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IID00250
 UniprotQ96KQ7
ProteinHistone-lysine N-methyltransferase EHMT2
GeneEHMT2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1210
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 179-190 Hetero dimer : IID00245Complex
 Evidence X-RAY 3dm1 B Reference
       Region 3dm1 B 179-186 order
       Region 3dm1 B 187-190 disorder
 Evidence X-RAY 3dm1 D Reference
       Region 3dm1 D 179-179 disorder
       Region 3dm1 D 180-189 order
       Region 3dm1 D 190-190 disorder
 Evidence X-RAY 3dm1 F Reference
       Region 3dm1 F 179-187 order
       Region 3dm1 F 188-190 disorder
 Evidence X-RAY 3dm1 H Reference
       Region 3dm1 H 179-185 order
       Region 3dm1 H 186-190 disorder
Seq 419-552 Homo tetramer :
 Evidence X-RAY 6mm1 D Reference
       Region 6mm1 D 419-552 order
 Evidence X-RAY 6mm1 C Reference
       Region 6mm1 C 419-550 order
       Region 6mm1 C 551-552 disorder
 Evidence X-RAY 6mm1 B Reference
       Region 6mm1 B 419-552 order
 Evidence X-RAY 6mm1 A Reference
       Region 6mm1 A 419-550 order
       Region 6mm1 A 551-552 disorder
Seq 913-1193 Hetero dimer : IID00062Complex
 Evidence X-RAY 5t0k A Reference
       Region 5t0k A 913-919 disorder
       Region 5t0k A 920-1090 order
       Region 5t0k A 1091-1094 disorder
       Region 5t0k A 1095-1187 order
       Region 5t0k A 1188-1193 disorder
 Evidence X-RAY 5t0k B Reference
       Region 5t0k B 913-920 disorder
       Region 5t0k B 921-1003 order
       Region 5t0k B 1004-1010 disorder
       Region 5t0k B 1011-1192 order
       Region 5t0k B 1193-1193 disorder
 Evidence X-RAY 5t0m A Reference
       Region 5t0m A 913-920 disorder
       Region 5t0m A 921-1090 order
       Region 5t0m A 1091-1094 disorder
       Region 5t0m A 1095-1184 order
       Region 5t0m A 1185-1193 disorder
 Evidence X-RAY 5t0m B Reference
       Region 5t0m B 913-915 disorder
       Region 5t0m B 916-1186 order
       Region 5t0m B 1187-1193 disorder
Seq 913-1193 Monomer :
 Evidence X-RAY 2o8j A Reference
       Region 2o8j A 913-919 disorder
       Region 2o8j A 920-1090 order
       Region 2o8j A 1091-1094 disorder
       Region 2o8j A 1095-1160 order
       Region 2o8j A 1161-1164 disorder
       Region 2o8j A 1165-1181 order
       Region 2o8j A 1182-1193 disorder
 Evidence X-RAY 2o8j B Reference
       Region 2o8j B 913-921 disorder
       Region 2o8j B 922-1192 order
       Region 2o8j B 1193-1193 disorder
 Evidence X-RAY 2o8j C Reference
       Region 2o8j C 913-921 disorder
       Region 2o8j C 922-1089 order
       Region 2o8j C 1090-1094 disorder
       Region 2o8j C 1095-1188 order
       Region 2o8j C 1189-1193 disorder
 Evidence X-RAY 2o8j D Reference
       Region 2o8j D 913-921 disorder
       Region 2o8j D 922-1089 order
       Region 2o8j D 1090-1095 disorder
       Region 2o8j D 1096-1159 order
       Region 2o8j D 1160-1165 disorder
       Region 2o8j D 1166-1181 order
       Region 2o8j D 1182-1193 disorder
 Evidence X-RAY 3k5k A Reference
       Region 3k5k A 913-916 disorder
       Region 3k5k A 917-1092 order
       Region 3k5k A 1093-1094 disorder
       Region 3k5k A 1095-1190 order
       Region 3k5k A 1191-1193 disorder
 Evidence X-RAY 3k5k B Reference
       Region 3k5k B 913-918 disorder
       Region 3k5k B 919-1091 order
       Region 3k5k B 1092-1094 disorder
       Region 3k5k B 1095-1190 order
       Region 3k5k B 1191-1193 disorder
 Evidence X-RAY 5vse A Reference
       Region 5vse A 917-918 disorder
       Region 5vse A 919-1091 order
       Region 5vse A 1092-1094 disorder
       Region 5vse A 1095-1190 order
 Evidence X-RAY 5vse B Reference
       Region 5vse B 917-1090 order
