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IID00235
 UniprotP36956
ProteinSterol regulatory element-binding protein 1
GeneSREBF1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1147
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 319-400 Homo tetramer :
 Evidence X-RAY 1am9 D Reference
       Region 1am9 D 319-394 order
       Region 1am9 D 395-400 disorder
 Evidence X-RAY 1am9 C Reference
       Region 1am9 C 319-400 order
 Evidence X-RAY 1am9 B Reference
       Region 1am9 B 319-319 disorder
       Region 1am9 B 320-394 order
       Region 1am9 B 395-400 disorder
 Evidence X-RAY 1am9 A Reference
       Region 1am9 A 319-398 order
       Region 1am9 A 399-400 disorder
Seqphosphorylation
    117-117 Phosphoserine
    457-457 Phosphoserine
    1060-1060 Phosphoserine
    402-402 Phosphoserine; by SIK1
    396-396 Phosphoserine; by AMPK
    337-337 Phosphoserine; by SIK1
    338-338 Phosphoserine; by SIK1
    98-98 Phosphoserine
 
Prediction
NeProc
Disorder 1-20,25-322,402-538,649-652,825-836,846-851,995-1004,1068-1076,1141-1147
Order 21-24,323-401,539-648,653-752,757-824,837-845,856-988,1009-1067,1077-1140
ProS 1-8,14-20,25-49,289-293,301-309,410-415,426-430,461-465,483-538,649-652,825-836,995-999,1068-1076,1141-1147
AlphaFold
Disorder 1-325,397-397,399-480,502-543,649-654,752-754,781-784,820-830,851-868,931-938,959-962,990-1004,1062-1081,1103-1105,1123-1123,1139-1147
Order 326-396,398-398,481-501,544-648,655-751,755-780,785-819,831-850,869-930,939-958,963-989,1005-1061,1082-1102,1106-1122,1124-1138
Pfam Hmmer
PF00010 324-374 2.8e-18
SEG 62-82 ,87-107 ,143-159 ,164-179 ,184-201 ,215-238 ,438-461 ,544-566 ,599-612 ,657-672 ,690-703 ,987-998 ,1062-1075
Function
Function in SwissProt
Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway (By similarity). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3').