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IID00265
 UniprotP06396
ProteinGelsolin
GeneGSN
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
782
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-782 Monomer :
 Evidence X-RAY 3ffn A Reference
       Region 3ffn A 1-49 disorder
       Region 3ffn A 50-285 order
       Region 3ffn A 286-290 disorder
       Region 3ffn A 291-782 order
 Evidence X-RAY 3ffn B Reference
       Region 3ffn B 1-53 disorder
       Region 3ffn B 54-285 order
       Region 3ffn B 286-291 disorder
       Region 3ffn B 292-782 order
Seq 28-782 Homo dimer :
 Evidence X-RAY 6jco A Reference
       Region 6jco A 56-63 disorder
       Region 6jco A 64-179 order
       Region 6jco A 180-184 disorder
       Region 6jco A 185-282 order
       Region 6jco A 283-290 disorder
       Region 6jco A 291-306 order
       Region 6jco A 307-307 disorder
       Region 6jco A 308-554 order
       Region 6jco A 555-555 disorder
       Region 6jco A 556-674 order
       Region 6jco A 675-677 disorder
       Region 6jco A 678-782 order
 Evidence X-RAY 6jco B Reference
       Region 6jco B 56-180 order
       Region 6jco B 181-182 disorder
       Region 6jco B 183-285 order
       Region 6jco B 286-290 disorder
       Region 6jco B 291-307 order
       Region 6jco B 308-308 disorder
       Region 6jco B 309-400 order
       Region 6jco B 401-403 disorder
       Region 6jco B 404-674 order
       Region 6jco B 675-675 disorder
       Region 6jco B 676-782 order
 Evidence X-RAY 6jeg A Reference
       Region 6jeg A 54-284 order
       Region 6jeg A 285-290 disorder
       Region 6jeg A 291-305 order
       Region 6jeg A 306-308 disorder
       Region 6jeg A 309-398 order
       Region 6jeg A 399-404 disorder
       Region 6jeg A 405-782 order
 Evidence X-RAY 6jeg B Reference
       Region 6jeg B 54-54 disorder
       Region 6jeg B 55-284 order
       Region 6jeg B 285-290 disorder
       Region 6jeg B 291-304 order
       Region 6jeg B 305-308 disorder
       Region 6jeg B 309-782 order
 Evidence X-RAY 6jeh A Reference
       Region 6jeh A 56-180 order
       Region 6jeh A 181-184 disorder
       Region 6jeh A 185-282 order
       Region 6jeh A 283-290 disorder
       Region 6jeh A 291-304 order
       Region 6jeh A 305-308 disorder
       Region 6jeh A 309-657 order
       Region 6jeh A 658-658 disorder
       Region 6jeh A 659-780 order
       Region 6jeh A 781-782 disorder
 Evidence X-RAY 6jeh B Reference
       Region 6jeh B 56-56 disorder
       Region 6jeh B 57-180 order
       Region 6jeh B 181-183 disorder
       Region 6jeh B 184-282 order
       Region 6jeh B 283-290 disorder
       Region 6jeh B 291-304 order
       Region 6jeh B 305-308 disorder
       Region 6jeh B 309-398 order
       Region 6jeh B 399-407 disorder
       Region 6jeh B 408-657 order
       Region 6jeh B 658-658 disorder
       Region 6jeh B 659-781 order
       Region 6jeh B 782-782 disorder
 Evidence X-RAY 7p2b A Reference
       Region 7p2b A 28-55 disorder
       Region 7p2b A 56-180 order
       Region 7p2b A 181-183 disorder
       Region 7p2b A 184-286 order
       Region 7p2b A 287-289 disorder
       Region 7p2b A 290-305 order
       Region 7p2b A 306-308 disorder
       Region 7p2b A 309-781 order
       Region 7p2b A 782-782 disorder
 Evidence X-RAY 7p2b B Reference
       Region 7p2b B 28-55 disorder
       Region 7p2b B 56-284 order
       Region 7p2b B 285-290 disorder
