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IID00270  Mitogen-activated protein kinase 8 (Homo sapiens) P45983
  :order  :disorder  :conflict  :PDB cluster  :ProS  :SCOP Domain  :Pfam Domain
Networkxml
Experiment
427
fasta
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-363 Hetero dimer : Q9BY84
 Evidence X-RAY 4yr8 E Reference
       Region 4yr8 E 1-6 disorder
       Region 4yr8 E 7-32 order
       Region 4yr8 E 33-37 disorder
       Region 4yr8 E 38-174 order
       Region 4yr8 E 175-186 disorder
       Region 4yr8 E 187-330 order
       Region 4yr8 E 331-352 disorder
       Region 4yr8 E 353-362 order
       Region 4yr8 E 363-363 disorder
 Evidence X-RAY 4yr8 A Reference
       Region 4yr8 A 1-7 disorder
       Region 4yr8 A 8-33 order
       Region 4yr8 A 34-37 disorder
       Region 4yr8 A 38-173 order
       Region 4yr8 A 174-186 disorder
       Region 4yr8 A 187-330 order
       Region 4yr8 A 331-348 disorder
       Region 4yr8 A 349-362 order
       Region 4yr8 A 363-363 disorder
 Evidence X-RAY 4yr8 C Reference
       Region 4yr8 C 1-9 disorder
       Region 4yr8 C 10-13 order
       Region 4yr8 C 14-16 disorder
       Region 4yr8 C 17-33 order
       Region 4yr8 C 34-38 disorder
       Region 4yr8 C 39-171 order
       Region 4yr8 C 172-187 disorder
       Region 4yr8 C 188-339 order
       Region 4yr8 C 340-350 disorder
       Region 4yr8 C 351-362 order
       Region 4yr8 C 363-363 disorder
 Evidence X-RAY 4yr8 F Reference
       Region 4yr8 F 1-9 disorder
       Region 4yr8 F 10-33 order
       Region 4yr8 F 34-37 disorder
       Region 4yr8 F 38-45 order
       Region 4yr8 F 46-49 disorder
       Region 4yr8 F 50-57 order
       Region 4yr8 F 58-59 disorder
       Region 4yr8 F 60-93 order
       Region 4yr8 F 94-103 disorder
       Region 4yr8 F 104-171 order
       Region 4yr8 F 172-187 disorder
       Region 4yr8 F 188-283 order
       Region 4yr8 F 284-285 disorder
       Region 4yr8 F 286-338 order
       Region 4yr8 F 339-353 disorder
       Region 4yr8 F 354-362 order
       Region 4yr8 F 363-363 disorder
Seq 1-364 Hetero dimer :
 Evidence X-RAY 2no3 B Reference
       Region 2no3 B 1-6 disorder
       Region 2no3 B 7-363 order
       Region 2no3 B 364-364 disorder
Seq 1-364 Hetero dimer :
 Evidence X-RAY 2no3 A Reference
       Region 2no3 A 1-7 disorder
       Region 2no3 A 8-364 order
Seq 1-364 Hetero octamer : O14733
 Evidence X-RAY 4ux9 A Reference
       Region 4ux9 A 1-7 disorder
       Region 4ux9 A 8-36 order
       Region 4ux9 A 37-37 disorder
       Region 4ux9 A 38-58 order
       Region 4ux9 A 59-59 disorder
       Region 4ux9 A 60-178 order
       Region 4ux9 A 179-183 disorder
       Region 4ux9 A 184-338 order
       Region 4ux9 A 339-344 disorder
       Region 4ux9 A 345-363 order
       Region 4ux9 A 364-364 disorder
 Evidence X-RAY 4ux9 B Reference
       Region 4ux9 B 1-7 disorder
       Region 4ux9 B 8-34 order
       Region 4ux9 B 35-38 disorder
       Region 4ux9 B 39-177 order
       Region 4ux9 B 178-183 disorder
       Region 4ux9 B 184-284 order
       Region 4ux9 B 285-288 disorder
       Region 4ux9 B 289-338 order
       Region 4ux9 B 339-352 disorder
       Region 4ux9 B 353-362 order
       Region 4ux9 B 363-364 disorder
 Evidence X-RAY 4ux9 C Reference
       Region 4ux9 C 1-7 disorder
       Region 4ux9 C 8-35 order
       Region 4ux9 C 36-36 disorder
       Region 4ux9 C 37-177 order
       Region 4ux9 C 178-184 disorder
       Region 4ux9 C 185-281 order
       Region 4ux9 C 282-288 disorder
       Region 4ux9 C 289-338 order
       Region 4ux9 C 339-346 disorder
       Region 4ux9 C 347-363 order
       Region 4ux9 C 364-364 disorder
 Evidence X-RAY 4ux9 D Reference
       Region 4ux9 D 1-8 disorder
       Region 4ux9 D 9-32 order
       Region 4ux9 D 33-38 disorder
       Region 4ux9 D 39-283 order
       Region 4ux9 D 284-286 disorder
       Region 4ux9 D 287-339 order
       Region 4ux9 D 340-342 disorder
       Region 4ux9 D 343-364 order
