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IID00232
 UniprotO00571
ProteinATP-dependent RNA helicase DDX3X
GeneDDX3X
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
662
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 2-10 Hetero trimer : P01889
 Evidence X-RAY 4o2c C Reference
       Region 4o2c C 2-10 order
 Evidence X-RAY 4o2e C Reference
       Region 4o2e C 2-10 order
 Evidence X-RAY 4o2e F Reference
       Region 4o2e F 2-10 order
 Evidence X-RAY 4o2f C Reference
       Region 4o2f C 3-10 order
 Evidence X-RAY 4o2f F Reference
       Region 4o2f F 3-10 order
Seqdisorder 5-167
 Evidence CD Reference
       Region 5-167 disorder
Seq 71-90 Hetero pentamer : IID90010Complex
 Evidence X-RAY 3jrv E Reference
       Region 3jrv E 71-81 disorder
       Region 3jrv E 82-86 order
       Region 3jrv E 87-90 disorder
 Evidence X-RAY 3jrv D Reference
       Region 3jrv D 71-81 disorder
       Region 3jrv D 82-88 order
       Region 3jrv D 89-90 disorder
 Evidence X-RAY 3jrv C Reference
       Region 3jrv C 71-80 disorder
       Region 3jrv C 81-89 order
       Region 3jrv C 90-90 disorder
Seq 133-584 Monomer :
 Evidence X-RAY 5e7i B Reference
       Region 5e7i B 133-133 disorder
       Region 5e7i B 134-153 order
       Region 5e7i B 154-165 disorder
       Region 5e7i B 166-256 order
       Region 5e7i B 257-262 disorder
       Region 5e7i B 263-472 order
       Region 5e7i B 473-480 disorder
       Region 5e7i B 481-577 order
       Region 5e7i B 578-584 disorder
 Evidence X-RAY 5e7i A Reference
       Region 5e7i A 133-133 disorder
       Region 5e7i A 134-153 order
       Region 5e7i A 154-163 disorder
       Region 5e7i A 164-256 order
       Region 5e7i A 257-260 disorder
       Region 5e7i A 261-577 order
       Region 5e7i A 578-584 disorder
 Evidence X-RAY 5e7i C Reference
       Region 5e7i C 133-133 disorder
       Region 5e7i C 134-153 order
       Region 5e7i C 154-164 disorder
       Region 5e7i C 165-255 order
       Region 5e7i C 256-262 disorder
       Region 5e7i C 263-575 order
       Region 5e7i C 576-584 disorder
 Evidence X-RAY 5e7j A Reference
       Region 5e7j A 133-154 order
       Region 5e7j A 155-165 disorder
       Region 5e7j A 166-255 order
       Region 5e7j A 256-263 disorder
       Region 5e7j A 264-584 order
 Evidence X-RAY 5e7m A Reference
       Region 5e7m A 133-133 disorder
       Region 5e7m A 134-153 order
       Region 5e7m A 154-165 disorder
       Region 5e7m A 166-255 order
       Region 5e7m A 256-261 disorder
       Region 5e7m A 262-575 order
       Region 5e7m A 576-584 disorder
 Evidence X-RAY 2i4i A Reference
       Region 2i4i A 168-406 order
       Region 2i4i A 407-410 disorder
       Region 2i4i A 411-534 order
       Region 2i4i A 535-536 disorder
       Region 2i4i A 537-580 order
       Region 2i4i A 581-582 disorder
 Evidence X-RAY 4pxa A Reference
       Region 4pxa A 135-576 order
       Region 4pxa A 577-582 disorder
Seq 135-407 Monomer :
 Evidence X-RAY 4px9 A Reference
       Region 4px9 A 135-151 order
       Region 4px9 A 152-162 disorder
       Region 4px9 A 163-407 order
 Evidence X-RAY 4px9 B Reference
       Region 4px9 B 135-151 order
       Region 4px9 B 152-162 disorder
