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IID00270
 UniprotP45983
ProteinMitogen-activated protein kinase 8
GeneMAPK8
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
427
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-363 Hetero dimer : Q9BY84
 Evidence X-RAY 4yr8 E Reference
       Region 4yr8 E 1-6 disorder
       Region 4yr8 E 7-32 order
       Region 4yr8 E 33-37 disorder
       Region 4yr8 E 38-174 order
       Region 4yr8 E 175-186 disorder
       Region 4yr8 E 187-330 order
       Region 4yr8 E 331-352 disorder
       Region 4yr8 E 353-362 order
       Region 4yr8 E 363-363 disorder
 Evidence X-RAY 4yr8 A Reference
       Region 4yr8 A 1-7 disorder
       Region 4yr8 A 8-33 order
       Region 4yr8 A 34-37 disorder
       Region 4yr8 A 38-173 order
       Region 4yr8 A 174-186 disorder
       Region 4yr8 A 187-330 order
       Region 4yr8 A 331-348 disorder
       Region 4yr8 A 349-362 order
       Region 4yr8 A 363-363 disorder
 Evidence X-RAY 4yr8 C Reference
       Region 4yr8 C 1-9 disorder
       Region 4yr8 C 10-13 order
       Region 4yr8 C 14-16 disorder
       Region 4yr8 C 17-33 order
       Region 4yr8 C 34-38 disorder
       Region 4yr8 C 39-171 order
       Region 4yr8 C 172-187 disorder
       Region 4yr8 C 188-339 order
       Region 4yr8 C 340-350 disorder
       Region 4yr8 C 351-362 order
       Region 4yr8 C 363-363 disorder
 Evidence X-RAY 4yr8 F Reference
       Region 4yr8 F 1-9 disorder
       Region 4yr8 F 10-33 order
       Region 4yr8 F 34-37 disorder
       Region 4yr8 F 38-45 order
       Region 4yr8 F 46-49 disorder
       Region 4yr8 F 50-57 order
       Region 4yr8 F 58-59 disorder
       Region 4yr8 F 60-93 order
       Region 4yr8 F 94-103 disorder
       Region 4yr8 F 104-171 order
       Region 4yr8 F 172-187 disorder
       Region 4yr8 F 188-283 order
       Region 4yr8 F 284-285 disorder
       Region 4yr8 F 286-338 order
       Region 4yr8 F 339-353 disorder
       Region 4yr8 F 354-362 order
       Region 4yr8 F 363-363 disorder
Seq 1-364 Monomer :
 Evidence X-RAY 4awi A Reference
       Region 4awi A 1-7 disorder
       Region 4awi A 8-173 order
       Region 4awi A 174-178 disorder
       Region 4awi A 179-364 order
 Evidence X-RAY 3elj A Reference
       Region 3elj A 1-6 disorder
       Region 3elj A 7-172 order
       Region 3elj A 173-178 disorder
       Region 3elj A 179-338 order
       Region 3elj A 339-343 disorder
       Region 3elj A 344-364 order
 Evidence X-RAY 4l7f A Reference
       Region 4l7f A 7-172 order
       Region 4l7f A 173-185 disorder
       Region 4l7f A 186-362 order
 Evidence X-RAY 3pze A Reference
       Region 3pze A 7-172 order
       Region 3pze A 173-178 disorder
       Region 3pze A 179-183 order
       Region 3pze A 184-186 disorder
       Region 3pze A 187-362 order
       Region 3pze A 363-364 disorder
 Evidence X-RAY 4qtd A Reference
       Region 4qtd A 1-5 disorder
       Region 4qtd A 6-175 order
       Region 4qtd A 176-178 disorder
       Region 4qtd A 179-363 order
Seq 1-364 Hetero tetramer : IID50056Complex
 Evidence X-RAY 3o17 B Reference
       Region 3o17 B 1-6 disorder
       Region 3o17 B 7-363 order
