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IID00200  Serine/threonine-protein kinase PLK1 (Homo sapiens) P53350
  :order  :disorder  :conflict  :PDB cluster  :ProS  :SCOP Domain  :Pfam Domain
Networkxml
Experiment
603
fasta
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 13-345 Homo dimer :
 Evidence X-RAY 3fc2 A Reference
       Region 3fc2 A 13-36 disorder
       Region 3fc2 A 37-329 order
       Region 3fc2 A 330-345 disorder
 Evidence X-RAY 3kb7 A Reference
       Region 3kb7 A 36-38 disorder
       Region 3kb7 A 39-328 order
       Region 3kb7 A 329-345 disorder
 Evidence X-RAY 2yac A Reference
       Region 2yac A 36-38 disorder
       Region 2yac A 39-328 order
       Region 2yac A 329-345 disorder
Seq 13-345 Monomer :
 Evidence X-RAY 4j52 A Reference
       Region 4j52 A 38-330 order
 Evidence X-RAY 4j53 A Reference
       Region 4j53 A 38-330 order
 Evidence X-RAY 2ou7 A Reference
       Region 2ou7 A 13-36 disorder
       Region 2ou7 A 37-328 order
       Region 2ou7 A 329-345 disorder
 Evidence X-RAY 2owb A Reference
       Region 2owb A 13-36 disorder
       Region 2owb A 37-330 order
       Region 2owb A 331-345 disorder
 Evidence X-RAY 2rku A Reference
       Region 2rku A 37-330 order
 Evidence X-RAY 5ta6 A Reference
       Region 5ta6 A 13-36 disorder
       Region 5ta6 A 37-330 order
       Region 5ta6 A 331-345 disorder
 Evidence X-RAY 5ta8 A Reference
       Region 5ta8 A 13-36 disorder
       Region 5ta8 A 37-330 order
       Region 5ta8 A 331-345 disorder
 Evidence X-RAY 3thb A Reference
       Region 3thb A 13-41 disorder
       Region 3thb A 42-328 order
       Region 3thb A 329-345 disorder
 Evidence X-RAY 4a4l A Reference
       Region 4a4l A 36-38 disorder
       Region 4a4l A 39-328 order
       Region 4a4l A 329-345 disorder
 Evidence X-RAY 4a4o A Reference
       Region 4a4o A 36-38 disorder
       Region 4a4o A 39-328 order
       Region 4a4o A 329-345 disorder
Seq 33-345 Hetero dimer :
 Evidence X-RAY 2v5q A Reference
       Region 2v5q A 33-38 disorder
       Region 2v5q A 39-323 order
       Region 2v5q A 324-345 disorder
Seq 33-345 Hetero dimer :
 Evidence X-RAY 2v5q B Reference
       Region 2v5q B 33-38 disorder
       Region 2v5q B 39-323 order
       Region 2v5q B 324-345 disorder
Seq 345-603 Hetero dimer :
 Evidence X-RAY 1q4k A Reference
       Region 1q4k A 345-371 disorder
       Region 1q4k A 372-593 order
       Region 1q4k A 594-603 disorder
Seq 345-603 Hetero dimer :
 Evidence X-RAY 1q4k B Reference
       Region 1q4k B 345-370 disorder
       Region 1q4k B 371-594 order
       Region 1q4k B 595-603 disorder
Seq 345-603 Hetero dimer :
 Evidence X-RAY 1q4k C Reference
       Region 1q4k C 345-371 disorder
       Region 1q4k C 372-494 order
       Region 1q4k C 495-502 disorder
       Region 1q4k C 503-593 order
       Region 1q4k C 594-603 disorder
Seq 365-603 Monomer :
 Evidence X-RAY 4dfw A Reference
       Region 4dfw A 367-372 disorder
       Region 4dfw A 373-466 order
       Region 4dfw A 467-468 disorder
       Region 4dfw A 469-593 order
       Region 4dfw A 594-603 disorder
 Evidence X-RAY 4e67 A Reference
       Region 4e67 A 371-373 disorder
       Region 4e67 A 374-499 order
       Region 4e67 A 500-507 disorder
       Region 4e67 A 508-594 order
 Evidence X-RAY 4e9c A Reference
       Region 4e9c A 371-371 disorder
       Region 4e9c A 372-594 order
 Evidence X-RAY 4e9d A Reference
       Region 4e9d A 371-372 disorder
       Region 4e9d A 373-594 order
 Evidence X-RAY 4h5x B Reference
       Region 4h5x B 367-370 disorder
       Region 4h5x B 371-500 order
       Region 4h5x B 501-506 disorder
       Region 4h5x B 507-594 order
       Region 4h5x B 595-603 disorder
