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IID00233
 UniprotP24588
ProteinA-kinase anchor protein 5
GeneAKAP5
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
427
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 77-92 Hetero dimer : P0DP24
 Evidence X-RAY 5nin D Reference
       Region 5nin D 77-77 disorder
       Region 5nin D 78-88 order
       Region 5nin D 89-92 disorder
 Evidence X-RAY 5nin C Reference
       Region 5nin C 77-77 disorder
       Region 5nin C 78-88 order
       Region 5nin C 89-92 disorder
Seq 336-346 Hetero trimer : IID00069Complex
 Evidence X-RAY 3ll8 E Reference
       Region 3ll8 E 336-346 order
Seq 391-412 Hetero trimer : P12368
 Evidence NMR 2h9r C Reference
       Region 2h9r C 391-412 order
       Region 2h9r C 409-412 high_rmsd
SeqProS predicted 78-88 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero dimer : P0DP24
       Region 5nin C 78-88 order
       Region 5nin D 78-88 order
Seqphosphorylation
    22-22 Phosphoserine
    22-22 Phosphoserine
 
Prediction
NeProc
Disorder 1-386,400-405,416-427
Order 387-399,406-415
ProS 5-24,33-40,77-87,103-117,123-134,159-164,208-226,268-273,283-310,335-386,400-405,416-427
AlphaFold
Disorder 1-4,13-31,33-33,44-77,79-79,81-81,84-125,138-144,147-334,347-349,351-351,355-355,358-358,360-360,362-383,422-427
Order 5-12,32-32,34-43,78-78,80-80,82-83,126-137,145-146,335-346,350-350,352-354,356-357,359-359,361-361,384-421
Pfam Hmmer
PF03832 73-103 4.2e-13
SEG 38-51 ,227-239 ,324-333
Function
Function in SwissProt
Multivalent scaffold protein that anchors the cAMP-dependent protein kinase/PKA to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors (PubMed:1512224). Association with the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade. Plays a role in long term synaptic potentiation by regulating protein trafficking from the dendritic recycling endosomes to the plasma membrane and controlling both structural and functional plasticity at excitatory synapses (PubMed:25589740).
Biological Process
Diagram with PDB data
AKAP5/CALM1Crystal Structure of AKAP79 calmodulin binding domain peptide in complex with Ca2+/Calmodulin
AKAP5/PPP3CA/PPP3R1Crystal Structure of Calcineurin in Complex with AKAP79 Peptide
AKAP5/Prkar2aDocking and dimerization domain (D/D) of the regulatory subunit of the Type II-alpha cAMP-dependent protein kinase A associated with a Peptide derived from an A-kinase anchoring protein (AKAP)