       Region 5vse B 1091-1094 disorder
       Region 5vse B 1095-1190 order
Seq 913-1193 Homo dimer :
 Evidence X-RAY 3rjw A Reference
       Region 3rjw A 913-917 disorder
       Region 3rjw A 918-1162 order
       Region 3rjw A 1163-1164 disorder
       Region 3rjw A 1165-1187 order
       Region 3rjw A 1188-1193 disorder
 Evidence X-RAY 3rjw B Reference
       Region 3rjw B 913-920 disorder
       Region 3rjw B 921-1091 order
       Region 3rjw B 1092-1094 disorder
       Region 3rjw B 1095-1193 order
 Evidence X-RAY 4nvq A Reference
       Region 4nvq A 913-915 disorder
       Region 4nvq A 916-1089 order
       Region 4nvq A 1090-1093 disorder
       Region 4nvq A 1094-1163 order
       Region 4nvq A 1164-1164 disorder
       Region 4nvq A 1165-1187 order
       Region 4nvq A 1188-1193 disorder
 Evidence X-RAY 4nvq B Reference
       Region 4nvq B 913-917 disorder
       Region 4nvq B 918-987 order
       Region 4nvq B 988-992 disorder
       Region 4nvq B 993-1090 order
       Region 4nvq B 1091-1095 disorder
       Region 4nvq B 1096-1190 order
       Region 4nvq B 1191-1193 disorder
 Evidence X-RAY 5tuy A Reference
       Region 5tuy A 921-1187 order
 Evidence X-RAY 5tuy B Reference
       Region 5tuy B 921-922 disorder
       Region 5tuy B 923-1090 order
       Region 5tuy B 1091-1093 disorder
       Region 5tuy B 1094-1187 order
 Evidence X-RAY 5v9i A Reference
       Region 5v9i A 913-915 disorder
       Region 5v9i A 916-1090 order
       Region 5v9i A 1091-1094 disorder
       Region 5v9i A 1095-1185 order
       Region 5v9i A 1186-1193 disorder
 Evidence X-RAY 5v9i B Reference
       Region 5v9i B 913-917 disorder
       Region 5v9i B 918-1090 order
       Region 5v9i B 1091-1094 disorder
       Region 5v9i B 1095-1189 order
       Region 5v9i B 1190-1193 disorder
 Evidence X-RAY 5v9i C Reference
       Region 5v9i C 913-915 disorder
       Region 5v9i C 916-1090 order
       Region 5v9i C 1091-1095 disorder
       Region 5v9i C 1096-1184 order
       Region 5v9i C 1185-1193 disorder
 Evidence X-RAY 5v9i D Reference
       Region 5v9i D 913-917 disorder
       Region 5v9i D 918-1090 order
       Region 5v9i D 1091-1094 disorder
       Region 5v9i D 1095-1186 order
       Region 5v9i D 1187-1193 disorder
 Evidence X-RAY 5vsc A Reference
       Region 5vsc A 916-917 disorder
       Region 5vsc A 918-1090 order
       Region 5vsc A 1091-1094 disorder
       Region 5vsc A 1095-1190 order
 Evidence X-RAY 5vsc B Reference
       Region 5vsc B 916-1090 order
       Region 5vsc B 1091-1093 disorder
       Region 5vsc B 1094-1190 order
 Evidence X-RAY 7btv A Reference
       Region 7btv A 913-917 disorder
       Region 7btv A 918-1091 order
       Region 7btv A 1092-1092 disorder
       Region 7btv A 1093-1189 order
       Region 7btv A 1190-1193 disorder
 Evidence X-RAY 7btv B Reference
       Region 7btv B 913-915 disorder
       Region 7btv B 916-1091 order
       Region 7btv B 1092-1093 disorder
       Region 7btv B 1094-1189 order
       Region 7btv B 1190-1193 disorder
 Evidence X-RAY 7buc A Reference
       Region 7buc A 913-917 disorder
       Region 7buc A 918-1190 order
       Region 7buc A 1191-1193 disorder
 Evidence X-RAY 7buc B Reference
       Region 7buc B 913-917 disorder
       Region 7buc B 918-1090 order
       Region 7buc B 1091-1094 disorder
       Region 7buc B 1095-1190 order
       Region 7buc B 1191-1193 disorder
 Evidence X-RAY 7dcf A Reference
       Region 7dcf A 913-917 disorder
       Region 7dcf A 918-987 order
       Region 7dcf A 988-993 disorder
       Region 7dcf A 994-1092 order
       Region 7dcf A 1093-1094 disorder
       Region 7dcf A 1095-1185 order
