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IID00207
 UniprotQ04206
ProteinTranscription factor p65
GeneRELA
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
551
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 20-291 Hetero tetramer : IID00710Complex
 Evidence X-RAY 3gut A Reference
       Region 3gut A 20-291 order
 Evidence X-RAY 3gut C Reference
       Region 3gut C 20-291 order
 Evidence X-RAY 3gut E Reference
       Region 3gut E 20-291 order
 Evidence X-RAY 3gut G Reference
       Region 3gut G 20-291 order
Seq 20-291 Hetero tetramer : IID00079Complex,IID00491Complex,IID00710Complex
 Evidence X-RAY 2o61 A Reference
       Region 2o61 A 20-291 order
Seq 20-320 Hetero trimer : IID00654Complex,IID00710Complex
 Evidence X-RAY 1nfi A Reference
       Region 1nfi A 20-314 order
       Region 1nfi A 315-320 disorder
 Evidence X-RAY 1nfi C Reference
       Region 1nfi C 20-320 order
Seq 38-51 Hetero dimer : IID00301Complex
 Evidence X-RAY 7bi3 P Reference
       Region 7bi3 P 39-42 disorder
       Region 7bi3 P 43-51 order
 Evidence X-RAY 7biq P Reference
       Region 7biq P 39-42 disorder
       Region 7biq P 43-51 order
 Evidence X-RAY 7biw P Reference
       Region 7biw P 39-42 disorder
       Region 7biw P 43-51 order
 Evidence X-RAY 7biy P Reference
       Region 7biy P 39-42 disorder
       Region 7biy P 43-51 order
 Evidence X-RAY 7bjb P Reference
       Region 7bjb P 39-42 disorder
       Region 7bjb P 43-51 order
 Evidence X-RAY 7bjf P Reference
       Region 7bjf P 39-42 disorder
       Region 7bjf P 43-51 order
 Evidence X-RAY 7bjl P Reference
       Region 7bjl P 39-42 disorder
       Region 7bjl P 43-51 order
 Evidence X-RAY 7bjw P Reference
       Region 7bjw P 39-42 disorder
       Region 7bjw P 43-51 order
 Evidence X-RAY 7bkh P Reference
       Region 7bkh P 39-42 disorder
       Region 7bkh P 43-51 order
 Evidence X-RAY 7nj9 P Reference
       Region 7nj9 P 39-42 disorder
       Region 7nj9 P 43-51 order
 Evidence X-RAY 7njb P Reference
       Region 7njb P 39-42 disorder
       Region 7njb P 43-51 order
 Evidence X-RAY 7nk3 P Reference
       Region 7nk3 P 39-42 disorder
       Region 7nk3 P 43-50 order
       Region 7nk3 P 51-51 disorder
 Evidence X-RAY 7nk5 P Reference
       Region 7nk5 P 39-42 disorder
       Region 7nk5 P 43-51 order
 Evidence X-RAY 7nla P Reference
       Region 7nla P 39-42 disorder
       Region 7nla P 43-49 order
       Region 7nla P 50-51 disorder
 Evidence X-RAY 7nle P Reference
       Region 7nle P 39-43 disorder
       Region 7nle P 44-51 order
 Evidence X-RAY 7nm1 P Reference
       Region 7nm1 P 39-42 disorder
       Region 7nm1 P 43-51 order
 Evidence X-RAY 7nm3 P Reference
       Region 7nm3 P 39-42 disorder
       Region 7nm3 P 43-51 order
 Evidence X-RAY 7nm9 P Reference
       Region 7nm9 P 39-42 disorder
       Region 7nm9 P 43-48 order
       Region 7nm9 P 49-51 disorder
 Evidence X-RAY 7nmh P Reference
       Region 7nmh P 39-42 disorder
       Region 7nmh P 43-51 order
 Evidence X-RAY 7nqp P Reference
       Region 7nqp P 39-42 disorder