 Evidence X-RAY 4h5x A Reference
       Region 4h5x A 367-371 disorder
       Region 4h5x A 372-593 order
       Region 4h5x A 594-603 disorder
 Evidence X-RAY 4h71 B Reference
       Region 4h71 B 367-371 disorder
       Region 4h71 B 372-500 order
       Region 4h71 B 501-506 disorder
       Region 4h71 B 507-593 order
       Region 4h71 B 594-603 disorder
 Evidence X-RAY 4h71 A Reference
       Region 4h71 A 367-370 disorder
       Region 4h71 A 371-501 order
       Region 4h71 A 502-502 disorder
       Region 4h71 A 503-593 order
       Region 4h71 A 594-603 disorder
 Evidence X-RAY 4hab A Reference
       Region 4hab A 371-593 order
 Evidence X-RAY 4hab B Reference
       Region 4hab B 371-372 disorder
       Region 4hab B 373-466 order
       Region 4hab B 467-469 disorder
       Region 4hab B 470-593 order
 Evidence X-RAY 4hab C Reference
       Region 4hab C 371-372 disorder
       Region 4hab C 373-388 order
       Region 4hab C 389-400 disorder
       Region 4hab C 401-402 order
       Region 4hab C 403-405 disorder
       Region 4hab C 406-464 order
       Region 4hab C 465-469 disorder
       Region 4hab C 470-501 order
       Region 4hab C 502-507 disorder
       Region 4hab C 508-546 order
       Region 4hab C 547-549 disorder
       Region 4hab C 550-567 order
       Region 4hab C 568-572 disorder
       Region 4hab C 573-593 order
 Evidence X-RAY 4hco B Reference
       Region 4hco B 367-370 disorder
       Region 4hco B 371-500 order
       Region 4hco B 501-504 disorder
       Region 4hco B 505-594 order
       Region 4hco B 595-603 disorder
 Evidence X-RAY 4hco A Reference
       Region 4hco A 367-372 disorder
       Region 4hco A 373-503 order
       Region 4hco A 504-504 disorder
       Region 4hco A 505-593 order
       Region 4hco A 594-603 disorder
 Evidence X-RAY 3hih A Reference
       Region 3hih A 371-593 order
 Evidence X-RAY 3hih B Reference
       Region 3hih B 371-431 order
       Region 3hih B 432-432 disorder
       Region 3hih B 433-487 order
       Region 3hih B 488-488 disorder
       Region 3hih B 489-497 order
       Region 3hih B 498-499 disorder
       Region 3hih B 500-500 order
       Region 3hih B 501-505 disorder
       Region 3hih B 506-577 order
       Region 3hih B 578-578 disorder
       Region 3hih B 579-593 order
 Evidence X-RAY 3hik A Reference
       Region 3hik A 367-370 disorder
       Region 3hik A 371-594 order
       Region 3hik A 595-603 disorder
 Evidence X-RAY 4hy2 A Reference
       Region 4hy2 A 371-372 disorder
       Region 4hy2 A 373-499 order
       Region 4hy2 A 500-507 disorder
       Region 4hy2 A 508-595 order
 Evidence X-RAY 4lkl A Reference
       Region 4lkl A 372-499 order
       Region 4lkl A 500-507 disorder
       Region 4lkl A 508-593 order
 Evidence X-RAY 4lkm A Reference
       Region 4lkm A 371-502 order
       Region 4lkm A 503-507 disorder
       Region 4lkm A 508-601 order
 Evidence X-RAY 4lkm C Reference
       Region 4lkm C 371-497 order
       Region 4lkm C 498-505 disorder
       Region 4lkm C 506-594 order
       Region 4lkm C 595-601 disorder
 Evidence X-RAY 5nei A Reference
       Region 5nei A 371-498 order
       Region 5nei A 499-506 disorder
       Region 5nei A 507-594 order
       Region 5nei A 595-603 disorder
 Evidence X-RAY 5nmm A Reference
       Region 5nmm A 371-498 order
       Region 5nmm A 499-506 disorder
       Region 5nmm A 507-593 order
       Region 5nmm A 594-603 disorder
 Evidence X-RAY 5nn1 A Reference
       Region 5nn1 A 371-498 order
       Region 5nn1 A 499-507 disorder
       Region 5nn1 A 508-593 order
       Region 5nn1 A 594-603 disorder
 Evidence X-RAY 5nn2 A Reference
       Region 5nn2 A 371-498 order
       Region 5nn2 A 499-506 disorder