       Region 7dcf A 1186-1193 disorder
 Evidence X-RAY 7dcf B Reference
       Region 7dcf B 913-919 disorder
       Region 7dcf B 920-998 order
       Region 7dcf B 999-1000 disorder
       Region 7dcf B 1001-1007 order
       Region 7dcf B 1008-1009 disorder
       Region 7dcf B 1010-1092 order
       Region 7dcf B 1093-1094 disorder
       Region 7dcf B 1095-1184 order
       Region 7dcf B 1185-1193 disorder
 Evidence X-RAY 7x73 A Reference
       Region 7x73 A 913-916 disorder
       Region 7x73 A 917-1190 order
       Region 7x73 A 1191-1193 disorder
 Evidence X-RAY 7x73 B Reference
       Region 7x73 B 913-915 disorder
       Region 7x73 B 916-1006 order
       Region 7x73 B 1007-1009 disorder
       Region 7x73 B 1010-1191 order
       Region 7x73 B 1192-1193 disorder
 Evidence X-RAY 7xua A Reference
       Region 7xua A 913-915 disorder
       Region 7xua A 916-1188 order
       Region 7xua A 1189-1193 disorder
 Evidence X-RAY 7xua B Reference
       Region 7xua B 913-916 disorder
       Region 7xua B 917-1091 order
       Region 7xua B 1092-1093 disorder
       Region 7xua B 1094-1192 order
       Region 7xua B 1193-1193 disorder
 Evidence X-RAY 7xub A Reference
       Region 7xub A 913-915 disorder
       Region 7xub A 916-1185 order
       Region 7xub A 1186-1193 disorder
 Evidence X-RAY 7xub B Reference
       Region 7xub B 913-916 disorder
       Region 7xub B 917-1091 order
       Region 7xub B 1092-1094 disorder
       Region 7xub B 1095-1185 order
       Region 7xub B 1186-1193 disorder
 Evidence X-RAY 7xuc A Reference
       Region 7xuc A 913-915 disorder
       Region 7xuc A 916-1008 order
       Region 7xuc A 1009-1010 disorder
       Region 7xuc A 1011-1189 order
       Region 7xuc A 1190-1193 disorder
 Evidence X-RAY 7xuc B Reference
       Region 7xuc B 913-916 disorder
       Region 7xuc B 917-1005 order
       Region 7xuc B 1006-1009 disorder
       Region 7xuc B 1010-1189 order
       Region 7xuc B 1190-1193 disorder
 Evidence X-RAY 7xud A Reference
       Region 7xud A 913-915 disorder
       Region 7xud A 916-1004 order
       Region 7xud A 1005-1009 disorder
       Region 7xud A 1010-1188 order
       Region 7xud A 1189-1193 disorder
 Evidence X-RAY 7xud B Reference
       Region 7xud B 913-916 disorder
       Region 7xud B 917-1006 order
       Region 7xud B 1007-1009 disorder
       Region 7xud B 1010-1189 order
       Region 7xud B 1190-1193 disorder
Seq 913-1193 Homo tetramer :
 Evidence X-RAY 5ttf D Reference
       Region 5ttf D 913-917 disorder
       Region 5ttf D 918-1090 order
       Region 5ttf D 1091-1094 disorder
       Region 5ttf D 1095-1182 order
       Region 5ttf D 1183-1193 disorder
 Evidence X-RAY 5ttf C Reference
       Region 5ttf C 913-920 disorder
       Region 5ttf C 921-1091 order
       Region 5ttf C 1092-1094 disorder
       Region 5ttf C 1095-1188 order
       Region 5ttf C 1189-1193 disorder
 Evidence X-RAY 5ttf B Reference
       Region 5ttf B 913-917 disorder
       Region 5ttf B 918-1091 order
       Region 5ttf B 1092-1094 disorder
       Region 5ttf B 1095-1188 order
       Region 5ttf B 1189-1193 disorder
 Evidence X-RAY 5ttf A Reference
       Region 5ttf A 913-917 disorder
       Region 5ttf A 918-1090 order
       Region 5ttf A 1091-1094 disorder
       Region 5ttf A 1095-1186 order
       Region 5ttf A 1187-1193 disorder
 Evidence X-RAY 7t7l D Reference
       Region 7t7l D 913-916 disorder
       Region 7t7l D 917-1091 order
       Region 7t7l D 1092-1094 disorder
       Region 7t7l D 1095-1188 order
       Region 7t7l D 1189-1193 disorder
 Evidence X-RAY 7t7l C Reference
       Region 7t7l C 913-917 disorder
       Region 7t7l C 918-1091 order
