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IID00263  Pro-epidermal growth factor (Homo sapiens) P01133
  :order  :disorder  :conflict  :PDB cluster  :ProS  :SCOP Domain  :Pfam Domain
Networkxml
Experiment
1207
fasta
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 971-1021 Homo dimer :
 Evidence X-RAY 1jl9 A Reference
       Region 1jl9 A 971-975 disorder
       Region 1jl9 A 976-1017 order
       Region 1jl9 A 1018-1021 disorder
 Evidence X-RAY 1jl9 B Reference
       Region 1jl9 B 971-975 disorder
       Region 1jl9 B 976-1020 order
       Region 1jl9 B 1021-1021 disorder
Seq 971-1023 Hetero tetramer : IID00262Complex
 Evidence X-RAY 1ivo C Reference
       Region 1ivo C 971-974 disorder
       Region 1ivo C 975-1021 order
       Region 1ivo C 1022-1023 disorder
 Evidence X-RAY 1ivo D Reference
       Region 1ivo D 971-974 disorder
       Region 1ivo D 975-1021 order
       Region 1ivo D 1022-1023 disorder
 Evidence X-RAY 3njp C Reference
       Region 3njp C 975-1021 order
 Evidence X-RAY 3njp D Reference
       Region 3njp D 975-1021 order
Seq 971-1023 Hetero dimer : IID00262Complex
 Evidence X-RAY 3njp C Reference
       Region 3njp C 975-1021 order
 Evidence X-RAY 3njp D Reference
       Region 3njp D 975-1021 order
 Evidence X-RAY 1nql B Reference
       Region 1nql B 971-972 disorder
       Region 1nql B 973-1020 order
       Region 1nql B 1021-1023 disorder
Seq 971-1023 Monomer :
 Evidence NMR 2kv4 A Reference
       Region 2kv4 A 971-1023 order
       Region 2kv4 A 971-971 high_rmsd
 Evidence NMR 1p9j A Reference
       Region 1p9j A 976-1022 order
       Region 1p9j A 976-979 high_rmsd
 
Prediction
DICHOT
Disorder 1-43,437-446,1019-1032,1056-1207
Known Domain 44-436,447-773,839-940,974-1018,1033-1055
Cryptic Domain 774-838,941-973
SCOPe RPS-Blast
     1ijqA1 46-306 7e-47 b.68.5.1 Low density lipoprotein (LDL) receptor
     2y5fL 316-361 5e-05 g.3.11.1 Activated protein c (autoprothrombin I...
     1uzkA1 356-395 2e-10 g.3.11.1 Activated protein c (autoprothrombin ...
     2bz6L 441-483 7e-07 g.3.11.1 Activated protein c (autoprothrombin I...
     1ijqA1 483-740 1e-98 b.68.5.1 Low density lipoprotein (LDL) receptor
     2y5fL 745-784 4e-08 g.3.11.1 Activated protein c (autoprothrombin I...
     1uzkA1 869-912 3e-07 g.3.11.1 Activated protein c (autoprothrombin ...
     1uzkA1 912-953 3e-04 g.3.11.1 Activated protein c (autoprothrombin ...
     1egfA 971-1023 2e-16 g.3.11.1 Activated protein c (autoprothrombin I...
SCOP Hmmer
     1ijqA1 46-288 6.4e-37 b.68.5.1 Low density lipo...
     1kigL_ 318-367 9.7e-10 g.3.11.1 Activated prote...
     1apqA_ 349-397 2.4e-13 g.3.11.1 Activated prote...
     1kigL_ 401-438 1e-06 g.3.11.1 Activated protein...
     1pfxL2 443-484 3.4e-07 g.3.11.1 Activated prote...
     1ijqA1 483-737 7.7e-51 b.68.5.1 Low density lip...
     1kliL_ 742-789 2.3e-12 g.3.11.1 Activated prote...
     1faxL_ 831-881 1.7e-07 g.3.11.1 Activated prote...
     1faxL_ 870-923 3.6e-11 g.3.11.1 Activated prote...
     1apqA_ 906-949 1e-08 g.3.11.1 Activated protein...
     1moxC_ 974-1018 1.7e-13 g.3.11.1 Activated prot...
Pfam RPS-Blast
     PF16472 47-265 8e-11 Domain of unknown function (...
     PF14670 359-395 1e-05 Coagulation Factor Xa inhib...
     PF14670 408-436 7e-04 Coagulation Factor Xa inhib...
     PF14670 439-476 1e-04 Coagulation Factor Xa inhib...
     PF00058 524-564 6e-08 Low-density lipoprotein rec...
     PF00058 567-607 8e-08 Low-density lipoprotein rec...
     PF00058 611-650 2e-10 Low-density lipoprotein rec...
     PF00058 654-693 6e-08 Low-density lipoprotein rec...
     PF14670 745-780 4e-05 Coagulation Factor Xa inhib...
     PF07645 870-910 2e-04 Calcium-binding EGF domain
     PF12947 916-951 2e-04 EGF domain
Pfam Hmmer
    PF07645 356-395 8.1e-11 Calcium-binding EGF domain
    PF00058 524-564 4.9e-08 Low-density lipoprotein re...
    PF00058 568-607 3.6e-11 Low-density lipoprotein re...
    PF00058 611-650 8.1e-10 Low-density lipoprotein re...
    PF00058 654-693 2.3e-13 Low-density lipoprotein re...
    PF14670 745-780 6.7e-12 Coagulation Factor Xa inhi...
    PF07645 870-910 1.2e-13 Calcium-binding EGF domain
    PF07645 912-941 2.5e-12 Calcium-binding EGF domain
    PF00008 981-1011 2.8e-08 EGF-like domain