       Region 5nn2 A 507-594 order
 Evidence X-RAY 4o6w A Reference
       Region 4o6w A 371-372 disorder
       Region 4o6w A 373-501 order
       Region 4o6w A 502-506 disorder
       Region 4o6w A 507-594 order
       Region 4o6w A 595-603 disorder
 Evidence X-RAY 4o9w A Reference
       Region 4o9w A 373-391 order
       Region 4o9w A 392-393 disorder
       Region 4o9w A 394-498 order
       Region 4o9w A 499-507 disorder
       Region 4o9w A 508-594 order
 Evidence X-RAY 2ogq A Reference
       Region 2ogq A 365-370 disorder
       Region 2ogq A 371-494 order
       Region 2ogq A 495-506 disorder
       Region 2ogq A 507-593 order
       Region 2ogq A 594-603 disorder
 Evidence X-RAY 3p2w A Reference
       Region 3p2w A 371-500 order
       Region 3p2w A 501-506 disorder
       Region 3p2w A 507-594 order
 Evidence X-RAY 3p2z A Reference
       Region 3p2z A 371-384 order
       Region 3p2z A 385-398 disorder
       Region 3p2z A 399-499 order
       Region 3p2z A 500-502 disorder
       Region 3p2z A 503-593 order
       Region 3p2z A 594-594 disorder
 Evidence X-RAY 3p34 A Reference
       Region 3p34 A 371-592 order
       Region 3p34 A 593-594 disorder
 Evidence X-RAY 3p36 A Reference
       Region 3p36 A 371-371 disorder
       Region 3p36 A 372-500 order
       Region 3p36 A 501-506 disorder
       Region 3p36 A 507-594 order
 Evidence X-RAY 3p37 A Reference
       Region 3p37 A 371-594 order
 Evidence X-RAY 3p37 B Reference
       Region 3p37 B 371-372 disorder
       Region 3p37 B 373-501 order
       Region 3p37 B 502-504 disorder
       Region 3p37 B 505-594 order
 Evidence X-RAY 3p37 C Reference
       Region 3p37 C 371-372 disorder
       Region 3p37 C 373-501 order
       Region 3p37 C 502-503 disorder
       Region 3p37 C 504-594 order
 Evidence X-RAY 1q4o A Reference
       Region 1q4o A 367-371 disorder
       Region 1q4o A 372-492 order
       Region 1q4o A 493-507 disorder
       Region 1q4o A 508-593 order
       Region 1q4o A 594-603 disorder
 Evidence X-RAY 1q4o B Reference
       Region 1q4o B 367-370 disorder
       Region 1q4o B 371-493 order
       Region 1q4o B 494-507 disorder
       Region 1q4o B 508-592 order
       Region 1q4o B 593-603 disorder
 Evidence X-RAY 4rcp A Reference
       Region 4rcp A 372-502 order
       Region 4rcp A 503-507 disorder
       Region 4rcp A 508-599 order
 Evidence X-RAY 3rq7 A Reference
       Region 3rq7 A 371-372 disorder
       Region 3rq7 A 373-495 order
       Region 3rq7 A 496-498 disorder
       Region 3rq7 A 499-500 order
       Region 3rq7 A 501-507 disorder
       Region 3rq7 A 508-594 order
       Region 3rq7 A 595-603 disorder
 Evidence X-RAY 4whh A Reference
       Region 4whh A 371-372 disorder
       Region 4whh A 373-497 order
       Region 4whh A 498-507 disorder
       Region 4whh A 508-592 order
       Region 4whh A 593-603 disorder
 Evidence X-RAY 4whk A Reference
       Region 4whk A 371-372 disorder
       Region 4whk A 373-592 order
       Region 4whk A 593-603 disorder
 Evidence X-RAY 4whl A Reference
       Region 4whl A 371-498 order
       Region 4whl A 499-504 disorder
       Region 4whl A 505-592 order
       Region 4whl A 593-603 disorder
 Evidence X-RAY 4x9r A Reference
       Region 4x9r A 371-372 disorder
       Region 4x9r A 373-592 order
       Region 4x9r A 593-603 disorder
 Evidence X-RAY 4x9v A Reference
       Region 4x9v A 371-371 disorder
       Region 4x9v A 372-498 order
       Region 4x9v A 499-505 disorder
       Region 4x9v A 506-595 order
       Region 4x9v A 596-603 disorder
 Evidence X-RAY 4x9w A Reference
       Region 4x9w A 371-371 disorder
       Region 4x9w A 372-597 order
       Region 4x9w A 598-603 disorder
 Evidence X-RAY 3fvh A Reference