       Region 7p2b B 291-305 order
       Region 7p2b B 306-307 disorder
       Region 7p2b B 308-398 order
       Region 7p2b B 399-407 disorder
       Region 7p2b B 408-781 order
       Region 7p2b B 782-782 disorder
 Evidence X-RAY 6q9r A Reference
       Region 6q9r A 28-57 disorder
       Region 6q9r A 58-179 order
       Region 6q9r A 180-183 disorder
       Region 6q9r A 184-285 order
       Region 6q9r A 286-288 disorder
       Region 6q9r A 289-306 order
       Region 6q9r A 307-308 disorder
       Region 6q9r A 309-781 order
       Region 6q9r A 782-782 disorder
 Evidence X-RAY 6q9r B Reference
       Region 6q9r B 28-57 disorder
       Region 6q9r B 58-285 order
       Region 6q9r B 286-289 disorder
       Region 6q9r B 290-305 order
       Region 6q9r B 306-306 disorder
       Region 6q9r B 307-400 order
       Region 6q9r B 401-404 disorder
       Region 6q9r B 405-779 order
       Region 6q9r B 780-782 disorder
 Evidence X-RAY 6q9z A Reference
       Region 6q9z A 28-55 disorder
       Region 6q9z A 56-181 order
       Region 6q9z A 182-184 disorder
       Region 6q9z A 185-285 order
       Region 6q9z A 286-290 disorder
       Region 6q9z A 291-305 order
       Region 6q9z A 306-307 disorder
       Region 6q9z A 308-595 order
       Region 6q9z A 596-597 disorder
       Region 6q9z A 598-625 order
       Region 6q9z A 626-627 disorder
       Region 6q9z A 628-644 order
       Region 6q9z A 645-648 disorder
       Region 6q9z A 649-781 order
       Region 6q9z A 782-782 disorder
 Evidence X-RAY 6q9z B Reference
       Region 6q9z B 28-55 disorder
       Region 6q9z B 56-284 order
       Region 6q9z B 285-290 disorder
       Region 6q9z B 291-400 order
       Region 6q9z B 401-404 disorder
       Region 6q9z B 405-781 order
       Region 6q9z B 782-782 disorder
 Evidence X-RAY 6qbf A Reference
       Region 6qbf A 28-53 disorder
       Region 6qbf A 54-181 order
       Region 6qbf A 182-183 disorder
       Region 6qbf A 184-285 order
       Region 6qbf A 286-290 disorder
       Region 6qbf A 291-305 order
       Region 6qbf A 306-307 disorder
       Region 6qbf A 308-399 order
       Region 6qbf A 400-404 disorder
       Region 6qbf A 405-781 order
       Region 6qbf A 782-782 disorder
 Evidence X-RAY 6qbf B Reference
       Region 6qbf B 28-54 disorder
       Region 6qbf B 55-180 order
       Region 6qbf B 181-183 disorder
       Region 6qbf B 184-285 order
       Region 6qbf B 286-289 disorder
       Region 6qbf B 290-306 order
       Region 6qbf B 307-308 disorder
       Region 6qbf B 309-557 order
       Region 6qbf B 558-559 disorder
       Region 6qbf B 560-600 order
       Region 6qbf B 601-601 disorder
       Region 6qbf B 602-781 order
       Region 6qbf B 782-782 disorder
Seq 52-176 Hetero tetramer : IID50082Complex,P28289,P29536
 Evidence X-RAY 4z94 G Reference
       Region 4z94 G 52-176 order
Seq 52-176 Hetero trimer : IID50082Complex,P28289
 Evidence X-RAY 4pkh B Reference
       Region 4pkh B 52-53 disorder
       Region 4pkh B 54-176 order
Seq 52-176 Hetero trimer : IID50082Complex,P28289
 Evidence X-RAY 4pkh G Reference
       Region 4pkh G 52-176 order
Seq 52-176 Hetero trimer : IID50082Complex,P28289
 Evidence X-RAY 4pkg G Reference
       Region 4pkg G 52-176 order
Seq 52-176 Hetero trimer : IID50082Complex
 Evidence X-RAY 3cjc G Reference
       Region 3cjc G 52-176 order
Seq 52-176 Hetero dimer : P07830
 Evidence X-RAY 3a5l S Reference