       Region 3o17 B 364-364 disorder
 Evidence X-RAY 3o17 A Reference
       Region 3o17 A 1-6 disorder
       Region 3o17 A 7-363 order
       Region 3o17 A 364-364 disorder
Seq 1-364 Hetero dimer :
 Evidence X-RAY 2no3 A Reference
       Region 2no3 A 1-7 disorder
       Region 2no3 A 8-364 order
Seq 1-364 Hetero dimer :
 Evidence X-RAY 2no3 B Reference
       Region 2no3 B 1-6 disorder
       Region 2no3 B 7-363 order
       Region 2no3 B 364-364 disorder
Seq 1-364 Hetero dimer : IID00227Complex
 Evidence X-RAY 4e73 A Reference
       Region 4e73 A 1-7 disorder
       Region 4e73 A 8-173 order
       Region 4e73 A 174-188 disorder
       Region 4e73 A 189-281 order
       Region 4e73 A 282-289 disorder
       Region 4e73 A 290-331 order
       Region 4e73 A 332-344 disorder
       Region 4e73 A 345-361 order
       Region 4e73 A 362-363 disorder
 Evidence X-RAY 2g01 A Reference
       Region 2g01 A 1-9 disorder
       Region 2g01 A 10-364 order
 Evidence X-RAY 2g01 B Reference
       Region 2g01 B 1-8 disorder
       Region 2g01 B 9-364 order
 Evidence X-RAY 2gmx A Reference
       Region 2gmx A 1-7 disorder
       Region 2gmx A 8-364 order
 Evidence X-RAY 2gmx B Reference
       Region 2gmx B 1-6 disorder
       Region 2gmx B 7-363 order
       Region 2gmx B 364-364 disorder
 Evidence X-RAY 2h96 A Reference
       Region 2h96 A 1-6 disorder
       Region 2h96 A 7-364 order
 Evidence X-RAY 2h96 B Reference
       Region 2h96 B 1-6 disorder
       Region 2h96 B 7-363 order
       Region 2h96 B 364-364 disorder
 Evidence X-RAY 4hys A Reference
       Region 4hys A 1-7 disorder
       Region 4hys A 8-172 order
       Region 4hys A 173-187 disorder
       Region 4hys A 188-281 order
       Region 4hys A 282-289 disorder
       Region 4hys A 290-334 order
       Region 4hys A 335-344 disorder
       Region 4hys A 345-361 order
       Region 4hys A 362-363 disorder
 Evidence X-RAY 4hyu A Reference
       Region 4hyu A 1-7 disorder
       Region 4hyu A 8-172 order
       Region 4hyu A 173-187 disorder
       Region 4hyu A 188-281 order
       Region 4hyu A 282-288 disorder
       Region 4hyu A 289-334 order
       Region 4hyu A 335-344 disorder
       Region 4hyu A 345-361 order
       Region 4hyu A 362-363 disorder
 Evidence X-RAY 4izy A Reference
       Region 4izy A 1-7 disorder
       Region 4izy A 8-172 order
       Region 4izy A 173-187 disorder
       Region 4izy A 188-281 order
       Region 4izy A 282-288 disorder
       Region 4izy A 289-334 order
       Region 4izy A 335-344 disorder
       Region 4izy A 345-361 order
       Region 4izy A 362-363 disorder
 Evidence X-RAY 3vud A Reference
       Region 3vud A 1-6 disorder
       Region 3vud A 7-179 order
       Region 3vud A 180-182 disorder
       Region 3vud A 183-364 order
 Evidence X-RAY 3vug A Reference
       Region 3vug A 1-6 disorder
       Region 3vug A 7-179 order
       Region 3vug A 180-182 disorder
       Region 3vug A 183-364 order
 Evidence X-RAY 3vuh A Reference
       Region 3vuh A 1-6 disorder
       Region 3vuh A 7-179 order
       Region 3vuh A 180-182 disorder
       Region 3vuh A 183-364 order
 Evidence X-RAY 3vui A Reference