       Region 3fvh A 371-603 order
Seq 365-603 Hetero dimer : IID00198Complex
 Evidence X-RAY 3bzi A Reference
       Region 3bzi A 365-370 disorder
       Region 3bzi A 371-593 order
       Region 3bzi A 594-603 disorder
 Evidence X-RAY 2ojx A Reference
       Region 2ojx A 365-372 disorder
       Region 2ojx A 373-488 order
       Region 2ojx A 489-506 disorder
       Region 2ojx A 507-594 order
       Region 2ojx A 595-603 disorder
Seq 367-594 Hetero dimer : O96561
 Evidence X-RAY 5j19 A Reference
       Region 5j19 A 367-370 disorder
       Region 5j19 A 371-392 order
       Region 5j19 A 393-394 disorder
       Region 5j19 A 395-593 order
       Region 5j19 A 594-594 disorder
 Evidence X-RAY 5j19 B Reference
       Region 5j19 B 367-594 order
Seq 367-603 Hetero dimer :
 Evidence X-RAY 4o56 A Reference
       Region 4o56 A 367-603 order
Seq 367-603 Hetero dimer :
 Evidence X-RAY 1umw B Reference
       Region 1umw B 367-372 disorder
       Region 1umw B 373-594 order
       Region 1umw B 595-603 disorder
Seq 367-603 Hetero dimer :
 Evidence X-RAY 1umw A Reference
       Region 1umw A 367-372 disorder
       Region 1umw A 373-594 order
       Region 1umw A 595-603 disorder
Seq 371-594 Homo trimer :
 Evidence X-RAY 3p35 A Reference
       Region 3p35 A 371-371 disorder
       Region 3p35 A 372-500 order
       Region 3p35 A 501-506 disorder
       Region 3p35 A 507-594 order
 Evidence X-RAY 3p35 B Reference
       Region 3p35 B 371-371 disorder
       Region 3p35 B 372-593 order
       Region 3p35 B 594-594 disorder
 Evidence X-RAY 3p35 C Reference
       Region 3p35 C 371-371 disorder
       Region 3p35 C 372-593 order
       Region 3p35 C 594-594 disorder
Seq 371-594 Hetero dimer : O14776
 Evidence X-RAY 3q1i A Reference
       Region 3q1i A 371-371 disorder
       Region 3q1i A 372-500 order
       Region 3q1i A 501-507 disorder
       Region 3q1i A 508-594 order
Seq 373-593 Hetero dimer :
 Evidence X-RAY 3c5l A Reference
       Region 3c5l A 373-502 order
       Region 3c5l A 503-506 disorder
       Region 3c5l A 507-593 order
SeqProS verified 489-506 This region binds to a phosphopeptide corresponding to Cdc25C. Hetero dimer : IID00198Complex
       Region 3bzi A 371-593 order
       Region 2ojx A 489-506 disorder
SeqProS verified 489-506 This region binds to a phosphopeptide corresponding to Partner of Numb. Hetero dimer : O96561
       Region 5j19 A 395-593 order
       Region 5j19 B 367-594 order
       Region 2ojx A 489-506 disorder
Seqphosphorylation
    6-6 Phosphothreonine
    103-103 Phosphoserine
    137-137 Phosphoserine
    210-210 Phosphothreonine; by AURKA
    214-214 Phosphothreonine
    269-269 Phosphoserine; by autocatalysis
    335-335 Phosphoserine
    375-375 Phosphoserine
    450-450 Phosphoserine
    498-498 Phosphothreonine
Seqacetylation
    2-2 N-acetylserine
 
Prediction
DICHOT
Disorder 1-38,331-372,595-603
Known Domain 39-330,373-594
SCOPe RPS-Blast
     4b6lA 43-323 e-140 d.144.1.0 automated matches
     3rq7A1 373-500 3e-47 d.223.1.2 Serine/threonine-protein kinase plk ...
     3rq7A2 508-594 1e-30 d.223.1.2 Serine/threonine-protein kinase plk ...
SCOP Hmmer
     1omwA3 51-338 3.5e-88 d.144.1.7 3-phosphoinosit...
     1umwA1 374-498 3.8e-46 d.223.1.2 Serine/threoni...
     1umwA2 503-593 5.7e-34 d.223.1.2 Serine/threoni...
Pfam RPS-Blast
     PF10707 57-187 3e-06 PhoP regulatory network prot...
     PF14531 171-252 2e-06 Kinase-like
     PF00659 418-472 9e-09 POLO box duplicated region
     PF00659 516-558 7e-06 POLO box duplicated region
Pfam Hmmer
    PF00069 53-305 3.1e-72 Protein kinase domain
    PF00659 418-479 6.6e-25 POLO box duplicated region
    PF00659 516-583 1.8e-22 POLO box duplicated region