       Region 7nqp P 43-51 order
 Evidence X-RAY 7nr7 P Reference
       Region 7nr7 P 39-42 disorder
       Region 7nr7 P 43-51 order
 Evidence X-RAY 7nsv P Reference
       Region 7nsv P 39-42 disorder
       Region 7nsv P 43-49 order
       Region 7nsv P 50-51 disorder
 Evidence X-RAY 6nv2 P Reference
       Region 6nv2 P 39-41 disorder
       Region 6nv2 P 42-50 order
       Region 6nv2 P 51-51 disorder
 Evidence X-RAY 7nv4 P Reference
       Region 7nv4 P 39-42 disorder
       Region 7nv4 P 43-51 order
 Evidence X-RAY 7nvi P Reference
       Region 7nvi P 39-42 disorder
       Region 7nvi P 43-51 order
 Evidence X-RAY 7nws P Reference
       Region 7nws P 39-42 disorder
       Region 7nws P 43-51 order
 Evidence X-RAY 7nxs P Reference
       Region 7nxs P 39-42 disorder
       Region 7nxs P 43-51 order
 Evidence X-RAY 7nxt P Reference
       Region 7nxt P 39-42 disorder
       Region 7nxt P 43-51 order
 Evidence X-RAY 7nxw P Reference
       Region 7nxw P 39-42 disorder
       Region 7nxw P 43-51 order
 Evidence X-RAY 7nxy P Reference
       Region 7nxy P 39-42 disorder
       Region 7nxy P 43-51 order
 Evidence X-RAY 7ny4 P Reference
       Region 7ny4 P 39-42 disorder
       Region 7ny4 P 43-51 order
 Evidence X-RAY 7nye P Reference
       Region 7nye P 39-42 disorder
       Region 7nye P 43-51 order
 Evidence X-RAY 7nyf P Reference
       Region 7nyf P 39-42 disorder
       Region 7nyf P 43-51 order
 Evidence X-RAY 7nyg P Reference
       Region 7nyg P 39-42 disorder
       Region 7nyg P 43-51 order
 Evidence X-RAY 7nz6 P Reference
       Region 7nz6 P 39-42 disorder
       Region 7nz6 P 43-51 order
 Evidence X-RAY 7nzg P Reference
       Region 7nzg P 39-42 disorder
       Region 7nzg P 43-51 order
 Evidence X-RAY 7nzk P Reference
       Region 7nzk P 39-42 disorder
       Region 7nzk P 43-51 order
 Evidence X-RAY 7nzv P Reference
       Region 7nzv P 39-42 disorder
       Region 7nzv P 43-51 order
 Evidence X-RAY 7o34 P Reference
       Region 7o34 P 39-43 disorder
       Region 7o34 P 44-51 order
 Evidence X-RAY 7o3a P Reference
       Region 7o3a P 39-42 disorder
       Region 7o3a P 43-51 order
 Evidence X-RAY 7o3f P Reference
       Region 7o3f P 39-42 disorder
       Region 7o3f P 43-51 order
 Evidence X-RAY 7o3p P Reference
       Region 7o3p P 39-42 disorder
       Region 7o3p P 43-51 order
 Evidence X-RAY 7o3q P Reference
       Region 7o3q P 39-42 disorder
       Region 7o3q P 43-51 order
 Evidence X-RAY 7o3r P Reference
       Region 7o3r P 39-42 disorder
       Region 7o3r P 43-51 order
 Evidence X-RAY 7o3s P Reference
       Region 7o3s P 39-43 disorder
       Region 7o3s P 44-51 order
 Evidence X-RAY 7o57 P Reference
       Region 7o57 P 39-42 disorder
       Region 7o57 P 43-51 order
 Evidence X-RAY 7o59 P Reference
       Region 7o59 P 39-42 disorder
       Region 7o59 P 43-51 order
 Evidence X-RAY 7o5a P Reference
       Region 7o5a P 39-42 disorder
       Region 7o5a P 43-51 order
 Evidence X-RAY 7o5c P Reference
       Region 7o5c P 39-42 disorder
       Region 7o5c P 43-51 order
 Evidence X-RAY 7o5d P Reference