       Region 3a5l S 53-53 disorder
       Region 3a5l S 54-176 order
 Evidence X-RAY 3a5m S Reference
       Region 3a5m S 53-53 disorder
       Region 3a5m S 54-176 order
 Evidence X-RAY 3a5n S Reference
       Region 3a5n S 53-53 disorder
       Region 3a5n S 54-176 order
 Evidence X-RAY 3a5o S Reference
       Region 3a5o S 53-53 disorder
       Region 3a5o S 54-176 order
 Evidence X-RAY 1c0f S Reference
       Region 1c0f S 53-176 order
 Evidence X-RAY 1c0g S Reference
       Region 1c0g S 53-176 order
 Evidence X-RAY 3ci5 G Reference
       Region 3ci5 G 52-176 order
 Evidence X-RAY 3cip G Reference
       Region 3cip G 52-176 order
 Evidence X-RAY 1nlv G Reference
       Region 1nlv G 52-53 disorder
       Region 1nlv G 54-176 order
 Evidence X-RAY 1nm1 G Reference
       Region 1nm1 G 52-53 disorder
       Region 1nm1 G 54-176 order
 Evidence X-RAY 1nmd G Reference
       Region 1nmd G 52-53 disorder
       Region 1nmd G 54-176 order
Seq 52-176 Hetero hexamer : P68139
 Evidence X-RAY 1mdu A Reference
       Region 1mdu A 52-52 disorder
       Region 1mdu A 53-176 order
 Evidence X-RAY 1mdu D Reference
       Region 1mdu D 52-53 disorder
       Region 1mdu D 54-176 order
Seq 52-176 Hetero trimer : IID50082Complex,P28289
 Evidence X-RAY 4pki G Reference
       Region 4pki G 52-176 order
Seq 52-176 Hetero dimer : P60010
 Evidence X-RAY 1yvn G Reference
       Region 1yvn G 52-176 order
 Evidence X-RAY 1yag G Reference
       Region 1yag G 52-176 order
Seq 52-177 Hetero dimer : P0DM41
 Evidence X-RAY 1d4x G Reference
       Region 1d4x G 52-53 disorder
       Region 1d4x G 54-177 order
Seq 52-179 Hetero trimer : IID00256Complex,IID50082Complex
 Evidence X-RAY 2ff3 A Reference
       Region 2ff3 A 52-54 disorder
       Region 2ff3 A 55-179 order
Seq 52-179 Hetero trimer : IID50082Complex,Q8IRS7
 Evidence X-RAY 2ff6 G Reference
       Region 2ff6 G 52-54 disorder
       Region 2ff6 G 55-179 order
Seq 52-187 Hetero dimer : IID50082Complex
 Evidence X-RAY 3cjb G Reference
       Region 3cjb G 52-176 order
 Evidence X-RAY 1eqy S Reference
       Region 1eqy S 52-176 order
 Evidence X-RAY 1esv S Reference
       Region 1esv S 52-176 order
 Evidence X-RAY 1p8z G Reference
       Region 1p8z G 52-52 disorder
       Region 1p8z G 53-183 order
       Region 1p8z G 184-187 disorder
 Evidence X-RAY 4pkh E Reference
       Region 4pkh E 52-52 disorder
       Region 4pkh E 53-176 order
 Evidence X-RAY 4pkh J Reference
       Region 4pkh J 52-176 order
 Evidence X-RAY 5ubo S Reference
       Region 5ubo S 52-53 disorder
       Region 5ubo S 54-178 order
Seq 52-426 Hetero dimer : IID50082Complex
 Evidence X-RAY 3ffk A Reference
       Region 3ffk A 52-54 disorder
       Region 3ffk A 55-401 order
       Region 3ffk A 402-426 disorder
 Evidence X-RAY 3ffk D Reference
       Region 3ffk D 52-53 disorder
       Region 3ffk D 54-399 order
       Region 3ffk D 400-426 disorder
Seq 53-174 Hetero trimer : IID50082Complex,Q5NBX1
 Evidence X-RAY 3tu5 B Reference
       Region 3tu5 B 53-174 order
Seq 53-176 Hetero dimer : P10992
 Evidence X-RAY 1dej S Reference
       Region 1dej S 53-176 order
Seq 55-179 Hetero trimer : IID50082Complex,P20065
 Evidence X-RAY 1t44 G Reference
       Region 1t44 G 55-179 order
Seq 55-187 Monomer :
 Evidence NMR 5h3m A Reference
       Region 5h3m A 55-187 order
       Region 5h3m A 55-56 high_rmsd
       Region 5h3m A 105-106 high_rmsd
       Region 5h3m A 172-187 high_rmsd
