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IID00278
 UniprotQ14118
ProteinDystroglycan
GeneDAG1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
895
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 52-315 Monomer :
 Evidence X-RAY 5llk A Reference
       Region 5llk A 52-60 disorder
       Region 5llk A 61-162 order
       Region 5llk A 163-180 disorder
       Region 5llk A 181-304 order
       Region 5llk A 305-315 disorder
Seq 316-325 Hetero tetramer : Q8WZA1
 Evidence X-RAY 5ggp C Reference
       Region 5ggp C 316-316 disorder
       Region 5ggp C 317-321 order
       Region 5ggp C 322-325 disorder
 Evidence X-RAY 5ggp D Reference
       Region 5ggp D 316-316 disorder
       Region 5ggp D 317-325 order
Seq 419-427 Monomer :
 Evidence NMR 2mk7 A Reference
       Region 2mk7 A 419-427 order
Seq 881-895 Hetero dimer : IID00267Complex
 Evidence X-RAY 1eg4 P Reference
       Region 1eg4 P 881-881 disorder
       Region 1eg4 P 882-894 order
       Region 1eg4 P 895-895 disorder
SeqProS predicted 317-325 The unbound state of this region is predicted to be disordered by DICHOT and MobiDB. Hetero tetramer : Q8WZA1
       Region 5ggp C 317-321 order
       Region 5ggp D 317-325 order
SeqProS predicted 882-894 The unbound state of this region is predicted to be disordered by DICHOT and MobiDB. Hetero dimer : IID00267Complex
       Region 1eg4 P 882-894 order
Seqphosphorylation
    892-892 Phosphotyrosine; by SRC
    790-790 Phosphothreonine
    790-790 Phosphothreonine
    892-892 Phosphotyrosine; by SRC
 
Prediction
NeProc
Disorder 1-49,164-174,318-492,724-740,807-895
Order 50-159,175-303,311-317,493-723,746-780,786-806
ProS 1-49,318-340,367-381,415-423,443-448,459-465,724-728,818-824,846-855,860-869,877-895
AlphaFold
Disorder 1-63,160-180,304-492,542-543,600-602,652-654,721-748,779-895
Order 64-159,181-303,493-541,544-599,603-651,655-720,749-778
SEG 7-23 ,340-353 ,413-467 ,528-540 ,754-771 ,807-816 ,858-872 ,885-895
Function
Function in SwissProt
Alpha-dystroglycan is an extracellular peripheral glycoprotein that acts as a receptor for both extracellular matrix proteins containing laminin-G domains. Receptor for laminin-2 (LAMA2) and agrin in peripheral nerve Schwann cells.Beta-dystroglycan is a transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.
(Microbial infection) Alpha-dystroglycan acts as a receptor for lassa virus and lymphocytic choriomeningitis virus glycoprotein and class C new-world arenaviruses (PubMed:16254364, PubMed:19324387, PubMed:17360738). Alpha-dystroglycan acts as a Schwann cell receptor for Mycobacterium leprae, the causative organism of leprosy, but only in the presence of the G-domain of LAMA2 (PubMed:9851927).