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IID00246  Werner syndrome ATP-dependent helicase (Homo sapiens) Q14191
  :order  :disorder  :conflict  :PDB cluster  :ProS  :SCOP Domain  :Pfam Domain
xml
Experiment
1432
fasta
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 38-236 Monomer :
 Evidence X-RAY 2fbt A Reference
       Region 2fbt A 38-231 order
       Region 2fbt A 232-236 disorder
 Evidence X-RAY 2fbv A Reference
       Region 2fbv A 38-230 order
       Region 2fbv A 231-236 disorder
 Evidence X-RAY 2fbx A Reference
       Region 2fbx A 38-231 order
       Region 2fbx A 232-236 disorder
 Evidence X-RAY 2fby A Reference
       Region 2fby A 38-231 order
       Region 2fby A 232-236 disorder
 Evidence X-RAY 2fc0 A Reference
       Region 2fc0 A 38-231 order
       Region 2fc0 A 232-236 disorder
Seq 949-1079 Homo dimer :
 Evidence X-RAY 3aaf A Reference
       Region 3aaf A 949-955 disorder
       Region 3aaf A 956-1064 order
       Region 3aaf A 1065-1079 disorder
 Evidence X-RAY 3aaf B Reference
       Region 3aaf B 949-955 disorder
       Region 3aaf B 956-1064 order
       Region 3aaf B 1065-1079 disorder
Seq 949-1092 Monomer :
 Evidence NMR 2axl A Reference
       Region 2axl A 949-954 disorder
       Region 2axl A 949-953 high_rmsd
       Region 2axl A 955-1068 order
       Region 2axl A 1069-1092 disorder
       Region 2axl A 1073-1092 high_rmsd
Seq 1140-1242 Monomer :
 Evidence X-RAY 2e1e A Reference
       Region 2e1e A 1142-1235 order
       Region 2e1e A 1236-1242 disorder
 Evidence X-RAY 2e1f A Reference
       Region 2e1f A 1142-1235 order
       Region 2e1f A 1236-1242 disorder
 Evidence NMR 2dgz A Reference
       Region 2dgz A 1140-1239 order
       Region 2dgz A 1140-1141 high_rmsd
       Region 2dgz A 1235-1239 high_rmsd
Seqphosphorylation
    426-426 Phosphoserine
    440-440 Phosphoserine
    453-453 Phosphoserine
    467-467 Phosphoserine
    478-478 Phosphoserine
    1133-1133 Phosphoserine
    1400-1400 Phosphoserine
Seqacetylation
    2-2 N-acetylserine
 
Prediction
DICHOT
Disorder 1-37,232-539,1093-1141,1236-1274,1353-1432
Known Domain 38-231,540-1092,1142-1235
Cryptic Domain 1275-1352
SCOPe RPS-Blast
     2q3sA2 53-227 9e-45 c.55.3.5 Arenavirus nucleoprotein C-terminal do...
     1oywA2 540-725 2e-69 c.37.1.19 ATP-dependent RNA helicase DDX25
     1oywA3 730-941 2e-67 c.37.1.19 ATP-dependent RNA helicase DDX25
     2axlA1 949-1092 2e-42 a.4.5.43 DNA helicase RecQ DNA-binding domain
     2e1fA 1142-1235 3e-28 a.60.8.1 HRDC domain from RecQ helicase
SCOP Hmmer
     1vk0A_ 72-227 3.3e-41 Ribonuclease H-like
     1m6nA3 444-714 7.4e-22 c.37.1.19 ATP-dependent ...
     1wp9A2 589-877 6.8e-54 c.37.1.19 ATP-dependent ...
     2axlA1 952-1091 2.1e-34 a.4.5.43 DNA helicase R...
     2e1fA1 1147-1233 2.6e-21 HRDC-like
Pfam RPS-Blast
     PF01612 76-228 2e-08 3'-5' exonuclease
     PF00271 762-859 6e-04 Helicase conserved C-termin...
     PF16124 872-939 2e-05 RecQ zinc-binding
     PF09382 956-1051 8e-11 RQC domain
     PF00570 1153-1219 5e-07 HRDC domain
     PF14493 1258-1351 2e-17 Helix-turn-helix domain
Pfam Hmmer
    PF01612 60-228 5e-39 3'-5' exonuclease
    PF00270 551-710 1.8e-17 DEAD/DEAH box helicase
    PF00271 763-858 7e-19 Helicase conserved C-termina...
    PF16124 871-940 5.1e-13 RecQ zinc-binding
    PF09382 955-1053 8e-22 RQC domain
    PF00570 1156-1213 2.2e-15 HRDC domain
    PF14493 1259-1352 9.1e-17 Helix-turn-helix domain