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IID00256  Neural Wiskott-Aldrich syndrome protein (Homo sapiens) O00401
  :order  :disorder  :conflict  :PDB cluster  :ProS  :SCOP Domain  :Pfam Domain
Networkxml
Experiment
505
fasta
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 207-270 Hetero trimer : IID90008Complex
 Evidence NMR 2lnh A Reference
       Region 2lnh A 207-270 order
       Region 2lnh A 207-207 high_rmsd
Seq 346-357 Hetero dimer : Q6XZF7
 Evidence X-RAY 4cc2 B Reference
       Region 4cc2 B 346-357 order
 Evidence X-RAY 4cc2 D Reference
       Region 4cc2 D 346-347 disorder
       Region 4cc2 D 348-357 order
 Evidence X-RAY 4cc7 B Reference
       Region 4cc7 B 346-346 disorder
       Region 4cc7 B 347-356 order
       Region 4cc7 B 357-357 disorder
 Evidence X-RAY 4cc7 D Reference
       Region 4cc7 D 346-357 order
 Evidence X-RAY 4cc7 F Reference
       Region 4cc7 F 346-357 order
 Evidence X-RAY 4cc7 H Reference
       Region 4cc7 H 346-357 order
 Evidence X-RAY 4cc7 J Reference
       Region 4cc7 J 346-356 order
       Region 4cc7 J 357-357 disorder
 Evidence X-RAY 4cc7 L Reference
       Region 4cc7 L 346-356 order
       Region 4cc7 L 357-357 disorder
 Evidence X-RAY 4cc7 N Reference
       Region 4cc7 N 346-357 order
Seq 392-484 Hetero dimer : IID50082Complex
 Evidence X-RAY 2vcp D Reference
       Region 2vcp D 392-432 disorder
       Region 2vcp D 433-451 order
       Region 2vcp D 452-484 disorder
 Evidence X-RAY 2vcp E Reference
       Region 2vcp E 392-432 disorder
       Region 2vcp E 433-451 order
       Region 2vcp E 452-484 disorder
Seq 451-465 Hetero trimer : IID00265Complex
 Evidence X-RAY 2ff3 C Reference
       Region 2ff3 C 451-453 order
       Region 2ff3 C 454-465 disorder
SeqProS possible 207-270 This region is called GBD(GTPase binding domain). WASP (IID00269) also has GBD, whose sequence is identical to this region and disordered in the free state. Hetero trimer : IID90008Complex
       Region 2lnh A 207-270 order
SeqProS possible 346-357 This region is included in the proline rich domain and binds upon SH3 domain. Hetero dimer : Q6XZF7
       Region 4cc2 B 346-357 order
       Region 4cc2 D 348-357 order
       Region 4cc7 B 347-356 order
       Region 4cc7 D 346-357 order
       Region 4cc7 F 346-357 order
       Region 4cc7 H 346-357 order
       Region 4cc7 J 346-356 order
       Region 4cc7 L 346-356 order
       Region 4cc7 N 346-357 order
SeqProS possible 433-451 This region is called WH2 domain. WASP (IID00269) also has WH2, whose sequence is identical to this region and disordered in the free state. Hetero dimer : IID50082Complex
       Region 2vcp D 433-451 order
       Region 2vcp E 433-451 order
SeqProS possible 451-453 This region is called WH2 domain. WASP (IID00269) also has WH2, whose sequence is identical to this region and disordered in the free state. Hetero trimer : IID00265Complex
       Region 2ff3 C 451-453 order
Seqphosphorylation
    242-242 Phosphoserine; by TNK2
    256-256 Phosphotyrosine; by FAK1 and TNK2
    484-484 Phosphoserine
    485-485 Phosphoserine
Seqacetylation
    2-2 N-acetylserine
 
Prediction
DICHOT
Disorder 1-28,143-206,271-416,486-505
Known Domain 29-142,207-270,417-485
SCOPe RPS-Blast
     1mkeA1 29-142 1e-46 b.55.1.4 Actin regulatory protein WASP
     1ej5A 207-308 1e-20 a.68.1.1 Wiscott-Aldrich syndrome protein, WASP,...
     3otgA1 304-388 3e-05 c.87.1.0 automated matches
SCOP Hmmer
     1mkeA1 30-141 3.9e-43 b.55.1.4 Actin regulatory...
     1ej5A_ 207-303 1.8e-28 a.68.1.1 Wiscott-Aldrich...
     1ej5A_ 382-493 1.3e-27 a.68.1.1 Wiscott-Aldrich...
Pfam RPS-Blast
     PF00568 31-136 1e-24 WH1 domain
     PF00786 204-259 4e-07 P21-Rho-binding domain
     PF15782 273-394 6e-09 Gene regulated by oestrogen...
Pfam Hmmer
    PF00568 32-136 3.5e-44 WH1 domain
    PF00786 202-260 1.8e-22 P21-Rho-binding domain
    PF02205 404-427 6.6e-11 WH2 motif
    PF02205 431-451 1.7e-10 WH2 motif