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IID00269  Wiskott-Aldrich syndrome protein (Homo sapiens) P42768
  :order  :disorder  :conflict  :PDB cluster  :ProS  :SCOP Domain  :Pfam Domain
Networkxml
Experiment
502
fasta
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 230-288 Hetero dimer : IID00308Complex
 Evidence NMR 1cee B Reference
       Region 1cee B 230-288 order
Seq 242-310 Hetero dimer : IID90008Complex
 Evidence NMR 2k42 A Reference
       Region 2k42 A 242-310 order
       Region 2k42 A 242-244 high_rmsd
Seq 242-310,461-492 Hetero dimer :
 Evidence NMR 1ej5 A Reference
       Region 1ej5 A 242-310 order
       Region 1ej5 A 461-492 order
Seq 242-310,461-492 Hetero dimer :
 Evidence NMR 1t84 A Reference
       Region 1t84 A 242-310 order
       Region 1t84 A 242-248 high_rmsd
       Region 1t84 A 461-492 order
       Region 1t84 A 461-462 high_rmsd
       Region 1t84 A 481-492 high_rmsd
Seq 430-458 Hetero trimer : IID50082Complex
 Evidence X-RAY 2a3z C Reference
       Region 2a3z C 430-430 disorder
       Region 2a3z C 431-447 order
       Region 2a3z C 448-458 disorder
Seqdisorder 230-310,461-492
 Evidence NMR¸ CD Reference
       Region 230-310 disorder
       Region 461-492 disorder
Seq 488-502 Hetero octamer : P00883
 Evidence X-RAY 2ot0 E Reference
       Region 2ot0 E 488-497 disorder
       Region 2ot0 E 498-501 order
       Region 2ot0 E 502-502 disorder
 Evidence X-RAY 2ot0 F Reference
       Region 2ot0 F 488-497 disorder
       Region 2ot0 F 498-501 order
       Region 2ot0 F 502-502 disorder
 Evidence X-RAY 2ot0 G Reference
       Region 2ot0 G 488-497 disorder
       Region 2ot0 G 498-501 order
       Region 2ot0 G 502-502 disorder
 Evidence X-RAY 2ot0 H Reference
       Region 2ot0 H 488-497 disorder
       Region 2ot0 H 498-501 order
       Region 2ot0 H 502-502 disorder
SeqProS verified 230-288 Hetero dimer : IID00308Complex
       Region 1cee B 230-288 order
       Region 230-310 disorder
SeqProS verified 242-310 Hetero dimer : IID90008Complex
       Region 2k42 A 242-310 order
       Region 230-310 disorder
SeqProS verified 242-310,461-492 This region takes an ordered structure when it binds upon another region of this protein, which inhibits the binding upon Cdc42. Hetero dimer :
       Region 1ej5 A 242-310 order
       Region 1ej5 A 461-492 order
       Region 230-310 disorder
       Region 461-492 disorder
SeqProS verified 242-310,461-492 This region takes an ordered structure when it binds upon another region of this protein, which inhibits the binding upon Cdc42. Hetero dimer :
       Region 1t84 A 242-310 order
       Region 1t84 A 461-492 order
       Region 230-310 disorder
       Region 461-492 disorder
SeqProS verified 431-447 This region is described to be disordered in the free state. (PubMed=10724160) Hetero trimer : IID50082Complex
       Region 2a3z C 431-447 order
Seqphosphorylation
    221-221 Phosphoserine
    291-291 Phosphotyrosine; by FYN and HCK
    483-483 Phosphoserine; by CK2
    484-484 Phosphoserine; by CK2
 
Prediction
DICHOT
Disorder 1-34,149-238,311-429,491-502
Known Domain 35-148,239-310,430-490
SCOPe RPS-Blast
     1mkeA1 35-148 2e-44 b.55.1.4 Actin regulatory protein WASP
     1ej5A 242-320 8e-19 a.68.1.1 Wiscott-Aldrich syndrome protein, WASP,...
     1rmgA 363-426 3e-04 b.80.1.3 Polygalacturonase
SCOP Hmmer
     1mkeA1 35-148 6.8e-42 b.55.1.4 Actin regulatory...
     1ej5A_ 242-371 2.9e-33 a.68.1.1 Wiscott-Aldrich...
     1ej5A_ 430-490 4.9e-15 a.68.1.1 Wiscott-Aldrich...
Pfam RPS-Blast
     PF00568 38-144 1e-28 WH1 domain
     PF00786 239-294 4e-06 P21-Rho-binding domain
     PF15782 276-436 3e-07 Gene regulated by oestrogen...
Pfam Hmmer
    PF00568 36-144 1.1e-46 WH1 domain
    PF00786 237-294 8.1e-21 P21-Rho-binding domain
    PF02205 427-454 2.7e-12 WH2 motif