       Region 4px9 B 163-407 order
 Evidence X-RAY 4px9 C Reference
       Region 4px9 C 135-407 order
Seq 409-580 Monomer :
 Evidence X-RAY 2jgn A Reference
       Region 2jgn A 409-410 disorder
       Region 2jgn A 411-438 order
       Region 2jgn A 439-439 disorder
       Region 2jgn A 440-472 order
       Region 2jgn A 473-480 disorder
       Region 2jgn A 481-499 order
       Region 2jgn A 500-505 disorder
       Region 2jgn A 506-576 order
       Region 2jgn A 577-580 disorder
 Evidence X-RAY 2jgn B Reference
       Region 2jgn B 409-439 order
       Region 2jgn B 440-441 disorder
       Region 2jgn B 442-501 order
       Region 2jgn B 502-506 disorder
       Region 2jgn B 507-576 order
       Region 2jgn B 577-580 disorder
 Evidence X-RAY 2jgn C Reference
       Region 2jgn C 409-411 disorder
       Region 2jgn C 412-436 order
       Region 2jgn C 437-437 disorder
       Region 2jgn C 438-439 order
       Region 2jgn C 440-441 disorder
       Region 2jgn C 442-476 order
       Region 2jgn C 477-479 disorder
       Region 2jgn C 480-575 order
       Region 2jgn C 576-580 disorder
SeqProS verified 81-89 Hetero pentamer : IID90010Complex
       Region 3jrv C 81-89 order
       Region 3jrv D 82-88 order
       Region 5-167 disorder
Seqphosphorylation
    612-612 Phosphoserine
    594-594 Phosphoserine
    605-605 Phosphoserine
    543-543 Phosphoserine; by CSNK1E and TBK1; in vitro
    542-542 Phosphothreonine; by TBK1; in vitro
    520-520 Phosphoserine; by TBK1; in vitro
    470-470 Phosphoserine; by CSNK1E; in vitro
    469-469 Phosphothreonine; by CSNK1E; in vitro
    456-456 Phosphoserine; by TBK1; in vitro
    442-442 Phosphoserine; by TBK1; in vitro
    438-438 Phosphothreonine; by TBK1; in vitro
    429-429 Phosphoserine; by CSNK1E and TBK1; in vitro
    269-269 Phosphoserine; by TBK1; in vitro
    240-240 Phosphoserine; by TBK1; in vitro
    183-183 Phosphoserine; by TBK1
    181-181 Phosphoserine; by TBK1; in vitro
    131-131 Phosphoserine
    104-104 Phosphotyrosine
    102-102 Phosphoserine; by IKKE
    90-90 Phosphoserine
    86-86 Phosphoserine
    82-82 Phosphoserine
Seqacetylation
    118-118 N6-acetyllysine
    55-55 N6-acetyllysine
    2-2 N-acetylserine
 
Prediction
NeProc
Disorder 1-147,254-257,579-662
Order 148-248,262-578
ProS 1-25,36-46,57-147,595-605,610-662
AlphaFold
Disorder 1-37,40-41,44-133,153-163,226-227,253-262,409-411,500-508,535-536,579-662
Order 38-39,42-43,134-152,164-225,228-252,263-408,412-499,509-534,537-578
Pfam Hmmer
PF00270 204-392 7.7e-71
PF00271 460-536 1.3e-37
SEG 54-67 ,70-106 ,581-598 ,600-656
Function
Function in SwissProt
(Microbial infection) Appears to be a prime target for viral manipulations. Hepatitis B virus (HBV) polymerase and possibly vaccinia virus (VACV) protein K7 inhibit IFNB induction probably by dissociating DDX3X from TBK1 or IKBKE. Is involved in hepatitis C virus (HCV) replication; the function may involve the association with HCV core protein. HCV core protein inhibits the IPS1-dependent function in viral RNA sensing and may switch the function from a INFB inducing to a HCV replication mode. Involved in HIV-1 replication. Acts as a cofactor for XPO1-mediated nuclear export of incompletely spliced HIV-1 Rev RNAs.