 Evidence NMR 5h3n A Reference
       Region 5h3n A 55-187 order
       Region 5h3n A 55-55 high_rmsd
       Region 5h3n A 171-187 high_rmsd
Seq 55-188 Homo dimer :
 Evidence X-RAY 5zz0 G Reference
       Region 5zz0 G 55-55 disorder
       Region 5zz0 G 56-177 order
       Region 5zz0 G 178-188 disorder
 Evidence X-RAY 5zz0 A Reference
       Region 5zz0 A 55-177 order
       Region 5zz0 A 178-188 disorder
Seq 177-196 Monomer :
 Evidence NMR 1sol A Reference
       Region 1sol A 177-196 order
Seq 178-293 Monomer :
 Evidence X-RAY 5fae A Reference
       Region 5fae A 178-182 order
       Region 5fae A 183-184 disorder
       Region 5fae A 185-284 order
       Region 5fae A 285-293 disorder
 Evidence X-RAY 5faf A Reference
       Region 5faf A 178-287 order
       Region 5faf A 288-293 disorder
 Evidence X-RAY 1kcq A Reference
       Region 1kcq A 185-185 disorder
       Region 1kcq A 186-288 order
 Evidence X-RAY 6qw3 A Reference
       Region 6qw3 A 178-184 disorder
       Region 6qw3 A 185-293 order
Seq 178-293 Hetero dimer :
 Evidence X-RAY 6h1f B Reference
       Region 6h1f B 178-183 disorder
       Region 6h1f B 184-285 order
       Region 6h1f B 286-293 disorder
Seq 178-293 Homo dimer :
 Evidence X-RAY 5o2z B Reference
       Region 5o2z B 178-285 order
       Region 5o2z B 286-293 disorder
 Evidence X-RAY 5o2z A Reference
       Region 5o2z A 178-180 disorder
       Region 5o2z A 181-284 order
       Region 5o2z A 285-293 disorder
Seq 186-288 Hetero dimer :
 Evidence X-RAY 4s10 D Reference
       Region 4s10 D 186-186 disorder
       Region 4s10 D 187-288 order
Seq 186-288 Hetero dimer :
 Evidence X-RAY 4s10 C Reference
       Region 4s10 C 186-286 order
       Region 4s10 C 287-288 disorder
Seq 297-397 Homo dimer :
 Evidence X-RAY 6ljf B Reference
       Region 6ljf B 297-397 order
 Evidence X-RAY 6ljf A Reference
       Region 6ljf A 297-397 order
 Evidence X-RAY 6lje B Reference
       Region 6lje B 297-397 order
 Evidence X-RAY 6lje A Reference
       Region 6lje A 297-397 order
Seq 439-769 Hetero dimer : IID50082Complex
 Evidence X-RAY 1h1v G Reference
       Region 1h1v G 439-482 order
       Region 1h1v G 483-486 disorder
       Region 1h1v G 487-769 order
Seq 439-782 Monomer :
 Evidence X-RAY 2fh1 A Reference
       Region 2fh1 A 439-662 order
       Region 2fh1 A 663-664 disorder
       Region 2fh1 A 665-734 order
       Region 2fh1 A 735-741 disorder
       Region 2fh1 A 742-768 order
       Region 2fh1 A 769-782 disorder
 Evidence X-RAY 2fh1 B Reference
       Region 2fh1 B 439-440 disorder
       Region 2fh1 B 441-481 order
       Region 2fh1 B 482-485 disorder
       Region 2fh1 B 486-768 order
       Region 2fh1 B 769-782 disorder
 Evidence X-RAY 2fh1 C Reference
       Region 2fh1 C 439-440 disorder
       Region 2fh1 C 441-480 order
       Region 2fh1 C 481-486 disorder
       Region 2fh1 C 487-768 order
       Region 2fh1 C 769-782 disorder
 Evidence X-RAY 2fh2 A Reference
       Region 2fh2 A 439-662 order
       Region 2fh2 A 663-664 disorder
       Region 2fh2 A 665-734 order
       Region 2fh2 A 735-741 disorder
       Region 2fh2 A 742-768 order
       Region 2fh2 A 769-782 disorder
 Evidence X-RAY 2fh2 B Reference
       Region 2fh2 B 439-440 disorder
       Region 2fh2 B 441-481 order
       Region 2fh2 B 482-485 disorder
       Region 2fh2 B 486-768 order
       Region 2fh2 B 769-782 disorder
 Evidence X-RAY 2fh2 C Reference