       Region 7o5d P 39-42 disorder
       Region 7o5d P 43-49 order
       Region 7o5d P 50-51 disorder
 Evidence X-RAY 7o5f P Reference
       Region 7o5f P 39-42 disorder
       Region 7o5f P 43-51 order
 Evidence X-RAY 7o5g P Reference
       Region 7o5g P 39-42 disorder
       Region 7o5g P 43-51 order
 Evidence X-RAY 7o5o P Reference
       Region 7o5o P 39-42 disorder
       Region 7o5o P 43-51 order
 Evidence X-RAY 7o5p P Reference
       Region 7o5p P 39-42 disorder
       Region 7o5p P 43-51 order
 Evidence X-RAY 7o5s P Reference
       Region 7o5s P 39-42 disorder
       Region 7o5s P 43-50 order
       Region 7o5s P 51-51 disorder
 Evidence X-RAY 7o5u P Reference
       Region 7o5u P 39-42 disorder
       Region 7o5u P 43-51 order
 Evidence X-RAY 7o5x P Reference
       Region 7o5x P 39-42 disorder
       Region 7o5x P 43-51 order
 Evidence X-RAY 7o6f P Reference
       Region 7o6f P 39-42 disorder
       Region 7o6f P 43-50 order
       Region 7o6f P 51-51 disorder
 Evidence X-RAY 7o6g P Reference
       Region 7o6g P 39-42 disorder
       Region 7o6g P 43-51 order
 Evidence X-RAY 7o6i P Reference
       Region 7o6i P 39-42 disorder
       Region 7o6i P 43-51 order
 Evidence X-RAY 7o6j P Reference
       Region 7o6j P 39-42 disorder
       Region 7o6j P 43-51 order
 Evidence X-RAY 7o6k P Reference
       Region 7o6k P 39-42 disorder
       Region 7o6k P 43-51 order
 Evidence X-RAY 7o6m P Reference
       Region 7o6m P 39-42 disorder
       Region 7o6m P 43-51 order
 Evidence X-RAY 7o6o P Reference
       Region 7o6o P 39-42 disorder
       Region 7o6o P 43-51 order
 Evidence X-RAY 6qhl P Reference
       Region 6qhl P 38-42 disorder
       Region 6qhl P 43-51 order
 Evidence X-RAY 6yow P Reference
       Region 6yow P 39-42 disorder
       Region 6yow P 43-51 order
 Evidence X-RAY 6yox P Reference
       Region 6yox P 39-42 disorder
       Region 6yox P 43-51 order
 Evidence X-RAY 6yoy P Reference
       Region 6yoy P 39-42 disorder
       Region 6yoy P 43-51 order
 Evidence X-RAY 6yp2 P Reference
       Region 6yp2 P 39-42 disorder
       Region 6yp2 P 43-51 order
 Evidence X-RAY 6yp3 P Reference
       Region 6yp3 P 39-42 disorder
       Region 6yp3 P 43-51 order
 Evidence X-RAY 6yp8 P Reference
       Region 6yp8 P 39-42 disorder
       Region 6yp8 P 43-51 order
 Evidence X-RAY 6ypl P Reference
       Region 6ypl P 39-42 disorder
       Region 6ypl P 43-51 order
 Evidence X-RAY 6ypy P Reference
       Region 6ypy P 39-42 disorder
       Region 6ypy P 43-51 order
 Evidence X-RAY 6yq2 P Reference
       Region 6yq2 P 39-42 disorder
       Region 6yq2 P 43-50 order
       Region 6yq2 P 51-51 disorder
Seq 275-287 Hetero dimer : IID00301Complex
 Evidence X-RAY 6qhm P Reference
       Region 6qhm P 275-279 disorder
       Region 6qhm P 280-282 order
       Region 6qhm P 283-287 disorder
Seq 294-315 Hetero hexamer : IID00749Complex
 Evidence X-RAY 7lf4 E Reference
       Region 7lf4 E 294-298 disorder
       Region 7lf4 E 299-311 order
       Region 7lf4 E 312-315 disorder
 Evidence X-RAY 7lf4 D Reference
