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IID00263
 UniprotP01133
ProteinPro-epidermal growth factor
GeneEGF
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1207
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 971-1021 Homo dimer :
 Evidence X-RAY 1jl9 B Reference
       Region 1jl9 B 971-975 disorder
       Region 1jl9 B 976-1020 order
       Region 1jl9 B 1021-1021 disorder
 Evidence X-RAY 1jl9 A Reference
       Region 1jl9 A 971-975 disorder
       Region 1jl9 A 976-1017 order
       Region 1jl9 A 1018-1021 disorder
Seq 971-1023 Hetero tetramer : IID00262Complex
 Evidence X-RAY 3njp D Reference
       Region 3njp D 975-1021 order
 Evidence X-RAY 3njp C Reference
       Region 3njp C 975-1021 order
 Evidence X-RAY 1ivo D Reference
       Region 1ivo D 971-974 disorder
       Region 1ivo D 975-1021 order
       Region 1ivo D 1022-1023 disorder
 Evidence X-RAY 1ivo C Reference
       Region 1ivo C 971-974 disorder
       Region 1ivo C 975-1021 order
       Region 1ivo C 1022-1023 disorder
Seq 971-1023 Hetero dimer : IID00262Complex
 Evidence X-RAY 1nql B Reference
       Region 1nql B 971-972 disorder
       Region 1nql B 973-1020 order
       Region 1nql B 1021-1023 disorder
 Evidence X-RAY 3njp D Reference
       Region 3njp D 975-1021 order
 Evidence X-RAY 3njp C Reference
       Region 3njp C 975-1021 order
Seq 971-1023 Monomer :
 Evidence NMR 1p9j A Reference
       Region 1p9j A 976-1022 order
       Region 1p9j A 976-979 high_rmsd
 Evidence NMR 2kv4 A Reference
       Region 2kv4 A 971-1023 order
       Region 2kv4 A 971-971 high_rmsd
 
Prediction
NeProc
Disorder 791-824,1056-1091,1100-1207
Order 1-790,825-1055,1092-1099
ProS 791-824,1056-1091,1100-1149,1159-1178,1188-1207
AlphaFold
Disorder 1-43,179-179,221-224,242-248,264-267,279-279,286-292,306-343,348-348,350-353,363-363,384-385,387-387,389-390,396-411,413-419,422-443,455-458,508-512,681-684,722-723,741-744,746-750,758-763,783-839,848-853,877-879,925-926,940-982,996-996,1006-1006,1015-1034,1060-1207
Order 44-178,180-220,225-241,249-263,268-278,280-285,293-305,344-347,349-349,354-362,364-383,386-386,388-388,391-395,412-412,420-421,444-454,459-507,513-680,685-721,724-740,745-745,751-757,764-782,840-847,854-876,880-924,927-939,983-995,997-1005,1007-1014,1035-1059
Pfam Hmmer
PF00008 318-354 0.00016
PF07645 356-395 2.7e-08
PF00008 401-436 3.6e-09
PF00058 524-565 3.9e-07
PF00058 567-608 2.5e-08
PF00058 610-652 5.9e-07
PF00058 654-695 3.2e-11
PF00008 745-780 0.00011
PF00008 835-868 1.4e-07
PF07645 870-910 1.7e-14
PF07645 912-951 7.5e-08
PF00008 976-1012 6.5e-09
SEG 1033-1051
Function
Function in SwissProt
EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. Can induce neurite outgrowth in motoneurons of the pond snail Lymnaea stagnalis in vitro (PubMed:10964941).
Biological Process
See also
Diagram with PDB data
ERRFI1/EGFRcrystal structure of EGFR kinase domain in complex with Mitogen-inducible gene 6 protein
ERRFI1/EGFRCrystal structure of the complex between the EGFR kinase domain and a Mig6 peptide