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IID00243
 UniprotQ13133
ProteinOxysterols receptor LXR-alpha
GeneNR1H3
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
447
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 182-447 Hetero tetramer : IID00083Complex
 Evidence X-RAY 5avi A Reference
       Region 5avi A 182-203 disorder
       Region 5avi A 204-222 order
       Region 5avi A 223-233 disorder
       Region 5avi A 234-239 order
       Region 5avi A 240-243 disorder
       Region 5avi A 244-446 order
       Region 5avi A 447-447 disorder
 Evidence X-RAY 5avi C Reference
       Region 5avi C 182-203 disorder
       Region 5avi C 204-222 order
       Region 5avi C 223-233 disorder
       Region 5avi C 234-239 order
       Region 5avi C 240-245 disorder
       Region 5avi C 246-446 order
       Region 5avi C 447-447 disorder
 Evidence X-RAY 5avl A Reference
       Region 5avl A 182-203 disorder
       Region 5avl A 204-222 order
       Region 5avl A 223-234 disorder
       Region 5avl A 235-238 order
       Region 5avl A 239-246 disorder
       Region 5avl A 247-447 order
 Evidence X-RAY 5hjs A Reference
       Region 5hjs A 182-204 disorder
       Region 5hjs A 205-222 order
       Region 5hjs A 223-232 disorder
       Region 5hjs A 233-239 order
       Region 5hjs A 240-245 disorder
       Region 5hjs A 246-446 order
       Region 5hjs A 447-447 disorder
 Evidence X-RAY 5hjs B Reference
       Region 5hjs B 182-204 disorder
       Region 5hjs B 205-222 order
       Region 5hjs B 223-232 disorder
       Region 5hjs B 233-239 order
       Region 5hjs B 240-245 disorder
       Region 5hjs B 246-446 order
       Region 5hjs B 447-447 disorder
 Evidence X-RAY 3ipq A Reference
       Region 3ipq A 182-204 disorder
       Region 3ipq A 205-222 order
       Region 3ipq A 223-235 disorder
       Region 3ipq A 236-239 order
       Region 3ipq A 240-247 disorder
       Region 3ipq A 248-445 order
       Region 3ipq A 446-447 disorder
 Evidence X-RAY 3ips A Reference
       Region 3ips A 182-204 disorder
       Region 3ips A 205-222 order
       Region 3ips A 223-234 disorder
       Region 3ips A 235-239 order
       Region 3ips A 240-245 disorder
       Region 3ips A 246-446 order
       Region 3ips A 447-447 disorder
 Evidence X-RAY 3ips B Reference
       Region 3ips B 182-204 disorder
       Region 3ips B 205-222 order
       Region 3ips B 223-232 disorder
       Region 3ips B 233-239 order
       Region 3ips B 240-245 disorder
       Region 3ips B 246-446 order
       Region 3ips B 447-447 disorder
 Evidence X-RAY 3ipu A Reference
       Region 3ipu A 182-203 disorder
       Region 3ipu A 204-239 order
       Region 3ipu A 240-243 disorder
       Region 3ipu A 244-445 order
       Region 3ipu A 446-447 disorder
 Evidence X-RAY 3ipu B Reference
       Region 3ipu B 182-204 disorder
       Region 3ipu B 205-239 order
       Region 3ipu B 240-245 disorder
       Region 3ipu B 246-445 order
       Region 3ipu B 446-447 disorder
Seq 207-447 Hetero tetramer : IID00082Complex,IID00368Complex
 Evidence X-RAY 1uhl B Reference
       Region 1uhl B 207-229 order
       Region 1uhl B 230-247 disorder
       Region 1uhl B 248-314 order
       Region 1uhl B 315-317 disorder
       Region 1uhl B 318-445 order
       Region 1uhl B 446-447 disorder
 
Prediction
NeProc
Disorder 1-94,176-206
Order 95-175,207-238,252-447
ProS 1-13,45-49
AlphaFold
Disorder 1-93,189-203,446-447
Order 94-188,204-445
Pfam Hmmer
PF00105 96-171 6e-40
PF00104 262-442 7.6e-54
SEG 24-37 ,197-211
Function
Function in SwissProt
Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (PubMed:19481530, PubMed:25661920). Interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES (By similarity). LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides (By similarity). Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (PubMed:19481530). Interplays functionally with RORA for the regulation of genes involved in liver metabolism.
Biological Process
See also
Diagram with PDB data
NCOA1/RARACrystal structure of RARalpha ligand binding domain in complex with an agonist ligand (Am580) and a coactivator fragment