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IID00198
 UniprotP30307
ProteinM-phase inducer phosphatase 3
GeneCDC25C
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
473
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 126-134 Hetero dimer : IID00200Complex
 Evidence X-RAY 3bzi E Reference
       Region 3bzi E 126-132 order
       Region 3bzi E 133-134 disorder
 Evidence X-RAY 2ojx E Reference
       Region 2ojx E 126-132 order
       Region 2ojx E 133-134 disorder
Seq 207-226 Hetero tetramer : IID00061Complex
 Evidence X-RAY 5m37 D Reference
       Region 5m37 D 207-223 order
       Region 5m37 D 224-226 disorder
 Evidence X-RAY 5m37 C Reference
       Region 5m37 C 207-207 disorder
       Region 5m37 C 208-224 order
       Region 5m37 C 225-226 disorder
Seq 207-244 Hetero trimer : IID00061Complex
 Evidence X-RAY 5m36 D Reference
       Region 5m36 D 207-211 disorder
       Region 5m36 D 212-220 order
       Region 5m36 D 221-244 disorder
 Evidence X-RAY 5m36 C Reference
       Region 5m36 C 207-225 order
       Region 5m36 C 226-244 disorder
Seq 211-220 Hetero tetramer : IID00061Complex
 Evidence X-RAY 5m35 D Reference
       Region 5m35 D 213-219 order
 Evidence X-RAY 5m35 C Reference
       Region 5m35 C 211-220 order
Seq 270-462 Homo dimer :
 Evidence X-RAY 3op3 A Reference
       Region 3op3 A 270-279 disorder
       Region 3op3 A 280-379 order
       Region 3op3 A 380-381 disorder
       Region 3op3 A 382-448 order
       Region 3op3 A 449-462 disorder
SeqProS predicted 126-132 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero dimer : IID00200Complex
       Region 3bzi E 126-132 order
       Region 2ojx E 126-132 order
SeqProS predicted 207-225 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero tetramer : IID00061Complex
       Region 5m35 C 211-220 order
       Region 5m35 D 213-219 order
SeqProS predicted 207-225 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero trimer : IID00061Complex
       Region 5m36 C 207-225 order
       Region 5m36 D 212-220 order
SeqProS predicted 207-225 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero tetramer : IID00061Complex
       Region 5m37 C 208-224 order
       Region 5m37 D 207-223 order
Seqphosphorylation
    61-61 Phosphoserine
    64-64 Phosphoserine
    130-130 Phosphothreonine
    122-122 Phosphoserine; by CDK1
    67-67 Phosphothreonine
    129-129 Phosphoserine
    48-48 Phosphothreonine
    57-57 Phosphoserine
    38-38 Phosphoserine
    20-20 Phosphoserine
    61-61 Phosphoserine
    168-168 Phosphoserine
    61-61 Phosphoserine
    472-472 Phosphoserine
    216-216 Phosphoserine; by CHEK1
    214-214 Phosphoserine; by CDK1
    198-198 Phosphoserine; by PLK3
    191-191 Phosphoserine; by PLK3
Seqacetylation
    2-2 N-acetylserine
 
Prediction
NeProc
Disorder 1-282,450-473
Order 283-449
ProS 14-44,50-80,97-101,129-138,209-214,260-265,279-282,450-473
AlphaFold
Disorder 1-280,472-473
Order 281-471
Pfam Hmmer
PF06617 93-272 1.9e-82
PF00581 314-422 1.1e-35
SEG 6-23
Function
Function in SwissProt
Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle (PubMed:8119945). When phosphorylated, highly effective in activating G2 cells into prophase (PubMed:8119945). Directly dephosphorylates CDK1 and activates its kinase activity (PubMed:8119945).