       Region 3vui A 1-6 disorder
       Region 3vui A 7-179 order
       Region 3vui A 180-182 disorder
       Region 3vui A 183-364 order
 Evidence X-RAY 3vuk A Reference
       Region 3vuk A 1-6 disorder
       Region 3vuk A 7-179 order
       Region 3vuk A 180-182 disorder
       Region 3vuk A 183-364 order
 Evidence X-RAY 3vul A Reference
       Region 3vul A 1-6 disorder
       Region 3vul A 7-174 order
       Region 3vul A 175-188 disorder
       Region 3vul A 189-364 order
 Evidence X-RAY 3vum A Reference
       Region 3vum A 1-6 disorder
       Region 3vum A 7-174 order
       Region 3vum A 175-188 disorder
       Region 3vum A 189-364 order
 Evidence X-RAY 4g1w A Reference
       Region 4g1w A 1-7 disorder
       Region 4g1w A 8-172 order
       Region 4g1w A 173-187 disorder
       Region 4g1w A 188-281 order
       Region 4g1w A 282-288 disorder
       Region 4g1w A 289-334 order
       Region 4g1w A 335-344 disorder
       Region 4g1w A 345-361 order
       Region 4g1w A 362-363 disorder
Seq 1-364 Hetero octamer : O14733
 Evidence X-RAY 4ux9 D Reference
       Region 4ux9 D 1-8 disorder
       Region 4ux9 D 9-32 order
       Region 4ux9 D 33-38 disorder
       Region 4ux9 D 39-283 order
       Region 4ux9 D 284-286 disorder
       Region 4ux9 D 287-339 order
       Region 4ux9 D 340-342 disorder
       Region 4ux9 D 343-364 order
 Evidence X-RAY 4ux9 C Reference
       Region 4ux9 C 1-7 disorder
       Region 4ux9 C 8-35 order
       Region 4ux9 C 36-36 disorder
       Region 4ux9 C 37-177 order
       Region 4ux9 C 178-184 disorder
       Region 4ux9 C 185-281 order
       Region 4ux9 C 282-288 disorder
       Region 4ux9 C 289-338 order
       Region 4ux9 C 339-346 disorder
       Region 4ux9 C 347-363 order
       Region 4ux9 C 364-364 disorder
 Evidence X-RAY 4ux9 B Reference
       Region 4ux9 B 1-7 disorder
       Region 4ux9 B 8-34 order
       Region 4ux9 B 35-38 disorder
       Region 4ux9 B 39-177 order
       Region 4ux9 B 178-183 disorder
       Region 4ux9 B 184-284 order
       Region 4ux9 B 285-288 disorder
       Region 4ux9 B 289-338 order
       Region 4ux9 B 339-352 disorder
       Region 4ux9 B 353-362 order
       Region 4ux9 B 363-364 disorder
 Evidence X-RAY 4ux9 A Reference
       Region 4ux9 A 1-7 disorder
       Region 4ux9 A 8-36 order
       Region 4ux9 A 37-37 disorder
       Region 4ux9 A 38-58 order
       Region 4ux9 A 59-59 disorder
       Region 4ux9 A 60-178 order
       Region 4ux9 A 179-183 disorder
       Region 4ux9 A 184-338 order
       Region 4ux9 A 339-344 disorder
       Region 4ux9 A 345-363 order
       Region 4ux9 A 364-364 disorder
Seq 1-366 Hetero dimer : IID50056Complex
 Evidence X-RAY 3o2m A Reference
       Region 3o2m A 1-6 disorder
       Region 3o2m A 7-364 order
 Evidence X-RAY 3o2m B Reference
       Region 3o2m B 1-6 disorder
       Region 3o2m B 7-364 order
 Evidence X-RAY 1ukh A Reference
       Region 1ukh A 1-8 disorder
       Region 1ukh A 9-172 order
       Region 1ukh A 173-189 disorder
       Region 1ukh A 190-281 order
       Region 1ukh A 282-286 disorder
       Region 1ukh A 287-336 order
       Region 1ukh A 337-348 disorder