Seq 1-364 Monomer :
 Evidence X-RAY 4awi A Reference
       Region 4awi A 1-7 disorder
       Region 4awi A 8-173 order
       Region 4awi A 174-178 disorder
       Region 4awi A 179-364 order
 Evidence X-RAY 3elj A Reference
       Region 3elj A 1-6 disorder
       Region 3elj A 7-172 order
       Region 3elj A 173-178 disorder
       Region 3elj A 179-338 order
       Region 3elj A 339-343 disorder
       Region 3elj A 344-364 order
 Evidence X-RAY 4l7f A Reference
       Region 4l7f A 7-172 order
       Region 4l7f A 173-185 disorder
       Region 4l7f A 186-362 order
 Evidence X-RAY 3pze A Reference
       Region 3pze A 7-172 order
       Region 3pze A 173-178 disorder
       Region 3pze A 179-183 order
       Region 3pze A 184-186 disorder
       Region 3pze A 187-362 order
       Region 3pze A 363-364 disorder
 Evidence X-RAY 4qtd A Reference
       Region 4qtd A 1-5 disorder
       Region 4qtd A 6-175 order
       Region 4qtd A 176-178 disorder
       Region 4qtd A 179-363 order
Seq 1-364 Hetero tetramer : IID50056Complex
 Evidence X-RAY 3o17 A Reference
       Region 3o17 A 1-6 disorder
       Region 3o17 A 7-363 order
       Region 3o17 A 364-364 disorder
 Evidence X-RAY 3o17 B Reference
       Region 3o17 B 1-6 disorder
       Region 3o17 B 7-363 order
       Region 3o17 B 364-364 disorder
Seq 1-364 Hetero dimer : IID00227Complex
 Evidence X-RAY 4e73 A Reference
       Region 4e73 A 1-7 disorder
       Region 4e73 A 8-173 order
       Region 4e73 A 174-188 disorder
       Region 4e73 A 189-281 order
       Region 4e73 A 282-289 disorder
       Region 4e73 A 290-331 order
       Region 4e73 A 332-344 disorder
       Region 4e73 A 345-361 order
       Region 4e73 A 362-363 disorder
 Evidence X-RAY 2g01 A Reference
       Region 2g01 A 1-9 disorder
       Region 2g01 A 10-364 order
 Evidence X-RAY 2g01 B Reference
       Region 2g01 B 1-8 disorder
       Region 2g01 B 9-364 order
 Evidence X-RAY 2gmx A Reference
       Region 2gmx A 1-7 disorder
       Region 2gmx A 8-364 order
 Evidence X-RAY 2gmx B Reference
       Region 2gmx B 1-6 disorder
       Region 2gmx B 7-363 order
       Region 2gmx B 364-364 disorder
 Evidence X-RAY 2h96 A Reference
       Region 2h96 A 1-6 disorder
       Region 2h96 A 7-364 order
 Evidence X-RAY 2h96 B Reference
       Region 2h96 B 1-6 disorder
       Region 2h96 B 7-363 order
       Region 2h96 B 364-364 disorder
 Evidence X-RAY 4hys A Reference
       Region 4hys A 1-7 disorder
       Region 4hys A 8-172 order
       Region 4hys A 173-187 disorder
       Region 4hys A 188-281 order
       Region 4hys A 282-289 disorder
       Region 4hys A 290-334 order
       Region 4hys A 335-344 disorder
       Region 4hys A 345-361 order
       Region 4hys A 362-363 disorder
 Evidence X-RAY 4hyu A Reference
       Region 4hyu A 1-7 disorder
       Region 4hyu A 8-172 order
       Region 4hyu A 173-187 disorder
       Region 4hyu A 188-281 order
       Region 4hyu A 282-288 disorder
       Region 4hyu A 289-334 order
       Region 4hyu A 335-344 disorder
       Region 4hyu A 345-361 order
       Region 4hyu A 362-363 disorder
 Evidence X-RAY 4izy A Reference
       Region 4izy A 1-7 disorder
       Region 4izy A 8-172 order
       Region 4izy A 173-187 disorder
       Region 4izy A 188-281 order
       Region 4izy A 282-288 disorder
       Region 4izy A 289-334 order
       Region 4izy A 335-344 disorder
       Region 4izy A 345-361 order
       Region 4izy A 362-363 disorder
 Evidence X-RAY 3vud A Reference
       Region 3vud A 1-6 disorder
       Region 3vud A 7-179 order
       Region 3vud A 180-182 disorder
       Region 3vud A 183-364 order
 Evidence X-RAY 3vug A Reference
       Region 3vug A 1-6 disorder
       Region 3vug A 7-179 order
       Region 3vug A 180-182 disorder
       Region 3vug A 183-364 order
 Evidence X-RAY 3vuh A Reference
       Region 3vuh A 1-6 disorder
       Region 3vuh A 7-179 order
       Region 3vuh A 180-182 disorder