       Region 7lf4 D 294-297 disorder
       Region 7lf4 D 298-311 order
       Region 7lf4 D 312-315 disorder
Seq 294-315 Hetero trimer : IID50009Complex
 Evidence X-RAY 7let C Reference
       Region 7let C 294-298 disorder
       Region 7let C 299-304 order
       Region 7let C 305-315 disorder
Seq 294-315 Hetero trimer : IID50009Complex
 Evidence X-RAY 7leu C Reference
       Region 7leu C 294-298 disorder
       Region 7leu C 299-304 order
       Region 7leu C 305-315 disorder
 Evidence X-RAY 7leu B Reference
       Region 7leu B 294-298 disorder
       Region 7leu B 299-306 order
       Region 7leu B 307-315 disorder
Seq 302-316 Hetero dimer : Q8TBK2
 Evidence X-RAY 3rc0 P Reference
       Region 3rc0 P 302-306 disorder
       Region 3rc0 P 307-312 order
       Region 3rc0 P 313-316 disorder
Seq 302-316 Hetero dimer : Q8TBK2
 Evidence X-RAY 3qxy P Reference
       Region 3qxy P 302-302 disorder
       Region 3qxy P 303-303 order
       Region 3qxy P 304-316 disorder
 Evidence X-RAY 3qxy Q Reference
       Region 3qxy Q 302-302 disorder
       Region 3qxy Q 303-303 order
       Region 3qxy Q 304-316 disorder
 Evidence X-RAY 3rc0 Q Reference
       Region 3rc0 Q 302-302 disorder
       Region 3rc0 Q 303-303 order
       Region 3rc0 Q 304-316 disorder
Seq 304-316 Hetero dimer : IID00111Complex
 Evidence NMR 2lsp A Reference
       Region 2lsp A 304-316 order
Seq 308-314 Hetero dimer : IID00111Complex
 Evidence X-RAY 4kv4 B Reference
       Region 4kv4 B 308-312 order
       Region 4kv4 B 313-314 disorder
Seq 308-314 Hetero dimer : IID00111Complex
 Evidence X-RAY 4kv1 C Reference
       Region 4kv1 C 308-314 order
 Evidence X-RAY 4kv1 D Reference
       Region 4kv1 D 308-314 order
Seqdisorder 428-551
 Evidence NMR Reference
       Region 428-551 disorder
Seq 521-551 Hetero dimer : IID50021Complex
 Evidence NMR 5urn B Reference
       Region 5urn B 521-551 order
       Region 5urn B 521-531 high_rmsd
       Region 5urn B 550-551 high_rmsd
Seq 521-551 Hetero dimer : IID50008Complex
 Evidence NMR 5u4k B Reference
       Region 5u4k B 521-551 order
       Region 5u4k B 521-530 high_rmsd
SeqProS possible 42-51 The pS45 and pS281 sites are located in unstructured loop regions of p65 (pmid=32501683). Hetero dimer : IID00301Complex
       Region 6qhl P 43-51 order
       Region 6nv2 P 42-50 order
SeqProS possible 280-282 The pS45 and pS281 sites are located in unstructured loop regions of p65 (pmid=32501683). Hetero dimer : IID00301Complex
       Region 6qhm P 280-282 order
SeqProS verified 298-311 Nuclear Localization Signal (NLS) Hetero hexamer : IID00749Complex
       Region 7lf4 D 298-311 order
       Region 7lf4 E 299-311 order
       Region 3qxy P 302-302 disorder
       Region 3qxy P 304-316 disorder
SeqProS verified 298-311 Nuclear Localization Signal (NLS) Hetero trimer : IID50009Complex
       Region 7leu B 299-306 order
       Region 7leu C 299-304 order
       Region 3qxy P 302-302 disorder
       Region 3qxy P 304-316 disorder
SeqProS verified 298-311 Nuclear Localization Signal (NLS) Hetero trimer : IID50009Complex