       Region 1ukh A 349-363 order
 Evidence X-RAY 1uki A Reference
       Region 1uki A 1-8 disorder
       Region 1uki A 9-174 order
       Region 1uki A 175-187 disorder
       Region 1uki A 188-281 order
       Region 1uki A 282-286 disorder
       Region 1uki A 287-337 order
       Region 1uki A 338-346 disorder
       Region 1uki A 347-363 order
 Evidence X-RAY 3v3v A Reference
       Region 3v3v A 1-6 disorder
       Region 3v3v A 7-179 order
       Region 3v3v A 180-183 disorder
       Region 3v3v A 184-286 order
       Region 3v3v A 287-288 disorder
       Region 3v3v A 289-363 order
       Region 3v3v A 364-366 disorder
Seq 1-379 Hetero dimer : IID00466Complex
 Evidence X-RAY 2xs0 A Reference
       Region 2xs0 A 1-5 disorder
       Region 2xs0 A 6-173 order
       Region 2xs0 A 174-187 disorder
       Region 2xs0 A 188-365 order
       Region 2xs0 A 366-379 disorder
 Evidence X-RAY 2xrw A Reference
       Region 2xrw A 2-172 order
       Region 2xrw A 173-188 disorder
       Region 2xrw A 189-364 order
Seq 2-363 Hetero trimer : IID00227Complex
 Evidence X-RAY 5lw1 H Reference
       Region 5lw1 H 2-7 disorder
       Region 5lw1 H 8-362 order
       Region 5lw1 H 363-363 disorder
Seq 2-363 Hetero trimer : IID50056Complex
 Evidence X-RAY 6f5e B Reference
       Region 6f5e B 2-6 disorder
       Region 6f5e B 7-32 order
       Region 6f5e B 33-38 disorder
       Region 6f5e B 39-181 order
       Region 6f5e B 182-185 disorder
       Region 6f5e B 186-362 order
       Region 6f5e B 363-363 disorder
Seq 2-363 Hetero trimer : IID00227Complex
 Evidence X-RAY 5lw1 B Reference
       Region 5lw1 B 2-7 disorder
       Region 5lw1 B 8-362 order
       Region 5lw1 B 363-363 disorder
Seq 2-363 Hetero trimer : IID00227Complex
 Evidence X-RAY 5lw1 E Reference
       Region 5lw1 E 2-7 disorder
       Region 5lw1 E 8-362 order
       Region 5lw1 E 363-363 disorder
Seqphosphorylation
    301-301 Phosphoserine
    377-377 Phosphoserine
    377-377 Phosphoserine
    183-183 Phosphothreonine; by MAP2K7
    185-185 Phosphotyrosine; by MAP2K4
    377-377 Phosphoserine
 
Prediction
NeProc
Disorder 1-5,370-427
Order 6-369
ProS 370-373,422-427
AlphaFold
Disorder 1-7,170-187,338-338,340-340,368-427
Order 8-169,188-337,339-339,341-367
Pfam Hmmer
PF00069 26-321 1.9e-75
SEG 387-403
Function
Function in SwissProt
JNK1 isoforms display different binding patterns: beta-1 preferentially binds to c-Jun, whereas alpha-1, alpha-2, and beta-2 have a similar low level of binding to both c-Jun or ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms.
Biological Process
See also
Diagram with PDB data
TP53/EP300Structural Basis for the Regulation of p53 Function by p300
TP53/CREBBPNMR Structure of CBP Bromodomain in complex with p53 peptide
TP53/SETD7Crystal structure of a ternary complex of the methyltransferase SET9 (also known as SET7/9) with a P53 peptide and SAH
TP53/SMYD2Structure of SMYD2 in complex with p53 and SAH
TP53/MDM2Crystal Structure of an MDM2/P53 Peptide Complex
NEATC3/MAPK8Linear binding motifs for JNK and for calcineurin antagonistically control the nuclear shuttling of NFAT4
Diagram without PDB data
FOXO4Stress signals in FOXO regulation