       Region 3vuh A 183-364 order
 Evidence X-RAY 3vui A Reference
       Region 3vui A 1-6 disorder
       Region 3vui A 7-179 order
       Region 3vui A 180-182 disorder
       Region 3vui A 183-364 order
 Evidence X-RAY 3vuk A Reference
       Region 3vuk A 1-6 disorder
       Region 3vuk A 7-179 order
       Region 3vuk A 180-182 disorder
       Region 3vuk A 183-364 order
 Evidence X-RAY 3vul A Reference
       Region 3vul A 1-6 disorder
       Region 3vul A 7-174 order
       Region 3vul A 175-188 disorder
       Region 3vul A 189-364 order
 Evidence X-RAY 3vum A Reference
       Region 3vum A 1-6 disorder
       Region 3vum A 7-174 order
       Region 3vum A 175-188 disorder
       Region 3vum A 189-364 order
 Evidence X-RAY 4g1w A Reference
       Region 4g1w A 1-7 disorder
       Region 4g1w A 8-172 order
       Region 4g1w A 173-187 disorder
       Region 4g1w A 188-281 order
       Region 4g1w A 282-288 disorder
       Region 4g1w A 289-334 order
       Region 4g1w A 335-344 disorder
       Region 4g1w A 345-361 order
       Region 4g1w A 362-363 disorder
Seq 1-366 Hetero dimer : IID50056Complex
 Evidence X-RAY 3o2m A Reference
       Region 3o2m A 1-6 disorder
       Region 3o2m A 7-364 order
 Evidence X-RAY 3o2m B Reference
       Region 3o2m B 1-6 disorder
       Region 3o2m B 7-364 order
 Evidence X-RAY 1ukh A Reference
       Region 1ukh A 1-8 disorder
       Region 1ukh A 9-172 order
       Region 1ukh A 173-189 disorder
       Region 1ukh A 190-281 order
       Region 1ukh A 282-286 disorder
       Region 1ukh A 287-336 order
       Region 1ukh A 337-348 disorder
       Region 1ukh A 349-363 order
 Evidence X-RAY 1uki A Reference
       Region 1uki A 1-8 disorder
       Region 1uki A 9-174 order
       Region 1uki A 175-187 disorder
       Region 1uki A 188-281 order
       Region 1uki A 282-286 disorder
       Region 1uki A 287-337 order
       Region 1uki A 338-346 disorder
       Region 1uki A 347-363 order
 Evidence X-RAY 3v3v A Reference
       Region 3v3v A 1-6 disorder
       Region 3v3v A 7-179 order
       Region 3v3v A 180-183 disorder
       Region 3v3v A 184-286 order
       Region 3v3v A 287-288 disorder
       Region 3v3v A 289-363 order
       Region 3v3v A 364-366 disorder
Seq 1-379 Hetero dimer : IID00466Complex
 Evidence X-RAY 2xrw A Reference
       Region 2xrw A 2-172 order
       Region 2xrw A 173-188 disorder
       Region 2xrw A 189-364 order
 Evidence X-RAY 2xs0 A Reference
       Region 2xs0 A 1-5 disorder
       Region 2xs0 A 6-173 order
       Region 2xs0 A 174-187 disorder
       Region 2xs0 A 188-365 order
       Region 2xs0 A 366-379 disorder
Seq 2-363 Hetero trimer : IID00227Complex
 Evidence X-RAY 5lw1 H Reference
       Region 5lw1 H 2-7 disorder
       Region 5lw1 H 8-362 order
       Region 5lw1 H 363-363 disorder
Seq 2-363 Hetero trimer : IID00227Complex
 Evidence X-RAY 5lw1 B Reference
       Region 5lw1 B 2-7 disorder
       Region 5lw1 B 8-362 order
       Region 5lw1 B 363-363 disorder
Seq 2-363 Hetero trimer : IID50056Complex
 Evidence X-RAY 6f5e B Reference
       Region 6f5e B 2-6 disorder
       Region 6f5e B 7-32 order
       Region 6f5e B 33-38 disorder
       Region 6f5e B 39-181 order
       Region 6f5e B 182-185 disorder
       Region 6f5e B 186-362 order
       Region 6f5e B 363-363 disorder
Seq 2-363 Hetero trimer : IID00227Complex
 Evidence X-RAY 5lw1 E Reference
       Region 5lw1 E 2-7 disorder
       Region 5lw1 E 8-362 order
       Region 5lw1 E 363-363 disorder
Seqphosphorylation
    183-183 Phosphothreonine; by MAP2K7
    185-185 Phosphotyrosine; by MAP2K4
    377-377 Phosphoserine
 
Prediction
DICHOT
Disorder 1-1,365-427
Known Domain 2-364
SCOPe RPS-Blast
     2xrwA1 2-362 e-160 d.144.1.7 3-phosphoinositide dependent protein k...
SCOP Hmmer
     2b1pA1 12-357 2.8e-95 Protein kinase-like (PK-...
Pfam RPS-Blast
     PF06293 54-181 2e-09 Lipopolysaccharide kinase (K...
Pfam Hmmer
    PF00069 26-321 4.1e-67 Protein kinase domain