       Region 7let C 299-304 order
       Region 3qxy P 302-302 disorder
       Region 3qxy P 304-316 disorder
SeqProS verified 302-316 Hetero dimer : IID00111Complex
       Region 2lsp A 304-316 order
       Region 3qxy P 302-302 disorder
       Region 3qxy P 304-316 disorder
SeqProS verified 302-316 Hetero trimer : IID00654Complex,IID00710Complex
       Region 1nfi A 20-314 order
       Region 1nfi C 20-320 order
       Region 3qxy P 302-302 disorder
       Region 3qxy P 304-316 disorder
SeqProS verified 308-314 Hetero dimer : IID00111Complex
       Region 4kv4 B 308-312 order
       Region 3qxy P 302-302 disorder
       Region 3qxy P 304-316 disorder
SeqProS verified 308-314 Hetero dimer : IID00111Complex
       Region 4kv1 C 308-314 order
       Region 4kv1 D 308-314 order
       Region 3qxy P 302-302 disorder
       Region 3qxy P 304-316 disorder
SeqProS verified 521-551 Hetero dimer : IID50008Complex
       Region 5u4k B 521-551 order
       Region 428-551 disorder
SeqProS verified 521-551 Hetero dimer : IID50021Complex
       Region 5urn B 521-551 order
       Region 428-551 disorder
Seqphosphorylation
    75-75 (Microbial infection) Phosphoserine
    254-254 Phosphothreonine
    276-276 Phosphoserine; by RPS6KA4 and RPS6KA5
    281-281 Phosphoserine
    311-311 Phosphoserine; by PKC/PRKCZ
    435-435 Phosphothreonine
    468-468 Phosphoserine; by IKKB and IKKE
    505-505 Phosphothreonine; by CHEK1
    529-529 Phosphoserine; by CK2
    536-536 Phosphoserine; by IKKB
Seqacetylation
    1-1 N-acetylmethionine
    122-122 N6-acetyllysine; by PCAF and EP300; alternate
    123-123 N6-acetyllysine; by PCAF and EP300; alternate
    218-218 N6-acetyllysine
    221-221 N6-acetyllysine
    310-310 N6-acetyllysine; alternate
 
Prediction
NeProc
Disorder 1-15,304-551
Order 16-303
ProS 1-8,304-315,329-333,344-350,401-406,438-452,464-478,493-505,532-551
AlphaFold
Disorder 1-16,316-471,473-496,500-502,504-551
Order 17-315,472-472,497-499,503-503
Pfam Hmmer
PF00554 21-186 3e-108
PF01833 194-289 9.3e-22
SEG 374-431 ,506-528
Function
Function in SwissProt
NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The heterodimeric RELA-NFKB1 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. The NF-kappa-B heterodimeric RELA-NFKB1 and RELA-REL complexes, for instance, function as transcriptional activators. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The inhibitory effect of I-kappa-B on NF-kappa-B through retention in the cytoplasm is exerted primarily through the interaction with RELA. RELA shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Beside its activity as a direct transcriptional activator, it is also able to modulate promoters accessibility to transcription factors and thereby indirectly regulate gene expression. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1. Essential for cytokine gene expression in T-cells (PubMed:15790681). The NF-kappa-B homodimeric RELA-RELA complex appears to be involved in invasin-mediated activation of IL-8 expression. Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148).