx1 H 461-466 disorder
 Evidence X-RAY 5dx1 I Reference
       Region 5dx1 I 449-451 disorder
       Region 5dx1 I 452-462 order
       Region 5dx1 I 463-466 disorder
 Evidence X-RAY 5dx8 E Reference
       Region 5dx8 E 449-451 disorder
       Region 5dx8 E 452-460 order
       Region 5dx8 E 461-466 disorder
 Evidence X-RAY 5dx8 F Reference
       Region 5dx8 F 449-452 disorder
       Region 5dx8 F 453-461 order
       Region 5dx8 F 462-466 disorder
Seq 449-466 Hetero tetramer : Q86X55
 Evidence X-RAY 5dxa F Reference
       Region 5dxa F 449-457 disorder
       Region 5dxa F 458-464 order
       Region 5dxa F 465-466 disorder
 Evidence X-RAY 5dxa G Reference
       Region 5dxa G 449-457 disorder
       Region 5dxa G 458-463 order
       Region 5dxa G 464-466 disorder
Seq 449-466 Hetero tetramer : Q86X55
 Evidence X-RAY 5dx8 G Reference
       Region 5dx8 G 449-453 disorder
       Region 5dx8 G 454-460 order
       Region 5dx8 G 461-466 disorder
 Evidence X-RAY 5dx8 H Reference
       Region 5dx8 H 449-453 disorder
       Region 5dx8 H 454-461 order
       Region 5dx8 H 462-466 disorder
Seq 456-464 Hetero octamer : Q9WVG6
 Evidence X-RAY 5lgs E Reference
       Region 5lgs E 456-456 disorder
       Region 5lgs E 457-464 order
 Evidence X-RAY 5lgs F Reference
       Region 5lgs F 456-464 order
 Evidence X-RAY 5lgs G Reference
       Region 5lgs G 456-456 disorder
       Region 5lgs G 457-464 order
 Evidence X-RAY 5lgs H Reference
       Region 5lgs H 456-456 disorder
       Region 5lgs H 457-464 order
Seq 456-466 Hetero octamer : Q9WVG6
 Evidence X-RAY 5lgq E Reference
       Region 5lgq E 456-456 disorder
       Region 5lgq E 457-464 order
       Region 5lgq E 465-466 disorder
 Evidence X-RAY 5lgq F Reference
       Region 5lgq F 456-456 disorder
       Region 5lgq F 457-464 order
       Region 5lgq F 465-466 disorder
 Evidence X-RAY 5lgq G Reference
       Region 5lgq G 456-456 disorder
       Region 5lgq G 457-464 order
       Region 5lgq G 465-466 disorder
 Evidence X-RAY 5lgq H Reference
       Region 5lgq H 456-464 order
       Region 5lgq H 465-466 disorder
Seq 498-636 Monomer :
 Evidence NMR 1g9l A Reference
       Region 1g9l A 498-636 order
       Region 1g9l A 498-542 high_rmsd
       Region 1g9l A 623-636 high_rmsd
Seq 541-623 Hetero dimer : Q8R050
 Evidence NMR 2rqg B Reference
       Region 2rqg B 541-623 order
       Region 2rqg B 541-542 high_rmsd
       Region 2rqg B 622-623 high_rmsd
Seq 541-623 Hetero dimer : Q8R050
 Evidence NMR 2rqh B Reference
       Region 2rqh B 541-623 order
       Region 2rqh B 541-541 high_rmsd
       Region 2rqh B 619-623 high_rmsd
Seq 543-621 Hetero dimer : Q92615
 Evidence X-RAY 3pth A Reference
       Region 3pth A 543-543 disorder
       Region 3pth A 544-618 order
       Region 3pth A 619-621 disorder
Seq 544-617 Monomer :
 Evidence X-RAY 3kur A Reference
       Region 3kur A 544-616 order
       Region 3kur A 617-617 disorder
 Evidence X-RAY 3kur B Reference
       Region 3kur B 544-616 order
       Region 3kur B 617-617 disorder
 Evidence X-RAY 3kur C Reference
       Region 3kur C 544-615 order
       Region 3kur C 616-617 disorder
 Evidence X-RAY 3kur D Reference
       Region 3kur D 544-544 disorder
       Region 3kur D 545-615 order
       Region 3kur D 616-617 disorder
 Evidence X-RAY 3kur E Reference
       Region 3kur E 544-615 order
       Region 3kur E 616-617 disorder
 Evidence X-RAY 3kur F Reference
       Region 3kur F 544-615 order
       Region 3kur F 616-617 disorder
 Evidence X-RAY 3kur G Reference
       Region 3kur G 544-615 order
       Region 3kur G 616-617 disorder
 Evidence X-RAY 3kur H Reference
       Region 3kur H 544-616 order
       Region 3kur H 617-617 disorder
Seq 544-626 Hetero dimer : IID00573Complex
 Evidence X-RAY 3kuj A Reference