       Region 7t7l C 1092-1093 disorder
       Region 7t7l C 1094-1185 order
       Region 7t7l C 1186-1193 disorder
 Evidence X-RAY 7t7l B Reference
       Region 7t7l B 913-920 disorder
       Region 7t7l B 921-1090 order
       Region 7t7l B 1091-1093 disorder
       Region 7t7l B 1094-1187 order
       Region 7t7l B 1188-1193 disorder
 Evidence X-RAY 7t7l A Reference
       Region 7t7l A 913-920 disorder
       Region 7t7l A 921-1091 order
       Region 7t7l A 1092-1093 disorder
       Region 7t7l A 1094-1188 order
       Region 7t7l A 1189-1193 disorder
Seq 916-1189 Hetero tetramer : IID00062Complex
 Evidence X-RAY 5jhn A Reference
       Region 5jhn A 916-1188 order
       Region 5jhn A 1189-1189 disorder
 Evidence X-RAY 5jhn B Reference
       Region 5jhn B 916-918 disorder
       Region 5jhn B 919-1090 order
       Region 5jhn B 1091-1094 disorder
       Region 5jhn B 1095-1189 order
 Evidence X-RAY 5jin A Reference
       Region 5jin A 916-1188 order
       Region 5jin A 1189-1189 disorder
 Evidence X-RAY 5jin B Reference
       Region 5jin B 916-918 disorder
       Region 5jin B 919-1090 order
       Region 5jin B 1091-1094 disorder
       Region 5jin B 1095-1189 order
 Evidence X-RAY 5jiy A Reference
       Region 5jiy A 916-1188 order
       Region 5jiy A 1189-1189 disorder
 Evidence X-RAY 5jiy B Reference
       Region 5jiy B 916-918 disorder
       Region 5jiy B 919-1090 order
       Region 5jiy B 1091-1094 disorder
       Region 5jiy B 1095-1189 order
 Evidence X-RAY 5jj0 A Reference
       Region 5jj0 A 916-1188 order
       Region 5jj0 A 1189-1189 disorder
 Evidence X-RAY 5jj0 B Reference
       Region 5jj0 B 916-918 disorder
       Region 5jj0 B 919-1090 order
       Region 5jj0 B 1091-1094 disorder
       Region 5jj0 B 1095-1189 order
SeqProS predicted 179-189 This region is predicted to be disordered by AlphaFold (pLDDT <68.5) and NeProc. Hetero dimer : IID00245Complex
       Region 3dm1 B 179-186 order
       Region 3dm1 D 180-189 order
       Region 3dm1 F 179-187 order
       Region 3dm1 H 179-185 order
Seqphosphorylation
    40-40 Phosphoserine
    44-44 Phosphothreonine
    47-47 Phosphoserine
    140-140 Phosphoserine
    173-173 Phosphoserine
    232-232 Phosphoserine
    242-242 Phosphoserine
    246-246 Phosphoserine
    350-350 Phosphoserine
    412-412 Phosphoserine
    413-413 Phosphoserine
    555-555 Phosphothreonine
    569-569 Phosphoserine
    1204-1204 Phosphoserine
    1210-1210 Phosphothreonine
Seqacetylation
    2-2 N-acetylalanine
 
Prediction
NeProc
Disorder 1-283,334-422,552-631,1183-1210
Order 284-333,423-551,632-1182
ProS 26-40,127-131,177-182,270-273,348-355,385-397,417-422,612-615,627-631,1183-1188
AlphaFold
Disorder 1-425,513-513,551-606,643-647,910-918,1193-1210
Order 426-512,514-550,607-642,648-909,919-1192
Pfam Hmmer
PF00023 684-716 9.3e-10
PF00023 717-749 0.00036
PF00023 750-783 3.2e-08
PF00023 784-816 1.3e-08
PF00023 817-849 0.00075
PF00023 850-882 5.3e-09
PF05033 925-1030 4.6e-43
PF00856 1032-1162 9.9e-54
SEG 2-23 ,96-110 ,114-128 ,155-176 ,232-242 ,300-326 ,331-350 ,354-371 ,555-567 ,1194-1207
Function
Function in SwissProt
Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself. Recruited to the promoters of target genes through interaction with transcriptional repressor MSX1, leading to the inhibition of myoblast differentiation via transcriptional repression of differentiation factors (By similarity).
Biological Process
Diagram with PDB data
EHMT2/CBX3Crystal structure of the complex of human chromobox homolog 3 (CBX3) with peptide
See also
Diagram with PDB data
REST/Sin3bSolution structure of the NRSF/REST-mSin3B PAH1 complex