IDEAL List

IDEAL

IID00281
UniprotQ7Z589
ProteinBRCA2-interacting transcriptional repressor EMSY
GeneEMSY
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
Network xml rdf

Structure

Experiment

:order disorder conflict PDB cluster ProS Pfam Domain SEG

1322

order/disorder by at least rule

disorder by at least rule

order by at least rule

order/disorder by majority rule

Seq 1-108 Homo dimer :

Evidence X-RAY 1uz3 B Reference

Region 1uz3 B 1-1 disorder

Region 1uz3 B 2-98 order

Region 1uz3 B 99-100 disorder

Evidence X-RAY 1uz3 A Reference

Region 1uz3 A 1-100 order

Evidence X-RAY 1utu B Reference

Region 1utu B 1-9 disorder

Region 1utu B 10-104 order

Region 1utu B 105-108 disorder

Evidence X-RAY 1utu A Reference

Region 1utu A 1-10 disorder

Region 1utu A 11-106 order

Region 1utu A 107-108 disorder

Seq 9-139 Hetero decamer : IID00275Complex

Evidence X-RAY 2fmm E Reference

Region 2fmm E 9-124 order

Region 2fmm E 125-139 disorder

Seqphosphorylation

207-207 Phosphothreonine

209-209 Phosphoserine

213-213 Phosphoserine

238-238 Phosphoserine

818-818 Phosphoserine

821-821 Phosphoserine

1136-1136 Phosphoserine

Prediction

NeProc

Disorder 109-1322

Order 1-108

ProS 109-127,136-141,1273-1276,1281-1289

AlphaFold

Disorder 1-1,135-178,190-931,933-936,939-1322

Order 2-134,179-189,932-932,937-938

Pfam Hmmer

PF03735 16-88 1.9e-19

SEG 110-123 ,145-162 ,209-213 ,262-284 ,326-344 ,349-368 ,405-442 ,563-576 ,578-593 ,717-734 ,857-866 ,916-932 ,941-956 ,1248-1266

Function

Function in SwissProt

Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin (PubMed:14651845). Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2 (PubMed:14651845). Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:19131338).