       Region 2fh2 C 439-440 disorder
       Region 2fh2 C 441-480 order
       Region 2fh2 C 481-486 disorder
       Region 2fh2 C 487-768 order
       Region 2fh2 C 769-782 disorder
 Evidence X-RAY 2fh3 A Reference
       Region 2fh3 A 439-662 order
       Region 2fh3 A 663-664 disorder
       Region 2fh3 A 665-734 order
       Region 2fh3 A 735-741 disorder
       Region 2fh3 A 742-768 order
       Region 2fh3 A 769-782 disorder
 Evidence X-RAY 2fh3 B Reference
       Region 2fh3 B 439-440 disorder
       Region 2fh3 B 441-481 order
       Region 2fh3 B 482-485 disorder
       Region 2fh3 B 486-768 order
       Region 2fh3 B 769-782 disorder
 Evidence X-RAY 2fh3 C Reference
       Region 2fh3 C 439-440 disorder
       Region 2fh3 C 441-480 order
       Region 2fh3 C 481-486 disorder
       Region 2fh3 C 487-768 order
       Region 2fh3 C 769-782 disorder
 Evidence X-RAY 2fh4 A Reference
       Region 2fh4 A 439-552 order
       Region 2fh4 A 553-556 disorder
       Region 2fh4 A 557-662 order
       Region 2fh4 A 663-664 disorder
       Region 2fh4 A 665-672 order
       Region 2fh4 A 673-682 disorder
       Region 2fh4 A 683-734 order
       Region 2fh4 A 735-741 disorder
       Region 2fh4 A 742-768 order
       Region 2fh4 A 769-782 disorder
 Evidence X-RAY 2fh4 B Reference
       Region 2fh4 B 439-440 disorder
       Region 2fh4 B 441-481 order
       Region 2fh4 B 482-485 disorder
       Region 2fh4 B 486-551 order
       Region 2fh4 B 552-556 disorder
       Region 2fh4 B 557-768 order
       Region 2fh4 B 769-782 disorder
 Evidence X-RAY 2fh4 C Reference
       Region 2fh4 C 439-440 disorder
       Region 2fh4 C 441-480 order
       Region 2fh4 C 481-486 disorder
       Region 2fh4 C 487-552 order
       Region 2fh4 C 553-556 disorder
       Region 2fh4 C 557-768 order
       Region 2fh4 C 769-782 disorder
 Evidence X-RAY 1p8x A Reference
       Region 1p8x A 439-662 order
       Region 1p8x A 663-664 disorder
       Region 1p8x A 665-672 order
       Region 1p8x A 673-682 disorder
       Region 1p8x A 683-734 order
       Region 1p8x A 735-736 disorder
       Region 1p8x A 737-768 order
       Region 1p8x A 769-782 disorder
 Evidence X-RAY 1p8x B Reference
       Region 1p8x B 439-440 disorder
       Region 1p8x B 441-482 order
       Region 1p8x B 483-485 disorder
       Region 1p8x B 486-768 order
       Region 1p8x B 769-782 disorder
 Evidence X-RAY 1p8x C Reference
       Region 1p8x C 439-440 disorder
       Region 1p8x C 441-482 order
       Region 1p8x C 483-486 disorder
       Region 1p8x C 487-768 order
       Region 1p8x C 769-782 disorder
Seqphosphorylation
    742-742 Phosphothreonine
    651-651 Phosphotyrosine; by SRC; in vitro
    409-409 Phosphotyrosine; by SRC; in vitro
    603-603 Phosphotyrosine; by SRC; in vitro
    465-465 Phosphotyrosine; by SRC
    86-86 Phosphotyrosine; by SRC; in vitro
Seqacetylation
    584-584 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-56,404-433,552-558
Order 57-403,434-551,559-657,662-782
ProS 7-22,40-46,404-426,552-558
AlphaFold
Disorder 1-54,285-292,306-308,400-406
Order 55-284,293-305,309-399,407-782
Pfam Hmmer
PF00626 75-158 2.1e-24
PF00626 196-271 3.8e-24
PF00626 312-390 1.3e-21
PF00626 454-536 5.8e-27
PF00626 574-642 5.8e-10
PF00626 679-757 3.6e-23
SEG 6-24
Function
Function in SwissProt
Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed (PubMed:19666512). Plays a role in ciliogenesis (PubMed:20393563).