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IID00213
 UniprotQ16236
ProteinNuclear factor erythroid 2-related factor 2
GeneNFE2L2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
605
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 69-84 Hetero dimer : IID00384Complex
 Evidence X-RAY 2flu P Reference
       Region 2flu P 69-84 order
 Evidence X-RAY 4ifl P Reference
       Region 4ifl P 69-84 order
Seq 76-82 Hetero trimer : IID00384Complex
 Evidence X-RAY 3zgc C Reference
       Region 3zgc C 76-82 order
Seq 445-523 Monomer :
 Evidence NMR 2lz1 A Reference
       Region 2lz1 A 445-523 order
       Region 2lz1 A 445-452 high_rmsd
       Region 2lz1 A 507-523 high_rmsd
SeqProS possible 69-84 Same region of mouse homolog (Q60795, 94%identity) is disordered in the free state. (PubMed=16581765) Hetero trimer : IID00384Complex
       Region 3zgc C 76-82 order
SeqProS possible 69-84 Same region of mouse homolog (Q60795, 94%identity) is disordered in the free state. (PubMed=16581765) Hetero dimer : IID00384Complex
       Region 2flu P 69-84 order
       Region 4ifl P 69-84 order
Seqphosphorylation
    40-40 Phosphoserine; by PKC
    215-215 Phosphoserine
Seqacetylation
    596-596 N6-acetyllysine; by CREBBP
    599-599 N6-acetyllysine; by CREBBP
 
Prediction
NeProc
Disorder 1-17,69-452,597-605
Order 18-68,453-596
ProS 1-6,11-17,69-87,117-142,182-212,225-231,239-255,281-297,304-309,316-327,337-353,359-408,449-452
AlphaFold
Disorder 1-11,30-37,39-39,87-114,128-182,197-452,598-605
Order 12-29,38-38,40-86,115-127,183-196,453-597
Pfam Hmmer
PF00170 495-559 7.8e-06
SEG 41-68 ,524-548
Function
Function in SwissProt
Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.