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IID00256
 UniprotO00401
ProteinNeural Wiskott-Aldrich syndrome protein
GeneWASL
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
505
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 207-270 Hetero trimer : IID90008Complex
 Evidence NMR 2lnh A Reference
       Region 2lnh A 207-270 order
       Region 2lnh A 207-207 high_rmsd
Seq 346-357 Hetero dimer : Q6XZF7
 Evidence X-RAY 4cc7 N Reference
       Region 4cc7 N 346-357 order
 Evidence X-RAY 4cc7 L Reference
       Region 4cc7 L 346-356 order
       Region 4cc7 L 357-357 disorder
 Evidence X-RAY 4cc7 J Reference
       Region 4cc7 J 346-356 order
       Region 4cc7 J 357-357 disorder
 Evidence X-RAY 4cc7 H Reference
       Region 4cc7 H 346-357 order
 Evidence X-RAY 4cc7 F Reference
       Region 4cc7 F 346-357 order
 Evidence X-RAY 4cc7 D Reference
       Region 4cc7 D 346-357 order
 Evidence X-RAY 4cc7 B Reference
       Region 4cc7 B 346-346 disorder
       Region 4cc7 B 347-356 order
       Region 4cc7 B 357-357 disorder
 Evidence X-RAY 4cc2 D Reference
       Region 4cc2 D 346-347 disorder
       Region 4cc2 D 348-357 order
 Evidence X-RAY 4cc2 B Reference
       Region 4cc2 B 346-357 order
Seq 392-484 Hetero dimer : IID50082Complex
 Evidence X-RAY 2vcp E Reference
       Region 2vcp E 392-432 disorder
       Region 2vcp E 433-451 order
       Region 2vcp E 452-484 disorder
 Evidence X-RAY 2vcp D Reference
       Region 2vcp D 392-432 disorder
       Region 2vcp D 433-451 order
       Region 2vcp D 452-484 disorder
Seq 451-465 Hetero trimer : IID00265Complex
 Evidence X-RAY 2ff3 C Reference
       Region 2ff3 C 451-453 order
       Region 2ff3 C 454-465 disorder
SeqProS possible 207-270 This region is called GBD(GTPase binding domain). WASP (IID00269) also has GBD, whose sequence is identical to this region and disordered in the free state. Hetero trimer : IID90008Complex
       Region 2lnh A 207-270 order
SeqProS possible 346-357 This region is included in the proline rich domain and binds upon SH3 domain. Hetero dimer : Q6XZF7
       Region 4cc2 B 346-357 order
       Region 4cc2 D 348-357 order
       Region 4cc7 B 347-356 order
       Region 4cc7 D 346-357 order
       Region 4cc7 F 346-357 order
       Region 4cc7 H 346-357 order
       Region 4cc7 J 346-356 order
       Region 4cc7 L 346-356 order
       Region 4cc7 N 346-357 order
SeqProS possible 433-453 This region is called WH2 domain. WASP (IID00269) also has WH2, whose sequence is identical to this region and disordered in the free state. Hetero trimer : IID00265Complex
       Region 2ff3 C 451-453 order
SeqProS possible 433-453 Hetero dimer : IID50082Complex
       Region 2vcp D 433-451 order
       Region 2vcp E 433-451 order
Seqphosphorylation
    242-242 Phosphoserine; by TNK2
    256-256 Phosphotyrosine; by FAK1 and TNK2
    485-485 Phosphoserine
    484-484 Phosphoserine
Seqacetylation
    2-2 N-acetylserine
 
Prediction
NeProc
Disorder 1-18,139-220,264-505
Order 19-138,221-263
ProS 14-18,139-144,164-168,212-220,276-279,391-395,465-484,498-505
AlphaFold
Disorder 1-14,145-197,199-199,201-203,206-216,218-218,227-227,275-311,313-326,328-346,349-357,364-372,389-409,412-413,415-435,444-444,446-465,483-505
Order 15-144,198-198,200-200,204-205,217-217,219-226,228-274,312-312,327-327,347-348,358-363,373-388,410-411,414-414,436-443,445-445,466-482
Pfam Hmmer
PF00568 34-138 6e-61
PF00786 202-261 6.6e-20
PF02205 405-422 1.8e-05
PF02205 433-450 7.1e-07
SEG 5-11 ,186-200 ,276-393 ,486-505
Function
Function in SwissProt
Regulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex (PubMed:9422512, PubMed:16767080, PubMed:19366662, PubMed:19487689, PubMed:22847007, PubMed:22921828). Involved in various processes, such as mitosis and cytokinesis, via its role in the regulation of actin polymerization (PubMed:9422512, PubMed:19366662, PubMed:19487689, PubMed:22847007, PubMed:22921828). Together with CDC42, involved in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia (PubMed:9422512). In addition to its role in the cytoplasm, also plays a role in the nucleus by regulating gene transcription, probably by promoting nuclear actin polymerization (PubMed:16767080). Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression (By similarity). Plays a role in dendrite spine morphogenesis (By similarity). Decreasing levels of DNMBP (using antisense RNA) alters apical junction morphology in cultured enterocytes, junctions curve instead of being nearly linear (PubMed:19767742).