       Region 3kuj A 544-620 order
       Region 3kuj A 621-626 disorder
Seq 544-626 Hetero dimer : IID00587Complex
 Evidence X-RAY 2x04 A Reference
       Region 2x04 A 545-616 order
       Region 2x04 A 617-619 disorder
 Evidence X-RAY 2x04 B Reference
       Region 2x04 B 545-618 order
       Region 2x04 B 619-619 disorder
 Evidence X-RAY 3ktp A Reference
       Region 3ktp A 544-621 order
       Region 3ktp A 622-626 disorder
Seq 544-626 Hetero dimer : IID00571Complex
 Evidence X-RAY 3pkn A Reference
       Region 3pkn A 544-622 order
       Region 3pkn A 623-626 disorder
Seq 544-626 Hetero dimer : IID00580Complex
 Evidence X-RAY 3ktr A Reference
       Region 3ktr A 544-623 order
       Region 3ktr A 624-626 disorder
Seq 544-626 Hetero dimer : P15170
 Evidence X-RAY 3kui A Reference
       Region 3kui A 544-544 disorder
       Region 3kui A 545-625 order
       Region 3kui A 626-626 disorder
Seq 544-636 Hetero dimer : IID00586Complex
 Evidence NMR 1jh4 A Reference
       Region 1jh4 A 544-636 order
       Region 1jh4 A 620-636 high_rmsd
Seq 544-636 Hetero dimer : IID00582Complex
 Evidence NMR 1jgn A Reference
       Region 1jgn A 544-636 order
       Region 1jgn A 544-544 high_rmsd
       Region 1jgn A 624-636 high_rmsd
 Evidence X-RAY 3kus A Reference
       Region 3kus A 544-544 disorder
       Region 3kus A 545-626 order
 Evidence X-RAY 3kus B Reference
       Region 3kus B 544-552 disorder
       Region 3kus B 553-622 order
       Region 3kus B 623-626 disorder
 Evidence X-RAY 3kut A Reference
       Region 3kut A 544-626 order
 Evidence X-RAY 3kut B Reference
       Region 3kut B 544-544 disorder
       Region 3kut B 545-623 order
       Region 3kut B 624-626 disorder
SeqProS predicted 454-461 The unbound state of this region is predicted to be disordered by DICHOT and Foldindex. Hetero tetramer : Q86X55
       Region 5dx8 E 452-460 order
       Region 5dx8 F 453-461 order
       Region 5dx1 F 452-460 order
       Region 5dx1 G 452-461 order
       Region 5dx1 H 452-460 order
       Region 5dx1 I 452-462 order
SeqProS predicted 454-461 The unbound state of this region is predicted to be disordered by DICHOT and Foldindex. Hetero tetramer : Q86X55
       Region 5dx8 G 454-460 order
       Region 5dx8 H 454-461 order
SeqProS predicted 458-464 The unbound state of this region is predicted to be disordered by DICHOT and Foldindex. Hetero tetramer : Q86X55
       Region 5dxa F 458-464 order
       Region 5dxa G 458-463 order
SeqProS predicted 458-464 The unbound state of this region is predicted to be disordered by DICHOT and Foldindex. Hetero trimer : Q86X55
       Region 5dxa I 458-464 order
Seqphosphorylation
    315-315 Phosphoserine
    319-319 Phosphothreonine
Seqacetylation
    1-1 N-acetylmethionine
    512-512 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-7,377-560,618-636
Order 8-376,561-617
ProS 1-7,377-387,407-411,420-424,435-440,548-560,630-636
AlphaFold
Disorder 1-10,187-187,387-548,628-636
Order 11-186,188-386,549-627
Pfam Hmmer
PF00076 13-84 1.1e-27
PF00076 101-170 1.7e-25
PF00076 193-263 3.4e-31
PF00076 296-365 1.3e-22
PF00658 543-614 6.5e-48
SEG 455-462 ,492-509 ,615-626
Function
Function in SwissProt
Binds the poly(A) tail of mRNA, including that of its own transcript. May be involved in cytoplasmic regulatory processes of mRNA metabolism such as pre-mRNA splicing. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Involved in regulation of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons; for the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed. By binding to long poly(A) tails, may protect them from uridylation by ZCCHC6/ZCCHC11 and hence contribute to mRNA stability (PubMed:25480299). Positively regulates the replication of dengue virus (DENV) (PubMed:26735137).